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Article ; Online: Authors' reply to Tavabie.

Day, Chris / Glen, Jessica / Floros, Lefteris / Pryke, Rachel

2016 Volume 355, Page(s) i5436

Language	English
Publishing date	2016--11
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.i5436
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Article ; Online: Assessment and initial management of major trauma: summary of NICE guidance.

Glen, Jessica / Constanti, Margaret / Brohi, Karim

BMJ (Clinical research ed.)

2016 Volume 353, Page(s) i3051

MeSH term(s)	Bandages ; Blood Transfusion ; Hemorrhage/diagnostic imaging ; Hemorrhage/surgery ; Hemorrhage/therapy ; Hemostatics/therapeutic use ; Humans ; Multiple Trauma/diagnostic imaging ; Practice Guidelines as Topic ; Radiology, Interventional ; Thoracic Injuries/diagnostic imaging ; Tomography, X-Ray Computed ; Tourniquets ; Ultrasonography
Chemical Substances	Hemostatics
Language	English
Publishing date	2016-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.i3051
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Article ; Online: Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance.

Glen, Jessica / Floros, Lefteris / Day, Chris / Pryke, Rachel

BMJ (Clinical research ed.)

2016 Volume 354, Page(s) i4428

MeSH term(s)	Contraindications ; Health Promotion ; Healthy Lifestyle ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/therapy ; Practice Guidelines as Topic ; Referral and Consultation ; Risk Assessment ; Risk Factors
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2016-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.i4428
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Article ; Online: Less is more: A systematic review and meta-analysis of the outcomes of radical versus conservative primary resection in anorectal melanoma.

Smith, Henry G / Glen, Jessica / Turnbull, Nancy / Peach, Howard / Board, Ruth / Payne, Miranda / Gore, Martin / Nugent, Karen / Smith, Myles J F

European journal of cancer (Oxford, England : 1990)

2020 Volume 135, Page(s) 113–120

Abstract: Introduction: Anorectal melanoma (ARM) is a rare disease with a poor prognosis. There is no consensus as to the optimal primary surgical treatment for ARM, with advocates for both radical (abdominoperineal resection [APR]) and conservative strategies ( ... ...

Abstract	Introduction: Anorectal melanoma (ARM) is a rare disease with a poor prognosis. There is no consensus as to the optimal primary surgical treatment for ARM, with advocates for both radical (abdominoperineal resection [APR]) and conservative strategies (wide local excision [WLE]). Here, we report a systematic review of studies comparing outcomes between these strategies. Methods: Studies comparing APR with WLE in patients with ARM were included, and a systematic review using the Grading of Recommendations, Assessment, Development and Evaluation methodology was performed. Outcomes deemed critical included overall survival, disease-free survival, local recurrence and quality of life. Results: Forty studies were identified, of which 27 were suitable for inclusion. Twenty-three studies compared overall survival between WLE and APR, with no difference in outcomes noted (risk ratio [RR]: 0.80, 95% confidence interval [CI]: 0.60-1.07, p = 0.13). Seven studies compared disease-free survival, with no difference in outcomes noted (RR: 1.08, 95% CI: 0.61-1.91, p = 0.79). A total of 19 studies compared local recurrence rates, with again no significant difference in outcomes noted (RR: 0.71, 95% CI: 0.44-1.14, p = 0.16). None of the studies identified reported quality of life-related outcomes. Conclusion: There is no evidence to suggest that a radical primary surgical strategy improves outcomes in ARM. Therefore, given the well-documented morbidity associated with APR, WLE with regular surveillance for local recurrence should be the primary strategy in most patients.
MeSH term(s)	Anus Neoplasms/mortality ; Anus Neoplasms/pathology ; Anus Neoplasms/surgery ; Digestive System Surgical Procedures/adverse effects ; Digestive System Surgical Procedures/mortality ; Disease Progression ; Disease-Free Survival ; Humans ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/surgery ; Neoplasm Recurrence, Local ; Quality of Life ; Risk Assessment ; Risk Factors ; Time Factors
Language	English
Publishing date	2020-06-18
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.04.041
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management of anaemia in chronic kidney disease: summary of updated NICE guidance.

Padhi, Smita / Glen, Jessica / Pordes, Ben A J / Thomas, Mark E

BMJ (Clinical research ed.)

2015 Volume 350, Page(s) h2258

MeSH term(s)	Anemia/complications ; Anemia/diagnosis ; Anemia/therapy ; Humans ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
Language	English
Publishing date	2015-06-04
Publishing country	England
Document type	Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h2258
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Article ; Online: Venous Thromboembolism Prophylaxis Strategies for People Undergoing Elective Total Hip Replacement: A Systematic Review and Network Meta-Analysis.

Lewis, Sedina / Glen, Jessica / Dawoud, Dalia / Dias, Sofia / Cobb, Jill / Griffin, Xavier / Reed, Michael / Sharpin, Carlos / Stansby, Gerard / Barry, Peter

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

2019 Volume 22, Issue 8, Page(s) 953–969

Abstract: Objectives: To assess the efficacy and safety of venous thromboembolism prophylaxis in people undergoing elective total hip replacement.: Methods: Systematic review and Bayesian network meta-analyses of randomized controlled trials were conducted for ...

Abstract	Objectives: To assess the efficacy and safety of venous thromboembolism prophylaxis in people undergoing elective total hip replacement. Methods: Systematic review and Bayesian network meta-analyses of randomized controlled trials were conducted for 3 outcomes: deep vein thrombosis (DVT), pulmonary embolism (PE), and major bleeding (MB). MEDLINE, EMBASE, and Cochrane Library (CENTRAL) databases were searched. Study quality was assessed using the Cochrane risk-of-bias checklist. Fixed- and random-effects models were fitted and compared. The median relative risk (RR) and odds ratio (OR) compared with no prophylaxis, with their 95% credible intervals (CrIs), rank, and probability of being the best, were calculated. Results: Forty-two (n = 24 374, 26 interventions), 30 (n = 28 842, 23 interventions), and 24 (n = 31 792, 15 interventions) randomized controlled trials were included in the DVT, PE, and MB networks, respectively. Rivaroxaban had the highest probability of being the most effective intervention for DVT (RR 0.06 [95% CrI 0.01-0.29]). Strategy of low-molecular-weight heparin followed by aspirin had the highest probability of reducing the risk of PE and MB (RR 0.0011 [95% CrI 0.00-0.096] and OR 0.37 [95% CrI 0.00-26.96], respectively). The ranking of efficacy estimates across the 3 networks, particularly PE and MB, had very wide CrIs, indicating high degree of uncertainty. Conclusions: A strategy of low-molecular-weight heparin given for 10 days followed by aspirin for 28 days had the best benefit-risk balance, with the highest probability of being the best on the basis of the results of the PE and MB network meta-analyses. Nevertheless, there is considerable uncertainty around the median ranks of the interventions.
MeSH term(s)	Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/economics ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Aspirin/administration & dosage ; Aspirin/adverse effects ; Bayes Theorem ; Cost-Benefit Analysis ; Elective Surgical Procedures/adverse effects ; Elective Surgical Procedures/methods ; Hemorrhage/prevention & control ; Heparin, Low-Molecular-Weight/administration & dosage ; Heparin, Low-Molecular-Weight/adverse effects ; Humans ; Network Meta-Analysis ; Patient Preference ; Pulmonary Embolism/prevention & control ; Risk Assessment ; Rivaroxaban/administration & dosage ; Rivaroxaban/adverse effects ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants ; Heparin, Low-Molecular-Weight ; Rivaroxaban (9NDF7JZ4M3) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2019-05-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1471745-1
ISSN	1524-4733 ; 1098-3015
ISSN (online)	1524-4733
ISSN	1098-3015
DOI	10.1016/j.jval.2019.02.013
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Zs.A 5904: Show issues

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Article ; Online: Venous thromboembolism prophylaxis strategies for people undergoing elective total knee replacement: a systematic review and network meta-analysis.

Lewis, Sedina / Glen, Jessica / Dawoud, Dalia / Dias, Sofia / Cobb, Jill / Griffin, Xavier L / Rossiter, Nigel / Reed, Michael / Sharpin, Carlos / Stansby, Gerard / Barry, Peter

The Lancet. Haematology

2019 Volume 6, Issue 10, Page(s) e530–e539

Abstract: Background: Hospital-associated venous thromboembolism is a major patient safety concern. Provision of prophylaxis to patients admitted for elective total knee replacement surgery has been proposed as an effective strategy to reduce the incidence of ... ...

Abstract	Background: Hospital-associated venous thromboembolism is a major patient safety concern. Provision of prophylaxis to patients admitted for elective total knee replacement surgery has been proposed as an effective strategy to reduce the incidence of venous thromboembolism. We aimed to assess the relative efficacy and safety of all available prophylaxis strategies in this setting. Methods: We did a systematic review and Bayesian network meta-analyses of randomised controlled trials to assess the relative efficacy and safety of venous thromboembolism prophylaxis strategies and to populate an economic model that assessed the cost-effectiveness of these strategies and informed the updated National Institute for Health and Care Excellence (NICE) guideline recommendations for patients undergoing elective total knee replacement surgery. The Cochrane Library (CENTRAL), Embase, and Medline were last searched on June 19, 2017, with key terms relating to the population (venous thromboembolism and total knee replacement) and the interventions compared, including available pharmacological and mechanical interventions. Outcomes of interest were deep vein thrombosis (symptomatic and asymptomatic), pulmonary embolism, and major bleeding. Risk of bias was assessed, and relevant data extracted from the included randomised controlled trials for the network meta-analyses. Relative risks (RR; with 95% credible intervals [95% CrI]) compared to no prophylaxis, median ranks (with 95% CrI), and the probability of being the best intervention were calculated. The study was done in accordance with PRISMA guidelines. Findings: 25 randomised controlled trials were included in the network meta-analyses. 23 trials (19 interventions; n=15 028) were included in the deep vein thrombosis network, 12 in the pulmonary embolism network (13 interventions; n=15 555), and 19 in the major bleeding network (11 interventions; n=19 797). Risk of bias ranged from very low to high. Rivaroxaban ranked first for prevention of deep vein thrombosis (RR 0·12 [95% CrI 0·06-0·22]). Low molecular weight heparin (LMWH; standard prophylactic dose, 28-35 days) ranked first in the pulmonary embolism network (RR 0·02 [95% CrI 0·00-3·86]) and LMWH (low prophylactic dose, 10-14 days) ranked first in the major bleeding network (odds ratio 0·08 [95% CrI 0·00-1·76]), but the results for pulmonary embolism and major bleeding are highly uncertain. Interpretation: Single prophylaxis strategies are more effective in prevention of deep vein thrombosis in the elective total knee replacement population than combination strategies, with rivaroxaban being the most effective. The results of the pulmonary embolism and major bleeding meta-analyses are uncertain and no clear conclusion can be made other than what is biologically plausible (eg, that no prophylaxis and mechanical prophylaxis strategies should have the lowest risk of major bleeding). Funding: National Institute for Health and Care Excellence.
MeSH term(s)	Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Arthroplasty, Replacement, Knee ; Hemorrhage/etiology ; Heparin, Low-Molecular-Weight/adverse effects ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Odds Ratio ; Risk ; Venous Thromboembolism/pathology ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants ; Heparin, Low-Molecular-Weight
Language	English
Publishing date	2019-08-20
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	2352-3026
ISSN (online)	2352-3026
DOI	10.1016/S2352-3026(19)30155-3
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Article: Cost-Utility Analysis of Venous Thromboembolism Prophylaxis Strategies for People Undergoing Elective Total Hip and Total Knee Replacement Surgeries in the English National Health Service.

Dawoud, Dalia M / Wonderling, David / Glen, Jessica / Lewis, Sedina / Griffin, Xavier L / Hunt, Beverley J / Stansby, Gerard / Reed, Michael / Rossiter, Nigel / Chahal, Jagjot Kaur / Sharpin, Carlos / Barry, Peter

Frontiers in pharmacology

2018 Volume 9, Page(s) 1370

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2018-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01370
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Article ; Online: Ano-uro-genital mucosal melanoma UK national guidelines.

European journal of cancer (Oxford, England : 1990)

2020 Volume 135, Page(s) 22–30

Abstract: Ano-uro-genital (AUG) mucosal melanomas are rare cancers associated with poor outcomes and limited evidence-based management. The United Kingdom AUG mucosal melanoma guideline development group used an evidence-based systematic approach to make ... ...

Abstract	Ano-uro-genital (AUG) mucosal melanomas are rare cancers associated with poor outcomes and limited evidence-based management. The United Kingdom AUG mucosal melanoma guideline development group used an evidence-based systematic approach to make recommendations regarding the diagnosis, treatment and surveillance of patients diagnosed with AUG mucosal melanomas. The guidelines were sent for international peer review, and are accredited by The National Institute for Health and Clinical Excellence (NICE). A summary of the key recommendations is presented. The full documents are available on the Melanoma Focus website.
MeSH term(s)	Anus Neoplasms/mortality ; Anus Neoplasms/pathology ; Anus Neoplasms/therapy ; Consensus ; Female ; Humans ; Male ; Medical Oncology/standards ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Mucous Membrane/pathology ; Treatment Outcome ; United Kingdom ; Urogenital Neoplasms/mortality ; Urogenital Neoplasms/pathology ; Urogenital Neoplasms/therapy
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.04.030
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Diagnosis and Management of Iron Deficiency in CKD: A Summary of the NICE Guideline Recommendations and Their Rationale.

Ratcliffe, Laura E K / Thomas, Wayne / Glen, Jessica / Padhi, Smita / Pordes, Ben A J / Wonderling, David / Connell, Roy / Stephens, Suzanne / Mikhail, Ashraf I / Fogarty, Damian G / Cooper, Jan K / Dring, Belinda / Devonald, Mark A J / Brown, Chris / Thomas, Mark E

American journal of kidney diseases : the official journal of the National Kidney Foundation

2016 Volume 67, Issue 4, Page(s) 548–558

Abstract: The UK-based National Institute for Health and Care Excellence (NICE) has updated its guidance on iron deficiency and anemia management in chronic kidney disease. This report outlines the recommendations regarding iron deficiency and their rationale. ... ...

Abstract	The UK-based National Institute for Health and Care Excellence (NICE) has updated its guidance on iron deficiency and anemia management in chronic kidney disease. This report outlines the recommendations regarding iron deficiency and their rationale. Serum ferritin alone or transferrin saturation alone are no longer recommended as diagnostic tests to assess iron deficiency. Red blood cell markers (percentage hypochromic red blood cells, reticulocyte hemoglobin content, or reticulocyte hemoglobin equivalent) are better than ferritin level alone at predicting responsiveness to intravenous iron. When red blood cell markers are not available, a combination of transferrin saturation < 20% and ferritin level < 100ng/mL is an alternative. In comparisons of the cost-effectiveness of different iron status testing and treatment strategies, using percentage hypochromic red blood cells > 6% was the most cost-effective strategy for both hemodialysis and nonhemodialysis patients. A trial of oral iron replacement is recommended in people not receiving an erythropoiesis-stimulating agent (ESA) and not on hemodialysis therapy. For children receiving ESAs, but not treated by hemodialysis, oral iron should be considered. In adults and children receiving ESAs and/or on hemodialysis therapy, intravenous iron should be offered. When giving intravenous iron, high-dose low-frequency administration is recommended. For all children and for adults receiving in-center hemodialysis, low-dose high-frequency administration may be more appropriate.
MeSH term(s)	Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/etiology ; Anemia, Iron-Deficiency/therapy ; Erythropoietin/physiology ; Humans ; Iron/physiology ; Meta-Analysis as Topic ; Practice Guidelines as Topic ; Renal Insufficiency, Chronic/complications
Chemical Substances	Erythropoietin (11096-26-7) ; Iron (E1UOL152H7)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2015.11.012
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Zs.MO 468: Show issues

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