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  1. AU="Glendening, Gabrielle"
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  1. Article ; Online: Surface Contamination of Reusable Respirators and Face Shields During Care of Critically Ill COVID-19 Patients.

    Shah, Anand / Zhuang, Eileen / German, Jennifer / Tai, Sheldon / Schanz, Maria / Glendening, Gabrielle / Mason, Mackenzie / Kolesnik, Olga / Hines, Stella E

    Workplace health & safety

    2022  Volume 71, Issue 3, Page(s) 137–143

    Abstract: Background: With the emergence of SARS-CoV-2, healthcare workers (HCW) have relied on reusable personal protective equipment (PPE), including respirators and face shields (FSs). The effectiveness of decontamination procedures outside experimental ... ...

    Abstract Background: With the emergence of SARS-CoV-2, healthcare workers (HCW) have relied on reusable personal protective equipment (PPE), including respirators and face shields (FSs). The effectiveness of decontamination procedures outside experimental settings is unclear. We examined the prevalence of surface contamination on reusable PPE used by HCWs at a hospital incorporating daily centralized decontamination and post-use wiping by sampling for common pathogens.
    Method: Samples were collected from HCWs' CleanSpace Halo respirator face masks (FMs) and FSs at the start of shift, immediately after use, and after cleaning with disinfecting wipes. Samples were analyzed for pathogens using the Applied Biosystems™ TaqPath™ COVID-19 Combo Kit and ThermoFisher TaqMan Array Card. Patient charts were reviewed for clinical correlation.
    Findings: Of the 89 samples, 51 from FMs and 38 from FSs, none tested positive for SARS-CoV-2, despite 58 being obtained from PPE used in the care of patients with COVID-19, many with recent aerosol-generating procedures. Four samples tested positive (4.5%) for
    Conclusion/application to practice: Contamination of reusable PPE appears uncommon, especially with SARS-CoV-2, when regular decontamination programs are in place. The rare presence of
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Critical Illness ; Staphylococcus aureus ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Personal Protective Equipment ; Health Personnel ; Ventilators, Mechanical
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649181-3
    ISSN 2165-0969 ; 2165-0799
    ISSN (online) 2165-0969
    ISSN 2165-0799
    DOI 10.1177/21650799221135583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The structure of NAD

    Klontz, Erik / Obi, Juliet O / Wang, Yajing / Glendening, Gabrielle / Carr, Jahid / Tsibouris, Constantine / Buddula, Sahthi / Nallar, Shreeram / Soares, Alexei S / Beckett, Dorothy / Redzic, Jasmina S / Eisenmesser, Elan / Palm, Cheyenne / Schmidt, Katrina / Scudder, Alexis H / Obiorah, Trinity / Essuman, Kow / Milbrandt, Jeffrey / Diantonio, Aaron /
    Ray, Krishanu / Snyder, Michelle L D / Deredge, Daniel / Snyder, Greg A

    The Journal of biological chemistry

    2023  Volume 299, Issue 11, Page(s) 105290

    Abstract: Toll-like and interleukin-1/18 receptor/resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ ... ...

    Abstract Toll-like and interleukin-1/18 receptor/resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hydrolase activity in select bacteria, plants, and mammalian cells. We report the crystal structure of the Acinetobacter baumannii TIR domain protein (AbTir-TIR) with confirmed NAD
    MeSH term(s) Acinetobacter baumannii/genetics ; Acinetobacter baumannii/metabolism ; Bacteria/metabolism ; Bacterial Proteins/metabolism ; Deuterium ; Hydrolases/metabolism ; Mammals/metabolism ; NAD/metabolism ; Protein Domains
    Chemical Substances Bacterial Proteins ; Deuterium (AR09D82C7G) ; Hydrolases (EC 3.-) ; NAD (0U46U6E8UK)
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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