LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: MUC7 Level As A New Saliva Risk Factor For Dental Caries In Adult Patients.

    Szkaradkiewicz-Karpińska, Anna K / Ronij, Anna / Goślińska-Kuźniarek, Olga / Przybyłek, Izabela / Szkaradkiewicz, Andrzej

    International journal of medical sciences

    2019  Volume 16, Issue 2, Page(s) 241–246

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Adult ; Dental Caries/etiology ; Dental Caries/metabolism ; Humans ; Mucin-5B/metabolism ; Mucins/metabolism ; Risk Factors ; Saliva/metabolism ; Salivary Proteins and Peptides/metabolism
    Chemical Substances MUC5B protein, human ; MUC7 protein, human ; Mucin-5B ; Mucins ; Salivary Proteins and Peptides
    Language English
    Publishing date 2019-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.29027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Expression of cagA, virB/D Complex and/or vacA Genes in Helicobacter pylori Strains Originating from Patients with Gastric Diseases.

    Szkaradkiewicz, Andrzej / Karpiński, Tomasz M / Linke, Krzysztof / Majewski, Przemysław / Rożkiewicz, Dorota / Goślińska-Kuźniarek, Olga

    PloS one

    2016  Volume 11, Issue 2, Page(s) e0148936

    Abstract: In order to better understand pathogenicity of Helicobacter pylori, particularly in the context of its carcinogenic activity, we analysed expression of virulence genes: cagA, virB/D complex (virB4, virB7, virB8, virB9, virB10, virB11, virD4) and vacA in ... ...

    Abstract In order to better understand pathogenicity of Helicobacter pylori, particularly in the context of its carcinogenic activity, we analysed expression of virulence genes: cagA, virB/D complex (virB4, virB7, virB8, virB9, virB10, virB11, virD4) and vacA in strains of the pathogen originating from persons with gastric diseases. The studies were conducted on 42 strains of H. pylori isolated from patients with histological diagnosis of non-atrophic gastritis-NAG (group 1, including subgroup 1 containing cagA+ isolates and subgroup 2 containing cagA- strains), multifocal atrophic gastritis-MAG (group 2) and gastric adenocarcinoma-GC (group 3). Expression of H. pylori genes was studied using microarray technology. In group 1, in all strains of H. pylori cagA+ (subgroup 1) high expression of the gene as well as of virB/D was disclosed, accompanied by moderate expression of vacA. In strains of subgroup 2 a moderate expression of vacA was detected. All strains in groups 2 and 3 carried cagA gene but they differed in its expression: a high expression was detected in isolates of group 2 and its hyperexpression in strains of group 3 (hypervirulent strains). In both groups high expression of virB/D and vacA was disclosed. Our results indicate that chronic active gastritis may be induced by both cagA+ strains of H. pylori, manifesting high expression of virB/D complex but moderate activity of vacA, and cagA- strains with moderate expression of vacA gene. On the other hand, in progression of gastric pathology and carcinogenesis linked to H. pylori a significant role was played by hypervirulent strains, manifesting a very high expression of cagA and high activity of virB/D and vacA genes.
    MeSH term(s) Adult ; Aged ; Antigens, Bacterial/biosynthesis ; Antigens, Bacterial/genetics ; Antigens, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/biosynthesis ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Exons ; Female ; Gastritis, Atrophic/microbiology ; Gastroscopy ; Gene Expression Regulation, Bacterial ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter pylori/genetics ; Humans ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; Stomach Diseases/microbiology ; Stomach Neoplasms/microbiology
    Chemical Substances Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; VacA protein, Helicobacter pylori ; cagA protein, Helicobacter pylori
    Language English
    Publishing date 2016-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0148936
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: The Participation of p53 and bcl-2 Proteins in Gastric Carcinomas Associated with Helicobacterpylori and/or Epstein-Barr Virus (EBV).

    Szkaradkiewicz, Andrzej / Karpiński, Tomasz M / Majewski, Jan / Malinowska, Kamila / Goślińska-Kuźniarek, Olga / Linke, Krzysztof

    Polish journal of microbiology

    2015  Volume 64, Issue 3, Page(s) 211–216

    Abstract: In the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with Helicobacter pylori or EBV or without H. pylori/EBV infection. The studies were conducted on 64 adult patients with gastric ... ...

    Abstract In the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with Helicobacter pylori or EBV or without H. pylori/EBV infection. The studies were conducted on 64 adult patients with gastric adenocarcinomas: 16 patients with H. pylori (cagA+)-positivity (group 1), 14 with EBV-positive tumours (group 2), 12 with H. pylori/EBV-positive tumours (group 3) and 22 patients with H. pylori/EBV-negative tumours (group 4). H. pylori presence in gastric tumour specimens was detected using Giemsa staining and bacterial culture technique. Moreover, cagA gene was detected using PCR. EBV infection was detected based on EBER presence in the tissue by RNA in situ hybridization. Expressions of p53 and bcl-2 proteins were analysed using immunohistochemistry. Expression of p53 was noted in 14 (84%) patients from group 1, 8 (57%) patients from group 2, 7 (58%) patients from group 3, and 19 (86%) patients from group 4, whereas expression of bcl-2 was noted in 12 (75%) patients from group 1, in 10 (71%) patients from group 2, 9 (75%) patients from group 3, and 6 (27%) patients from group 4. The obtained results allow the conclusion, that H. pylori (cagA+)-associated development of the gastric adenocarcinoma is determined by abnormalities in the p53 protein function and overexpression of anti-apoptotic bcl-2 protein, whereas EBV-associated adenocarcinomas seem to be related with apoptosis resistance associated with bcl-2 overexpression.
    MeSH term(s) Adult ; Aged ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/microbiology ; Carcinoma/virology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/microbiology ; Epstein-Barr Virus Infections/virology ; Female ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter Infections/virology ; Helicobacter pylori/genetics ; Helicobacter pylori/physiology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/physiology ; Humans ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/virology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Proto-Oncogene Proteins c-bcl-2 ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2015
    Publishing country Poland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234080-4
    ISSN 1733-1331 ; 0137-1320
    ISSN 1733-1331 ; 0137-1320
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top