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  1. Article ; Online: Temperature sensing and context-dependent thermal behavior in nematodes.

    Glauser, Dominique A

    Current opinion in neurobiology

    2022  Volume 73, Page(s) 102525

    Abstract: As small ectotherms, whose temperature equilibrates almost instantly with that of their environment, free-living nematodes rely on their behavior for thermoregulation. Caenorhabditis elegans has been extensively used as a model to address the fundamental ...

    Abstract As small ectotherms, whose temperature equilibrates almost instantly with that of their environment, free-living nematodes rely on their behavior for thermoregulation. Caenorhabditis elegans has been extensively used as a model to address the fundamental mechanisms involved in thermosensation and the production of temperature-dependent behaviors. Behavioral responses include avoidance of acute noxious heat or cold stimuli and thermotactic responses to innocuous temperatures to produce oriented navigation in spatial thermogradients. In order to produce these behaviors, C. elegans relies on its ability to detect thermal cues with exquisite sensitivity, orchestrate a set of specific behavioral responses and adapt these responses in specific contexts, including according to past sensory experience and current internal states. The present review focuses on recent advances in our understanding of the processes occurring at the molecular, cellular, and circuit levels that enable thermosensory information processing and plasticity.
    MeSH term(s) Adaptation, Physiological ; Animals ; Behavior, Animal/physiology ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins ; Temperature ; Thermosensing/physiology
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2022.102525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.

    Jordan, Aurore / Glauser, Dominique A

    Genetics

    2023  Volume 224, Issue 1

    Abstract: The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest given their ... ...

    Abstract The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest given their relevance to understand and treat pain conditions that represent a major health burden. Recent genome-wide association studies (GWAS) have identified a rich set of polymorphisms related to different pain conditions and pointed to many human pain gene candidates, whose connection to the pain pathways is however often poorly understood. Here, we used a computer-assisted Caenorhabditis elegans thermal avoidance analysis pipeline to screen for behavioral defects in a set of 109 mutants for genes orthologous to human pain-related genes. We measured heat-evoked reversal thermosensitivity profiles, as well as spontaneous reversal rate, and compared naïve animals with adapted animals submitted to a series of repeated noxious heat stimuli, which in wild type causes a progressive habituation. Mutations affecting 28 genes displayed defects in at least one of the considered parameters and could be clustered based on specific phenotypic footprints, such as high-sensitivity mutants, nonadapting mutants, or mutants combining multiple defects. Collectively, our data reveal the functional architecture of a network of conserved pain-related genes in C. elegans and offer novel entry points for the characterization of poorly understood human pain genes in this genetic model.
    MeSH term(s) Animals ; Humans ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Nociception/physiology ; Genome-Wide Association Study ; Pain
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyad047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a

    Ippolito, Domenica / Glauser, Dominique A

    eLife

    2023  Volume 12

    Abstract: Nociceptive habituation is a conserved process through which pain sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation ... ...

    Abstract Nociceptive habituation is a conserved process through which pain sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation in
    MeSH term(s) Animals ; Active Transport, Cell Nucleus ; Caenorhabditis elegans/metabolism ; Calcium/metabolism ; Cell Nucleus/metabolism ; Nociceptors/metabolism ; Nuclear Localization Signals/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Caenorhabditis elegans Proteins/metabolism
    Chemical Substances Calcium (SY7Q814VUP) ; Nuclear Localization Signals ; cmk-1 protein, C elegans (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Caenorhabditis elegans Proteins
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.85260
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  4. Article ; Online: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans.

    Thapliyal, Saurabh / Beets, Isabel / Glauser, Dominique A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3052

    Abstract: Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional ... ...

    Abstract Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional behavioral changes remains poorly understood. Here, we show that C. elegans integrates environmental temperature and food availability over different timescales to engage in persistent dwelling, scanning, global or glocal search strategies matching thermoregulatory and feeding needs. Transition between states, in each case, involves regulating multiple processes including AFD or FLP tonic sensory neurons activity, neuropeptide expression and downstream circuit responsiveness. State-specific FLP-6 or FLP-5 neuropeptide signaling acts on a distributed set of inhibitory GPCR(s) to promote scanning or glocal search, respectively, bypassing dopamine and glutamate-dependent behavioral state control. Integration of multimodal context via multisite regulation in sensory circuits might represent a conserved regulatory logic for a flexible prioritization on the valence of multiple inputs when operating persistent behavioral state transitions.
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Sensory Receptor Cells/metabolism ; Neuropeptides/metabolism ; Signal Transduction
    Chemical Substances Caenorhabditis elegans Proteins ; Neuropeptides
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38685-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of

    Rudgalvyte, Martina / Atzei, Paola / de Brito Francisco, Rita / Naef, Reto / Glauser, Dominique A

    microPublication biology

    2024  Volume 2024

    Abstract: The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms ...

    Abstract The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms to human. Here we show that TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.001090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A system for the high-throughput analysis of acute thermal avoidance and adaptation in

    Lia, Andrei-Stefan / Glauser, Dominique A

    Journal of biological methods

    2020  Volume 7, Issue 1, Page(s) e129

    Abstract: Nociception and its plasticity are essential biological processes controlling adaptive behavioral responses in animals. These processes are also linked to different pain conditions in human and have received considerable attention, ... ...

    Abstract Nociception and its plasticity are essential biological processes controlling adaptive behavioral responses in animals. These processes are also linked to different pain conditions in human and have received considerable attention, notably
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 2326-9901
    ISSN (online) 2326-9901
    DOI 10.14440/jbm.2020.324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ca

    Ippolito, Domenica / Thapliyal, Saurabh / Glauser, Dominique A

    eLife

    2021  Volume 10

    Abstract: Sensory and behavioral plasticity are essential for animals to thrive in changing environments. As key effectors of intracellular calcium signaling, ... ...

    Abstract Sensory and behavioral plasticity are essential for animals to thrive in changing environments. As key effectors of intracellular calcium signaling, Ca
    MeSH term(s) Adaptation, Physiological ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Calcium Signaling ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Nucleus/metabolism ; Karyopherins/metabolism ; Sensory Receptor Cells/metabolism ; Thermosensing
    Chemical Substances Caenorhabditis elegans Proteins ; Karyopherins ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.71443
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  8. Article ; Online: Tissue-specific DamID protocol using nanopore sequencing.

    Gómez-Saldivar, Georgina / Glauser, Dominique A / Meister, Peter

    Journal of biological methods

    2021  Volume 8, Issue 3, Page(s) e152

    Abstract: DNA adenine methylation identification (DamID) is a powerful method to determine DNA binding profiles of proteins at a genomic scale. The method leverages the fusion between a protein of interest and the Dam methyltransferase ... ...

    Abstract DNA adenine methylation identification (DamID) is a powerful method to determine DNA binding profiles of proteins at a genomic scale. The method leverages the fusion between a protein of interest and the Dam methyltransferase of
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article
    ISSN 2326-9901
    ISSN (online) 2326-9901
    DOI 10.14440/jbm.2021.362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The multiplicity of alternative splicing decisions in Caenorhabditis elegans is linked to specific intronic regulatory motifs and minisatellites.

    Glauser, Dominique A

    BMC genomics

    2014  Volume 15, Page(s) 364

    Abstract: Background: Alternative splicing diversifies the pool of messenger RNA molecules encoded by individual genes. This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons. We know very ...

    Abstract Background: Alternative splicing diversifies the pool of messenger RNA molecules encoded by individual genes. This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons. We know very little on how the multiple decisions occurring during the maturation of single transcripts are coordinated and whether specific sequence elements might be involved.
    Results: Here, the Caenorhabditis elegans genome was surveyed in order to identify sequence elements that might play a specific role in the regulation of multiple splicing decisions. The introns flanking alternate exons in transcripts whose maturation involves multiple alternative splicing decisions were compared to those whose maturation involves a single decision. Fifty-eight penta-, hexa-, and hepta-meric elements, clustered in 17 groups, were significantly over-represented in genes subject to multiple alternative splicing decisions. Most of these motifs relate to known splicing regulatory elements and appear to be well conserved in the related species Caenorhabditis briggsae. The usage of specific motifs is not linked to the gene product function, but rather depends on the gene structure, since it is influenced by the distance separating the multiple splicing decision sites. Two of these motifs are part of the CeRep25B minisatellite, which is also over-represented at the vicinity of alternative splicing regions. Most of the remaining motifs are not part of repeated sequence elements, but tend to occur in specific heterologous pairs in genes subject to multiple alternative splicing decisions.
    Conclusions: The existence of specific intronic sequence elements linked to multiple alternative splicing decisions is intriguing and suggests that these elements might have some specialized regulatory role during splicing.
    MeSH term(s) Alternative Splicing/genetics ; Animals ; Base Sequence ; Caenorhabditis/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cluster Analysis ; Conserved Sequence ; Exons ; Genome ; Introns ; Minisatellite Repeats ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; RNA, Messenger ; RNA-Binding Proteins
    Language English
    Publishing date 2014-05-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/1471-2164-15-364
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  10. Article: How and why Caenorhabditis elegans uses distinct escape and avoidance regimes to minimize exposure to noxious heat.

    Glauser, Dominique A

    Worm

    2013  Volume 2, Issue 4, Page(s) e27285

    Abstract: Minimizing the exposure to deleterious extremes of temperature is essential for animals to avoid tissue damages. Because their body temperature equilibrates very rapidly with their surroundings, small invertebrates are particularly vulnerable to the ... ...

    Abstract Minimizing the exposure to deleterious extremes of temperature is essential for animals to avoid tissue damages. Because their body temperature equilibrates very rapidly with their surroundings, small invertebrates are particularly vulnerable to the deleterious impact of high temperatures, which jeopardizes their growth, fertility, and survival. The present article reviews recent analyses of Caenorhabditis elegans behavior in temperature gradients covering innocuous and noxious temperatures. These analyses have highlighted that worm uses two separate, multi-componential navigational strategies: an avoidance strategy, aiming at staying away from noxious heat, and an escape strategy, aiming at running away after exposure. Here, I explain why efficient escape and avoidance mechanisms are mutually exclusive and why worm needs to switch between distinct behavioral regimes to achieve efficient protective thermoregulation. Collectively, these findings reveal some largely unrecognized strategies improving worm goal-directed navigation and the fascinating level of sophistication of the behavioral responses deployed to minimize the exposure to noxious heat. Because switching between avoidance and escape regimes circumvents constraints that are valid for navigation behaviors in general, similar solutions might be used by worms and also other organisms in response to various environmental parameters covering an innocuous/noxious, non-toxic/toxic range.
    Language English
    Publishing date 2013-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682460-7
    ISSN 2162-4054 ; 2162-4046
    ISSN (online) 2162-4054
    ISSN 2162-4046
    DOI 10.4161/worm.27285
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