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  1. Article: Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses

    Blanton, Laura V / San Roman, Adrianna K / Wood, Geryl / Buscetta, Ashley / Banks, Nicole / Skaletsky, Helen / Godfrey, Alexander K / Pham, Thao T / Hughes, Jennifer F / Brown, Laura G / Kruszka, Paul / Lin, Angela E / Kastner, Daniel L / Muenke, Maximilian / Page, David C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract Recent
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.18.585578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.

    Godfrey, Alexander K / Naqvi, Sahin / Chmátal, Lukáš / Chick, Joel M / Mitchell, Richard N / Gygi, Steven P / Skaletsky, Helen / Page, David C

    Genome research

    2020  Volume 30, Issue 6, Page(s) 860–873

    Abstract: Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 ... ...

    Abstract Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundreds of individuals. Although it is often said that Y-Chromosome genes are lowly expressed outside the testis, we report many instances of elevated Y-Chromosome gene expression in a nonreproductive tissue. A notable example is
    MeSH term(s) Chromosomes, Human, X/genetics ; Chromosomes, Human, Y ; Computational Biology/methods ; Evolution, Molecular ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Genes, X-Linked ; Genes, Y-Linked ; Humans ; Male ; MicroRNAs/genetics ; Organ Specificity/genetics ; Transcriptome
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1284872-4
    ISSN 1549-5469 ; 1088-9051 ; 1054-9803
    ISSN (online) 1549-5469
    ISSN 1088-9051 ; 1054-9803
    DOI 10.1101/gr.261248.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3729: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 8: Show issues

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  3. Article ; Online: Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.

    Naqvi, Sahin / Godfrey, Alexander K / Hughes, Jennifer F / Goodheart, Mary L / Mitchell, Richard N / Page, David C

    Science (New York, N.Y.)

    2019  Volume 365, Issue 6450

    Abstract: Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression ...

    Abstract Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain ~12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences.
    MeSH term(s) Animals ; Base Sequence ; Binding Sites ; Conserved Sequence ; Dogs ; Evolution, Molecular ; Female ; Gene Expression ; Humans ; Macaca fascicularis ; Male ; Mice ; Rats ; Sex Characteristics ; Sex Factors ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaw7317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  4. Article ; Online: The human inactive X chromosome modulates expression of the active X chromosome.

    San Roman, Adrianna K / Godfrey, Alexander K / Skaletsky, Helen / Bellott, Daniel W / Groff, Abigail F / Harris, Hannah L / Blanton, Laura V / Hughes, Jennifer F / Brown, Laura / Phou, Sidaly / Buscetta, Ashley / Kruszka, Paul / Banks, Nicole / Dutra, Amalia / Pak, Evgenia / Lasutschinkow, Patricia C / Keen, Colleen / Davis, Shanlee M / Tartaglia, Nicole R /
    Samango-Sprouse, Carole / Muenke, Maximilian / Page, David C

    Cell genomics

    2023  Volume 3, Issue 2, Page(s) 100259

    Abstract: The "inactive" X chromosome (Xi) has been assumed to have little impact, ... ...

    Abstract The "inactive" X chromosome (Xi) has been assumed to have little impact, in
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The human Y and inactive X chromosomes similarly modulate autosomal gene expression.

    San Roman, Adrianna K / Skaletsky, Helen / Godfrey, Alexander K / Bokil, Neha V / Teitz, Levi / Singh, Isani / Blanton, Laura V / Bellott, Daniel W / Pyntikova, Tatyana / Lange, Julian / Koutseva, Natalia / Hughes, Jennifer F / Brown, Laura / Phou, Sidaly / Buscetta, Ashley / Kruszka, Paul / Banks, Nicole / Dutra, Amalia / Pak, Evgenia /
    Lasutschinkow, Patricia C / Keen, Colleen / Davis, Shanlee M / Lin, Angela E / Tartaglia, Nicole R / Samango-Sprouse, Carole / Muenke, Maximilian / Page, David C

    Cell genomics

    2023  Volume 4, Issue 1, Page(s) 100462

    Abstract: Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the ... ...

    Abstract Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46
    MeSH term(s) Humans ; Male ; Female ; Y Chromosome ; Transcription Factors/genetics ; Chromosomes, Human, X/genetics ; Sex Chromosome Aberrations ; Gene Expression/genetics
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The human Y and inactive X chromosomes similarly modulate autosomal gene expression.

    San Roman, Adrianna K / Skaletsky, Helen / Godfrey, Alexander K / Bokil, Neha V / Teitz, Levi / Singh, Isani / Blanton, Laura V / Bellott, Daniel W / Pyntikova, Tatyana / Lange, Julian / Koutseva, Natalia / Hughes, Jennifer F / Brown, Laura / Phou, Sidaly / Buscetta, Ashley / Kruszka, Paul / Banks, Nicole / Dutra, Amalia / Pak, Evgenia /
    Lasutschinkow, Patricia C / Keen, Colleen / Davis, Shanlee M / Lin, Angela E / Tartaglia, Nicole R / Samango-Sprouse, Carole / Muenke, Maximilian / Page, David C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the ... ...

    Abstract Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.05.543763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Meioc maintains an extended meiotic prophase I in mice.

    Soh, Y Q Shirleen / Mikedis, Maria M / Kojima, Mina / Godfrey, Alexander K / de Rooij, Dirk G / Page, David C

    PLoS genetics

    2017  Volume 13, Issue 4, Page(s) e1006704

    Abstract: The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I that is many times longer than prophase of mitosis. Here we show that, in mice, maintenance of an extended meiotic prophase ... ...

    Abstract The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I that is many times longer than prophase of mitosis. Here we show that, in mice, maintenance of an extended meiotic prophase I requires the gene Meioc, a germ-cell specific factor conserved in most metazoans. In mice, Meioc is expressed in male and female germ cells upon initiation of and throughout meiotic prophase I. Mouse germ cells lacking Meioc initiate meiosis: they undergo pre-meiotic DNA replication, they express proteins involved in synapsis and recombination, and a subset of cells progress as far as the zygotene stage of prophase I. However, cells in early meiotic prophase-as early as the preleptotene stage-proceed to condense their chromosomes and assemble a spindle, as if having progressed to metaphase. Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program. MEIOC interacts with YTHDC2, and the two proteins pull-down an overlapping set of mitosis-associated transcripts. We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts.
    MeSH term(s) Animals ; Cell Cycle Proteins/biosynthesis ; Cell Cycle Proteins/genetics ; Chromosome Pairing/genetics ; Cyclin A2/biosynthesis ; Cyclin A2/genetics ; Gene Expression Regulation, Developmental ; Male ; Meiosis/genetics ; Mice ; Mitosis/genetics ; Prophase/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Spermatocytes ; Spermatogenesis/genetics ; Spermatogonia/growth & development ; Spermatogonia/metabolism
    Chemical Substances CCNA2 protein, mouse ; Cell Cycle Proteins ; Cyclin A2 ; MEIOC protein, mouse ; RNA-Binding Proteins ; YTHDF2 protein, mouse
    Language English
    Publishing date 2017-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1006704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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