Article ; Online: Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β
2024 Volume 14, Issue 4
Abstract: This study assessed the suitability of the complementarity-determining region 2 (CDR2) of the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) targeting active-state ... ...
Abstract | This study assessed the suitability of the complementarity-determining region 2 (CDR2) of the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) targeting active-state β |
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MeSH term(s) | Receptors, Adrenergic, beta-2/metabolism ; Receptors, Adrenergic, beta-2/chemistry ; Humans ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/pharmacology ; Single-Domain Antibodies/metabolism ; Molecular Dynamics Simulation ; Peptides/chemistry ; Peptides/pharmacology ; Peptides/metabolism ; Complementarity Determining Regions/chemistry ; Molecular Docking Simulation ; Protein Binding ; Amino Acid Sequence ; Protein Conformation ; Cyclic AMP/metabolism |
Chemical Substances | Receptors, Adrenergic, beta-2 ; Single-Domain Antibodies ; Peptides ; Complementarity Determining Regions ; Cyclic AMP (E0399OZS9N) |
Language | English |
Publishing date | 2024-03-30 |
Publishing country | Switzerland |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2701262-1 |
ISSN | 2218-273X ; 2218-273X |
ISSN (online) | 2218-273X |
ISSN | 2218-273X |
DOI | 10.3390/biom14040423 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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