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Article ; Online: Schistosomiasis in returning travellers and migrants: gaps and research priorities.

Buonfrate, Dora / Tamarozzi, Francesca / Gobbi, Federico

2023 Volume 30, Issue 7

MeSH term(s)	Humans ; Transients and Migrants ; Research ; Schistosomiasis/diagnosis ; Schistosomiasis/prevention & control
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Editorial
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad118
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Zs.A 4120: Show issues

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Article ; Online: The search for better treatment strategies for mansonellosis: an expert perspective.

Ferreira, Marcelo U / Crainey, James Lee / Gobbi, Federico G

Expert opinion on pharmacotherapy

2023 Volume 24, Issue 15, Page(s) 1685–1692

Abstract: Introduction: Four species of the : Areas covered: We searched the PubMed and SciELO databases for publications on mansonelliasis in English, Spanish, Portuguese, or French that appeared until 1 May 2023. Literature data show that anthelmintics - ... ...

Abstract	Introduction: Four species of the Areas covered: We searched the PubMed and SciELO databases for publications on mansonelliasis in English, Spanish, Portuguese, or French that appeared until 1 May 2023. Literature data show that anthelmintics - single-dose ivermectin for Expert opinion: We recommend that human infections with
MeSH term(s)	Adult ; Animals ; Humans ; Mansonelliasis/complications ; Mansonelliasis/drug therapy ; Mansonella ; Ivermectin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Anthelmintics/therapeutic use ; Arthralgia/complications ; Arthralgia/drug therapy
Chemical Substances	Ivermectin (70288-86-7) ; Anti-Bacterial Agents ; Anthelmintics
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2023.2240235
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Zs.A 5130: Show issues

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Article ; Online: Confirmed Autochthonous Case of Human Alveolar Echinococcosis, Italy, 2023.

Tamarozzi, Francesca / Ronzoni, Niccolò / Degani, Monica / Oliboni, Eugenio / Tappe, Dennis / Gruener, Beate / Gobbi, Federico

Emerging infectious diseases

2024 Volume 30, Issue 2, Page(s) 350–353

Abstract: In September 2023, a patient in Italy who had never traveled abroad was referred for testing for suspected hepatic cystic echinococcosis. Lesions were incompatible with cystic echinococcosis; instead, autochthonous alveolar echinococcosis was confirmed. ... ...

Abstract	In September 2023, a patient in Italy who had never traveled abroad was referred for testing for suspected hepatic cystic echinococcosis. Lesions were incompatible with cystic echinococcosis; instead, autochthonous alveolar echinococcosis was confirmed. Alveolar echinococcosis can be fatal, and awareness must be raised of the infection's expanding distribution.
MeSH term(s)	Humans ; Echinococcosis/diagnosis ; Italy/epidemiology ; Travel
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3002.231527
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Zs.A 4778: Show issues

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Article: The Renin-Angiotensin System (RAS) in COVID-19 Disease: Where We Are 3 Years after the Beginning of the Pandemic.

Prato, Marco / Tiberti, Natalia / Mazzi, Cristina / Gobbi, Federico / Piubelli, Chiara / Longoni, Silvia Stefania

Microorganisms

2024 Volume 12, Issue 3

Abstract: The RAS is a hormonal system playing a pivotal role in the control of blood pressure and electrolyte homeostasis, the alteration of which is associated with different pathologies, including acute respiratory distress syndrome (ARDS). As such, it is not ... ...

Abstract	The RAS is a hormonal system playing a pivotal role in the control of blood pressure and electrolyte homeostasis, the alteration of which is associated with different pathologies, including acute respiratory distress syndrome (ARDS). As such, it is not surprising that a number of studies have attempted to elucidate the role and balance of the renin-angiotensin system (RAS) in COVID-19. In this review article, we will describe the evidence collected regarding the two main enzymes of the RAS (i.e., ACE and ACE2) and their principal molecular products (i.e., AngII and Ang1-7) in SARS-CoV-2 infection, with the overarching goal of drawing conclusions on their possible role as clinical markers in association with disease severity, progression, and outcome. Moreover, we will bring into the picture new experimental data regarding the systemic activity of ACE and ACE2 as well as the concentration of AngII and Ang1-7 in a cohort of 47 COVID-19 patients hospitalized at the IRCCS Sacro Cuore-Don Calabria Hospital (Negrar, Italy) between March and April 2020. Finally, we will discuss the possibility of considering this systemic pathway as a clinical marker for COVID-19.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030583
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Article ; Online: Physiopathology and clinical management of blackwater fever: a scoping review.

Rodari, Paola / Tamarozzi, Francesca / Fittipaldo, Veronica A / Buonfrate, Dora / Gobbi, Federico

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 30, Issue 1, Page(s) 59–65

Abstract: Background: Blackwater fever (BWF) is a severe syndrome occurring in patients with malaria upon antimalarial treatment, characterized by massive intravascular haemolysis and haemoglobinuria. BWF is a neglected condition and management recommendations ... ...

Abstract	Background: Blackwater fever (BWF) is a severe syndrome occurring in patients with malaria upon antimalarial treatment, characterized by massive intravascular haemolysis and haemoglobinuria. BWF is a neglected condition and management recommendations are unavailable. Objectives: We performed a scoping review to appraise available data on clinical picture, treatment and physiopathology of BWF, which could guide rationally its clinical management. Methods: MEDLINE, EMBASE, LILACS, Web of Science, and Scopus databases, and the reference list of relevant publications, were searched. Papers reporting original data on BWF cases or investigating the physiopathology of BWF were eligible. Data regarding case characteristics, trigger event, clinical management and outcome were extracted. For papers investigating the physiopathology of BWF, study design and principal findings were extracted. No quality assessment was performed. Data are presented as numbers and percentages, and summary of findings, grouped by paper focus (clinical description or physiopathology). Results: 101 papers were included. The majority of BWF cases were observed in autochthonous children (75.7%) and adults (15.3%), in contrast with historical perception that BWF patients were typically expatriates. Clinical management was described for 794 cases; corticosteroids were used in 23. Outcome was reported for 535 patients, with 18.1% mortality. The trigger was reported for 552 (47.5%) cases; in 70.4% identified as quinine. However, two RCT comparing artesunate and quinine for falciparum malaria treatment did not find significant difference in BWF occurrence after their administration. Two case-control studies did not find significant difference in G6PDH deficiency between malaria patients with and without BWF. Conclusions: The physiopathology and optimal treatment of BWF remain similarly unknown as they were over a century ago. Empirical supporting treatment approach seems reasonable, while change of antimalarial drug and use of corticosteroids remain object of debate.
MeSH term(s)	Child ; Adult ; Humans ; Blackwater Fever/drug therapy ; Blackwater Fever/epidemiology ; Blackwater Fever/pathology ; Quinine/adverse effects ; Malaria, Falciparum/complications ; Malaria, Falciparum/drug therapy ; Antimalarials/therapeutic use ; Malaria/complications ; Malaria/drug therapy ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Quinine (A7V27PHC7A) ; Antimalarials ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.09.009
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Autochthonous schistosomiasis in Europe: A silent threat.

Arsuaga, Marta / Díaz-Menéndez, Marta / Gobbi, Federico Giovanni

Travel medicine and infectious disease

2021 Volume 45, Page(s) 102244

MeSH term(s)	Europe/epidemiology ; Humans ; Schistosomiasis/epidemiology ; Schistosomiasis mansoni
Language	English
Publishing date	2021-12-21
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2021.102244
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Zs.A 6236: Show issues

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Article ; Online: Finding the missing many: improving Tuberculosis care in Kajiado county through active case finding and community approaches.

Morino, Gianfranco / Mulongo, Caleb Mike / Cattaneo, Paolo / De Vita, Maria Vittoria / Paone, Gabriele / Scarlata, Simone / Gobbi, Federico / Kinyita, Salome / Odhiambo, Hillary

BMC public health

2024 Volume 24, Issue 1, Page(s) 144

Abstract: Background: Tuberculosis related deaths remain a priority globally. Despite advancements in TB care, access to quality care remains inequitable to the disadvantage of those in rural and urban informal settlements. The Awareness, Traditions, and ... ...

Abstract	Background: Tuberculosis related deaths remain a priority globally. Despite advancements in TB care, access to quality care remains inequitable to the disadvantage of those in rural and urban informal settlements. The Awareness, Traditions, and Innovation in combating Tuberculosis (ATI TB) project incorporated active case finding (ACF), use of GeneXpert technology and decentralized services to improve TB care in Kajiado County. This study sought to establish the impact of the project as well as implementation lessons learnt during its tenure in Kajiado County, Kenya. Methods: This evaluation adopted a mixed-methods approach with retrospective cohort analysis for the quantitative data and qualitative data sought through key informant interviews with 28 purposively sampled respondents. The qualitative data was analyzed thematically using Taguette while quantitative data was analyzed using R Software yielding descriptive statistics and measures of association. Results: While the males were a minority among the presumptive cases (623; 46%), they were the majority (59.3%) among the confirmed TB cases. 70% of the confirmed cases were aged between 15 and 44 years; with those aged between 25- and 34-years being majority (30% of the cases). Majority of the confirmed cases within the project were from rural Kajiado West (79; 66.9%). Though 61% of the presumptive cases were through ACF, only 7% of these tested positive. Conversely, 13% of the self-referrals tested positive. 53% (66) of the positive cases with valid data were self-referrals while ACF accounted for 47% (58) of the positives. Conclusion: Continued capacity development among health workers, sustained and targeted sensitization and screening among vulnerable groups, strategic collaborations, alongside increased budgetary prioritization of health and TB care by government and partners, and government investments in Social Determinants of Health can ensure gains in TB care are sustained.
MeSH term(s)	Male ; Humans ; Adolescent ; Young Adult ; Adult ; Kenya ; Retrospective Studies ; Altruism ; Budgets ; Data Accuracy
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-17631-2
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Article ; Online: Urinary bladder lesions in a migrant from Africa.

Tamarozzi, Francesca / Gobbi, Federico

Journal of travel medicine

2019 Volume 26, Issue 2

MeSH term(s)	Animals ; Gambia ; Humans ; Italy ; Male ; Praziquantel/therapeutic use ; Schistosoma haematobium/isolation & purification ; Schistosomiasis haematobia/diagnosis ; Schistosomiasis haematobia/drug therapy ; Transients and Migrants ; Ultrasonography ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/parasitology ; Young Adult
Chemical Substances	Praziquantel (6490C9U457)
Language	English
Publishing date	2019-02-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taz006
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Zs.A 4120: Show issues

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Article ; Online: Spleen nodules in Loa loa infection: re-emerging knowledge and future perspectives.

Tamarozzi, Francesca / Buonfrate, Dora / Ricaboni, Davide / Ursini, Tamara / Foti, Giovanni / Gobbi, Federico

The Lancet. Infectious diseases

2022 Volume 22, Issue 7, Page(s) e197–e206

Abstract: Loiasis, the infection with the vector-borne filarial nematode Loa loa, is widely distributed in central and west Africa. Long considered a rather benign infection, recently loiasis with high microfilarial burden was associated with increased mortality ... ...

Abstract	Loiasis, the infection with the vector-borne filarial nematode Loa loa, is widely distributed in central and west Africa. Long considered a rather benign infection, recently loiasis with high microfilarial burden was associated with increased mortality risk. Eyeworm and Calabar swelling are pathognomonic signs of the infection, but other atypical, non-specific manifestations can also occur. For instance, splenic nodules have been seldom reported. In this Grand Round, we report two cases of loiasis in migrants who presented with spleen nodules, which could be followed up over time (up to 27 months) with multiple imaging techniques until their resolution. We comment on the clinical implications of these observations, including differential diagnosis with similar imaging findings, and critically review the evidence of spleen involvement in loiasis and other filarial infections.
MeSH term(s)	Animals ; Diagnosis, Differential ; Humans ; Loa ; Loiasis/complications ; Loiasis/diagnosis ; Loiasis/drug therapy ; Spleen ; Transients and Migrants
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(21)00632-0
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Zs.A 5743: Show issues

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Article ; Online: Presumptive treatment or serological screening for schistosomiasis in migrants from Sub-Saharan Africa could save both lives and money for the Italian National Health System: results of an economic evaluation.

Zammarchi, Lorenzo / Botta, Annarita / Tilli, Marta / Gobbi, Federico / Bartoloni, Alessandro / Boccalini, Sara

Journal of travel medicine

2022 Volume 30, Issue 1

Abstract: Background: Schistosomiasis can lead to severe irreversible complications and death if left untreated. Italian and European guidelines recommend serological screening for this infection in migrants from Sub-Saharan Africa (SSA). However, studies on ... ...

Abstract	Background: Schistosomiasis can lead to severe irreversible complications and death if left untreated. Italian and European guidelines recommend serological screening for this infection in migrants from Sub-Saharan Africa (SSA). However, studies on clinical and economic impact of this strategy in the Italian and European settings are lacking. This study aims to compare benefits and costs of different strategies to manage schistosomiasis in migrants from SSA to Italy. Methods: A decision tree and a Markov model were developed to assess the health and economic impacts of three interventions: (i) passive diagnosis for symptomatic patients (current practice in Italy); (ii) serological screening of all migrants and treating those found positive and (iii) presumptive treatment for all migrants with praziquantel in a single dose. The time horizon of analysis was one year to determine the exact expenses, and 28 years to consider possible sequelae, in the Italian health-care perspective. Data input was derived from available literature; costs were taken from the price list of Careggi University Hospital, Florence, and from National Hospitals Records. Results: Assuming a population of 100 000 migrants with schistosomiasis prevalence of 21·2%, the presumptive treatment has a greater clinical impact with 86.3% of the affected being cured (75.2% in screening programme and 44.9% in a passive diagnosis strategy). In the first year, the presumptive treatment and the screening strategy compared with passive diagnosis prove cost-effective (299 and 595 cost/QALY, respectively). In the 28-year horizon, the two strategies (screening and presumptive treatment) compared with passive diagnosis become dominant (less expensive with more QALYs) and cost-saving. Conclusion: The results of the model suggest that presumptive treatment and screening strategies are more favourable than the current passive diagnosis in the public health management of schistosomiasis in SSA migrants, especially in a longer period analysis.
MeSH term(s)	Humans ; Cost-Benefit Analysis ; Transients and Migrants ; Schistosomiasis/drug therapy ; Praziquantel/therapeutic use ; Italy ; Mass Screening
Chemical Substances	Praziquantel (6490C9U457)
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taac140
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