Article ; Online: Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study.
2024 Volume 41, Issue 4, Page(s) 317–321
Abstract: Summary: Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the ... ...
| Abstract | Summary: Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the presurgical evaluation, we present a proof-of-concept for using this approach in a patient with nonlesional frontal lobe epilepsy who underwent two resective surgeries to achieve seizure control. We conducted a post-hoc investigation using four neuroimaging and neurophysiology modalities: diffusion tensor imaging, resting-state functional MRI, and stereoelectroencephalography at rest and during seizures. We computed region-of-interest-based connectivity for each modality and applied betweenness centrality to identify key network hubs across modalities. Our results revealed that despite seizure semiology and stereoelectroencephalography indicating dysfunction in the right orbitofrontal region, the maximum overlap on the hubs across modalities extended to right temporal areas. Notably, the right middle temporal lobe region served as an overlap hub across diffusion tensor imaging, resting-state functional MRI, and rest stereoelectroencephalography networks and was only included in the resected area in the second surgery, which led to long-term seizure control of this patient. Our findings demonstrated that transmodal hubs could help identify key areas related to epileptogenic network. Therefore, this case presents a promising perspective of using a multimodal approach to improve the presurgical evaluation of patients with epilepsy. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Humans ; Electroencephalography/methods ; Diffusion Tensor Imaging ; Multimodal Imaging ; Magnetic Resonance Imaging/methods ; Neuroimaging/methods ; Adult ; Male ; Female ; Brain/surgery ; Brain/physiopathology ; Brain/diagnostic imaging ; Epilepsy/surgery ; Epilepsy/physiopathology ; Epilepsy/diagnostic imaging ; Epilepsy, Frontal Lobe/surgery ; Epilepsy, Frontal Lobe/physiopathology ; Epilepsy, Frontal Lobe/diagnostic imaging | |||||
| Language | English | |||||
| Publishing date | 2024-02-20 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 605640-4 | |||||
| ISSN | 1537-1603 ; 0736-0258 | |||||
| ISSN (online) | 1537-1603 | |||||
| ISSN | 0736-0258 | |||||
| DOI | 10.1097/WNP.0000000000001071 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1921: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.