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Article ; Online: Rehabilitation following total laryngectomy: Oncologic, functional, socio-occupational and psychological aspects.

Antin, F / Breheret, R / Goineau, A / Capitain, O / Laccourreye, L

European annals of otorhinolaryngology, head and neck diseases

2020 Volume 138, Issue 1, Page(s) 19–22

Abstract: Goal: To review rehabilitation following total laryngectomy by an analysis of epidemiological, oncologic and functional data.: Materials and methods: This retrospective observational study focused on patients having undergone total laryngectomy or ... ...

Abstract	Goal: To review rehabilitation following total laryngectomy by an analysis of epidemiological, oncologic and functional data. Materials and methods: This retrospective observational study focused on patients having undergone total laryngectomy or pharyngolaryngectomy between January 1, 2005 and December 31, 2016. Oncologic data notably comprised survival and relapse and predictive factors. The impact of the procedure on quality of life and the voice was analyzed by self-administered questionnaires (EORTC QLQ-C30 and H&N35, VHI 30). A satisfaction questionnaire was also sent to patients. Results: One hundred and thirty three patients were included. Overall specific 5-year survival was 65%. The relapse rate was 32%. Factors influencing survival were WHO performance status ≥2 (P<0.05), tumor location (P=0.07), metastatic lymphadenopathy (P=0.017) and positive resection margins (P=0.01). Quality of life was moderately degraded (global EORTC QLQ-C30 status: 61.4±23.9). Type of rehabilitation (P=0.03), tube feeding (P=0.03) and relapse (P<0.01) influenced quality of life. There were no differences in voice quality according to rehabilitation method, and no predictive factors for failure of voice rehabilitation. More than 90% of patients were satisfied with their hospital stay; 43%, however, were not satisfied with community caregiver training for laryngectomy patients. Conclusion: Rehabilitation of laryngectomized patients is a current therapeutic challenge. A therapeutic education tool was designed to better meet patient expectations.
MeSH term(s)	Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy ; Quality of Life ; Surveys and Questionnaires ; Voice ; Voice Quality
Language	English
Publishing date	2020-06-22
Publishing country	France
Document type	Journal Article ; Observational Study
ZDB-ID	2558008-5
ISSN	1879-730X ; 1879-7296
ISSN (online)	1879-730X
ISSN	1879-7296
DOI	10.1016/j.anorl.2020.06.006
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Article ; Online: Novel benthic foraminifera are abundant and diverse in an area of the abyssal equatorial Pacific licensed for polymetallic nodule exploration.

Goineau, Aurélie / Gooday, Andrew J

Scientific reports

2017 Volume 7, Page(s) 45288

Abstract: The benthic biota of the Clarion-Clipperton Zone (CCZ, abyssal eastern equatorial Pacific) is the focus of a major research effort linked to possible future mining of polymetallic nodules. Within the framework of ABYSSLINE, a biological baseline study ... ...

Abstract	The benthic biota of the Clarion-Clipperton Zone (CCZ, abyssal eastern equatorial Pacific) is the focus of a major research effort linked to possible future mining of polymetallic nodules. Within the framework of ABYSSLINE, a biological baseline study conducted on behalf of Seabed Resources Development Ltd. in the UK-1 exploration contract area (eastern CCZ, ~4,080 m water depth), we analysed foraminifera (testate protists), including 'live' (Rose Bengal stained) and dead tests, in 5 cores (0-1 cm layer, >150-μm fraction) recovered during separate megacorer deployments inside a 30 by 30 km seafloor area. In both categories (live and dead) we distinguished between complete and fragmented specimens. The outstanding feature of these assemblages is the overwhelming predominance of monothalamids, a group often ignored in foraminiferal studies. These single-chambered foraminifera, which include agglutinated tubes, spheres and komokiaceans, represented 79% of 3,607 complete tests, 98% of 1,798 fragments and 76% of the 416 morphospecies (live and dead combined) in our samples. Only 3.1% of monothalamid species and 9.8% of all species in the UK-1 assemblages are scientifically described and many are rare (29% singletons). Our results emphasise how little is known about foraminifera in abyssal areas that may experience major impacts from future mining activities.
Language	English
Publishing date	2017-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep45288
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Article ; Online: Incidental Detection of a Hodgkin Lymphoma on 18F-Choline PET/CT and Comparison With 18FDG PET/CT in a Patient With Prostate Cancer: Reply.

Goineau, Aurore / Supiot, Stéphane

Clinical nuclear medicine

2016 Volume 41, Issue 9, Page(s) 746–747

MeSH term(s)	Choline ; Fluorodeoxyglucose F18 ; Hodgkin Disease ; Humans ; Male ; Multimodal Imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnosis ; Radiopharmaceuticals ; Tomography, X-Ray Computed
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000001239
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Article ; Online: Place de la radiothérapie dans la prise en charge des cancers de prostate avec atteinte ganglionnaire pelvienne initiale sans métastase à distance.

Supiot, S / Doré, M / Rio, E / Cellier, P / Mesguez-Nebout, N / Goineau, A

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2016 Volume 20, Issue 6-7, Page(s) 442–444

Abstract: Node-positive prostate cancer patients represent a small proportion of all prostate cancers for whom limited prospective information is available. Most retrospective or cohort data strongly suggest however that radiotherapy combined with androgen- ... ...

Title translation	Role of radiotherapy in the management of node-positive prostate cancer.
Abstract	Node-positive prostate cancer patients represent a small proportion of all prostate cancers for whom limited prospective information is available. Most retrospective or cohort data strongly suggest however that radiotherapy combined with androgen-depriving therapies is the preferable treatment in this setting. Only randomized clinical trials would be able to better define both radiotherapy (dose? volume? fractionation?) and androgen-depriving therapies (duration? role of novel androgen-depriving therapy?) modalities.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Humans ; Lymphatic Metastasis ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiotherapy, Adjuvant
Chemical Substances	Androgen Antagonists
Language	French
Publishing date	2016-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2016.06.002
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Zs.A 4832: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Fonctions sexuelles après traitement du cancer rectal : impact des doses aux plexus pelviens autonomes.

Goineau, A / Mahé, M-A / Paineau, J / Campion, L / Rio, E

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2014 Volume 18, Issue 8, Page(s) 757–762

Abstract: Purpose: Prospective evaluation of sexual function after treatment of rectal cancer and identification of predictive factors.: Patients and methods: Thirty-three patients were treated with curative intent by chemoradiation and surgery for localized ... ...

Title translation	Sexual functions after treatment for rectal cancer: impact of doses in autonomic pelvic nerves.
Abstract	Purpose: Prospective evaluation of sexual function after treatment of rectal cancer and identification of predictive factors. Patients and methods: Thirty-three patients were treated with curative intent by chemoradiation and surgery for localized rectal adenocarcinoma. Sexual toxicity was assessed four times (before treatment and at 2, 6 and 12 months) using validated questionnaires: QLQ C30 and EORTC CR38 for all, simplified IIEF for men and FSFI for women. A correlation was sought between the toxicity and clinical and dosimetric parameters by Fisher and Mann-Whitney tests. Results: In men, erections and sexual satisfaction decreased significantly from the acute phase and then stabilized (respective scores of 84.5 and 86/100 in the initial phase, 66 and 70.4 at the end of radiotherapy, 70 and 70 at 6 months and 68.5 and 70 at 12 months). For women, the changes were not significant. This study confirms some risk factors for sexual toxicity already mentioned (original function, age, tumor volume) and highlights new (dose to the seminal vesicles and above all, doses to pelvic autonomic plexus). Conclusion: Sexual effects of combined treatment of rectal cancer have only recently been described but remain undervalued and poorly understood. The impact of the autonomic pelvic plexus doses is a completely new data that could be extended in the development of intensity-modulated radiotherapy.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/radiotherapy ; Adult ; Aged ; Autonomic Nervous System/radiation effects ; Chemoradiotherapy ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Radiotherapy Dosage ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Sexual Dysfunction, Physiological/etiology
Language	French
Publishing date	2014-12
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2014.10.005
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Article ; Online: Prise en charge du sujet âgé en radiothérapie : mythes et perspectives.

Goineau, Aurore / Campion, Loïc / Mahé, Marc-André

Geriatrie et psychologie neuropsychiatrie du vieillissement

2014 Volume 12, Issue 3, Page(s) 261–266

Abstract: In this single-center retrospective case-control study, 62 patients were divided into two age groups (80 years and older versus less than 65 years) treated with external beam radiation during the same period. The main objective was to investigate ... ...

Title translation	The elderly in radiotherapy: myths and prospects.
Abstract	In this single-center retrospective case-control study, 62 patients were divided into two age groups (80 years and older versus less than 65 years) treated with external beam radiation during the same period. The main objective was to investigate differences in care between these two populations. Two parameters appear statistically different between the two groups: the indication of patient weight (reported for 39% of elderly patients versus 71% of younger patients, p=0.039) and hypofractioned radiotherapy (61% and 23% of patients respectively, p=0.002). No significant difference was found for the purpose of this radiotherapy (curative or palliative), the terms of this treatment, place the patient's life and monitoring. The oncogeriatrics was born of a partnership between medical oncologists and geriatricians, it would be now useful to further develop collaboration with radiation oncologists.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Case-Control Studies ; Geriatrics ; Humans ; Middle Aged ; Neoplasms/radiotherapy ; Retrospective Studies
Language	French
Publishing date	2014-09
Publishing country	France
Document type	English Abstract ; Journal Article
ISSN	2115-7863
ISSN (online)	2115-7863
DOI	10.1684/pnv.2014.0485
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Article: Integrating Geriatric Assessment into Decision-Making after Prostatectomy: Adjuvant Radiotherapy, Salvage Radiotherapy, or None?

Goineau, Aurore / d'Aillières, Bénédicte / de Decker, Laure / Supiot, Stéphane

Frontiers in oncology

2015 Volume 5, Page(s) 227

Abstract: Despite current advancements in the field, management of older prostate cancer patients still remains a big challenge for Geriatric Oncology. The International Society of Geriatric Oncology (ISGO) has recently updated its recommendations in this area, ... ...

Abstract	Despite current advancements in the field, management of older prostate cancer patients still remains a big challenge for Geriatric Oncology. The International Society of Geriatric Oncology (ISGO) has recently updated its recommendations in this area, and these have been widely adopted, notably by the European Association of Urology. This article outlines the principles that should be observed in the management of elderly patients who have recently undergone prostatectomy for malignancy or with a biochemical relapse following prostatectomy. Further therapeutic intervention should not be considered in those patients who are classified as frail in the geriatric assessment. In patients presenting better health conditions, salvage radiotherapy is to be preferred to adjuvant radiotherapy, which is only indicated in certain exceptional cases. Radiotherapy of the operative bed presents a higher risk to the elderly. Additionally, hormone therapy clearly shows higher side effects in older patients and therefore it should not be administered to asymptomatic patients. We propose a decision tree based on the ISGO recommendations, with specific modifications for patients in biochemical relapse.
Language	English
Publishing date	2015-10-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2015.00227
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Article ; Online: Xenophyophores (Rhizaria, Foraminifera) from the Eastern Clarion-Clipperton Zone (equatorial Pacific): the Genus Psammina.

Gooday, Andrew J / Holzmann, Maria / Goineau, Aurélie / Kamenskaya, Olga / Melnik, Vyacheslav F / Pearce, Richard B / Weber, Alexandra A-T / Pawlowski, Jan

Protist

2018 Volume 169, Issue 6, Page(s) 926–957

Abstract: Xenophyophores are important megafaunal organisms in the abyssal Clarion-Clipperton Zone (CCZ; equatorial Pacific), a region hosting commercially significant deposits of polymetallic nodules. Previous studies assigned those with attached, fan-like tests ... ...

Abstract	Xenophyophores are important megafaunal organisms in the abyssal Clarion-Clipperton Zone (CCZ; equatorial Pacific), a region hosting commercially significant deposits of polymetallic nodules. Previous studies assigned those with attached, fan-like tests to Psammina limbata, a species described from the central CCZ based on morphology. Here, we redescribe the holotype of P. limbata and then show that limbata-like morphotypes collected in the eastern CCZ include three genetically distinct species. Psammina aff. limbata is closest morphologically to P. limbata. The others are described as P. microgranulata sp. nov. and P. rotunda sp. nov. These fan-shaped species form a well-supported clade with P. tortilis sp. nov., a morphologically variable species exhibiting features typical of both Psammina and Semipsammina. A second clade containing Psammina sp. 3, and two species questionably assigned to Galatheammina branches at the base of this group. The genus Psammina includes another 9 described species for which there are no genetic data, leaving open the question of whether Psammina as a whole is monophyletic. Our study increases the number of xenophyophore species described from the eastern CCZ from 8 to 11, with a further 25 morphotypes currently undescribed. Many additional species of these giant foraminifera undoubtedly await discovery in abyssal settings.
MeSH term(s)	Biodiversity ; Foraminifera/classification ; Foraminifera/genetics ; Foraminifera/growth & development ; Foraminifera/isolation & purification ; Pacific Ocean ; Seawater/microbiology
Language	English
Publishing date	2018-10-05
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036014-9
ISSN	1618-0941 ; 1434-4610
ISSN (online)	1618-0941
ISSN	1434-4610
DOI	10.1016/j.protis.2018.09.003
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Article ; Online: Incidental Detection of a Hodgkin Lymphoma on 18F-Choline PET/CT and Comparison With 18F-FDG in a Patient With Prostate Cancer.

Goineau, Aurore / Colombié, Mathilde / Rousseau, Caroline / Sadot-Lebouvier, Sophie / Supiot, Stéphane

Clinical nuclear medicine

2015 Volume 40, Issue 8, Page(s) 670–671

Abstract: Combined PET/CT scanning with (18)F-FDG is in current use in Hodgkin lymphoma. New tracers have been developed, such as (18)F-choline in prostate cancer. Its use is under investigation in other solid tumors (eg, brain, liver, lung). We report a case of ... ...

Abstract	Combined PET/CT scanning with (18)F-FDG is in current use in Hodgkin lymphoma. New tracers have been developed, such as (18)F-choline in prostate cancer. Its use is under investigation in other solid tumors (eg, brain, liver, lung). We report a case of Hodgkin lymphoma incidentally detected on (18)F-choline PET/CT in a prostate cancer patient and show a comparison with (18)F-FDG PET/CT. (18)F-choline PET/CT detected more lymph node lesions than the (18)F-FDG PET/CT for this patient. Comparative studies of the 2 tracers might help fine-tune treatments and, in particular, delineate target zones in radiation therapy.
MeSH term(s)	Aged ; Choline/analogs & derivatives ; Fluorodeoxyglucose F18 ; Hodgkin Disease/diagnostic imaging ; Humans ; Incidental Findings ; Male ; Multimodal Imaging ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals ; Tomography, X-Ray Computed
Chemical Substances	Radiopharmaceuticals ; fluoromethylcholine ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2015-06-08
Publishing country	United States
Document type	Case Reports ; Comparative Study ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000000817
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Article: Can Comprehensive Geriatric Assessment Predict Tolerance of Radiotherapy for Localized Prostate Cancer in Men Aged 75 Years or Older?

Goineau, Aurore / Campion, Loïc / Commer, Jean-Marie / Vié, Brigitte / Ghesquière, Agnès / Béra, Guillaume / Jaffres, Didier / Magné, Nicolas / Artignan, Xavier / Chamois, Jérôme / Bergerot, Philippe / Créhange, Gilles / Deniaud-Alexandre, Elisabeth / Buthaud, Xavier / Belkacémi, Yazid / Doré, Mélanie / De Decker, Laure / Supiot, Stéphane

Cancers

2020 Volume 12, Issue 3

Abstract: Curative radiotherapy for prostate cancer is common in the elderly. However, concerns about potential toxicity have inhibited access to radiotherapy for this population, for whom preserving quality of life (QoL) is crucial. The primary endpoint was to ... ...

Abstract	Curative radiotherapy for prostate cancer is common in the elderly. However, concerns about potential toxicity have inhibited access to radiotherapy for this population, for whom preserving quality of life (QoL) is crucial. The primary endpoint was to identify predictors of impaired QoL in men aged 75 years or older treated with curative intent radiotherapy with or without androgen deprivation therapy (ADT) for localized prostate cancer. We prospectively performed comprehensive geriatric assessment (CGA) and administered QoL questionnaires to 208 elderly (>75 years) patients prior to, plus two and six months after, radiotherapy (NCT02876237). The median age of the patients was 77 years (range 75-89). At the start of the study, comorbidities were highlighted in 65% of patients: 23% were depressed, 23% had cognitive impairment, and 16% had reduced independence. At six months, 9% of patients had a consistently decreased QoL (>20 points), and a further 16% had a more moderate reduction (10 to 20 points) in QoL. None of the parameters studied (tumor characteristic, treatment, or oncogeriatric parameters) were predictive of a reduced QoL following radiotherapy. Though co-existing geriatric impairment was common, QoL was maintained for 75% of patients six months after radiotherapy. CGA was poorly predictive of tolerance of prostatic radiotherapy. Geriatric assessments dedicated to quality of life following radiotherapy need to be developed.
Language	English
Publishing date	2020-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12030635
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