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  1. Article ; Online: Turnbull-Cutait pull-through technique for delayed coloanal anastomosis after ultralow rectal resection: A step-by-step video vignette.

    Pera, Meritxell / Barrios, Oriana / Pellino, Gianluca / Golda, Thomas / Biondo, Sebastiano / Espín-Basany, Eloy

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 7, Page(s) 889–890

    MeSH term(s) Anal Canal/surgery ; Anastomosis, Surgical/methods ; Colon/surgery ; Digestive System Surgical Procedures/methods ; Humans ; Proctectomy ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Double-barrelled wet colostomy for urinary reconstruction after pelvic exenteration: a step-by-step video vignette demonstration.

    Barrios, Oriana / Pera, Meritxell / Golda, Thomas / Pellino, Gianluca / Espín-Basany, Eloy / Biondo, Sebastiano

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 24, Issue 7, Page(s) 883–884

    MeSH term(s) Colostomy ; Humans ; Pelvic Exenteration ; Urinary Diversion ; Urinary Tract
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Short-term outcomes of chemoradiotherapy and local excision versus total mesorectal excision in T2-T3ab,N0,M0 rectal cancer: a multicentre randomised, controlled, phase III trial (the TAU-TEM study).

    Serra-Aracil, X / Pericay, C / Badia-Closa, J / Golda, T / Biondo, S / Hernández, P / Targarona, E / Borda-Arrizabalaga, N / Reina, A / Delgado, S / Vallribera, F / Caro, A / Gallego-Plazas, J / Pascual, M / Álvarez-Laso, C / Guadalajara-Labajo, H G / Mora-Lopez, L

    Annals of oncology : official journal of the European Society for Medical Oncology

    2022  Volume 34, Issue 1, Page(s) 78–90

    Abstract: Background: The standard treatment of T2-T3ab,N0,M0 rectal cancers is total mesorectal excision (TME) due to the high recurrence rates recorded with local excision. Initial reports of the combination of pre-operative chemoradiotherapy (CRT) and ... ...

    Abstract Background: The standard treatment of T2-T3ab,N0,M0 rectal cancers is total mesorectal excision (TME) due to the high recurrence rates recorded with local excision. Initial reports of the combination of pre-operative chemoradiotherapy (CRT) and transanal endoscopic microsurgery (TEM) have shown reductions in local recurrence. The TAU-TEM study aims to demonstrate the non-inferiority of local recurrence and the improvement in morbidity achieved with CRT-TEM compared with TME. Here we describe morbidity rates and pathological outcomes.
    Patients and methods: This was a prospective, multicentre, randomised controlled non-inferiority trial including patients with rectal adenocarcinoma staged as T2-T3ab,N0,M0. Patients were randomised to the CRT-TEM or the TME group. Patients included, tolerance of CRT and its adverse effects, surgical complications (Clavien-Dindo and Comprehensive Complication Index classifications) and pathological results (complete response in the CRT-TEM group) were recorded in both groups. Patients attended follow-up controls for local and systemic relapse.
    Trial registration: NCT01308190.
    Results: From July 2010 to October 2021, 173 patients from 17 Spanish hospitals were included (CRT-TEM: 86, TME: 87). Eleven were excluded after randomisation (CRT-TEM: 5, TME: 6). Modified intention-to-treat analysis thus included 81 patients in each group. There was no mortality after CRT. In the CRT-TEM group, one patient abandoned CRT, 1/81 (1.2%). The CRT-related morbidity rate was 29.6% (24/81). Post-operative morbidity was 17/82 (20.7%) in the CRT-TEM group and 41/81 (50.6%) in the TME group (P < 0.001, 95% confidence interval 42.9% to 16.7%). One patient died in each group (1.2%). Of the 81 patients in the CRT-TEM group who received the allocated treatment, 67 (82.7%) underwent organ preservation. Pathological complete response in the CRT-TEM group was 44.3% (35/79). In the TME group, pN1 were found in 17/81 (21%).
    Conclusion: CRT-TEM treatment obtains high pathological complete response rates (44.3%) and a high CRT compliance rate (98.8%). Post-operative complications and hospitalisation rates were significantly lower than those in the TME group. We await the results of the follow-up regarding cancer outcomes and quality of life.
    MeSH term(s) Humans ; Transanal Endoscopic Microsurgery/methods ; Treatment Outcome ; Prospective Studies ; Quality of Life ; Neoplasm Recurrence, Local/pathology ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Rectal Neoplasms/surgery ; Chemoradiotherapy ; Neoadjuvant Therapy/adverse effects ; Neoadjuvant Therapy/methods ; Neoplasm Staging
    Language English
    Publishing date 2022-10-08
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2022.09.160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact on defecatory, urinary and sexual function after high-tie sigmoidectomy: a post-hoc analysis of a multicenter randomized controlled trial comparing extended versus standard complete mesocolon excision.

    Planellas, Pere / Marinello, Franco / Elorza, Garazi / Golda, Thomas / Farrés, Ramon / Espín-Basany, Eloy / Enríquez-Navascués, Jose Maria / Kreisler, Esther / Cornejo, Lídia / Codina-Cazador, Antoni

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 293

    Abstract: Objective: To assess the effect of high inferior mesenteric artery tie on defecatory, urinary, and sexual function after surgery for sigmoid colon cancer. Performing a sigmoidectomy poses a notable risk of causing injury to the preaortic sympathetic ... ...

    Abstract Objective: To assess the effect of high inferior mesenteric artery tie on defecatory, urinary, and sexual function after surgery for sigmoid colon cancer. Performing a sigmoidectomy poses a notable risk of causing injury to the preaortic sympathetic nerves during the high ligation of the inferior mesenteric artery, as well as to the superior hypogastric plexus during dissection at the level of the sacral promontory. Postoperative defecatory and genitourinary dysfunction after sigmoid colon resection are often underestimated and underreported.
    Methods: This study is a secondary research of a multicenter, single-blind, randomized clinical trial. The trial involved patients with sigmoid cancer who underwent either extended complete mesocolic excision (e-CME) or standard CME (s-CME). Patients completed questionnaires to assess defecatory, urinary, and sexual function before, 1 month after surgery, and 1 year after surgery. Multivariate analysis was conducted to identify factors associated with functional dysfunction.
    Results: Seventy-nine patients completed functional assessments before and 1 year after surgery. One year after sigmoidectomy with a high tie of the inferior mesenteric artery, 15.2% of patients had minor low anterior resection syndrome (LARS) and 12.7% had major LARS; 22.2% of males and 29.4% of females had urinary dysfunction; and 43.8% of males and 27.3% of females had sexual dysfunction. After multivariate analysis, no significant associations were found between clinical and surgical factors and gastrointestinal or urinary dysfunction after 1 year of surgery. Age was identified as the only factor linked to sexual dysfunction in both sexes (women, β =  - 0.54, p = 0.002; men β =  - 0.38, p = 0.010). Regarding recovery outcomes, diabetes mellitus was identified as a contributing factor to suboptimal gastrointestinal recovery (p = 0.033) and urinary recovery in women (p = 0.039). Furthermore, the treatment arm was found to be significantly associated with the recovery of erectile function after 1 year of surgery (p = 0.046).
    Conclusions: A high tie of the inferior mesenteric artery during sigmoidectomy is associated with a high incidence of defecatory and genitourinary dysfunction. Age was identified as a significant factor associated with sexual dysfunction 1 year after sigmoid colon resection in both sexes.
    Trial registration: Clinical trials NCT03083951 HIGHLIGHTS: • One year after high-tie sigmoidectomy, 27.9% of patients had LARS; 22.2% of the men and 29.4% of the women had urinary dysfunction; and 43.8% of the men and 27.3% of the women had sexual dysfunction. • e-CME is associated with a high rate of urinary dysfunction in men 1 year after surgery. However, after multivariate analysis, no association was found between e-CME and urinary dysfunction in men. • Age was correlated with the recovery of sexual function in both sexes 1 year after surgery. Furthermore, diabetes mellitus was identified as the factor associated with poorer recovery of urinary function in females.
    MeSH term(s) Male ; Humans ; Female ; Colon, Sigmoid/surgery ; Mesocolon/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Rectal Neoplasms/surgery ; Single-Blind Method ; Laparoscopy ; Colectomy/adverse effects
    Language English
    Publishing date 2023-08-01
    Publishing country Germany
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-03026-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Update on advances and controversy in rectal cancer treatment.

    Biondo, S / Fraccalvieri, D / Golda, T / Frago, R / Trenti, L / Kreisler, E

    Techniques in coloproctology

    2016  Volume 20, Issue 3, Page(s) 145–152

    Abstract: Changes in the multidisciplinary treatment of rectal cancer have been recently proposed. We performed a comprehensive review of the current data on neoadjuvant and adjuvant treatment of rectal cancer, focussing on chemoradiotherapy treatment and timing ... ...

    Abstract Changes in the multidisciplinary treatment of rectal cancer have been recently proposed. We performed a comprehensive review of the current data on neoadjuvant and adjuvant treatment of rectal cancer, focussing on chemoradiotherapy treatment and timing of surgery. Six components were proposed as the framework for the treatment of rectal cancer: neoadjuvant therapy and changing patterns in patient selection, long- or short-course radiotherapy, adverse effects of radiotherapy, timing of surgery, non-operative management of rectal cancer and postoperative adjuvant therapy. Lack of a consistent difference in terms of local recurrence has been observed between short-course radiotherapy and long-course chemoradiotherapy. Indications for preoperative radiotherapy have been reconsidered in the last years. An interval of 10-11 weeks seemed to be the optimal timing, with no impact on patient safety. Since assessment criteria of clinical complete response are not well defined, and the basis for non-operative management of rectal cancer is still not clear, further investigations are required. There is controversy about standard treatments for patients with locally advanced rectal cancer that are being analyzed by ongoing studies. Tailored treatments could avoid over-treatment for a large number of patients without any impairment of the oncologic results.
    MeSH term(s) Chemoradiotherapy/trends ; Chemotherapy, Adjuvant ; Disease Management ; Humans ; Neoadjuvant Therapy/trends ; Neoplasm Recurrence, Local ; Patient Selection ; Rectal Neoplasms/therapy
    Language English
    Publishing date 2016-03
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-015-1418-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: From colorectal to general surgeon in the management of left colonic perforation: A cohort study.

    Golda, Thomas / Kreisler, Esther / Rodriguez, Gerardo / Miguel, Bernat / Biondo, Sebastiano

    International journal of surgery (London, England)

    2018  Volume 55, Page(s) 175–181

    Abstract: Background: Management of left colonic perforation in emergency depends largely upon the attending surgeon. The primary endpoint of this observational, retrospective study analyses surgical technique chosen by the colorectal specialized (CS) or general ... ...

    Abstract Background: Management of left colonic perforation in emergency depends largely upon the attending surgeon. The primary endpoint of this observational, retrospective study analyses surgical technique chosen by the colorectal specialized (CS) or general surgeon (GS) and changes over time.
    Materials and methods: Interventions for left colonic perforation from 2004 to 2015 are grouped for CS or GS. Type of operation (Hartmann (HP), primary anastomosis (RPA) ±covering ileostomy (IL)), year, Peritonitis Severity Score (PSS), morbidity, mortality, anastomotic dehiscence and stoma closure were recorded.
    Results: 190 patients were included. CS performed RPA ± IL in 83 pts (74.1%) and HP in 29 pts (25.9%) while GS performed RPA ± IL in 26 pts (33.3%) and HP in 52 pts (66.7%), (p < 0.001). CS performed over time more RPA with covering ileostomy to the detriment of HP. No differences were observed between the two surgeon-groups in terms of overall morbidity and mortality. Anastomotic dehiscence was higher among GS (20% vs 4.8%, p = 0.046). Mortality after HP overtrumped RPA (26.8% versus 11.0%, p = 0.009). Regression analysis showed that HP's probability increased 3.7 times by GS, 2.3 times by each PSS point and decreased 32.5% every forthcoming year (p < 0.001). A multinomial logistic model illustrates evolution of surgical management over time, CS leading towards extension of reconstructive techniques, subsequently adopted by GS.
    Conclusions: CS attempt bowel reconstruction in more patients than GS in left colonic perforation without differences in overall postoperative morbidity or mortality. CS introduced covering IL to further indicate primary anastomosis avoiding HP. GS stepwise adopted this management although results are improved by CS. These findings favor primary anastomosis with/without covering ileostomy in left colonic perforation in selected patients where PSS can be used as a tool to discriminate best candidates.
    MeSH term(s) Aged ; Aged, 80 and over ; Anastomosis, Surgical ; Colon/surgery ; Colonic Diseases/surgery ; Colorectal Surgery/methods ; Colorectal Surgery/statistics & numerical data ; Female ; General Surgery/methods ; General Surgery/statistics & numerical data ; Humans ; Ileostomy/adverse effects ; Ileostomy/methods ; Intestinal Perforation/surgery ; Logistic Models ; Male ; Middle Aged ; Peritonitis/epidemiology ; Peritonitis/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2018-05-29
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2018.05.732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Human Pose Estimation for Real-World Crowded Scenarios

    Golda, Thomas / Kalb, Tobias / Schumann, Arne / Beyerer, Jürgen

    2019  

    Abstract: Human pose estimation has recently made significant progress with the adoption of deep convolutional neural networks. Its many applications have attracted tremendous interest in recent years. However, many practical applications require pose estimation ... ...

    Abstract Human pose estimation has recently made significant progress with the adoption of deep convolutional neural networks. Its many applications have attracted tremendous interest in recent years. However, many practical applications require pose estimation for human crowds, which still is a rarely addressed problem. In this work, we explore methods to optimize pose estimation for human crowds, focusing on challenges introduced with dense crowds, such as occlusions, people in close proximity to each other, and partial visibility of people. In order to address these challenges, we evaluate three aspects of a pose detection approach: i) a data augmentation method to introduce robustness to occlusions, ii) the explicit detection of occluded body parts, and iii) the use of the synthetic generated datasets. The first approach to improve the accuracy in crowded scenarios is to generate occlusions at training time using person and object cutouts from the object recognition dataset COCO (Common Objects in Context). Furthermore, the synthetically generated dataset JTA (Joint Track Auto) is evaluated for the use in real-world crowd applications. In order to overcome the transfer gap of JTA originating from a low pose variety and less dense crowds, an extension dataset is created to ease the use for real-world applications. Additionally, the occlusion flags provided with JTA are utilized to train a model, which explicitly distinguishes between occluded and visible body parts in two distinct branches. The combination of the proposed additions to the baseline method help to improve the overall accuracy by 4.7% AP and thereby provide comparable results to current state-of-the-art approaches on the respective dataset.

    Comment: Accepted for the 16th IEEE International Conference on Advanced Video and Signal-based Surveillance (AVSS)
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 004
    Publishing date 2019-07-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Combined endoscopic-laparoscopic surgery (CELS) can avoid segmental colectomy in endoscopically unremovable colonic polyps: a cohort study over 10 years.

    Golda, Thomas / Lazzara, Claudio / Sorribas, Maria / Soriano, Antonio / Frago, Ricardo / Alrasheed, Abdulrahman / Kreisler, Esther / Biondo, Sebastiano

    Surgical endoscopy

    2021  Volume 36, Issue 1, Page(s) 196–205

    Abstract: Background: Combined-Endoscopic-Laparoscopic-Surgery (CELS) was developed for benign colonic polyps, endoscopically unresectable, to avoid segmental colectomy. This observational study aims to compare surgical outcomes of endoscopically unresectable ... ...

    Abstract Background: Combined-Endoscopic-Laparoscopic-Surgery (CELS) was developed for benign colonic polyps, endoscopically unresectable, to avoid segmental colectomy. This observational study aims to compare surgical outcomes of endoscopically unresectable colonic polyps treated laparoscopically before and since the institutional introduction of CELS. Primary endpoint was postoperative morbidity and mortality; secondary endpoints were time of hospitalization and histopathological findings.
    Methods: Charts of all patients with preoperative diagnosis of benign colonic tumors, treated laparoscopically at our institution from 1/2010 to 2/2020 were reviewed. Patients with polyps (1) affecting ileocecal valve, (2) occupying > 50% of the circumference, (3) ≥ 3 endoscopically unresectable polyps, (4) inflammatory bowel disease, (5) polyps within diverticular area post diverticulitis, (6) rectal polyps (7) foreseen impossibility of laparoscopy (8) preoperatively biopsy proven invasive adenocarcinoma were excluded. Group I consists of all patients potentially treatable by CELS but operated by laparoscopic colonic resection as CELS was not yet institutionally established. Group II includes all patients treated with CELS (since 11/2017).
    Results: One hundred-fifteen consecutive patients were reviewed. Applying exclusion criteria, twenty-three patients form group I and twenty-three group II (female 30.4%, median age 68 years). Groups distributed homogenously for age, BMI (body mass index) and polyps´ localization with most polyps (60.4%) localized in right colon; group II patients had significantly higher American Society of Anesthesiologists (ASA) score. Median operating time, hospital stay and morbidity were significantly less in group II. Postoperative morbidity occurred overall in 14 patients (30.4%), mostly Clavien-Dindo class I-II (26.1%) and significantly less in group II (p = 0.017), Clavien-Dindo III-IV distributed equally (one patient each group) without postoperative mortality. Definitive histopathology showed invasive adenocarcinoma in 8.3% without differences between groups. Two patients with invasive adenocarcinoma after CELS were advised for oncological resection.
    Conclusion: CELS is safe and efficient to treat complex, benign colonic polyps by a complete minimal invasive laparoscopic approach. CELS showed better surgical outcomes with less morbidity, no mortality and appropriate pathological results avoiding unnecessary laparoscopic surgery with intestinal anastomosis.
    MeSH term(s) Aged ; Cohort Studies ; Colectomy/methods ; Colonic Polyps/diagnosis ; Colonoscopy/methods ; Female ; Humans ; Laparoscopy/methods ; Retrospective Studies
    Language English
    Publishing date 2021-01-13
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-020-08255-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Incidence and management of anastomotic bleeding after ileocolic anastomosis.

    Golda, T / Zerpa, C / Kreisler, E / Trenti, L / Biondo, S

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2013  Volume 15, Issue 10, Page(s) 1301–1308

    Abstract: Aim: Ileocolic anastomosis is performed using a stapled or manual technique, but with either there is a risk of bleeding from the suture line. The aim of this study was to analyse, retrospectively, bleeding after different anastomotic techniques.: ... ...

    Abstract Aim: Ileocolic anastomosis is performed using a stapled or manual technique, but with either there is a risk of bleeding from the suture line. The aim of this study was to analyse, retrospectively, bleeding after different anastomotic techniques.
    Method: Patients having elective right colectomy were divided, according to the type of ileocolic anastomosis, into Group 1 (circular, double-stapled, end-to-side), Group 2 (linear-stapled, side-to-side) and Group 3 (handsewn, side-to-side). Postoperative lower gastrointestinal bleeding (LGIB) was studied in the three groups. Uni- and multivariate analysis was performed to study risk factors for LGIB and the need for postoperative allogeneic blood transfusion.
    Results: Three-hundred and fifty patients were included: 174 in Group 1, 59 in Group 2 and 117 in Group 3. The postoperative LGIB rate was 4.9% and occurred exclusively in Group 1. Five patients had severe anastomotic bleeding. Postoperative blood transfusion was indicated in Groups 1, 2 and 3 in 19.0%, 5.1% and 13.7% of patients. In the five patients with severe bleeding, four attempts of colonoscopic arrest were made, achieving bleeding control in one. Angiographic embolization was successful in one patient. There were no procedure-specific complications.
    Conclusion: End-to-side, circular, double-stapling ileocolic anastomosis seems to be related to an increased incidence of anastomotic bleeding and of postoperative blood transfusion compared with patients having other techniques of ileocolic anastomosis.
    MeSH term(s) Aged ; Aged, 80 and over ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Anticoagulants/adverse effects ; Blood Transfusion ; Colectomy ; Colon/surgery ; Colonoscopy ; Embolization, Therapeutic ; Female ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Ileum/surgery ; Male ; Middle Aged ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/therapy ; Retrospective Studies ; Suture Techniques/adverse effects ; Vitamin K/antagonists & inhibitors
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2013
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.12309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risk factors for ileocolic anastomosis dehiscence; a cohort study.

    Golda, Thomas / Lazzara, Claudio / Zerpa, Carla / Sobrino, Lucia / Fico, Valeria / Kreisler, Esther / Biondo, Sebastiano

    American journal of surgery

    2019  Volume 220, Issue 1, Page(s) 170–177

    Abstract: Background: Anastomotic leak (AL) after ileocolic anastomosis influences morbidity, mortality, length of hospitalization and costs. This study analyzes risk and protective factors for AL on ileocolic anastomoses.: Methods: We retrospectively analyzed ...

    Abstract Background: Anastomotic leak (AL) after ileocolic anastomosis influences morbidity, mortality, length of hospitalization and costs. This study analyzes risk and protective factors for AL on ileocolic anastomoses.
    Methods: We retrospectively analyzed our single institution patients' series undergoing elective ileocolic anastomosis for AL between 1/2008-12/2017. AL grade A/B (antibiotic treatment and/or radiological drainage) were summarized as mild, grade C (surgical re-intervention) corresponds to severe AL.
    Results: We included 470 patients (mean age 70.8 years, 43.2% females). Overall AL rate was 9.4% (44 patients) with 6.0% severe and 3.4% mild AL. There was no difference in AL between hand sewn and stapled anastomoses. Multivariate analysis revealed preoperative serum albumin (p = 0.004), smoking habits (p = 0.005) and perioperative blood transfusion (p = 0.038) as risk factors for AL. Suture oversewing as anastomotic reinforcement resulted as independent protective factor (p < 0.001).
    Conclusion: Poor nutritional status, smoking habits and perioperative blood transfusion are negative factors influencing on AL. Suture oversewing as anastomotic reinforcement associates with significantly less AL.
    MeSH term(s) Aged ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Colon/surgery ; Crohn Disease/surgery ; Female ; Humans ; Ileum/surgery ; Male ; Morbidity/trends ; Prognosis ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Spain/epidemiology ; Surgical Wound Dehiscence/complications ; Surgical Wound Dehiscence/epidemiology ; Survival Rate/trends
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2019.11.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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