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  1. Article: Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis.

    Langner, Ewa / Cheng, Tao / Kefaloyianni, Eirini / Gluck, Charles / Wang, Baolin / Mahjoub, Moe R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Defective centrosome function can disrupt embryonic kidney development, by causing changes to the renal interstitium that leads to fibrocystic disease pathologies. Yet, it remains unknown how mutations in centrosome genes impact kidney interstitial cells. ...

    Abstract Defective centrosome function can disrupt embryonic kidney development, by causing changes to the renal interstitium that leads to fibrocystic disease pathologies. Yet, it remains unknown how mutations in centrosome genes impact kidney interstitial cells. Here, we examined the consequences of defective centrosome biogenesis on stromal progenitor cell growth, differentiation and fate. Conditional deletion of
    Highlights: Defective centrosome biogenesis in kidney stroma causes:Reduced abundance of stromal progenitors, interstitial and mesangial cell populationsDefects in cell-autonomous and paracrine signalingAbnormal/delayed nephrogenesis and tubular dilationsAccelerates injury-induced fibrosis via defective TGF-β/Smad3-Gli2 signaling axis.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.04.535583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cep120 is essential for kidney stromal progenitor cell growth and differentiation.

    Langner, Ewa / Cheng, Tao / Kefaloyianni, Eirini / Gluck, Charles / Wang, Baolin / Mahjoub, Moe R

    EMBO reports

    2023  Volume 25, Issue 1, Page(s) 428–454

    Abstract: Mutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here, ...

    Abstract Mutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here, we examined the consequences of impaired centrosome duplication on kidney stromal progenitor cell growth, differentiation, and fate. Conditional deletion of the ciliopathy gene Cep120, which is essential for centrosome duplication, in the stromal mesenchyme resulted in reduced abundance of interstitial lineages including pericytes, fibroblasts and mesangial cells. These phenotypes were caused by a combination of delayed mitosis, activation of the mitotic surveillance pathway leading to apoptosis, and changes in both Wnt and Hedgehog signaling that are key for differentiation of stromal cells. Cep120 ablation resulted in small hypoplastic kidneys with medullary atrophy and delayed nephron maturation. Finally, Cep120 and centrosome loss in the interstitium sensitized kidneys of adult mice, causing rapid fibrosis after renal injury via enhanced TGF-β/Smad3-Gli2 signaling. Our study defines the cellular and developmental defects caused by loss of Cep120 and aberrant centrosome biogenesis in the embryonic kidney stroma.
    MeSH term(s) Mice ; Animals ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Kidney/pathology ; Cell Differentiation/genetics ; Stromal Cells ; Stem Cells ; Cell Cycle Proteins/metabolism
    Chemical Substances Hedgehog Proteins ; Cep120 protein, mouse ; Cell Cycle Proteins
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-023-00019-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Permanent good health;

    Gluck, Charles

    the control of our common foundation of disease,

    1937  

    Author's details by Charles Gluck, M. D
    MeSH term(s) Mercury/therapeutic use ; Nose/surgery
    Language English
    Size xv, 19-335 p., plates.
    Publisher The Permanent good health publishing company
    Publishing place New York, N. Y
    Document type Book
    Note A discussion of bichloride antisepticizing treatments to nose, throat, teeth and mouth. ; "First printing, 1934; second printing, 1935; third, revised and enlarged edition, 1936."
    Database Catalogue of the US National Library of Medicine (NLM)

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