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  1. Article ; Online: Methodology in the GBD study of China.

    Lin, Ping-I / Glatt, Stephen J / Tsuang, Ming T

    Lancet (London, England)

    2020  Volume 396, Issue 10243, Page(s) 25

    MeSH term(s) China ; Global Burden of Disease ; Morbidity ; Risk Factors ; Systems Analysis
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30483-9
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  2. Article ; Online: How should we interpret and value the pursuit of blood-based biomarkers for autism spectrum disorders?

    Glatt, Stephen J

    Journal of the American Academy of Child and Adolescent Psychiatry

    2013  Volume 52, Issue 12, Page(s) 1248–1250

    MeSH term(s) Biomarkers/blood ; Child Development Disorders, Pervasive/blood ; Child Development Disorders, Pervasive/diagnosis ; Humans ; Transcriptome/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2013.08.022
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  3. Article ; Online: Bipolar Disorder, Religion, and Spirituality: A Scoping Review.

    Jackson, Daniel C / McLawhorn, Donald E / Slutzky, Amy R / Glatt, Stephen J / Daly, Robert W

    Journal of religion and health

    2022  Volume 61, Issue 5, Page(s) 3589–3614

    Abstract: Mental health clinicians frequently study the religion and spirituality (R/S) of their patients. There is, however, a paucity of empirical research concerning R/S of patients with bipolar disorder. This lack is exacerbated by the absence of an evaluation ...

    Abstract Mental health clinicians frequently study the religion and spirituality (R/S) of their patients. There is, however, a paucity of empirical research concerning R/S of patients with bipolar disorder. This lack is exacerbated by the absence of an evaluation of how these studies relate to each other. Reviews to date concern almost exclusively quantitative studies; a review that synthesizes quantitative and qualitative research is needed. The aim of this paper is to provide a synthesis of empirical studies that is useful in clinical practice. Systematic searches for relevant journal articles in SCOPUS, PubMed, and PsycInfo found 14 quantitative and four qualitative studies. The research reveals that intrinsic religiosity and positive religious coping are the dimensions of R/S that have the most positive correlations with improvement of bipolar disorder symptoms as revealed by measures of clinical outcomes. Patients struggle with their religious experiences, and they wish that R/S would be taken into account by mental health professionals. The quantitative studies are not in conflict with the patient/person-centered focus of qualitative studies. This integration of quantitative data with a patient/person-centered focus shows how belief and illness affect each other. The tensions inherent in such an integration provide new insights for research and treatment. Unfortunately, the qualitative literature has not caught up with quantitative approaches in terms of diagnostic rigor.
    MeSH term(s) Adaptation, Psychological ; Bipolar Disorder/psychology ; Humans ; Mental Health ; Religion ; Spirituality
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2017250-3
    ISSN 1573-6571 ; 0022-4197
    ISSN (online) 1573-6571
    ISSN 0022-4197
    DOI 10.1007/s10943-022-01502-y
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  4. Article ; Online: miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease.

    Barnett, Michelle M / Reay, William R / Geaghan, Michael P / Kiltschewskij, Dylan J / Green, Melissa J / Weidenhofer, Judith / Glatt, Stephen J / Cairns, Murray J

    Science advances

    2023  Volume 9, Issue 48, Page(s) eadi4386

    Abstract: While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are ... ...

    Abstract While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are reflected in their extracellular vesicles (EVs), we hypothesized that the fractionation of neuron derived EVs provides an opportunity to specifically profile their encapsulated contents noninvasively from blood. To investigate this hypothesis, we determined miRNA expression in microtubule associated protein 1B (MAP1B)-enriched serum EVs derived from neurons from a large cohort of individuals with schizophrenia and nonpsychiatric comparison participants. We observed dysregulation of miRNA in schizophrenia subjects, in particular those with treatment-resistance and severe cognitive deficits. These data support the hypothesis that schizophrenia is associated with alterations in posttranscriptional regulation of synaptic gene expression and provides an example of the potential utility of tissue-specific EV analysis in brain disorders.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Schizophrenia/genetics ; Schizophrenia/metabolism ; Neurons/metabolism ; Extracellular Vesicles/metabolism ; Brain Diseases
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi4386
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  5. Article ; Online: Reward Functioning in General and Specific Psychopathology in Children and Adults.

    Saxena, Ankita / Hartman, Catharina A / Blatt, Steven D / Fremont, Wanda P / Glatt, Stephen J / Faraone, Stephen V / Zhang-James, Yanli

    Journal of attention disorders

    2023  Volume 28, Issue 1, Page(s) 77–88

    Abstract: Objective: Problems with reward processing have been implicated in multiple psychiatric disorders, but psychiatric comorbidities are common and their specificity to individual psychopathologies is unknown. Here, we evaluate the association between ... ...

    Abstract Objective: Problems with reward processing have been implicated in multiple psychiatric disorders, but psychiatric comorbidities are common and their specificity to individual psychopathologies is unknown. Here, we evaluate the association between reward functioning and general or specific psychopathologies.
    Method: 1,213 adults and their1,531 children (ages 6-12) completed various measures of the Positive Valence System domain from the Research Domain Criteria (RDoC). Psychopathology was assessed using the Child Behavior Checklist for children and the Adult Self Report for parents.
    Results: One general factor identified
    Conclusion: Reward dysfunction is significantly associated with both general and specific psychopathologies.
    MeSH term(s) Adult ; Humans ; Child ; Attention Deficit Disorder with Hyperactivity ; Psychopathology ; Comorbidity ; Self Report ; Reward
    Language English
    Publishing date 2023-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231201867
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  6. Article ; Online: Optimizing the chances of success in the search for epigenetic biomarkers: Embracing genetic variation.

    Philibert, Robert / Glatt, Stephen J

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2017  Volume 174, Issue 6, Page(s) 589–594

    Abstract: The emphasis on clinical translation in biomedical research continues to grow. This focus has been particularly notable in those investigators using epigenetic approaches to decipher the biology of complex behavioral disorders. As a result of these ... ...

    Abstract The emphasis on clinical translation in biomedical research continues to grow. This focus has been particularly notable in those investigators using epigenetic approaches to decipher the biology of complex behavioral disorders. As a result of these efforts, reproducible findings for several disorders, such as smoking, have been generated, giving rise to hopes that biomarkers for other behavioral illnesses would be forthcoming. Unfortunately, that biomedical cornucopia has not yet materialized. In this editorial, we review progress to date and discuss barriers to generating epigenetic biomarkers for complex behavioral disorders. We highlight the need to incorporate information on genetic variation and develop more powerful bioinformatics tools in order to optimize the likelihood of success. We emphasize that searches should focus on clearly defined, readily distinguishable behavioral constructs and suggest that some well-intentioned methods, such as correction for cellular heterogeneity, may actually impede the identification of clinically relevant biomarkers in peripheral blood. Finally, we describe how the understanding created by the development of these biomarkers may lead to more valid animal models of neuropsychiatric illness. We conclude that the prospects for epigenetic biomarkers for complex disorders are bright, but emphasize that the journey to the clinical implementation of these findings will be a slow, iterative process.
    MeSH term(s) Animals ; Biomarkers/analysis ; Epigenesis, Genetic ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108616-3
    ISSN 1552-485X ; 1552-4841 ; 0148-7299
    ISSN (online) 1552-485X
    ISSN 1552-4841 ; 0148-7299
    DOI 10.1002/ajmg.b.32569
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  7. Article ; Online: A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.

    Hess, Jonathan L / Mattheisen, Manuel / Greenwood, Tiffany A / Tsuang, Ming T / Edenberg, Howard J / Holmans, Peter / Faraone, Stephen V / Glatt, Stephen J

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2023  Volume 195, Issue 2, Page(s) e32957

    Abstract: Identifying heritable factors that moderate the genetic risk for schizophrenia (SCZ) could help clarify why some individuals remain unaffected despite having relatively high genetic liability. Previously, we developed a framework to mine genome-wide ... ...

    Abstract Identifying heritable factors that moderate the genetic risk for schizophrenia (SCZ) could help clarify why some individuals remain unaffected despite having relatively high genetic liability. Previously, we developed a framework to mine genome-wide association (GWAS) data for common genetic variants that protect high-risk unaffected individuals from SCZ, leading to derivation of the first-ever "polygenic resilience score" for SCZ (resilient controls n = 3786; polygenic risk score-matched SCZ cases n = 18,619). Here, we performed a replication study to verify the moderating effect of our polygenic resilience score on SCZ risk (OR = 1.09, p = 4.03 × 10
    MeSH term(s) Humans ; Schizophrenia/genetics ; Genome-Wide Association Study ; Resilience, Psychological ; Genetic Predisposition to Disease ; Multifactorial Inheritance/genetics ; Genomics ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108616-3
    ISSN 1552-485X ; 1552-4841 ; 0148-7299
    ISSN (online) 1552-485X
    ISSN 1552-4841 ; 0148-7299
    DOI 10.1002/ajmg.b.32957
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  8. Article ; Online: Psychiatric Genetics, Epigenetics, and Cellular Models in Coming Years.

    Liu, Chunyu / Faraone, Stephen V / Glatt, Stephen J

    Journal of psychiatry and brain science

    2019  Volume 4

    Abstract: Psychiatric genetic studies have uncovered hundreds of loci associated with various psychiatric disorders. We take the opportunity to review achievements in the past and provide our view of what is coming in the fields of molecular genetics, epigenetics, ...

    Abstract Psychiatric genetic studies have uncovered hundreds of loci associated with various psychiatric disorders. We take the opportunity to review achievements in the past and provide our view of what is coming in the fields of molecular genetics, epigenetics, and cellular models. We expect that SNP-array and sequencing-based studies of genetic associations will continue to expand, covering more disorders, drug responses, phenotypes, and diverse populations. Epigenetic studies of psychiatric disorders will be another promising field with the growing recognition that environmental factors impact the risk for psychiatric disorders by modulating epigenetic factors. Functional studies of genetic findings will be needed in cellular models to provide important connections between genetic and epigenetic variants and biological phenotypes.
    Language English
    Publishing date 2019-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2398-385X
    ISSN (online) 2398-385X
    DOI 10.20900/jpbs.20190012
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  9. Article: Inconsistent Methods Used to Set Airway Pressure Release Ventilation in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Regression Analysis.

    Lutz, Mark R / Charlamb, Jacob / Kenna, Joshua R / Smith, Abigail / Glatt, Stephen J / Araos, Joaquin D / Andrews, Penny L / Habashi, Nader M / Nieman, Gary F / Ghosh, Auyon J

    Journal of clinical medicine

    2024  Volume 13, Issue 9

    Abstract: Airway pressure release ventilation (APRV) is a protective mechanical ventilation mode for patients with acute respiratory distress syndrome (ARDS) that theoretically may reduce ventilator-induced lung injury (VILI) and ARDS-related mortality. However, ... ...

    Abstract Airway pressure release ventilation (APRV) is a protective mechanical ventilation mode for patients with acute respiratory distress syndrome (ARDS) that theoretically may reduce ventilator-induced lung injury (VILI) and ARDS-related mortality. However, there is no standard method to set and adjust the APRV mode shown to be optimal. Therefore, we performed a meta-regression analysis to evaluate how the four individual APRV settings impacted the outcome in these patients.
    Language English
    Publishing date 2024-05-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13092690
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