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  1. Article: Matrix Metalloproteases 8 Polymorphism as Risk Factor for Rotator Cuff Tear.

    Cavascan, Nathali Nunes / Assunção, Jorge Henrique / Godoy-Santos, Alexandre Leme / Neto, Arnaldo Amado Ferreira / Godoy Dos Santos, Maria Cristina Leme

    The archives of bone and joint surgery

    2023  Volume 11, Issue 9, Page(s) 565–569

    Abstract: Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-8 is a protein that degrades type I collagen, and it is known that MMP-8 has a ... ...

    Abstract Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-8 is a protein that degrades type I collagen, and it is known that MMP-8 has a polymorphism in which a T allele in the gene promoter region increases its transcription activity. This study aims to investigate the association between MMP-8 polymorphism g.-799 C>T (rs11225394) and RCT.
    Methods: To do that, we collected DNA samples from buccal epithelial cells of 128 patients (separated into RCT group and control group in a proportion 1:1) and genotyped the DNA using PCR. The statistical analyses were done using the ARLEQUIN Version 2.0, and the data normality was tested with the Shapiro-Wilk test.
    Results: The results showed a significantly higher frequency of T/T genotype in the test group (29% in the control group and 39% in the test group, p=0.0417), and that would represent a risk factor for increased collagen degradation.
    Conclusion: The MMP-8 g.-799 C>T (rs11225394) SNP was associated with RCT. With the description of a new risk factor, future research can be done to analyze how to prevent RCT or develop new treatment strategies since the disease's failure index is currently high.
    Language English
    Publishing date 2023-10-11
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2782053-1
    ISSN 2345-461X ; 2345-4644
    ISSN (online) 2345-461X
    ISSN 2345-4644
    DOI 10.22038/ABJS.2023.55108.2743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants.

    Campos, Maria Isabela Guimarães / Godoy dos Santos, Maria Cristina Leme / Trevilatto, Paula Cristina / Scarel-Caminaga, Raquel Mantuaneli / Bezerra, Fabio Jose / Line, Sergio Roberto Peres

    Implant dentistry

    2005  Volume 14, Issue 4, Page(s) 391–396

    Abstract: Single nucleotide polymorphisms in the promoter region of the human interleukin (IL)-2 (T-330G) and IL-6 (G-174C) genes have modified the transcriptional activity of these cytokines and are associated with several diseases. The aim of this study was to ... ...

    Abstract Single nucleotide polymorphisms in the promoter region of the human interleukin (IL)-2 (T-330G) and IL-6 (G-174C) genes have modified the transcriptional activity of these cytokines and are associated with several diseases. The aim of this study was to investigate the possible relationship between these single nucleotide polymorphisms and early implant failure. A sample of 74 nonsmokers was divided into 2 groups: test group comprising 34 patients (mean age 49.3 years) with >or=1 implants that failed and control group consisting of 40 patients (mean age 43.8 years) with >or=1 healthy implants. Genomic deoxyribonucleic acid from oral mucosa was amplified by polymerase chain reaction and analyzed by restriction fragment length polymorphism. Monte Carlo simulations (P < 0.05) were used to assess differences in allele and genotypes frequencies of the single nucleotide polymorphisms between the 2 groups. No significant differences were observed in the allele and genotypes distribution of both polymorphisms when the 2 groups were compared. The results indicate that polymorphisms in the IL-2 (T-330G) and IL-6 (G-174C) genes are not associated with early implant failure, suggesting that the presence of those single nucleotide polymorphisms does not constitute a genetic risk factor for implant loss in the studied population.
    MeSH term(s) Adult ; Case-Control Studies ; Dental Implants ; Dental Restoration Failure ; Female ; Humans ; Interleukin-2/genetics ; Interleukin-6/genetics ; Male ; Middle Aged ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Time Factors
    Chemical Substances Dental Implants ; Interleukin-2 ; Interleukin-6
    Language English
    Publishing date 2005-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1144907-x
    ISSN 1056-6163
    ISSN 1056-6163
    DOI 10.1097/01.id.0000188470.54417.98
    Database MEDical Literature Analysis and Retrieval System OnLINE

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