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  1. Article: Very Rare Peritoneal Surface Malignancies.

    Bhatt, Aditi / Glehen, Olivier

    Indian journal of surgical oncology

    2023  Volume 14, Issue Suppl 1, Page(s) 3–4

    Language English
    Publishing date 2023-01-24
    Publishing country India
    Document type Editorial
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-023-01706-y
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  2. Article: Hyperthermic Intraperitoneal Chemotherapy in the Treatment Armamentarium of Epithelial Ovarian Cancer: Time to End the Dichotomy.

    Bhatt, Aditi / Glehen, Olivier

    Visceral medicine

    2022  Volume 38, Issue 2, Page(s) 109–119

    Abstract: Background: Advanced epithelial ovarian cancer (EOC) is an incurable disease with over 75% of the patients developing recurrence in the peritoneum. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment option for both first-line ... ...

    Abstract Background: Advanced epithelial ovarian cancer (EOC) is an incurable disease with over 75% of the patients developing recurrence in the peritoneum. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment option for both first-line therapy and treatment of recurrence. In this article, we review the rationale and current evidence for performing HIPEC and the role of HIPEC in the light of targeted systemic therapies.
    Summary: There are few randomized trials and several retrospective studies on the role of HIPEC in the management of EOC. A 12-month-overall survival (OS) benefit of the addition of HIPEC to interval cytoreductive surgery (CRS) was demonstrated in 1 randomized trial following which HIPEC has been included as a treatment option for this indication in several national/international guidelines. One retrospective propensity score-matched analysis showed a 16-month OS benefit of adding HIPEC to primary CRS. One randomized trial showed no benefit of the addition of carboplatin HIPEC to secondary CRS over secondary CRS alone. For patients undergoing primary CRS and secondary CRS for recurrence, the results of ongoing randomized trials are needed to define the role of HIPEC in these situations. All clinical trials have shown that the morbidity of HIPEC performed after CRS is acceptable. Along with the emergence of HIPEC as a promising surgical therapy, targeted therapies like bevacizumab and poly adenosine diphosphate-ribose polymerase inhibitors have been developed that have shown a survival benefit in selected patients. In principle, HIPEC and targeted therapies work in different ways and it is plausible to assume that their benefit could be additive, and their combination should be evaluated in clinical trials. The impact of prognostic factors like the disease extent, pathological response to systemic chemotherapy (SC), the histological subtype and molecular profile on the benefit of HIPEC, and targeted therapies has not been evaluated in clinical trials.
    Key messages: HIPEC is an important therapeutic strategy in the treatment of EOC. While its role in patients undergoing interval CRS has been established, the results of ongoing randomized trials are needed to define its benefit at other time points. The morbidity of HIPEC in addition to CRS is acceptable. More research is needed to define subgroups that benefit most from HIPEC based on the extent of disease, response to SC, histology, and molecular profile. The combination of HIPEC and maintenance therapies should be evaluated in well-designed randomized clinical trials that evaluate not just the survival benefit and morbidity but also the cost-effectiveness of each therapy.
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2850733-2
    ISSN 2297-475X ; 2297-4725
    ISSN (online) 2297-475X
    ISSN 2297-4725
    DOI 10.1159/000521239
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2103: Show issues Location:
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  3. Article ; Online: Cytoreductive surgery in peritoneal carcinomatosis.

    Arquillière, J / Glehen, O / Passot, G

    Journal of visceral surgery

    2021  Volume 158, Issue 3, Page(s) 258–264

    MeSH term(s) Colorectal Neoplasms ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Humans ; Hyperthermia, Induced ; Peritoneal Neoplasms/surgery
    Language English
    Publishing date 2021-01-22
    Publishing country France
    Document type Journal Article
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2020.12.012
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  4. Article ; Online: ASO Author Reflections: Selected Multisite Metastatic Colorectal Cancer Patients May Benefit from Radical Multimodal Treatment.

    Kepenekian, Vahan / Grange, Rémi / Passot, Guillaume / Glehen, Olivier / Rousset, Pascal

    Annals of surgical oncology

    2024  Volume 31, Issue 4, Page(s) 2410–2411

    MeSH term(s) Humans ; Colonic Neoplasms ; Rectal Neoplasms ; Combined Modality Therapy ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/pathology
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-14929-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  5. Article ; Online: Spectral photon-counting CT: Hype or hope for colorectal peritoneal metastases imaging?

    Grange, Rémi / Si-Mohamed, Salim / Kepenekian, Vahan / Boccalini, Sara / Glehen, Olivier / Rousset, Pascal

    Diagnostic and interventional imaging

    2024  Volume 105, Issue 3, Page(s) 118–120

    MeSH term(s) Humans ; Peritoneal Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Peritoneum ; Colorectal Neoplasms/diagnostic imaging ; Phantoms, Imaging
    Language English
    Publishing date 2024-01-22
    Publishing country France
    Document type Letter
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2024.01.002
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  6. Article ; Online: ASO Author Reflections: Redefining Consolidation Cytoreductive Surgery for Ovarian Cancer.

    Bhatt, Aditi / Alcazer, Vincent / Frankinet, Lisa / Bakrin, Naoual / Glehen, Olivier

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3300–3301

    MeSH term(s) Humans ; Female ; Cytoreduction Surgical Procedures ; Ovarian Neoplasms/surgery ; Peritoneal Neoplasms
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13244-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  7. Article: Histopathological Evaluation and Molecular Diagnostic Tests for Peritoneal Metastases with Unknown Primary Site-a Review.

    Bhatt, Aditi / Mishra, Suniti / Glehen, Olivier

    Indian journal of surgical oncology

    2022  Volume 14, Issue Suppl 1, Page(s) 15–29

    Abstract: Cancer of unknown primary (CUP) is a well-studied entity with guidelines available for the management of patients with CUP. The peritoneum represents one of the metastatic sites in CUP, and peritoneal metastases (PM) could present as CUP. PM of unknown ... ...

    Abstract Cancer of unknown primary (CUP) is a well-studied entity with guidelines available for the management of patients with CUP. The peritoneum represents one of the metastatic sites in CUP, and peritoneal metastases (PM) could present as CUP. PM of unknown origin remains a poorly studied clinical entity. There is only one series of 15 cases, one population-based study, and few other case reports on this subject. Studies on CUP, in general, cover some common tumour histological types like adenocarcinomas and squamous carcinomas. Some of these tumours may have a good prognosis though majority have high-grade disease with a poor long-term outcome. Some of the histological tumour types commonly seen in the clinical scenario of PM like mucinous carcinoma have not been studied. In this review, we divide PM into five histological types-adenocarcinomas, serous carcinomas, mucinous carcinomas, sarcomas and other rare varieties. We provide algorithms to identify the primary tumour site using immunohistochemistry when imaging, and endoscopy fails to establish the primary tumour site. The role of molecular diagnostic tests for PM or unknown origin is also discussed. Current literature on site-specific systemic therapy based on gene expression profiling does not show a clear benefit of this approach over empirical systemic therapies.
    Language English
    Publishing date 2022-08-04
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01612-9
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  8. Article ; Online: Perspectives on Hyperthermic Intraperitoneal Chemotherapy for Advanced Ovarian Cancer.

    Bhatt, Aditi / Bhandoria, Geetu / Glehen, Olivier

    JAMA surgery

    2022  Volume 157, Issue 10, Page(s) 969–970

    MeSH term(s) Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Female ; Humans ; Hyperthermia, Induced ; Hyperthermic Intraperitoneal Chemotherapy ; Ovarian Neoplasms/drug therapy
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.2939
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.72: Show issues Location:
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  9. Article ; Online: Outcomes of a Phase II Study of Intraperitoneal Paclitaxel Plus Systemic Capecitabine and Oxaliplatin (XELOX) for Gastric Cancer with Peritoneal Metastases.

    Mariani, Antoine / Zaanan, Aziz / Glehen, Olivier / Karoui, Mehdi

    Annals of surgical oncology

    2022  

    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Letter
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12837-x
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: ASO Author Reflections: Tailoring the Extent of Peritoneal Resection for Peritoneal Metastases According to the Primary Tumor Site.

    Bhatt, Aditi / Glehen, Olivier

    Annals of surgical oncology

    2020  Volume 27, Issue 5, Page(s) 1471–1472

    MeSH term(s) Cytoreduction Surgical Procedures ; Humans ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/surgery
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08344-6
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    In stock of ZB MED Cologne/Königswinter

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