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  1. AU="Glickman, Scott"
  2. AU="Pokrovsky, Daniil"
  3. AU="Kotansky, Brian"
  4. AU="Kumaravel, Arthi"
  5. AU="Lordkipanize, David"
  6. AU="Kurzawinski, Tom R"
  7. AU="Wu, Xinwu"
  8. AU="Grijalva, Marcelo"
  9. AU="van Zuylen, Wendy J"
  10. AU="Asarnow, L D"
  11. AU="So, Ronald"
  12. AU="deSouza, Ashwin L"
  13. AU="Härtlova, Anetta"
  14. AU="Ghanem, Ahmed I"
  15. AU="Yue Lu"
  16. AU="Pincus, Laura B"
  17. AU="Ibrahim, Nashwan"
  18. AU=Bray Molly S AU=Bray Molly S
  19. AU="Bregy, Amadé"
  20. AU=Kaper J B
  21. AU="León-Ramón, Susana"
  22. AU="Simpson, Andrew"
  23. AU="Peters, Wibke"
  24. AU="Malik, Sajid Ali"
  25. AU="V, Gomathi"

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  1. Artikel: SWOT and Root Cause Analyses of Antimicrobial Resistance to Oral Antimicrobial Treatment of Cystitis.

    Tyagi, Pradeep / Tyagi, Shachi / Stewart, Laurence / Glickman, Scott

    Antibiotics (Basel, Switzerland)

    2024  Band 13, Heft 4

    Abstract: Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which uncomplicated cystitis triggers > 25% of outpatient prescriptions of oral antimicrobial treatment (OAT). OAT aids immune cells infiltrating the urothelium in ... ...

    Abstract Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which uncomplicated cystitis triggers > 25% of outpatient prescriptions of oral antimicrobial treatment (OAT). OAT aids immune cells infiltrating the urothelium in eliminating uropathogens capable of invading the urothelium and surviving hyperosmotic urine. This self-evident adaptability of uropathogens and the short interval between the introduction of Penicillin and the first report of antimicrobial resistance (AMR) implicate AMR as an evolutionary conserved heritable trait of mutant strains selected by the Darwinian principle to survive environmental threats through exponential proliferation. Therefore, AMR can only be countered by antimicrobial stewardship (AMS) following the principle of the five Ds-drug, dose, duration, drug route, and de-escalation. While convenient to administer, the onset of the minimum inhibitory concentration (MIC) for OAT in urine leaves a window of opportunity for uropathogens to survive the first contact with an antimicrobial and arm their descendant colonies with AMR for surviving subsequent higher urine antimicrobial levels. Meanwhile, the initial dose of intravesical antimicrobial treatment (IAT) may be well above the MIC. Therefore, the widespread clinical use of OAT for cystitis warrants an analysis of the strengths, weaknesses, opportunity, and threats (SWOTs) and a root cause analysis of the AMR associated with OAT and IAT.
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13040328
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Effective Treatments of UTI-Is Intravesical Therapy the Future?

    Morris, Chris J / Rohn, Jennifer L / Glickman, Scott / Mansfield, Kylie J

    Pathogens (Basel, Switzerland)

    2023  Band 12, Heft 3

    Abstract: Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research ... ...

    Abstract Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research scrutiny and the potential for dysbiosis is a cause for concern. Optimal treatment of UTI relies upon the selection of an agent which displays appropriate pharmacokinetic-pharmacodynamic (PK-PD) properties that will deliver appropriately high concentrations in the urinary tract after oral administration. Alternatively, high local concentrations of antibiotic at the urothelial surface can be achieved by direct instillation into the urinary tract. For antibiotics with the appropriate physicochemical properties, this can be of critical importance in cases for which an intracellular urothelial bacterial reservoir is suspected. In this review, we summarise the underpinning biopharmaceutical barriers to effective treatment of UTI and provide an overview of the evidence for the deployment of the intravesical administration route for antibiotics.
    Sprache Englisch
    Erscheinungsdatum 2023-03-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030417
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Kyphoplasty Solves Stabilization and Pain Control Inadequately Treated via Prior Hartshill Rectangle for Thoracolumbar Burst Fracture.

    Hassan, Omron / Surti, Tapasya / Glickman, Scott G

    Cureus

    2021  Band 13, Heft 10, Seite(n) e18525

    Abstract: Surgical management of spinal burst fractures has progressed to include minimally invasive techniques as preferred modalities of treatment. Burst fractures with indications for surgical treatment either through instability or intractable pain classically ...

    Abstract Surgical management of spinal burst fractures has progressed to include minimally invasive techniques as preferred modalities of treatment. Burst fractures with indications for surgical treatment either through instability or intractable pain classically have required pedicle screw fixation, which requires extensive dissection resulting in postoperative pain and significant recovery time, and also requires longer operative times with more potential blood loss. Balloon kyphoplasty is an established percutaneous technique that can provide quick pain relief for patients with intractable pain following compression and burst fractures, and vertebral body height can also be restored. In the present case, a female patient was seen in the emergency room with intractable pain and a dehiscent thoracolumbar incision after recently undergoing surgery with placement of a Hartshill rectangle and sublaminar wires at another institution for a T12 burst fracture (AO classification [AO] A4 and thoracolumbar injury classification and severity score [TLICS] 4) caused by a motor vehicle accident. Imaging identified an acute unhealed fracture at T12 and other vertebrae with questionable lesions. She underwent surgery to remove the Hartshill construct, stabilize the fracture, biopsy lesions (T7, T10, L2, and L4), and debride and close the wound. Following hardware removal, kyphoplasty was then performed through the open exposure at T12, which could have otherwise been done percutaneously. The patient experienced immediate and complete resolution of her pain associated with the fracture and had no neurological deficits. Modern minimally invasive techniques including kyphoplasty should be favored when indicated as alternative treatment options over more invasive treatment modalities, as they lead to quicker resolution of pain and recovery when compared to techniques requiring a large exposure.
    Sprache Englisch
    Erscheinungsdatum 2021-10-06
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.18525
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Emerging molecular mechanisms and genetic targets for developing novel therapeutic strategies for treating bladder diseases.

    Zoqlam, Randa / Lazauskaite, Sandra / Glickman, Scott / Zaitseva, Lyubov / Ilie, Petre-Cristian / Qi, Sheng

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2022  Band 173, Seite(n) 106167

    Abstract: Bladder diseases affect millions of patients worldwide and compromise their quality of life with a substantial economic impact. The not fully understood aetiologies of bladder diseases limit the current diagnosis and therapeutic options to primarily ... ...

    Abstract Bladder diseases affect millions of patients worldwide and compromise their quality of life with a substantial economic impact. The not fully understood aetiologies of bladder diseases limit the current diagnosis and therapeutic options to primarily symptomatic treatment. In addition, bladder targeted drug delivery is challenging due to its unique anatomical features and its natural physiological function of urine storage and frequent voiding. Therefore, current treatment options often fail to provide a highly effective, precisely targeted and long-lasting treatment. With the growing maturity of gene therapy, comprehensive studies are needed to provide a better understanding of the molecular mechanisms underpinning bladder diseases and help to identify novel gene therapeutic targets and biomarkers for treating bladder diseases. In this review, molecular mechanisms involved in pathology of bladder cancer, interstitial cystitis and overactive bladder syndrome are reviewed, with focus on establishing potential novel treatment options. Proposed novel therapies, including gene therapy combined with nanotechnology, localised drug delivery by nanoparticles, and probiotics, are discussed in regard to their safety profiles, efficacy, treatment lenght, precise targeting, and in comparison to conventional treatment methods.
    Mesh-Begriff(e) Biomarkers ; Cystitis, Interstitial ; Female ; Humans ; Male ; Nanoparticles ; Quality of Life ; Urinary Bladder
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2022-03-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2022.106167
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Concurrent syrinx and inflammatory central nervous system disease detected by magnetic resonance imaging: an illustrative case and review of the literature.

    Larner, A J / Muqit, Miratul M K / Glickman, Scott

    Medicine

    2001  Band 81, Heft 1, Seite(n) 41–50

    Mesh-Begriff(e) Adult ; Autoimmune Diseases ; Brain/pathology ; Encephalomyelitis/complications ; Encephalomyelitis/diagnosis ; Female ; Humans ; Lupus Vasculitis, Central Nervous System/complications ; Lupus Vasculitis, Central Nervous System/diagnosis ; Magnetic Resonance Imaging ; Spinal Cord/pathology ; Syringomyelia/complications ; Syringomyelia/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2001-12-20
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/00005792-200201000-00003
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  6. Artikel ; Online: The Code of Professional Conduct for the Neurocritical Care Society.

    Rubin, Michael / Bonomo, Jordan / Bar, Barak / Collins, Edward / Cruz-Flores, Salvador / Garvin, Rachel / Glickman, Scott / Grossman, Jonah / Henderson, Galen / Lawson, Tom / Mahanes, Dea / McFarlin, Jessica / Monchar, Sarah / Peled, Harry / Szalados, James

    Neurocritical care

    2015  Band 23, Heft 2, Seite(n) 145–148

    Abstract: Part of the responsibility of a professional society is to establish the expectations for appropriate behavior for its members. Some codes are so essential to a society that the code itself becomes the central document defining the organization and its ... ...

    Abstract Part of the responsibility of a professional society is to establish the expectations for appropriate behavior for its members. Some codes are so essential to a society that the code itself becomes the central document defining the organization and its tenets, as we see with the Hippocratic Oath. In that tradition, we have revised the code of professional conduct for the Neurocritical Care Society into its current version, which emphasizes guidelines for personal behavior, relationships with fellow members, relationships with patients, and our interactions with society as a whole. This will be a living document and updated as the needs of our society change in time.Available online: http://www.neurocriticalcare.org/about-us/bylaws-procedures-and-code-professional-conduct (1) Code of professional conduct (this document) (2) Leadership code of conduct (3) Disciplinary policy.
    Mesh-Begriff(e) Codes of Ethics ; Critical Care/ethics ; Ethics, Medical ; Humans ; Neurology/ethics ; Societies, Medical/ethics
    Sprache Englisch
    Erscheinungsdatum 2015-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-015-0175-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity.

    Glickman, Scott G / Marn, Charles S / Supiano, Mark A / Dengel, Donald R

    Journal of applied physiology (Bethesda, Md. : 1985)

    2004  Band 97, Heft 2, Seite(n) 509–514

    Abstract: A number of methods exist for the estimation of abdominal obesity, ranging from waist-to-hip ratio to computed tomography (CT). Although dual-energy X-ray absorptiometry (DXA) was originally used to measure bone density and total body composition, recent ...

    Abstract A number of methods exist for the estimation of abdominal obesity, ranging from waist-to-hip ratio to computed tomography (CT). Although dual-energy X-ray absorptiometry (DXA) was originally used to measure bone density and total body composition, recent improvements in software allow it to determine abdominal fat mass. Sixty-five men and women aged 18-72 yr participated in a series of studies to examine the validity and reliability of the DXA to accurately measure abdominal fat. Total body fat and abdominal regional fat were measured by DXA using a Lunar DPX-IQ. Multislice CT scans were performed between L1 and L4 vertebral bodies (region of interest) using a Picker PQ5000 CT scanner, and volumetric analyses were carried out on a Voxel Q workstation. Both abdominal total tissue mass (P = 0.02) and abdominal fat mass (P < 0.0001) in the L1-L4 region of interest were significantly lower as measured by DXA compared with multislice CT. However, Bland-Altman analysis demonstrated good concordance between DXA and CT for abdominal total tissue mass (i.e., limits of agreement = -1.56-2.54 kg) and fat mass (i.e., limits of agreement = -0.40-1.94 kg). DXA also showed excellent reliability among three different operators to determine total, fat, and lean body mass in the L1-L4 region of interest (intraclass correlations, R = 0.94, 0.97, and 0.89, respectively). In conclusion, the DXA L1-L4 region of interest compared with CT proved to be both reliable and accurate method to determine abdominal obesity.
    Mesh-Begriff(e) Abdomen ; Absorptiometry, Photon/standards ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Adolescent ; Adult ; Aged ; Body Composition ; Female ; Humans ; Lumbar Vertebrae ; Male ; Middle Aged ; Predictive Value of Tests ; Regression Analysis ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2004-08
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Validation Studies
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
    ISSN (online) 1522-1601
    ISSN 8750-7587 ; 0021-8987 ; 0161-7567
    DOI 10.1152/japplphysiol.01234.2003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Intravesical atropine compared to oral oxybutynin for neurogenic detrusor overactivity: a double-blind, randomized crossover trial.

    Fader, Mandy / Glickman, Scott / Haggar, Veronica / Barton, Rachel / Brooks, Rodney / Malone-Lee, James

    The Journal of urology

    2007  Band 177, Heft 1, Seite(n) 208–13; discussion 213

    Abstract: Purpose: We tested the efficacy and side effect profiles of intravesical atropine compared to oxybutynin immediate release when used by individuals with multiple sclerosis.: Materials and methods: We performed a study to determine the most effective ... ...

    Abstract Purpose: We tested the efficacy and side effect profiles of intravesical atropine compared to oxybutynin immediate release when used by individuals with multiple sclerosis.
    Materials and methods: We performed a study to determine the most effective dose of atropine. Eight participants used increasing doses of intravesical atropine during a 12-day period. Bladder diary data showed that the instillation of 6 mg atropine 4 times daily was most effective for increasing bladder capacity (voided/catheter volumes). We then did a randomized, double-blind crossover trial. Participants received 14 days of treatment with oral oxybutynin or with intravesical atropine, followed by 14 days of alternative treatment. Participants recorded a bladder diary and rated side effects and quality of life. The primary outcome variable was bladder capacity.
    Results: A total of 57 participants with multiple sclerosis completed the study. Average change in bladder capacity was higher in the atropine arm. The mean +/- SD oxybutynin change was 55.5 +/- 67.2 ml, the mean atropine change was 79.6 +/- 89.6 ml and the mean difference between arms was 24.1 ml (95% CI -0.4, 49.7; p = 0.053). Changes in incontinence events and voiding frequency were not statistically different between the arms. Changes in total side effect and dry mouth scores were significantly better in the atropine treatment arm.
    Conclusions: Intravesical atropine was as effective as oxybutynin immediate release for increasing bladder capacity and it was probably better with less antimuscarinic side effects. We recommend that intravesical atropine should be made available to patients with neurogenic detrusor overactivity and voiding problems requiring intermittent catheterization as an alternative to oral therapy, which often has troublesome side effects.
    Mesh-Begriff(e) Administration, Intravesical ; Administration, Oral ; Adult ; Aged ; Atropine/administration & dosage ; Cross-Over Studies ; Double-Blind Method ; Humans ; Mandelic Acids/administration & dosage ; Middle Aged ; Muscarinic Antagonists/administration & dosage ; Urinary Bladder, Neurogenic/drug therapy ; Urinary Bladder, Overactive/drug therapy
    Chemische Substanzen Mandelic Acids ; Muscarinic Antagonists ; Atropine (7C0697DR9I) ; oxybutynin (K9P6MC7092)
    Sprache Englisch
    Erscheinungsdatum 2007-01
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2006.08.099
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adults.

    Lee, Cathy C / Glickman, Scott G / Dengel, Donald R / Brown, Michael D / Supiano, Mark A

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2005  Band 60, Heft 7, Seite(n) 872–877

    Abstract: Background: An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to ... ...

    Abstract Background: An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women.
    Methods: Insulin sensitivity and abdominal adiposity were measured in healthy, nondiabetic older (64 +/- 6 years; mean +/- standard deviation) men (n = 23) and women (n = 31). Metabolic Insulin Sensitivity Index (S(I)) was determined from a frequently sampled insulin-assisted intravenous glucose tolerance test. Body fat mass and abdominal fat mass were determined from dual energy X-ray absorptiometry (DXA) scans. Anthropometric measures included waist and hip circumferences, height, and body weight.
    Results: Although waist circumference, waist index (waist circumference divided by height), and waist-hip ratio (WHR) were all lower in women than in men, there was no sex difference in DXA L1-L4 fat mass. In univariate analyses, S(I) was significantly inversely related with body weight, body mass index, waist circumference, waist index, percentage of total body and abdominal fat, and DXA L1-L4 fat mass but not with WHR. The DXA L1-L4 fat mass was identified as the best independent predictor of S(I), accounting for 41.2% of the variance (p <.0001) in a stepwise multiple regression model that controlled for sex.
    Conclusions: WHR is not associated with S(I) in either men or women. Abdominal adiposity measured by DXA L1-L4 fat mass provides a sex-independent predictor of S(I) in older men and women.
    Mesh-Begriff(e) Abdomen ; Absorptiometry, Photon ; Adipose Tissue/metabolism ; Aged ; Aged, 80 and over ; Aging/physiology ; Blood Glucose/metabolism ; Body Composition/physiology ; Female ; Follow-Up Studies ; Glucose ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents ; Insulin/blood ; Insulin Resistance/physiology ; Male ; Middle Aged
    Chemische Substanzen Blood Glucose ; Hypoglycemic Agents ; Insulin ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2005-03-25
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/60.7.872
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis.

    Jahanshahi, Marjan / Pieter, Socorro / Alusi, Sundus H / Jones, Catherine R G / Glickman, Scott / Stein, John / Aziz, Tipu / Bain, Peter G

    Behavioural neurology

    2009  Band 20, Heft 1-2, Seite(n) 1–9

    Abstract: Objective: To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition.: Methods: Eleven patients (3 males, 8 females) with multiple sclerosis participated in the study. Six subjects comprised the ... ...

    Abstract Objective: To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition.
    Methods: Eleven patients (3 males, 8 females) with multiple sclerosis participated in the study. Six subjects comprised the surgical group and five the matched control group. All patients were assessed at baseline and three months using a neuropsychological test battery that included measures of intellectual ability, memory, language, perception and executive function.
    Results: There were no significant differences between the surgical and control groups and no change from pre to post testing except for a decline in scores on the Mini-Mental State Examination (MMSE), WAIS-R Digit Span and Verbal Fluency in the surgical group.
    Conclusions: The results indicate that stereotactic lesional surgery does not result in major cognitive impairment in multiple sclerosis. However, the decline in MMSE scores, digit span and verbal fluency require further investigation in a larger sample.
    Mesh-Begriff(e) Adult ; Analysis of Variance ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Female ; Follow-Up Studies ; Humans ; Male ; Matched-Pair Analysis ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/surgery ; Neuropsychological Tests ; Recognition, Psychology ; Serial Learning ; Space Perception ; Stereotaxic Techniques/adverse effects ; Thalamus/surgery ; Treatment Outcome ; Tremor/complications ; Tremor/surgery ; Verbal Learning
    Sprache Englisch
    Erscheinungsdatum 2009-06-02
    Erscheinungsland Netherlands
    Dokumenttyp Controlled Clinical Trial ; Journal Article
    ZDB-ID 1001896-7
    ISSN 1875-8584 ; 0953-4180
    ISSN (online) 1875-8584
    ISSN 0953-4180
    DOI 10.3233/BEN-2008-0207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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