LIVIVO - Search results -

Search results

Result 1 - 7 of total 7

Search options

Article ; Online: Economic burden of in-hospital AKI: a one-year analysis of the nationwide French hospital discharge database.

Monard, Céline / Rimmelé, Thomas / Blanc, Esther / Goguillot, Mélanie / Bénard, Stève / Textoris, Julien

2023 Volume 24, Issue 1, Page(s) 343

Abstract: Background: Although Acute Kidney Injury (AKI) incidence is increasing worldwide, data investigating its cost are lacking. This population-wide study aimed to describe the characteristics and costs of hospital stays with, and without AKI, and to ... ...

Abstract	Background: Although Acute Kidney Injury (AKI) incidence is increasing worldwide, data investigating its cost are lacking. This population-wide study aimed to describe the characteristics and costs of hospital stays with, and without AKI, and to estimate the AKI-associated increases in costs and length of stay (LOS) in three subgroups (major open visceral surgery (MOV), cardiovascular surgery with extracorporeal circulation (CVEC), and sepsis). Methods: All hospital stays that occurred in France in 2018 were included. Stay and patient characteristics were collected in the French hospital discharge database and described. Medical conditions were identified using the 10 Results: 26,917,832 hospital stays, of which 415,067 (1.5%) with AKI, were included. AKI was associated with 83,553 (19.8%), 7,165 (17.9%), and 15,387 (9.2%) of the stays with sepsis, CVEC, and MOV, respectively. Compared to stays without AKI, stays with AKI were more expensive (median [IQR] €4,719[€2,963-€7782] vs. €735[€383-€1,805]) and longer (median [IQR] 9[4-16] vs. 0[0-2] days). AKI was associated with a mean [95%CI] increase in hospitalization cost of 70% [69;72], 48% [45;50], and 68% [65;70] in the sepsis, CVEC, and MOV groups respectively, after adjustment. Conclusion: This study confirms the major economic burden of in-hospital AKI in a developed country. Interventions to prevent AKI are urgently needed and their cost should be balanced with AKI-related costs.
MeSH term(s)	Humans ; Patient Discharge ; Financial Stress ; Length of Stay ; Hospitals ; Acute Kidney Injury/epidemiology ; Sepsis/epidemiology ; Retrospective Studies
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03396-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Severity and burden of sickle cell disease in France: a nationwide real-world study.

Brousse, Valentine / Bernaudin, Francoise / Melaine, Asma / Goguillot, Melanie / Gallagher, Meghan / Benard, Steve / Habibi, Anoosha

Haematologica

2023 Volume 108, Issue 9, Page(s) 2476–2486

Abstract: The burden of sickle cell disease (SCD) in France has been difficult to apprehend due to the paucity of reliable nationwide epidemiological data. We aimed to describe the epidemiology of SCD and evaluate its burden and costs. Patients with SCD and most ... ...

Abstract	The burden of sickle cell disease (SCD) in France has been difficult to apprehend due to the paucity of reliable nationwide epidemiological data. We aimed to describe the epidemiology of SCD and evaluate its burden and costs. Patients with SCD and most severely affected patients were identified between 2012 and 2018 from the French National Health Data System database (SNDS, Système national des données de santé). Outcomes of interest included rates of acute and chronic complications, healthcare resource utilization and associated costs, and were compared in subpopulations of patients before and after hematopoietic stem cell transplantation, initiating hydroxyurea or a chronic transfusion program. Between 2012 and 2018, 22,619 patients with SCD were identified, among which 4,270 patients were defined as most severely affected. Rates of vaso-occlusion episodes and acute chest syndrome were 86.29 (95% confidence interval [CI]: 85.75-86.83] and 12.90 (95% CI: 12.69-13.11) per 100 person years in the study population and 166.9 (95% CI: 165.4- 168.4) and 22.71 (95% CI: 22.16-23.27) per 100 person years in most severely affected patients. Median (Q1-Q3) annualized total costs were €5,073.63 (range, €1,633.74-14,000.94) and €13,295.67 (range, €5,754.67-26,385.23) in the study population and most severely affected patients. Median annualized costs were ten times lower after treatment intensification for hematopoietic stem cell transplantation (€29,011.75 vs. €2,465.98; P<0.001), they slightly decreased after hydroxyurea initiation (€13,057.79 vs. €12,752.44; P=0.003) and were five times higher after chronic transfusion program initiation (€4,643.11 vs. €22,715.85; P<0.001). SCD still places a significant demand on health resources, even after therapeutic intensification.
MeSH term(s)	Humans ; Hydroxyurea/therapeutic use ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/therapy ; Anemia, Sickle Cell/complications ; France/epidemiology ; Databases, Factual ; Hematopoietic Stem Cell Transplantation
Chemical Substances	Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2023-09-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2022.282098
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.76: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Suboptimal management of rheumatoid arthritis in France: a real-world study based on data from the French National Health Data System.

Gaujoux-Viala, Cécile / Bergmann, Jean-Francois / Goguillot, Mélanie / Mélaine, Asma / Guérin, Marie / Edouard, Alban / Bénard, Stève / Fautrel, Bruno

RMD open

2023 Volume 9, Issue 4

Abstract: Objectives: The emergence of targeted therapy is changing rheumatoid arthritis (RA) management, but real-world data remain limited. This study aimed to describe real-world RA treatment patterns using data from a French national claims database.: ... ...

Abstract	Objectives: The emergence of targeted therapy is changing rheumatoid arthritis (RA) management, but real-world data remain limited. This study aimed to describe real-world RA treatment patterns using data from a French national claims database. Methods: This longitudinal study used the French Permanent Representative Sample (Echantillon Généraliste des Bénéficiaires) claims database. Patients with RA were identified between 2013 and 2017, with treatment patterns, persistence and adherence described. Results: The study population included 2553 patients with RA. Disease-modifying antirheumatic drugs (DMARDs) were prescribed for 1512 (59.2%) patients, of whom 721 (47.6%) did not require discontinuation or treatment switch. There were 377 (24.9%) treatment discontinuations and 114 patients (7.5%) switched to a targeted DMARD (biological and synthetic (Janus kinase inhibitor) DMARDs). Among the 2315 patients with RA in 2017, almost half (n=1102, 47.6%) were not treated with a DMARD. Most (85.7%) received symptomatic treatment (analgesics (81.0%), steroids (49.2%), non-steroidal anti-inflammatory drugs (39.5%)). Of the 1142 treatment initiations identified, 713 (62.4%) were conventional synthetic DMARDs (csDMARDs), with methotrexate being the most frequent (n=553, 48.45%). One-year persistence rates varied between 55.9% (49.2-62.0%) for tumour necrosis factor inhibitors, and 63.4% (59.6-67.0%) for csDMARDs. Treatment adherence, assessed through medication possession ratio, varied between 71.9% and 90.8%, with ≥80% being the adherence cut-off. Almost half of DMARD initiations were associated with long-term (>6 months), high-dose oral steroid use (~7 mg/day prednisone equivalent). Conclusion: Despite a diverse therapeutic arsenal, there remains a medical need that is not covered by current RA management, which is frequently compensated for by overprescription of steroids.
MeSH term(s)	Humans ; Longitudinal Studies ; Retrospective Studies ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Antirheumatic Agents/therapeutic use ; Prednisone/therapeutic use
Chemical Substances	Antirheumatic Agents ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003075
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Incidence of Nd:YAG laser capsulotomy following cataract surgery: a population-based nation-wide study - FreYAG1 study.

Brézin, Antoine P / Labbe, Antoine / Schweitzer, Cédric / Lignereux, François / Rozot, Pascal / Goguillot, Mélanie / Bugnard, Françoise / Dot, Corinne

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 417

Abstract: Rationale: Nd:YAG (neodymium:yttrium-aluminum-garnet) capsulotomy (Nd:YAG-caps) is the gold standard for the treatment of PCO (Posterior Capsule Opacification). There is a lack of real-world data about Nd:YAG-caps use.: Purpose: This study's ... ...

Abstract	Rationale: Nd:YAG (neodymium:yttrium-aluminum-garnet) capsulotomy (Nd:YAG-caps) is the gold standard for the treatment of PCO (Posterior Capsule Opacification). There is a lack of real-world data about Nd:YAG-caps use. Purpose: This study's objectives were to estimate Nd:YAG-caps incidence in France, to describe the patient characteristics, and to analyze the time between surgeries and capsulotomies. Setting: The study was based on data extracted from the EGB database, a 1/97th sample representative of the French population. Design: observational, retrospective, cohort study using national claims data. Methods: French adult patients who underwent Nd:YAG-caps between 2014 and 2017 were selected. Main outcomes were the number of patients and procedures performed and the risk factors associated with early Nd:YAG-caps. Results: During the study period, Nd:YAG-caps were performed in 8,425 patients accounting for 10,774 procedures. The extrapolation to the French population led to estimate that 253.10 Conclusions: This study brought new real-world and large-scale data regarding Nd:YAG-caps use and gave an updated insight into the patients' characteristics.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Lenses, Intraocular ; Lens Implantation, Intraocular ; Retrospective Studies ; Cohort Studies ; Lasers, Solid-State/therapeutic use ; Incidence ; Lens Capsule, Crystalline/surgery ; Postoperative Complications/etiology ; Laser Therapy/adverse effects ; Capsule Opacification/epidemiology ; Capsule Opacification/etiology ; Capsule Opacification/surgery
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-03134-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reply.

Dot, Corinne / Schweitzer, Cédric / Labbe, Antoine / Lignereux, François / Rozot, Pascal / Goguillot, Mélanie / Bugnard, Françoise / Brezin, Antoine P

Ophthalmology

2023 Volume 130, Issue 12, Page(s) e43–e44

Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Letter
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2023.08.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 533: Show issues

Order via subito

Details ▾

Article ; Online: A database study of clinical and economic burden of invasive meningococcal disease in France.

Huang, Liping / Fievez, Stéphane / Goguillot, Mélanie / Marié, Lucile / Bénard, Stève / Elkaïm, Anne / Tin Tin Htar, Myint

PloS one

2022 Volume 17, Issue 4, Page(s) e0267786

Abstract: Objective: Invasive meningococcal disease (IMD) is life-threatening and associated with substantial morbidity and mortality. The study aimed to examine the clinical characteristics and hospital-based healthcare resource use and related costs following ... ...

Abstract	Objective: Invasive meningococcal disease (IMD) is life-threatening and associated with substantial morbidity and mortality. The study aimed to examine the clinical characteristics and hospital-based healthcare resource use and related costs following IMD diagnosis in France. Methods: Patients admitted to hospitals due to IMD between 2014 and 2016 were selected from the French hospital discharge database (PMSI). Demographics, clinical outcomes and health utilization (HRU) during index hospitalization were described. HRU and costs during the follow-up period were also examined. A generalized linear model was applied to examine 1-year costs after index hospitalization adjusting for age, type of IMD and presence of sequelae at index hospitalization. Results: A total of 1,344 patients were identified. About 30% cases were in children < 5 years old and 25% aged 10-24 years. Majority of patients presented as meningococcal meningitis (59%), 25% as meningococcaemia, and 9% both. The case fatality rate during the index hospitalization was 6%. About 15% of patients had at least one sequela at index hospital discharge. The median length of stay and the median cost of index hospitalization were 9 days and 8,045€, respectively. Patients with at least one sequela, with clinical manifestation as both meningitis and meningococcaemia, or aged 25 years and older were statistically significantly associated with higher costs than others. Conclusion: IMD is unpredictable and can occur in all ages. The study highlights the severity and high health and economic burdens associated with the disease. The data underlines the importance of prevention against IMD through vaccination.
MeSH term(s)	Child ; Child, Preschool ; Databases, Factual ; Financial Stress ; Hospitalization ; Humans ; Meningitis, Meningococcal/complications ; Meningitis, Meningococcal/epidemiology ; Meningococcal Infections/complications ; Sepsis/complications
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0267786
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Incidence of Retinal Detachment, Macular Edema, and Ocular Hypertension after Neodymium:Yttrium-Aluminum-Garnet Capsulotomy: A Population-Based Nationwide Study-The French YAG 2 Study.

Dot, Corinne / Schweitzer, Cédric / Labbé, Antoine / Lignereux, François / Rozot, Pascal / Goguillot, Mélanie / Bugnard, Françoise / Brézin, Antoine P

Ophthalmology

2022 Volume 130, Issue 5, Page(s) 478–487

Abstract: Purpose: To estimate the incidence and assess the risk factors associated with 3 adverse events (AEs) after neodymium:yttrium-aluminum-garnet posterior capsulotomy (Nd:YAG-caps): ocular hypertension (OHT), macular edema (ME), and retinal detachment (RD). ...

Abstract	Purpose: To estimate the incidence and assess the risk factors associated with 3 adverse events (AEs) after neodymium:yttrium-aluminum-garnet posterior capsulotomy (Nd:YAG-caps): ocular hypertension (OHT), macular edema (ME), and retinal detachment (RD). Design: Observational cohort study using a nationwide claims database. Participants: Adults who underwent Nd:YAG-caps between 2014 and 2017, with no ocular disease history in the year before. Methods: Patients who underwent Nd:YAG-caps were identified using data from the French national representative sample and followed up for 12 months postprocedure. The time to AE was assessed using the Kaplan-Meier method. Factors associated with AE were assessed using Cox models. Main outcome measures: Neodymium:YAG-caps epidemiology, patients' characteristics, proportion of patients with AE, and hazard ratios (HRs) associated with variables identified as factors associated with AEs. Results: During the study period, 6210 patients received Nd:YAG-caps (7958 procedures). The mean age (± standard deviation) at Nd:YAG-caps was 75.0 (± 10.3) years. The 3-month and 12-month overall AE rates (≥ 1 AE of interest) were 8.6% and 13.3%, respectively. Among patients with ≥ 1 AE of interest, 68.4% of AEs occurred within 3 months post-Nd:YAG-caps. Three-month rates were ≈5% for OHT and ME. Retinal detachment remained ≤ 0.5% over follow-up. Cox models showed that patients with Nd:YAG-caps performed within 1 year after cataract surgery had a higher risk of AEs than those with later Nd:YAG-caps (hazard ratio [HR], 1.314 [1.034-1.669], P = 0.0256), notably ME (HR, 1.500 [1.087-2.070], P = 0.0137). Diabetic patients were more at risk of OHT (HR, 1.233 [1.005-1.513], P = 0.0448) and ME (HR, 1.810 [1.446-2.266], P < 0.0001) than nondiabetic patients. Patients with Nd:YAG-caps performed between 1 and 2 years after cataract surgery were more at risk of OHT than patients with later Nd:YAG-caps (HR, 1.429 [1.185-1.723], P = 0.0002). Conclusions: According to a national claims database, OHT and ME were the most frequent AEs of interest post-Nd:YAG-caps, mainly observed within 3 months postprocedure, highlighting the need for a close follow-up during this period or a delayed capsulotomy. Diabetes and an early Nd:YAG-caps after cataract surgery were among the main drivers for AE occurrence. Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Cataract Extraction/adverse effects ; Neodymium ; Retinal Detachment/epidemiology ; Retinal Detachment/surgery ; Retinal Detachment/etiology ; Incidence ; Macular Edema/epidemiology ; Macular Edema/etiology ; Lens Capsule, Crystalline/surgery ; Laser Therapy/adverse effects ; Capsule Opacification/epidemiology ; Capsule Opacification/etiology ; Capsule Opacification/surgery ; Ocular Hypertension/epidemiology ; Ocular Hypertension/etiology ; Postoperative Complications/etiology
Chemical Substances	Neodymium (2I87U3734A) ; yttrium-aluminum-garnet
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2022.12.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 533: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Search results

Search options

Article ; Online: Economic burden of in-hospital AKI: a one-year analysis of the nationwide French hospital discharge database.

More links

Kategorien

Order via subito

Article ; Online: Severity and burden of sickle cell disease in France: a nationwide real-world study.

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: Suboptimal management of rheumatoid arthritis in France: a real-world study based on data from the French National Health Data System.

More links

Kategorien

Order via subito

Article ; Online: Incidence of Nd:YAG laser capsulotomy following cataract surgery: a population-based nation-wide study - FreYAG1 study.

More links

Kategorien

Order via subito

Article ; Online: Reply.

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: A database study of clinical and economic burden of invasive meningococcal disease in France.

More links

Kategorien

Order via subito

Article ; Online: Incidence of Retinal Detachment, Macular Edema, and Ocular Hypertension after Neodymium:Yttrium-Aluminum-Garnet Capsulotomy: A Population-Based Nationwide Study-The French YAG 2 Study.

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito