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  1. Article ; Online: Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Neonates with Early-Onset Infection.

    Yeo, Kee Thai / Goh, Guan Lin / Park, Woo Yeon / Wynn, James L / Aziz, Khyzer B

    Neonatology

    2023  Volume 120, Issue 6, Page(s) 796–800

    Abstract: Background: The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown.: Objectives: The objective of the study was to determine ... ...

    Abstract Background: The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown.
    Objectives: The objective of the study was to determine the utility of nSOFA for EOS mortality.
    Methods: Multicenter, retrospective cohort study of NICU patients with EOS between 2012 and 2023. nSOFA scores of survivors and non-survivors were compared, and area under the receiver operating characteristics curve (AUROC) for mortality was calculated.
    Results: 104 subjects were identified (88 lived, 16 died). AUROC at blood culture collection (T0), 6 h after collection (T6), and the maximum nSOFA at T0 or T6 (T0-6max) were 0.76 (95% CI: 0.62, 0.91), 0.89 (0.80, 0.99), and 0.87 (0.77, 0.97), respectively. Analyses restricted to birthweight (<1.5, <1 kg) or gestational age (<32, <29 week) cutoffs revealed AUROC ranges of 0.86-0.92 for T6 and 0.82-0.84 for T0-6max.
    Conclusions: The nSOFA showed good-to-excellent discrimination of mortality among infants with EOS in the NICU.
    MeSH term(s) Humans ; Infant, Newborn ; Hospital Mortality ; Intensive Care Units, Neonatal ; Organ Dysfunction Scores ; Retrospective Studies ; Sepsis
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Multicenter Study ; News
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000533467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Risk Factors for Mortality From Late-Onset Sepsis Among Preterm Very-Low-Birthweight Infants: A Single-Center Cohort Study From Singapore.

    Goh, Guan Lin / Lim, Charis Shu En / Sultana, Rehena / De La Puerta, Rowena / Rajadurai, Victor Samuel / Yeo, Kee Thai

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 801955

    Abstract: Objective: To determine the risk factors for mortality associated with late onset sepsis (LOS) among preterm very-low-birthweight (VLBW) infants.: Study design: We performed a retrospective cohort study of infants born <32 weeks gestation and <1,500 ... ...

    Abstract Objective: To determine the risk factors for mortality associated with late onset sepsis (LOS) among preterm very-low-birthweight (VLBW) infants.
    Study design: We performed a retrospective cohort study of infants born <32 weeks gestation and <1,500 gm admitted to a Singaporean tertiary-level neonatal intensive care unit. We determined the clinical, microbial, and laboratory risk factors associated with mortality due to culture-positive LOS in this cohort.
    Results: A total of 1,740 infants were admitted, of which 169 (9.7%) developed LOS and 27 (16%) died. Compared to survivors, those who died had lower birth gestational age (median 24 vs. 25 weeks,
    Conclusions: In a setting with predominantly Gram-negative bacterial infections, the need for inotropic support, leukopenia, and elevated I: T ratio were significantly associated with LOS mortality among preterm VLBW infants.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.801955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unplanned reattendances at the paediatric emergency department within 72 hours: a one-year experience in KKH.

    Goh, Guan Lin / Huang, Peiqi / Kong, Man Ching Patrick / Chew, So-Phia / Ganapathy, Sashikumar

    Singapore medical journal

    2016  Volume 57, Issue 6, Page(s) 307–313

    Abstract: Introduction: Unscheduled reattendances at the paediatric emergency department may contribute to overcrowding, which may increase financial burdens. The objectives of this study were to determine the rate of reattendances and characterise factors ... ...

    Abstract Introduction: Unscheduled reattendances at the paediatric emergency department may contribute to overcrowding, which may increase financial burdens. The objectives of this study were to determine the rate of reattendances and characterise factors influencing these reattendances and hospital admission during the return visits.
    Methods: Medical records of all patients who attended the emergency department at KK Women's and Children's Hospital, Singapore, from 1 June 2013 to 31 May 2014 were retrospectively reviewed. We collected data on patient demographics, attendance data and clinical characteristics. Planned reattendances, recalled cases, reattendances for unrelated complaints and patients who left without being seen were excluded. A multivariate analysis was conducted to determine the odds ratio of variables associated with hospital admission for reattendances.
    Results: Of 162,566 children, 6,968 (4.3%) returned within 72 hours, and 2,925 (42.0% of reattendance group) were admitted on their return visits. Children more likely to reattend were under three years of age, Chinese, triaged as Priority 2 at the first visit, and were initially diagnosed with respiratory or gastrointestinal conditions. However, children more likely to be admitted on their return visits were over 12 years of age, Malay, had a higher triage acuity or were uptriaged, had the presence of a comorbidity, and were diagnosed with gastrointestinal conditions.
    Conclusion: We identified certain subgroups in the population who were more likely to be admitted if they reattended. These findings would help in implementing further research and directing strategies to reduce potentially avoidable reattendances and admissions.
    MeSH term(s) Adolescent ; Asian Continental Ancestry Group ; Child ; Child, Preschool ; Electronic Health Records ; Emergency Medicine/organization & administration ; Emergency Service, Hospital/organization & administration ; Female ; Hospitals ; Humans ; Infant, Newborn ; Male ; Odds Ratio ; Patient Admission ; Patient Readmission ; Pediatrics/organization & administration ; Singapore ; Triage/methods
    Language English
    Publishing date 2016-06
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2016105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 589: Show issues Location:
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