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  1. Article ; Online: Novel Clinical Frailty Scale Scoring Tools for Community-Dwelling Older Persons: An Interim Analysis.

    Chong, Edward / Tham, Audrey / Chew, Justin / Chen, Wei Ting / Tan, Huei Nuo / Chan, Mark / Goh, Hern Yee / Lim, Wee Shiong

    Journal of the American Medical Directors Association

    2023  Volume 24, Issue 7, Page(s) 1007–1009.e2

    MeSH term(s) Humans ; Aged ; Frailty/diagnosis ; Independent Living ; Frail Elderly ; Geriatric Assessment
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2023.03.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prolonged QTc intervals in medicated patients with schizophrenia.

    Chong, Siow Ann / Mythily / Lum, Alvin / Goh, Hern Yee / Chan, Yiong Huak

    Human psychopharmacology

    2003  Volume 18, Issue 8, Page(s) 647–649

    Abstract: Psychotropic drugs have been associated with sudden deaths and the lengthening of corrected-QT interval (QTc) on the electrocardiogram which may be a precursor of life-threatening arrhythmias as reported with some of these drugs. The objectives of this ... ...

    Abstract Psychotropic drugs have been associated with sudden deaths and the lengthening of corrected-QT interval (QTc) on the electrocardiogram which may be a precursor of life-threatening arrhythmias as reported with some of these drugs. The objectives of this study were to measure the frequency of QTc lengthening in patients with schizophrenia receiving psychotropic drugs, and to assess whether QTc lengthening was associated with certain psychotropic drugs and other risk factors. One hundred and sixty three patients with schizophrenia (104 males and 59 females) were included in the study. Clinical and demographic data were collected from the case records. One hundred healthy volunteers were recruited to establish values for upper limits of normal for measurement of QTc interval and dispersion. Eleven (6.7%) of the patients had a prolonged QTc interval. The significant predictors obtained from a logistic regression modelling were chlorpromazine, flupenthixol decanoate and fluphenazine decanoate. Caution should be exercised and monitoring with ECG should be considered in patients prescribed chlorpromazine and depot antipsychotic medications even at recommended doses.
    MeSH term(s) Aged ; Aged, 80 and over ; Antipsychotic Agents/adverse effects ; Female ; Humans ; Long QT Syndrome/chemically induced ; Long QT Syndrome/epidemiology ; Male ; Risk Factors ; Schizophrenia/drug therapy ; Sex Factors
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2003-12
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 632931-7
    ISSN 1099-1077 ; 0885-6222
    ISSN (online) 1099-1077
    ISSN 0885-6222
    DOI 10.1002/hup.540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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