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Article: Radiomics-Based Classification of Tumor and Healthy Liver on Computed Tomography Images.

Zossou, Vincent-Béni Sèna / Gnangnon, Freddy Houéhanou Rodrigue / Biaou, Olivier / de Vathaire, Florent / Allodji, Rodrigue S / Ezin, Eugène C

Cancers

2024 Volume 16, Issue 6

Abstract: Liver malignancies, particularly hepatocellular carcinoma and metastasis, stand as prominent contributors to cancer mortality. Much of the data from abdominal computed tomography images remain underused by radiologists. This study explores the ... ...

Abstract	Liver malignancies, particularly hepatocellular carcinoma and metastasis, stand as prominent contributors to cancer mortality. Much of the data from abdominal computed tomography images remain underused by radiologists. This study explores the application of machine learning in differentiating tumor tissue from healthy liver tissue using radiomics features. Preoperative contrast-enhanced images of 94 patients were used. A total of 1686 features classified as first-order, second-order, higher-order, and shape statistics were extracted from the regions of interest of each patient's imaging data. Then, the variance threshold, the selection of statistically significant variables using the Student's
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061158
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Article ; Online: Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study.

Gnangnon, Freddy Houéhanou Rodrigue / Parenté, Alexis / Aboubakar, Moufalilou / Kiki-Migan, Yannick / Totah, Terence / Gbessi, Dansou Gaspard / Tonato-Bagnan, Josiane Angéline / Laleye, Anatole / Preux, Pierre-Marie / Denakpo, Justin Lewis / Blanquet, Véronique / Houinato, Dismand Stephan

BMC women's health

2024 Volume 24, Issue 1, Page(s) 295

Abstract: Background: In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim ... ...

Abstract	Background: In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim was to describe and analyze the clinical, histopathological, and prognostic aspects of breast cancer in Benin. Methods: A descriptive and analytical study was carried out at the CNHU-HKM and the CHU-MEL, two major tertiary referral hospitals for breast cancer management located in Cotonou, the capital city of Benin. All breast cancer medical records with histological evidence and immunohistochemistry studies were retrospectively collected between January 1, 2014, and September 30, 2020, in these two tertiary referral hospitals and analyzed in the current study. Results: Finally, 319 medical records were included. The mean age at diagnosis was 48.74 years. The tumors were most frequently classified as T4 (47.6%) with lymph node involvement N2 (34.5%), and metastases were clinically noted in 21.9% of cases. Stage was reported in the medical records of 284 patients. Tumors were diagnosed at very late AJCC stages: stage III (47.5%) and stage IV (24.7%). Grades SBR 2 (49.2%) and SBR 3 (32.6%) were the most frequent grades. Triple-negative breast cancer (31.3%) was the most common molecular type. The overall 5-year survival was 48.49%. In multivariable analysis, the poor prognostic factors were lymph node invasion (HR = 2.63; p = 0.026; CI: [1.12, 6.17]), the presence of metastasis (HR = 3.64; p < 0.001); CI: [2.36, 5.62] and the immunohistochemical profile (HR = 1.29; p < 0.001; CI: [1.13, 1.48]). Conclusions: Breast cancer in Beninese is predominant in young adults and is often diagnosed at a late stage. The survival of breast cancer patients in Benin can be improved by enhancing early diagnosis and multidisciplinary management.
MeSH term(s)	Humans ; Benin/epidemiology ; Female ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/diagnosis ; Middle Aged ; Prognosis ; Retrospective Studies ; Adult ; Neoplasm Staging ; Aged ; Lymphatic Metastasis ; Tertiary Care Centers/statistics & numerical data
Language	English
Publishing date	2024-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-024-03114-y
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Article: A giant metastatic low-grade endometrial sarcoma requiring surgical management.

Gnangnon, Freddy Houéhanou Rodrigue / Lawani, Ismaïl / Natta N'tcha, Habib Ndome / Haag, Edwin Kelly / Dossou, Francis Moïse / Mehinto, Delphin Kuassi

International journal of surgery case reports

2022 Volume 94, Page(s) 107163

Abstract: Introduction and importance: Low-grade endometrial stromal sarcomas are relatively rare tumors. We here report a case of a woman presenting with a giant metastatic low-grade endometrial stromal sarcoma with thromboembolic complications requiring urgent ... ...

Abstract	Introduction and importance: Low-grade endometrial stromal sarcomas are relatively rare tumors. We here report a case of a woman presenting with a giant metastatic low-grade endometrial stromal sarcoma with thromboembolic complications requiring urgent surgical management. Case presentation: A 58-year-old obese female was admitted, with a voluminous abdominopelvic mass, due to complications related to its size and extent. The tumor derived from the uterus and invaded the ureters, bladder and rectum. It compressed the right iliac vessels causing both deep vein thrombosis and pulmonary embolism. She developed a painful irreducible umbilical. We proceeded with a debulking surgery (hysterectomy with bilateral salpingo-oophorectomy). Histological findings were consistent with a low-grade endometrial stromal sarcoma. Clinical discussion: Low-grade endometrial stromal sarcomas are generally low-grade malignant neoplasms with an indolent clinical course. Surgery is the cornerstone of treatment. In low-income countries, malignancies are more often diagnosed at a late stage, which limits therapeutic options. Cytoreduction is recommended in advanced tumors with extrauterine manifestation, depending on symptoms and with palliative intent. Conclusion: Low-grade endometrial stromal sarcomas are indolent uterine malignancies with metastatic potential. Even in advanced cases, cytoreduction must be considered.
Language	English
Publishing date	2022-05-04
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.107163
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Article ; Online: Conformité des formulaires de demande et des comptes rendus anatomopathologiques de pièces opératoires de cancer du sein au Bénin.

Gnangnon, Freddy Houéhanou Rodrigue / Seidou, Falilatou / Laleye, Christel Marie / Odidi, Fèmi Perez / Flenon Nakou, Arielle / Tonato Bagnan, Josiane Angéline / Denakpo, Justin Lewis / Houinato, Dismand Stephan / Gbessi, Dansou Gaspard

Medecine tropicale et sante internationale

2023 Volume 3, Issue 4

Abstract: Introduction: Breast cancer requires multidisciplinary management. Pathologists and physicians communicate using the histopathology request form and the pathology report. There are some minimal criteria that both should respect.: Objective: We ... ...

Title translation	Adequacy of histopathology request forms and pathological reports of breast cancer surgical specimens in Benin.
Abstract	Introduction: Breast cancer requires multidisciplinary management. Pathologists and physicians communicate using the histopathology request form and the pathology report. There are some minimal criteria that both should respect. Objective: We assessed the adequacy of histopathology request forms and pathology reports in the management of female breast cancer specimens in Southern Benin. Method: This was a cross-sectional, descriptive and analytical study, with retrospective data collection over 57 months (4 years and 9 months). The adequacy of the histopathology request forms and pathology reports was assessed on the basis of the recommendations of the Haute Autorité de Santé (HAS) of France. Data processing was done using SPSS software. We checked frequencies with the Chi Results: 31.3% of histopathology request forms complied with HAS recommendations. Pathology reports were presented in a narrative way in 92.7% of cases and 68.8% met the minimal criteria. The presence of vascular embolus, of hormone receptors and the HER2 status were all reported in only 29.2% of the reports. Discussion: The draft of histopathology request forms and pathology reports did not comply to the required minimal criteria. This situation could mainly be explained by the inexistence of consensus between physicians and pathologists and by the lack of immunohistochemistry. Editing national referentials and using synoptic reports would give better results.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/surgery ; Cross-Sectional Studies ; Retrospective Studies ; Benin ; Pathologists
Language	French
Publishing date	2023-12-05
Publishing country	France
Document type	English Abstract ; Journal Article
ISSN	2778-2034
ISSN (online)	2778-2034
DOI	10.48327/mtsi.v3i4.2023.348
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Article ; Online: Ensuring Global Access to Cancer Medicines: A Generational Call to Action.

Dare, Anna J / Bayle, Arnauld / Hatoqai, Asma / Mungo, Chemtai / Velilla, Diego Gimenez / Soto-Perez-de-Celis, Enrique / Gnangnon, Freddy Houéhanou Rodrigue / Lim, Melissa Siaw Han / Ralefala, Tlotlo / Mushininga, Venus Dadirai

Cancer discovery

2023 Volume 13, Issue 2, Page(s) 269–274

Abstract: Summary: Essential cancer treatments are not accessible, affordable, or available to patients who need them in many parts of the world. A new Access to Oncology Medicines (ATOM) Coalition, using public-private partnerships, aims to bring essential ... ...

Abstract	Summary: Essential cancer treatments are not accessible, affordable, or available to patients who need them in many parts of the world. A new Access to Oncology Medicines (ATOM) Coalition, using public-private partnerships, aims to bring essential cancer medicines and diagnostics to patients in low- and lower middle-income countries.
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Medical Oncology ; Drugs, Essential/therapeutic use ; Health Services Accessibility ; Costs and Cost Analysis
Chemical Substances	Drugs, Essential
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-22-1372
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Article: Surgical management of erosive adenomatosis of the nipple: A case report.

Gnangnon, Freddy Houéhanou Rodrigue / Souaibou, Yacoubou Imorou / Gbessi, Dansou Gaspard / Agbo, Tiani Marie Gaston / Dossou, Francis Moïse / Méhinto, Delphin Kuassi

International journal of surgery case reports

2021 Volume 86, Page(s) 106234

Abstract: Introduction and importance: Known as a very uncommon disease, erosive adenomatosis of the nipple is a benign neoplasm of the breast. However, its destructive process can have a considerably negative impact on patient's quality of life.: Case ... ...

Abstract	Introduction and importance: Known as a very uncommon disease, erosive adenomatosis of the nipple is a benign neoplasm of the breast. However, its destructive process can have a considerably negative impact on patient's quality of life. Case presentation: We report the case of a 45-year-old woman who presented at the visceral surgery department of the National Teaching Hospital of Cotonou-Benin (CNHU-HKM) for a burgeoning mass of the left nipple. She was diagnosed an erosive adenomatosis of the nipple and underwent a nipple resection with reconstruction. Clinical discussion: Erosive adenomatosis is one differential diagnosis for lesion of the nipple. Clinically, it should be discussed with malignant nipple tumours including Paget's disease. Conclusion: Surgery is the cornerstone of the treatment, and the prognosis is excellent.
Language	English
Publishing date	2021-07-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2021.106234
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Article: Sister Mary Joseph's nodule revealing a jejunal adenocarcinoma: A case report.

Gbessi, Dansou Gaspard / Gnangnon, Freddy Houéhanou Rodrigue / Souaïbou, Yacoubou Imorou / Haag, Kelly Edwin / Lawani, Ismaïl / Mehinto, Delphin Kuassi

International journal of surgery case reports

2021 Volume 89, Page(s) 106620

Abstract: Introduction and importance: Adenocarcinoma of the jejunum is a diagnostic challenge for the physician because of its extreme rareness and the fact that it classically presents with vague clinical symptoms. On the other hand, the Sister Mary Joseph's ... ...

Abstract	Introduction and importance: Adenocarcinoma of the jejunum is a diagnostic challenge for the physician because of its extreme rareness and the fact that it classically presents with vague clinical symptoms. On the other hand, the Sister Mary Joseph's nodule is a rare clinical sign that refers to umbilical metastasis of an internal malignancy. We here report a rare case of jejunal adenocarcinoma revealed by a Sister Mary Joseph's nodule. Case presentation: A 55-year-old man presented with an ulcerated umbilical tumor, which was found to be a secondary lesion of an advanced jejunal adenocarcinoma invading the transverse colon. He underwent surgical resection of the umbilical tumor and the intestinal primitive. Clinical discussion: The presence of umbilical metastasis usually represents advanced disease but can be its first manifestation. Gastro-intestinal tract tumors such as jejunal adenocarcinomas and gynecologic malignancies are the most common primary sites. Conclusion: Practicians must be aware of clinical implication of Sister Mary Joseph nodule. Aggressive surgery when feasible can be beneficial for survival.
Language	English
Publishing date	2021-11-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2021.106620
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Article ; Online: Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques.

Kpossou, Aboudou Raïmi / Gbessi, Dansou Gaspard / Gnangnon, Freddy Houéhanou Rodrigue / Ba Boukari, Meissarath Modoukpè / Vignon, Rodolph Koffi / Sokpon, Comlan N Déhougbéa Martin / Sehonou, Jean

The Pan African medical journal

2021 Volume 39, Page(s) 18

Abstract: Introduction: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of ... ...

Title translation	Cancers of the pancreas at the National Hospital and University Center of Cotonou: epidemiological, diagnostic, therapeutic and prognostic features.
Abstract	Introduction: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of Cotonou. Methods: we conducted a cross-sectional descriptive and analytical study with a prospective and retrospective data collection over a period of ten years, from 1 October 2009 to 31 October 2019. Results: out of 15.102 hospitalizations, we identified 72 cases of CP, reflecting a hospitalization rate of 0.5%. The average age of patients was 59 years. The sex-ratio (H/F) was 1.5. The main reason for consultation was abdominal pain. More than half (51.4%) of patients had metastatic tumor at the time of diagnosis. Histological evidence of adenocarcinoma was only reported in 15.1% of cases. The rate of operable patients was 37.5% while the rate of resectable patients was 2.7%. Palliative chemotherapy was given to 13.9% of patients. The average cost of treatment was 955.882,4 FCFA (23.9 times the Guaranteed Interprofessional Minimum Wage in Benin). Median overall survival was 6 months. Mortality rate was 86.9% (53/61), survival rate at one year was 31.4%, and zero at five years. Palliative surgery (p = 0.021) and chemotherapy (p = 0.023) improved patient survival. Conclusion: cancer of the pancreas, due to its non-specific signs and insidious outcome, is often diagnosed at a late stage. A metastatic tumor and the limited individual and institutional therapeutic possibilities lead to more pejorative prognosis.
MeSH term(s)	Adenocarcinoma/epidemiology ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Benin ; Cross-Sectional Studies ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Palliative Care/methods ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Prognosis ; Prospective Studies ; Retrospective Studies ; Survival Rate
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2021-05-06
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2021.39.18.26261
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Article ; Online: Aspects épidémiologiques et histopathologiques des sarcomes à Cotonou (Bénin) de 2010 à 2020.

Gbessi, Dansou Gaspard / Gnangnon, Freddy Houéhanou Rodrigue / Seidou, Falilatou / Adanzounnon, Myrethe Olouwafemi / Chigblo, Sègla Pascal Éric / Imorou Souaïbou, Yacoubou / Attolou, Sètondji Gilles Roger / Dossou, Francis Moïse / Hans-Moevi Akue, Aristote / Gangbo, Flore / Mehinto, Delphin Kuassi

Medecine tropicale et sante internationale

2022 Volume 2, Issue 1

Abstract: Aims: To study the epidemiological and histopathological characteristics of sarcomas.: Procedure: This was a multi-center, descriptive, retrospective study realized over a 10-year period. We systematically recruited all medical reports of patients ... ...

Title translation	Epidemiological and histopathological aspects of sarcomas in Cotonou (Benin) from 2010 to 2020.
Abstract	Aims: To study the epidemiological and histopathological characteristics of sarcomas. Procedure: This was a multi-center, descriptive, retrospective study realized over a 10-year period. We systematically recruited all medical reports of patients with histologically confirmed sarcoma. Results: 159 reports of sarcoma were retained. The average age was 38.9 years. There was a female predominance with a 0.9 estimated sex ratio. Soft tissue sarcomas were the most common (65.4%). The most frequent location was the lower limbs (30.2%). Conclusion: Better access to diagnosis would contribute to a better assessment of the burden of this pathology in Benin.
MeSH term(s)	Adult ; Benin/epidemiology ; Female ; Humans ; Male ; Retrospective Studies ; Sarcoma/epidemiology ; Soft Tissue Neoplasms
Language	French
Publishing date	2022-01-27
Publishing country	France
Document type	Journal Article
ISSN	2778-2034
ISSN (online)	2778-2034
DOI	10.48327/mtsi.v2i1.2022.201
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Article ; Online: Challenge of gastro-intestinal stromal tumor management in low-income countries: example of Benin.

Gbessi, Dansou Gaspard / Gnangnon, Freddy Houéhanou Rodrigue / Kpossou, Aboudou Raïmi / Gbetchedji, Pacifique Prudent / Seidou, Falilatou / Imorou Souaïbou, Yacoubou / Attolou, Setondji Gilles Roger / Lawani, Ismaïl / Laleye, Marie-Christel / Gangbo, Flore / Dossou, Francis Moïse / Sehonou, Jean / Mehinto, Delphin Kuassi

World journal of surgical oncology

2022 Volume 20, Issue 1, Page(s) 247

Abstract: Background: GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa, ... ...

Abstract	Background: GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa, there are few studies about it. Imatinib, an oral targeted therapy, has been available in Benin since 2010 and free since 2016. This study describes the diagnosis and therapeutic management of GIST in Cotonou, Benin. Methods: This is a descriptive cross-sectional study, with retrospective data collection over a 10-year period from 2010 to 2020, focused on patients with histological confirmed gastro-intestinal stromal tumor (GIST). Cases were identified using the registry database and the archival files of the Hubert Koutoukou Maga National University Hospital of Cotonou (CNHU-HKM). Results: Fifteen GISTs were identified during the study period. The median age was 52 and the sex ratio was 2:1 (10 males and 5 females). The most frequent symptom was abdominal pain (n = 12). Delay in care seeking after onset of symptoms ranged from 24 h to 15 years. The most common site for GISTs was the stomach (n = 8). The median tumor size was 11 cm and the majority (n=10) was metastatic or locally advanced at the time of diagnosis. The tumors were often spindle-shaped at histology (n = 13) and the majority expressed KIT (n = 14). Most of the tumors (n = 12) were at high risk of recurrence according to the Joensuu scoring system. The availability of imatinib has improved the outcome of GIST with response in all cases it was used in neoadjuvant setting (n = 7). Conclusion: GISTs are rare tumors and preferentially affect the stomach in Cotonou). Most of the tumors were large, unresectable at the time of diagnosis and at high risk of recurrence. Access to imatinib has revolutionized the management of those tumors in our country.
MeSH term(s)	Female ; Male ; Humans ; Middle Aged ; Gastrointestinal Stromal Tumors/epidemiology ; Gastrointestinal Stromal Tumors/therapy ; Imatinib Mesylate/therapeutic use ; Benin/epidemiology ; Retrospective Studies ; Cross-Sectional Studies
Chemical Substances	Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2022-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-022-02709-9
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