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Article: Impact of coconut kernel extract on carcinogen-induced skin cancer model: Oxidative stress, C-MYC proto-oncogene and tumor formation.

Sandhya, Sorra / Talukdar, Joyeeta / Gogoi, Gayatri / Dey, Kumar Saurav / Das, Bikul / Baishya, Debabrat

2024 Volume 10, Issue 8, Page(s) e29385

Abstract: This study aimed at analysing the effects of coconut ( ...

Abstract	This study aimed at analysing the effects of coconut (
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29385
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Papillary carcinoma of breast: An institutional overview of a rare histopathologic type.

Gogoi, Gayatri / Dowerah, Swagata / Kashyap, Akankshya S / Terangpi, Monika

Journal of cancer research and therapeutics

2023 Volume 19, Issue 2, Page(s) 511–515

Abstract: Papillary carcinoma of the breast is a rare malignant tumor, constituting 1%-2% of all breast carcinomas in women. We studied a total of 6 cases of papillary cancer breast of which five were in female patients, and one was a male patient. Three were ... ...

Abstract	Papillary carcinoma of the breast is a rare malignant tumor, constituting 1%-2% of all breast carcinomas in women. We studied a total of 6 cases of papillary cancer breast of which five were in female patients, and one was a male patient. Three were invasive papillary carcinoma while one was encapsulated papillary carcinoma without invasion, one was encapsulated papillary carcinoma with invasion and one was a solid type of papillary carcinoma. The median age of the patients was 45.5 years. All the tumors except one were seen in the left breast. Grossly, the size of the tumors ranged from 2 cm × 2 cm × 1.5 cm to as large as 6 cm × 10 cm × 4 cm. Three of the cases had positive axillary nodes. To conclude, papillary carcinoma is a rare tumor with a better prognosis as compared to Infiltrating duct carcinoma breast, and hence, it is important to be aware of the different subtypes and diagnostic pitfalls of this tumor to correctly diagnose it.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Carcinoma, Papillary/diagnosis ; Carcinoma, Papillary/surgery ; Breast/surgery ; Breast Neoplasms/diagnosis ; Carcinoma ; Awareness
Language	English
Publishing date	2023-05-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_1202_21
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Article: Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues.

G K, Anil Vishnu / Gogoi, Gayatri / Kachappilly, Midhun C / Rangarajan, Annapoorni / Pandya, Hardik J

Journal of biological engineering

2023 Volume 17, Issue 1, Page(s) 68

Abstract: Background: Technologies for quick and label-free diagnosis of malignancies from breast tissues have the potential to be a significant adjunct to routine diagnostics. The biophysical phenotypes of breast tissues, such as its electrical, thermal, and ... ...

Abstract	Background: Technologies for quick and label-free diagnosis of malignancies from breast tissues have the potential to be a significant adjunct to routine diagnostics. The biophysical phenotypes of breast tissues, such as its electrical, thermal, and mechanical properties (ETM), have the potential to serve as novel markers to differentiate between normal, benign, and malignant tissue. Results: We report a system-of-biochips (SoB) integrated into a semi-automated mechatronic system that can characterize breast biopsy tissues using electro-thermo-mechanical sensing. The SoB, fabricated on silicon using microfabrication techniques, can measure the electrical impedance (Z), thermal conductivity (K), mechanical stiffness (k), and viscoelastic stress relaxation (%R) of the samples. The key sensing elements of the biochips include interdigitated electrodes, resistance temperature detectors, microheaters, and a micromachined diaphragm with piezoresistive bridges. Multi-modal ETM measurements performed on formalin-fixed tumour and adjacent normal breast biopsy samples from N = 14 subjects were able to differentiate between invasive ductal carcinoma (malignant), fibroadenoma (benign), and adjacent normal (healthy) tissues with a root mean square error of 0.2419 using a Gaussian process classifier. Carcinoma tissues were observed to have the highest mean impedance (110018.8 ± 20293.8 Ω) and stiffness (0.076 ± 0.009 kNm Conclusions: The work presents a novel strategy to characterize the multi-modal biophysical phenotype of breast biopsy tissues to aid in cancer diagnosis from small-sized tumour samples. The methodology envisions to supplement the existing technology gap in the analysis of breast tissue samples in the pathology laboratories to aid the diagnostic workflow.
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2391582-1
ISSN	1754-1611
ISSN	1754-1611
DOI	10.1186/s13036-023-00388-y
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Article ; Online: RapidET: a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues.

G K, Anil Vishnu / Gogoi, Gayatri / Behera, Bhagaban / Rila, Saeed / Rangarajan, Annapoorni / Pandya, Hardik J

Microsystems & nanoengineering

2022 Volume 8, Page(s) 1

Abstract: The rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility in pathology laboratories and operating rooms. We report a MEMS-based platform integrated with microchips that performs phenotyping of breast ... ...

Abstract	The rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility in pathology laboratories and operating rooms. We report a MEMS-based platform integrated with microchips that performs phenotyping of breast biopsy tissues using electrothermal sensing. The microchip, fabricated on a silicon substrate, incorporates a platinum microheater, interdigitated electrodes (IDEs), and resistance temperature detectors (RTDs) as on-chip sensing elements. The microchips are integrated onto the platform using a slide-fit contact enabling quick replacement for biological measurements. The bulk resistivity (
Language	English
Publishing date	2022-01-17
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-021-00337-z
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Article: An interpretative review of the wastewater-based surveillance of the SARS-CoV-2: where do we stand on its presence and concern?

Gogoi, Gayatri / Singh, Sarangthem Dinamani / Kalyan, Emon / Koch, Devpratim / Gogoi, Pronami / Kshattry, Suman / Mahanta, Hridoy Jyoti / Imran, Md / Pandey, Rajesh / Bharali, Pankaj

Frontiers in microbiology

2024 Volume 15, Page(s) 1338100

Abstract: Wastewater-based epidemiology (WBE) has been used for monitoring infectious diseases like polio, hepatitis, etc. since the 1940s. It is also being used for tracking the SARS-CoV-2 at the population level. This article aims to compile and assess the ... ...

Abstract	Wastewater-based epidemiology (WBE) has been used for monitoring infectious diseases like polio, hepatitis, etc. since the 1940s. It is also being used for tracking the SARS-CoV-2 at the population level. This article aims to compile and assess the information for the qualitative and quantitative detection of the SARS-CoV-2 in wastewater. Based on the globally published studies, we highlight the importance of monitoring SARS-CoV-2 presence/detection in the wastewater and concurrently emphasize the development of early surveillance techniques. SARS-CoV-2 RNA sheds in the human feces, saliva, sputum and mucus that ultimately reaches to the wastewater and brings viral RNA into it. For the detection of the virus in the wastewater, different detection techniques have been optimized and are in use. These are based on serological, biosensor, targeted PCR, and next generation sequencing for whole genome sequencing or targeted amplicon sequencing. The presence of the SARS-CoV-2 RNA in wastewater could be used as a potential tool for early detection and devising the strategies for eradication of the virus before it is spread in the community. Additionally, with the right and timely understanding of viral behavior in the environment, an accurate and instructive model that leverages WBE-derived data may be created. This might help with the creation of technological tools and doable plans of action to lessen the negative effects of current viral epidemics or future potential outbreaks on public health and the economy. Further work toward whether presence of viral load correlates with its ability to induce infection, still needs evidence. The current increasing incidences of JN.1 variant is a case in point for continued early detection and surveillance, including wastewater.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1338100
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Article ; Online: Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer From Adjacent Normal Tissue.

Pal, Uttam M / Nayak, Ashika / Medisetti, Tejaswi / Gogoi, Gayatri / Shekhar, Himanshu / Prasad, M S N / Vaidya, Jayant S / Pandya, Hardik J

IEEE transactions on bio-medical engineering

2021 Volume 68, Issue 12, Page(s) 3554–3563

Abstract: Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time- ... ...

Abstract	Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel. Method: We describe a Hybrid Spectral-IRDx - a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact tool could provide rapid diagnosis of cancer using formalin-fixed (FF) and deparaffinized (DP) breast biopsy tissues. Results: Using this new tool, measurements were performed on cancerous/fibroadenoma and its adjacent normal tissues from the same patients (N = 14). The acoustic attenuation coefficient (α) and reduced scattering coefficient (µ' Conclusion: We show that Hybrid Spectral-IRDx can accurately delineate between cancerous and adjacent normal breast biopsy tissue. Significance: The results obtained establish the proof-of-principle and large-scale testing of this multimodal breast cancer diagnostic platform for core biopsy diagnosis.
MeSH term(s)	Biopsy ; Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy, Segmental ; Spectroscopy, Near-Infrared
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2021.3077582
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Article ; Online: Antibody response after a single dose of ChAdOx1-nCOV (Covishield) vaccine in subjects with prior SARS-CoV2 infection: Is a single dose sufficient?

Borkakoty, Biswajyoti / Sarmah, Mandakini Das / Bhattacharjee, Chandra Kanta / Bali, Nargis / Gogoi, Gayatri

medRxiv

Abstract: It is crucial to know whether a single dose of vaccine against SARS-CoV-2 is sufficient to elicit immune response in previously infected people in India. A total of 121 participants (baseline seropositive 46 and seronegative 75) were included to study ... ...

Abstract	It is crucial to know whether a single dose of vaccine against SARS-CoV-2 is sufficient to elicit immune response in previously infected people in India. A total of 121 participants (baseline seropositive 46 and seronegative 75) were included to study the immune response to ChAdOx1-nCOV (Covishield) vaccine in previously infected or uninfected people. IgG antibodies were estimated at three different time intervals, i.e. pre-vaccination, 25-35 days post 1st vaccination and 25-35 days post 2nd vaccination. The IgG antibody titre was significantly high among previous seropositive subjects with single dose of vaccine compared to seronegative group with both doses of vaccine respectively (Mean:4.59,SD:1.04 vs Mean:3.08 SD:1.22, p-value: <0.0001). In conclusion, a single dose of Covishield vaccine might be sufficient to induce an effective immune response n subjects with prior SARS-CoV2 infection. Stratifying vacinees based on their SARS-CoV2 IgG antibody titre before vaccination would help in meeting the increasing vaccine demand and could be effective to circumvent further wave of the pandemic in India.
Keywords	covid19
Language	English
Publishing date	2021-06-15
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.06.15.21258346
Database	COVID19

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Article: Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis.

Borgohain, Mondita / Gogoi, Gayatri / Das, Dipak / Biswas, Manjusha

Indian journal of endocrinology and metabolism

2013 Volume 17, Issue 5, Page(s) 917–919

Abstract: Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to ... ...

Abstract	Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry.
Language	English
Publishing date	2013-09-23
Publishing country	India
Document type	Case Reports
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/2230-8210.117217
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Article ; Online: Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India.

Wahengbam, Romi / Bharali, Pankaj / Manna, Prasenjit / Phukan, Tridip / Singh, Moirangthem Goutam / Gogoi, Gayatri / Tapadar, Yasmin Begam / Singh, Anil Kumar / Konwar, Rituraj / Chikkaputtaiah, Channakeshavaiah / Velmurugan, Natarajan / Nagamani, Selvaraman / Mahanta, Hridoy Jyoti / Sarma, Himakshi / Sahu, Ravi Kumar / Dutta, Prachurjya / Wann, Sawlang Borsingh / Kalita, Jatin / Sastry, G Narahari

Indian journal of medical microbiology

2022 Volume 43, Page(s) 58–65

Abstract: Purpose: Seroepidemiology and genomic surveillance are valuable tools to investigate infection transmission during a pandemic. North East (NE) India is a strategically important region being the gateway connecting the country with Southeast Asia. Here, ... ...

Abstract	Purpose: Seroepidemiology and genomic surveillance are valuable tools to investigate infection transmission during a pandemic. North East (NE) India is a strategically important region being the gateway connecting the country with Southeast Asia. Here, we examined the spread of SARS-CoV-2 in NE India during the first and second waves of COVID-19 using serological and whole genome sequencing approaches. Methods: qRT-PCR analysis was performed on a selected population (n = 16,295) from June 2020 to July 2021, and metadata was collected. Immunoassays were studied (n = 2026) at three-time points (August 2020, February 2021, and June 2021) and in a cohort (n = 35) for a year. SARS-CoV-2 whole genomes (n = 914) were sequenced and analyzed with those obtained from the databases. Results: Test positivity rates (TPR) in the first and second waves were 6.34% and 6.64% in Assam, respectively, and a similar pattern was observed in other NE states. Seropositivity in the three time points was 10.63%, 40.3%, and 46.33%, respectively, and neutralizing antibody prevalence was 90.91%, 52.14%, and 69.30%, respectively. Persistence of pan-IgG-N SARS-CoV-2 antibody for over a year was observed among three subjects in the cohort group. Normal variants dominated the first wave, while B.1.617.2 and AY-sublineages dominated the second wave in the region. The prevalence of the variants co-related well with high TPR and seropositivity rate in the region and identified mostly among vaccinated individuals. Conclusion: The COVID-19 first wave in the region witnessed low transmission with the evolution of diverse variants. Seropositivity increased during the study period with over half of the individuals carrying neutralizing antibodies against SARS-CoV-2. High infection and seroprevalence in NE India during the second wave were associated with the dominant emergence of variants of concern.
MeSH term(s)	Humans ; Seroepidemiologic Studies ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; Genomics ; India/epidemiology ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Neutralizing
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.1016/j.ijmmb.2022.10.011
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Article: Giant Sclerosing Oral Rhabdomyosarcoma-A Unique Case.

Moran, Nirupama / Bhuyan, U T / Gogoi, Gayatri / Gohain, Mridushmita

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2015 Volume 68, Issue 3, Page(s) 384–386

Abstract: We present a case of oral Rhabdomyosarcoma in a 50 years old man presenting with a huge mass in the oral cavity. Pre operative investigations showed the mass to be Rhabdomyosarcoma. The mass was excised and subjected to histopathogical and ... ...

Abstract	We present a case of oral Rhabdomyosarcoma in a 50 years old man presenting with a huge mass in the oral cavity. Pre operative investigations showed the mass to be Rhabdomyosarcoma. The mass was excised and subjected to histopathogical and immunohistochemical examinations which confirmed to be Rhabdomyosarcoma.
Language	English
Publishing date	2015-09-22
Publishing country	India
Document type	Case Reports
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-015-0905-9
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