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Article ; Online: Hazardous Effects of Pesticides on Human Health.

Ádám, Balázs / Cocco, Pierluigi / Godderis, Lode

2024 Volume 12, Issue 3

Abstract: Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [ ... ]. ...

Abstract	Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [...].
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12030186
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Article ; Online: Multidimensional factors of burnout in general practice: a cross-sectional survey.

Bayot, Marie / Boone, Anke / Godderis, Lode / Lenoir, Anne-Laure

BJGP open

2024

Abstract: Background: General practitioners (GPs) are particularly vulnerable to job burnout. Tailored prevention and intervention strategies are needed.: Aim: To investigate organisational, interpersonal and individual factors contributing to exhaustion and ... ...

Abstract	Background: General practitioners (GPs) are particularly vulnerable to job burnout. Tailored prevention and intervention strategies are needed. Aim: To investigate organisational, interpersonal and individual factors contributing to exhaustion and disengagement at work among GPs. Design & setting: We conducted a cross-sectional study in a sample of Belgian GPs. Method: A total of 358 doctors (73% females, 301 with complete data) completed an online anonymous questionnaire assessing job burnout, psychosocial characteristics of the work environment, perceived social support in the private domain, emotional competence, and self-compassion. Results: GPs reported moderate levels of exhaustion and disengagement. Regression models showed that included factors jointly explained 69% of the variance in exhaustion and 63% in disengagement. Exhaustion was significantly predicted by sex (being a woman) (β effect size =-.1), high perceived emotional demands ( Conclusion: Organisational, interpersonal and intrapersonal factors interact to predict a substantial part of burnout in general practice. The most significant risk factors were perceived work-life conflict and poor meaning of work. Policy-makers should work to support more sustainable practices based on the specific needs and constraints reported by GPs.
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ISSN	2398-3795
ISSN (online)	2398-3795
DOI	10.3399/BJGPO.2023.0171
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Article ; Online: Return-to-work interventions for sick-listed employees with burnout: a systematic review.

Lambreghts, Charlotte / Vandenbroeck, Sofie / Goorts, Kaat / Godderis, Lode

Occupational and environmental medicine

2023 Volume 80, Issue 9, Page(s) 538–544

Abstract: Burnout is a work-related mental health problem that often causes long-term sickness absence. Return-to-work (RTW) interventions for burned-out sick-listed employees aim to prevent long-term work disability. This systematic review addresses two questions: ...

Abstract	Burnout is a work-related mental health problem that often causes long-term sickness absence. Return-to-work (RTW) interventions for burned-out sick-listed employees aim to prevent long-term work disability. This systematic review addresses two questions: (1) Which interventions for burned-out sick-listed employees have been studied?; (2) What is the effect of these interventions on RTW?We performed a systematic literature review and searched PubMed, Cochrane Central Register of Controlled Trials, Embase, CINAHL and Web of Science from 1 January 2000 to 31 December 2022. We searched for articles of interventions for burned-out sick-listed employees. We conducted the review in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Outcome was RTW.We identified 2160 articles after removal of all duplicates. Eight studies met inclusion criteria. RTW outcomes were number of sick-leave days, sick-leave rates, median period of RTW and worked hours per week. Five studies described person-directed interventions, one described a workplace-directed intervention, one described a combination of both intervention types and one study described all three types of intervention. Only the workplace-directed intervention showed a significant improvement in RTW compared with the comparator group: at 18-month follow-up, 89% of the intervention group had returned to work compared with 73% of the comparator group.Only a limited number of studies have explored interventions specifically focused on burned-out sick-listed employees and the effect on RTW. Due to heterogeneity and moderate to high risk of bias of these studies, no firm conclusions can be drawn on the described interventions and their effect on RTW.The study was registered with the International prospective register of systematic reviews (PROSPERO, registration number: CRD42018089155).
MeSH term(s)	Humans ; Return to Work/psychology ; Employment ; Workplace ; Burnout, Professional ; Sick Leave
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2023-108867
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Article ; Online: Lessons learned from the COVID-19 pandemic-what Occupational Safety and Health can bring to Public Health.

Godderis, Lode / Lerouge, Loic / Samant, Yogindra / Noone, Peter

Journal of public health policy

2023 Volume 44, Issue 1, Page(s) 138–146

Abstract: We strive to increase public (PH) and occupational health (OSH) inter-linkages by building a collaborative framework. Besides Covid-19 pandemic, recent approaches such as Human Exposome and Total Worker Health TM, have led to a shift to improving health ... ...

Abstract	We strive to increase public (PH) and occupational health (OSH) inter-linkages by building a collaborative framework. Besides Covid-19 pandemic, recent approaches such as Human Exposome and Total Worker Health TM, have led to a shift to improving health of working population and consequently the total population. These health objectives can be best realised through primary care actors in specific contexts. Work, school, home and leisure are the four multi-stakeholder contexts in which health and healthcare (goal-oriented care) objectives needs to be set and defined. PH policy makers need to establish a shared decision-making process involving employees, employers and OSH representatives to set PH goals and align with OSH goals. The policy making process in OSH can serve as a potential way forward, as the decisions and policies are being decided centrally in consultation with social partners and governments. This process can then be mirrored on company level to adopt and implement.
MeSH term(s)	Humans ; Occupational Health ; Public Health ; Pandemics ; COVID-19/epidemiology ; Delivery of Health Care
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	603208-4
ISSN	1745-655X ; 0197-5897
ISSN (online)	1745-655X
ISSN	0197-5897
DOI	10.1057/s41271-023-00394-w
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Article ; Online: Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents.

Jiménez-Garza, Octavio / Ghosh, Manosij / Barrow, Timothy M / Godderis, Lode

Frontiers in public health

2023 Volume 11, Page(s) 1073658

Abstract: Introduction: Epigenetic marks have been proposed as early changes, at the subcellular level, in disease development. To find more specific biomarkers of effect in occupational exposures to toxicants, DNA methylation studies in peripheral blood cells ... ...

Abstract	Introduction: Epigenetic marks have been proposed as early changes, at the subcellular level, in disease development. To find more specific biomarkers of effect in occupational exposures to toxicants, DNA methylation studies in peripheral blood cells have been performed. The goal of this review is to summarize and contrast findings about DNA methylation in blood cells from workers exposed to toxicants. Methods: A literature search was performed using PubMed and Web of Science. After first screening, we discarded all studies performed Discussion: Some evidence from longitudinal studies suggest that modifications observed in cross-sectional designs may be transitory; then, we cannot say that DNA methylation changes are predictive of disease development due to those exposures. Conclusion: Due to the heterogeneity in the genes studied, and scarcity of longitudinal studies, we are far away from considering DNA methylation changes as biomarkers of effect in occupational exposures, and nor can we establish a clear functional or pathological correlate for those epigenetic modifications associated with the studied exposures.
MeSH term(s)	DNA Methylation ; Cross-Sectional Studies ; Epigenesis, Genetic ; Biomarkers ; Blood Cells
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1073658
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Article ; Online: Commuting and sick leave: a retrospective longitudinal study among a Belgian military population.

Hinderijckx, Peter / Collée, Audrey / Godderis, Lode / Dhondt, Erwin / Goorts, Kaat

Occupational and environmental medicine

2023 Volume 80, Issue 12, Page(s) 674–679

Abstract: Objectives: In a military context, people often have to deal with long commuting distance. The aim of the current study is to investigate to what extent commuting distances predict sickness absence among a military population.: Methods: The present ... ...

Abstract	Objectives: In a military context, people often have to deal with long commuting distance. The aim of the current study is to investigate to what extent commuting distances predict sickness absence among a military population. Methods: The present study is based on a dynamic cohort of active-duty military personnel of the Belgian Defence. A proportional hazard Andersen-Gill model was used to determine the effect of commuting distance on the recurrence of sickness absence, considering relevant covariates. In a second model, an interaction term for commuting and traffic congestion was introduced. Results: Higher commuting distances led to higher risk of recurring sickness absence, which was 9%, 15%, 8% and 11% higher, respectively, for distances of 5-14 km, 15-29 km, 30-59 km or >60 km compared with a distance of <5 km.A commuting distance of 30-59 km increased the risk with 47%, 33%, 35% and 76% if the reported traffic congestion was, respectively, 5-20%, 20-40%, 40-70% and 70-100% compared with a commuting distance of <5 km and a reported traffic congestion of 0-5%. A commuting distance of >60 km increased the risk with 25% and 76%, respectively, for a reported traffic congestion of 5-20% and 70-100% compared with a commuting distance of <5 km and a reported traffic congestion of 0-5%. Conclusions: These findings support measures to reduce the distance and frequency of commuting in order to reduce sickness absence, considering for example remote working, a more responsible geographical distribution of the offices or a revision of the employees' job-changing policies.
MeSH term(s)	Humans ; Longitudinal Studies ; Military Personnel ; Retrospective Studies ; Sick Leave ; Belgium ; Transportation
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2023-108922
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Article: Epigenetic Mechanisms in Understanding Nanomaterial-Induced Toxicity.

Ghosh, Manosij / Godderis, Lode / Hoet, Peter

Advances in experimental medicine and biology

2022 Volume 1357, Page(s) 195–223

Abstract: The toxic effects of different forms of nanomaterials comprise a series of biological effects such as oxidative stress; DNA damage; inflammatory response; activation of nuclear transcription factors. Some of these are key characteristics of human ... ...

Abstract	The toxic effects of different forms of nanomaterials comprise a series of biological effects such as oxidative stress; DNA damage; inflammatory response; activation of nuclear transcription factors. Some of these are key characteristics of human carcinogens and have been considered for hazard identification of nanomaterials. In addition, epigenetic changes also play a key role in the multi-step sequential process of carcinogenesis. Epigenetic modifications may constitute changes in DNA methylation, histone modifications (methylation, acetylation etc), and changes in non-coding RNA, leading to an altered gene expression profile. In this chapter, we describe the state-of-the-art of epigenetic modifications induced by different nanomaterials, from a limited number of in vitro- in vivo and human studies, a majority of which is primarily focused on DNA methylation. We also highlight the potential challenges and future directions in the field of epigenetics research in nanomaterial toxicology.
MeSH term(s)	DNA Methylation ; Epigenesis, Genetic ; Epigenomics ; Histones/genetics ; Histones/metabolism ; Humans ; Nanostructures/toxicity
Chemical Substances	Histones
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-88071-2_9
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Article ; Online: Short-term effectiveness of face-to-face periodic occupational health screening versus electronic screening with targeted follow-up: results from a quasi-randomized controlled trial in four Belgian hospitals.

Steel, Jonas Stefaan / Godderis, Lode / Luyten, Jeroen

Scandinavian journal of work, environment & health

2022 Volume 48, Issue 3, Page(s) 220–228

Abstract: Objectives: In many countries, organisations are legally obliged to have occupational physicians screen employees regularly. However, this system is time-intensive, and there may be more cost-effective alternatives. Our objective is to compare the short- ...

Abstract	Objectives: In many countries, organisations are legally obliged to have occupational physicians screen employees regularly. However, this system is time-intensive, and there may be more cost-effective alternatives. Our objective is to compare the short-term effectiveness of periodic occupational health screening of hospital employees by an occupational physician with a system of electronic screening with targeted follow-up. Methods: A randomized controlled trial was set up among personnel of four Belgian hospitals, with three measurement moments between June 2019 and December 2020, to compare differences in self-assessed health, healthcare use, productivity and intermediate outcomes over 19 months. Mixed effects models were used to assess differences in effectiveness. Superiority and non-inferiority post-hoc tests were used as a robustness check. The experiment coincided with the first two COVID-19 waves during which hospital employees were exposed to an exceptional period of occupational stress. Results: In total, 1077 employees (34% of the target population) participated. Although we observed some immediate effects of the intervention (less trust in the physician, absenteeism, and healthcare use), all these effects disappeared over time. After 19 months, including two waves of COVID-19 hospitalizations, no significant differences were observed between employees screened through face-to-face contact and those screened electronically. Conclusions: Our study finds no indication that, in the short-term, substituting physician screening of the workforce with a quicker survey-based screening with targeted follow-up has different effects on the studied endpoints. However, as health and disease are often the result of a long-term process, more evidence is needed to determine long-term effects.
MeSH term(s)	Belgium ; COVID-19/epidemiology ; Electronics ; Hospitals ; Humans ; Occupational Health
Language	English
Publishing date	2022-01-17
Publishing country	Finland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	191563-0
ISSN	1795-990X ; 0355-3140
ISSN (online)	1795-990X
ISSN	0355-3140
DOI	10.5271/sjweh.4011
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Article ; Online: The association between work-related physical and psychosocial factors and musculoskeletal disorders in healthcare workers: Moderating role of fear of movement.

Keyaerts, Stijn / Godderis, Lode / Delvaux, Ellen / Daenen, Liesbeth

Journal of occupational health

2022 Volume 64, Issue 1, Page(s) e12314

Abstract: Objectives: Knowledge is lacking on the interaction between fear of movement (FOM) and work-related physical and psychosocial factors in the development and persistence of musculoskeletal disorders (MSDs).: Methods: In this cross-sectional study, 305 ...

Abstract	Objectives: Knowledge is lacking on the interaction between fear of movement (FOM) and work-related physical and psychosocial factors in the development and persistence of musculoskeletal disorders (MSDs). Methods: In this cross-sectional study, 305 healthcare workers from several Belgian hospitals filled out a questionnaire including sociodemographic factors, work-related factors (social support, autonomy at work, workload, and physical job demands), FOM, and MSDs for different body regions during the past year. Path analysis was performed to investigate (1) the association between the work-related factors, FOM and MSDs, and (2) the moderating role of FOM on the association between the work-related factors and MSDs among healthcare workers. Results: Complaints were most frequently located at the neck-shoulder region (79.5%) and lower back (72.4%). Physical job demands (odds ratio [OR] 2.38 and 95% confidence interval [CI] 1.52-3.74), autonomy at work (OR 1.64 CI [1.07-2.49]) and FOM (OR 1.07 CI [1.01-1.14] and OR 1.12 CI [1.06-1.19]) were positively associated with MSDs. Healthcare workers who experienced high social support at work (OR 0.61 CI [0.39-0.94]) were less likely to have MSDs. Fear of movement interacted negatively with workload (OR 0.92 CI [0.87-0.97]) and autonomy at work (OR 0.94 CI [0.88-1.00]) on MSDs. Conclusions: Work-related physical and psychosocial factors as well as FOM are related to MSDs in healthcare workers. FOM is an important moderator of this relationship and should be assessed in healthcare workers in addition to work-related physical and psychosocial factors to prevent or address MSDs.
MeSH term(s)	Cross-Sectional Studies ; Fear ; Health Personnel ; Humans ; Musculoskeletal Diseases/epidemiology ; Musculoskeletal Diseases/etiology ; Occupational Diseases/epidemiology ; Risk Factors ; Sociodemographic Factors ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1340985-2
ISSN	1348-9585 ; 1341-9145
ISSN (online)	1348-9585
ISSN	1341-9145
DOI	10.1002/1348-9585.12314
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Article ; Online: Challenges and opportunities for occupational health and safety after the COVID-19 lockdowns.

Godderis, Lode / Luyten, Jeroen

Occupational and environmental medicine

2020 Volume 77, Issue 8, Page(s) 511–512

MeSH term(s)	Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections ; Economic Recession ; Humans ; Occupational Health ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Socioeconomic Factors ; Spain
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2020-106645
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