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  1. Article ; Online: The search for better treatment strategies for mansonellosis: an expert perspective.

    Ferreira, Marcelo U / Crainey, James Lee / Gobbi, Federico G

    Expert opinion on pharmacotherapy

    2023  Volume 24, Issue 15, Page(s) 1685–1692

    Abstract: Introduction: Four species of the : Areas covered: We searched the PubMed and SciELO databases for publications on mansonelliasis in English, Spanish, Portuguese, or French that appeared until 1 May 2023. Literature data show that anthelmintics - ... ...

    Abstract Introduction: Four species of the
    Areas covered: We searched the PubMed and SciELO databases for publications on mansonelliasis in English, Spanish, Portuguese, or French that appeared until 1 May 2023. Literature data show that anthelmintics - single-dose ivermectin for
    Expert opinion: We recommend that human infections with
    MeSH term(s) Adult ; Animals ; Humans ; Mansonelliasis/complications ; Mansonelliasis/drug therapy ; Mansonella ; Ivermectin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Anthelmintics/therapeutic use ; Arthralgia/complications ; Arthralgia/drug therapy
    Chemical Substances Ivermectin (70288-86-7) ; Anti-Bacterial Agents ; Anthelmintics
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2240235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5130: Show issues Location:
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  2. Article ; Online: Loiasis from where you don't expect it: an illustrative case of misled diagnosis.

    Nicolini, Ambra Laura / Tamarozzi, Francesca / Pomari, Elena / Mistretta, Manuela / Camera, Marco / Sepulcri, Chiara / Bassetti, Matteo / Gobbi, Federico G

    Journal of travel medicine

    2022  Volume 29, Issue 7

    MeSH term(s) Humans ; Animals ; Loiasis/diagnosis ; Loiasis/drug therapy ; Loa
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taac060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4120: Show issues Location:
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  3. Article ; Online: Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.

    Tamarozzi, Francesca / Fittipaldo, Veronica A / Orth, Hans Martin / Richter, Joachim / Buonfrate, Dora / Riccardi, Niccolò / Gobbi, Federico G

    PLoS neglected tropical diseases

    2021  Volume 15, Issue 3, Page(s) e0009191

    Abstract: Background: Hepatosplenic schistosomiasis (HSS) is a disease caused by chronic infection with Schistosma spp. parasites residing in the mesenteric plexus; portal hypertension causing gastrointestinal bleeding is the most dangerous complication of this ... ...

    Abstract Background: Hepatosplenic schistosomiasis (HSS) is a disease caused by chronic infection with Schistosma spp. parasites residing in the mesenteric plexus; portal hypertension causing gastrointestinal bleeding is the most dangerous complication of this condition. HSS requires complex clinical management, but no specific guidelines exist. We aimed to provide a comprehensive picture of consolidated findings and knowledge gaps on the diagnosis and treatment of HSS.
    Methodology/principal findings: We reviewed relevant original publications including patients with HSS with no coinfections, published in the past 40 years, identified through MEDLINE and EMBASE databases. Treatment with praziquantel and HSS-associated pulmonary hypertension were not investigated. Of the included 60 publications, 13 focused on diagnostic aspects, 45 on therapeutic aspects, and 2 on both aspects. Results were summarized using effect direction plots. The most common diagnostic approaches to stratify patients based on the risk of variceal bleeding included the use of ultrasonography and platelet counts; on the contrary, evaluation and use of noninvasive tools to guide the choice of therapeutic interventions are lacking. Publications on therapeutic aspects included treatment with beta-blockers, local management of esophageal varices, surgical procedures, and transjugular intrahepatic portosystemic shunt. Overall, treatment approaches and measured outcomes were heterogeneous, and data on interventions for primary prevention of gastrointestinal bleeding and on the long-term follow-up after interventions were lacking.
    Conclusions: Most interventions have been developed on the basis of individual groups' experiences and almost never rigorously compared; furthermore, there is a lack of data regarding which parameters can guide the choice of intervention. These results highlight a dramatic need for the implementation of rigorous prospective studies with long-term follow-up in different settings to fill such fundamental gaps, still present for a disease affecting millions of patients worldwide.
    MeSH term(s) Humans ; Liver Diseases, Parasitic/diagnosis ; Liver Diseases, Parasitic/therapy ; Schistosomiasis/diagnosis ; Schistosomiasis/therapy ; Splenic Diseases/diagnosis ; Splenic Diseases/parasitology ; Splenic Diseases/therapy
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0009191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prospective cohort study using ultrasonography of Schistosoma haematobium-infected migrants.

    Tamarozzi, Francesca / Ursini, Tamara / Ronzoni, Niccolò / Badona Monteiro, Geraldo / Gobbi, Federico G / Angheben, Andrea / Richter, Joachim / Buonfrate, Dora / Bisoffi, Zeno

    Journal of travel medicine

    2021  Volume 28, Issue 6

    Abstract: Background: Chronic infection with Schistosoma haematobium may lead to serious complications, including bladder carcinoma. Although it is recommended that only bladder masses not regressing within 6 months after praziquantel intake should be ... ...

    Abstract Background: Chronic infection with Schistosoma haematobium may lead to serious complications, including bladder carcinoma. Although it is recommended that only bladder masses not regressing within 6 months after praziquantel intake should be investigated invasively, cystoendoscopy is still often performed at diagnosis even in the absence of further signs of concern. No prospective study so far evaluated the evolution of bladder lesions after treatment in case of no risk of reinfection, which could inform case management.
    Methods: Adult African migrants with active S. haematobium infection, as assessed by positive urine PCR or microscopy for eggs in urine or bladder biopsy, underwent urinary tract ultrasound at enrolment and at 1, 3, 6, 12 and 24 months after praziquantel treatment. Patients in advanced pregnancy or with known Schistosoma-unrelated chronic pathology of the urinary tract were excluded.
    Results: Twenty-one patients, aged 18-29 years, participated in the study; ten (47.6%) had bladder masses on ultrasound. Follow-up ≥6 months was completed by 16 (76.2%) patients; ≥12 months by 14 (66.7%) and 24 months by 11 (52.4%). All patients with bladder lesions on enrolment completed a follow-up of ≥6 months. Lesions resolved completely by 6 months in all cases and no new development/re-appearance was observed.
    Conclusions: This is the first prospective, long-term follow-up study with ultrasound of patients with urinary schistosomiasis outside endemic areas. Mucosal masses in young patients regressed after treatment without recurrence, supporting the recommendation that invasive procedures should be avoided unless lesions or other symptoms/signs of concern persist for > 6 months. Further studies should assess the evolution of bladder lesions after treatment in larger populations, including older age groups, and, ideally, with parallel assessment of other biomarkers of urinary pathology and of residual S. haematobium active infection.
    MeSH term(s) Adult ; Aged ; Animals ; Female ; Follow-Up Studies ; Humans ; Pregnancy ; Prospective Studies ; Schistosoma haematobium ; Schistosomiasis haematobia/diagnostic imaging ; Schistosomiasis haematobia/drug therapy ; Transients and Migrants ; Ultrasonography
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taab122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4120: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Infections with long latency in international refugees, immigrants, and migrants seen at GeoSentinel sites, 2016-2018.

    Barnett, Elizabeth D / Wheelock, Alyse B / MacLeod, William B / McCarthy, Anne E / Walker, Patricia F / Coyle, Christina M / Greenaway, Christina A / Castelli, Francesco / López-Vélez, Rogelio / Gobbi, Federico G / Trigo, Elena / Grobusch, Martin P / Gautret, Philippe / Hamer, Davidson H / Kuhn, Susan / Stauffer, William M

    Travel medicine and infectious disease

    2023  Volume 56, Page(s) 102653

    Abstract: Background: The continued increase in global migration compels clinicians to be aware of specific health problems faced by refugees, immigrants, and migrants (RIM). This analysis aimed to characterize RIM evaluated at GeoSentinel sites, their migration ... ...

    Abstract Background: The continued increase in global migration compels clinicians to be aware of specific health problems faced by refugees, immigrants, and migrants (RIM). This analysis aimed to characterize RIM evaluated at GeoSentinel sites, their migration history, and infectious diseases detected through screening and diagnostic workups.
    Methods: A case report form was used to collect data on demographics, migration route, infectious diseases screened, test results, and primary infectious disease diagnosis for RIM patients seen at GeoSentinel sites. Descriptive statistics were performed.
    Results: Between October 2016 and November 2018, 5,319 RIM patients were evaluated at GeoSentinel sites in 19 countries. Africa was the region of birth for 2,436 patients (46 %), followed by the Americas (1,644, 31 %), and Asia (1,098, 21 %). Tuberculosis (TB) was the most common infection screened and reported as positive (853/2,273, 38 % positive by any method). TB, strongyloidiasis, and hepatitis B surface antigen positivity were observed across all migration administrative categories and regions of birth. Chagas disease was reported only among RIM patients from the Americas (393/394, 100 %) and schistosomiasis predominantly in those from Africa (480/510, 94 %). TB infection (694/5,319, 13 %) and Chagas disease (524/5,319, 10 %) were the leading primary infectious disease diagnoses.
    Conclusions: Several infections of long latency (e.g. TB, hepatitis B, and strongyloidiasis) with potential for long-term sequelae were seen among RIM patients across all migration administrative categories and regions of origin. Obtaining detailed epidemiologic information from RIM patients is critical to optimize detection of diseases of individual and public health importance, particularly those with long latency periods.
    MeSH term(s) Humans ; Strongyloidiasis ; Transients and Migrants ; Refugees ; Emigrants and Immigrants ; Tuberculosis ; Hepatitis B ; Chagas Disease
    Language English
    Publishing date 2023-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102653
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    Zs.A 6236: Show issues Location:
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  6. Article ; Online: Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers.

    Kurth, Florian / Tober-Lau, Pinkus / Lingscheid, Tilman / Bardtke, Lara / Kim, Johanna / Angheben, Andrea / Gobbi, Federico G / Mbavu, Lena / Stegemann, Miriam S / Heim, Katrin M / Pfäfflin, Frieder / Menner, Nikolai / Schürmann, Mariana / Mikolajewska, Agata / Witzenrath, Martin / Sander, Leif E / Mayer, Beate / Zoller, Thomas

    Journal of travel medicine

    2023  Volume 30, Issue 3

    Abstract: Background: Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes of delayed haemolysis occur in up to 57.9% of patients with severe malaria treated with intravenous artesunate, ... ...

    Abstract Background: Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes of delayed haemolysis occur in up to 57.9% of patients with severe malaria treated with intravenous artesunate, mainly caused by 'pitting' of infected red blood cells in the spleen and the delayed loss of these once-infected RBCs (oiRBCs). Several reports indicate that post-treatment haemolysis (PTH) also occurs in uncomplicated malaria treated with oral ACT, calling for systematic investigation.
    Methods: A prospective observational study to identify the incidence of PTH after oral ACT, defined as increased lactate dehydrogenase activity and low haptoglobin level on Day 14 after treatment. Patients were enrolled at two study centres in Germany and Italy. Study visits took place on Days 1, 3, 7, 14 and 28. Laboratory investigations included extended clinical routine laboratory tests, quantitative PfHRP2, anti-RBC antibodies and oiRBCs. The state of semi-immunity to malaria was assessed from childhood and ongoing exposure to Plasmodium spp. as per patient history.
    Results: A total of 134 patients with uncomplicated malaria and 3-day ACT treatment were recruited. Thirty-seven (37.4%) of 99 evaluable patients with Pf and none of 9 patients with non-Pf malaria exhibited PTH on d14. Patients with PTH had higher initial parasitaemia, higher oiRBC counts on d3 and a 10-fold decrease in oiRBCs between d7 and d14 compared with patients without PTH. In patients with PTH, loss of haemoglobin was 4-fold greater in non-Africans than in Africans (-1.3 vs -0.3 g/dl). Semi-immune African patients with PTH showed markedly increased erythropoiesis on d14 compared with not semi-immune African and non-African patients with PTH.
    Conclusions: PTH is common in patients with uncomplicated malaria and oral ACT. While the observed loss of haemoglobin will often not be clinically relevant, it could aggravate pre-existing anaemia, warranting follow-up examinations in populations at risk.
    MeSH term(s) Humans ; Child ; Antimalarials/adverse effects ; Hemolysis ; Artemisinins/adverse effects ; Malaria/drug therapy ; Malaria/complications ; Hemoglobins/therapeutic use ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/complications ; Drug Therapy, Combination
    Chemical Substances Antimalarials ; Artemisinins ; Hemoglobins
    Language English
    Publishing date 2023-01-07
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4120: Show issues Location:
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  7. Article ; Online: A large case series of travel-related Mansonella perstans (vector-borne filarial nematode): a TropNet study in Europe.

    Tamarozzi, Francesca / Rodari, Paola / Salas-Coronas, Joaquín / Bottieau, Emmanuel / Salvador, Fernando / Soriano-Pérez, Manuel Jesús / Cabeza-Barrera, María Isabel / Van Esbroeck, Marjan / Treviño, Begoña / Buonfrate, Dora / Gobbi, Federico G

    Journal of travel medicine

    2022  Volume 29, Issue 7

    Abstract: Background: Infection with Mansonella perstans is a neglected filariasis, widely distributed in sub-Saharan Africa, characterized by an elusive clinical picture; treatment for mansonellosis is not standardized. This retrospective study aimed to describe ...

    Abstract Background: Infection with Mansonella perstans is a neglected filariasis, widely distributed in sub-Saharan Africa, characterized by an elusive clinical picture; treatment for mansonellosis is not standardized. This retrospective study aimed to describe the clinical features, treatment schemes and evolution, of a large cohort of imported cases of M. perstans infection seen in four European centres for tropical diseases.
    Methods: Mansonella perstans infections, diagnosed by identification of blood microfilariae in migrants, expatriates and travellers, collected between 1994 and 2018, were retrospectively analysed. Data concerning demographics, clinical history and laboratory examinations at diagnosis and at follow-up time points were retrieved.
    Results: A total of 392 patients were included in the study. Of the 281 patients for whom information on symptoms could be retrieved, 150 (53.4%) reported symptoms, abdominal pain and itching being the most frequent. Positive serology and eosinophilia were present in 84.4% and 66.1%, respectively, of those patients for whom these data were available. Concomitant parasitic infections were reported in 23.5% of patients. Treatment, administered to 325 patients (82.9%), was extremely heterogeneous between and within centres; the most commonly used regimen was mebendazole 100 mg twice a day for 1 month. A total of 256 (65.3%) patients attended a first follow-up, median 3 months (interquartile range 2-12) after the first visit; 83.1% of patients having received treatment based on mebendazole and/or doxycycline, targeting Wolbachia, became amicrofilaremic, 41.1-78.4% of whom within 12 months from single treatment.
    Conclusions: Lack of specific symptoms, together with the inconstant positivity of parasitological and antibody-based assays in the infected population, makes the clinical suspicion and screening for mansonellosis particularly difficult. Prospective studies evaluating prevalence of infection in migrants from endemic areas, infection-specific morbidity, presence of Wolbachia endosymbionts in M. perstans populations from different geographical areas and efficacy of treatment regimens are absolutely needed to optimize the clinical management of infection.
    MeSH term(s) Animals ; Humans ; Mansonella ; Mansonelliasis/diagnosis ; Mansonelliasis/drug therapy ; Mansonelliasis/epidemiology ; Retrospective Studies ; Travel ; Mebendazole/therapeutic use ; Prospective Studies ; Travel-Related Illness ; Wolbachia
    Chemical Substances Mebendazole (81G6I5V05I)
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taac048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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