Article ; Online: Efficacy and safety of intravenous beta-blockers in acute atrial fibrillation and flutter is dependent on beta-1 selectivity: a systematic review and meta-analysis of randomised trials.
Clinical research in cardiology : official journal of the German Cardiac Society
2023
Abstract: Background: Intravenous beta-blockers are commonly used to manage patients with acute atrial fibrillation (AF) and atrial flutter (AFl), but the choice of specific agent is often not evidence-based.: Methods: A prospectively-registered systematic ... ...
| Abstract | Background: Intravenous beta-blockers are commonly used to manage patients with acute atrial fibrillation (AF) and atrial flutter (AFl), but the choice of specific agent is often not evidence-based. Methods: A prospectively-registered systematic review and meta-analysis of randomised trials (PROSPERO: CRD42020204772) to compare the safety and efficacy of intravenous beta-blockers against alternative pharmacological agents. Results: Twelve trials comparing beta-blockers with diltiazem, digoxin, verapamil, anti-arrhythmic drugs and placebo were included, with variable risk of bias and 1152 participants. With high heterogeneity (I Conclusions: Across all intravenous beta-blockers, there was no difference with other medications for acute heart rate control in atrial fibrillation and flutter. Efficacy and safety may be improved by choosing beta-blockers with higher beta-1 selectivity. |
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| Language | English | |||||
| Publishing date | 2023-09-01 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2213295-8 | |||||
| ISSN | 1861-0692 ; 1861-0684 | |||||
| ISSN (online) | 1861-0692 | |||||
| ISSN | 1861-0684 | |||||
| DOI | 10.1007/s00392-023-02295-0 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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