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  1. Book ; Online: Come As You Are, After Eve Kosofsky Sedgwick

    Goldberg, Jonathan / Kosofsky Sedgwick, Eve

    2021  

    Keywords Literary studies: fiction, novelists & prose writers ; Gay & Lesbian studies ; difference, identification, literary studies, ontology, queer studies, queer temporality, fabric art
    Size 1 electronic resource (134 pages)
    Publisher punctum books
    Publishing place Brooklyn, NY
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021048399
    ISBN 9781953035431 ; 1953035434
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Sappho: Fragments

    Goldberg, Jonathan / Fradenburg Joy, L.O. Aranye

    2018  

    Abstract: In Sappho, Jonathan Goldberg takes as his model the fragmentary state in which this sublime poet's writing survives, a set of compositional and theoretical resources for living and thinking in more fully erotic ways in the present and the future. This ... ...

    Abstract In Sappho, Jonathan Goldberg takes as his model the fragmentary state in which this sublime poet's writing survives, a set of compositional and theoretical resources for living and thinking in more fully erotic ways in the present and the future. This book thus offers fragmentary commentary on disparate (Sapphic) works, such as the comics of Alison Bechdel, the paintings and cartoons of Leonardo da Vinci, Robert Reid-Pharr's "Living as a Lesbian," Madeleine de Scudéry's Histoire de Sapho, John Donne's "Sapho to Philaenis," Todd Haynes and Patricia Highsmith's Carol, Virginia Woolf's Orlando, writings by Willa Cather, and the paintings and writings of Simeon Solomon, among other works. Goldberg challenges readers to imagine and experience what Sarah Orne Jewett named the "country of our friendship," a love both exceedingly strange and compellingly familiar. Just as Sappho's coinage "bitter-sweet" describes eros as inextricably contradictory - two things at once, one thing after another, each interrupting, complicating, each other - the juxtapositions in this book mean to continually call into question categories of identity and identification in the wake of a quintessential woman writer from Lesbos. Over and over again, Goldberg's Sappho: ]fragments inquires into how race, sexuality, and gender cross each other. The theoretical genius of Eve Kosofsky Sedgwick presides over this set of meditations and mediations on likeness and desire. Rather than homogenizing its many subjects, it invites the reader to explore and inhabit new transits within and through what Audre Lorde called "the very house of difference."
    Keywords Literature (General)
    Size 1 electronic resource (168 p.)
    Publisher punctum books
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020102588
    ISBN 9781947447974 ; 9781947447981 ; 1947447971 ; 194744798X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Images in Anesthesiology: A Case of Mistaken Atrial Myxoma.

    Goldberg, Jonathan S / Hankins, Samuel J

    Anesthesiology

    2016  Volume 124, Issue 6, Page(s) 1394

    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000000988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  4. Article ; Online: TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.

    Ma, Wenfu / Goldberg, Jonathan

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 36, Page(s) 10061–10066

    Abstract: The supramolecular cargo procollagen is loaded into coat protein complex II (COPII)-coated carriers at endoplasmic reticulum (ER) exit sites by the receptor molecule TANGO1/cTAGE5. Electron microscopy studies have identified a tubular carrier of suitable ...

    Abstract The supramolecular cargo procollagen is loaded into coat protein complex II (COPII)-coated carriers at endoplasmic reticulum (ER) exit sites by the receptor molecule TANGO1/cTAGE5. Electron microscopy studies have identified a tubular carrier of suitable dimensions that is molded by a distinctive helical array of the COPII inner coat protein Sec23/24•Sar1; the helical arrangement is absent from canonical COPII-coated small vesicles. In this study, we combined X-ray crystallographic and biochemical analysis to characterize the association of TANGO1/cTAGE5 with COPII proteins. The affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Sec23 recognizes merely a PPP motif. The PRDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor can bind multiple copies of coat protein in a close-packed array. We propose that TANGO1/cTAGE5 promotes the accretion of inner coat proteins to the helical lattice. Furthermore, we show that PPP motifs in the outer coat protein Sec31 also bind to Sec23, suggesting that stepwise COPII coat assembly will ultimately displace TANGO1/cTAGE5 and compartmentalize its operation to the base of the growing COPII tubule.
    MeSH term(s) Amino Acid Motifs ; Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Aryl Hydrocarbon Receptor Nuclear Translocator/chemistry ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism ; Binding Sites ; COP-Coated Vesicles/chemistry ; COP-Coated Vesicles/genetics ; COP-Coated Vesicles/metabolism ; Crystallography, X-Ray ; Endoplasmic Reticulum/metabolism ; Gene Expression ; Humans ; Models, Molecular ; Monomeric GTP-Binding Proteins/chemistry ; Monomeric GTP-Binding Proteins/genetics ; Monomeric GTP-Binding Proteins/metabolism ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Procollagen/chemistry ; Procollagen/genetics ; Procollagen/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Transport ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Vesicular Transport Proteins/chemistry ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism
    Chemical Substances ARNT protein, human ; Antigens, Neoplasm ; MIA2 protein, human ; Neoplasm Proteins ; Procollagen ; Recombinant Proteins ; SEC23A protein, human ; SEC31A protein, human ; Vesicular Transport Proteins ; Aryl Hydrocarbon Receptor Nuclear Translocator (138391-32-9) ; SAR1A protein, human (EC 3.6.1.-) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2016-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1605916113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online: Idiosyncratic investment risk and business cycles

    Goldberg, Jonathan E

    (Finance and economics discussion series ; 2014,05)

    2014  

    Author's details Jonathan E. Goldberg
    Series title Finance and economics discussion series ; 2014,05
    Language English
    Size Online-Ressource (27 S.)
    Publisher Div. of Research & Statistics and Monetary Affairs, Federal Reserve Board
    Publishing place Washington, DC
    Document type Book ; Online
    Database ECONomics Information System

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  6. Book: This distracted globe

    Frank, Marcie / Goldberg, Jonathan / Newman, Karen

    worldmaking in early modern literature

    2016  

    Abstract: These essays investigate the materiality of the world in Spenser, Cary and Marlowe; its sociability, sexuality and sovereignty in Shakespeare; and the universality of spirit, gender and empire in Vaughan, Donne and the dastan (tale) of Chouboli, a ... ...

    Author's details edited by Marcie Frank, Jonathan Goldberg, Karen Newman
    Abstract "These essays investigate the materiality of the world in Spenser, Cary and Marlowe; its sociability, sexuality and sovereignty in Shakespeare; and the universality of spirit, gender and empire in Vaughan, Donne and the dastan (tale) of Chouboli, a Rastanjani princess"--

    "Worldmaking takes many forms in early modern literature and thus challenges any single interpretive approach. The essays in this collection investigate the material stuff of the world in Spenser, Cary, and Marlowe; the sociable bonds of authorship, sexuality, and sovereignty in Shakespeare and others; and the universal status of spirit, gender, and empire in the worlds of Vaughan, Donne, and the dastan (tale) of Chouboli, a Rajasthani princess. Together, these essays make the case that to address what it takes to make a world in the early modern period requires the kinds of thinking exemplified by theory"--
    Keywords English literature/History and criticism ; Literature and society/History ; Material culture in literature
    Language English
    Size pages cm
    Publisher Fordham University Press
    Publishing place New York
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9780823270286 ; 9780823270293 ; 0823270289 ; 0823270297
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book ; Online: Credit-crunch dynamics with uninsured investment risk

    Goldberg, Jonathan E

    (Finance and economics discussion series ; 2013,47)

    2013  

    Author's details Jonathan E. Goldberg
    Series title Finance and economics discussion series ; 2013,47
    Language English
    Size Online-Ressource (27 S.)
    Publisher Div. of Research & Statistics and Monetary Affairs, Federal Reserve Board
    Publishing place Washington, DC
    Document type Book ; Online
    Database ECONomics Information System

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  8. Book ; Online: Credit-crunch dynamics with uninsured investment risk

    Goldberg, Jonathan E

    (Finance and economics discussion series ; 2013,31)

    2013  

    Author's details Jonathan E. Goldberg
    Series title Finance and economics discussion series ; 2013,31
    Language English
    Size Online-Ressource (27 S.)
    Publisher Div. of Research & Statistics and Monetary Affairs, Federal Reserve Board
    Publishing place Washington, DC
    Document type Book ; Online
    Database ECONomics Information System

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  9. Article ; Online: Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor-positive Breast Cancer.

    Goldberg, Jonathan / Qiao, Na / Guerriero, Jennifer L / Gross, Brett / Meneksedag, Yagiz / Lu, Yoshimi F / Philips, Anne V / Rahman, Tasnim / Meric-Bernstam, Funda / Roszik, Jason / Chen, Ken / Jeselsohn, Rinath / Tolaney, Sara M / Peoples, George E / Alatrash, Gheath / Mittendorf, Elizabeth A

    Cancer research communications

    2024  Volume 4, Issue 2, Page(s) 496–504

    Abstract: Estrogen receptor-positive (ER+) breast cancer is not considered immunogenic and, to date, has been proven resistant to immunotherapy. Endocrine therapy remains the cornerstone of treatment for ER+ breast cancers. However, constitutively activating ... ...

    Abstract Estrogen receptor-positive (ER+) breast cancer is not considered immunogenic and, to date, has been proven resistant to immunotherapy. Endocrine therapy remains the cornerstone of treatment for ER+ breast cancers. However, constitutively activating mutations in the estrogen receptor alpha (ESR1) gene can emerge during treatment, rendering tumors resistant to endocrine therapy. Although these mutations represent a pathway of resistance, they also represent a potential source of neoepitopes that can be targeted by immunotherapy. In this study, we investigated ESR1 mutations as novel targets for breast cancer immunotherapy. Using machine learning algorithms, we identified ESR1-derived peptides predicted to form stable complexes with HLA-A*0201. We then validated the binding affinity and stability of the top predicted peptides through in vitro binding and dissociation assays and showed that these peptides bind HLA-A*0201 with high affinity and stability. Using tetramer assays, we confirmed the presence and expansion potential of antigen-specific CTLs from healthy female donors. Finally, using in vitro cytotoxicity assays, we showed the lysis of peptide-pulsed targets and breast cancer cells expressing common ESR1 mutations by expanded antigen-specific CTLs. Ultimately, we identified five peptides derived from the three most common ESR1 mutations (D538G, Y537S, and E380Q) and their associated wild-type peptides, which were the most immunogenic. Overall, these data confirm the immunogenicity of epitopes derived from ESR1 and highlight the potential of these peptides to be targeted by novel immunotherapy strategies.
    Significance: Estrogen receptor (ESR1) mutations have emerged as a key factor in endocrine therapy resistance. We identified and validated five novel, immunogenic ESR1-derived peptides that could be targeted through vaccine-based immunotherapy.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/genetics ; Receptors, Estrogen/genetics ; Mutation ; Immunotherapy ; Peptides/genetics
    Chemical Substances Receptors, Estrogen ; Peptides
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-23-0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.

    Ma, Wenfu / Goldberg, Elena / Goldberg, Jonathan

    eLife

    2017  Volume 6

    Abstract: Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process ... ...

    Abstract Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostasis regulator 4-phenylbutyrate (4-PBA), which we show targets COPII protein to reduce the stringency of retention. 4-PBA competes with p24 proteins to bind COPII. When p24 protein uptake is blocked, COPII vesicles package resident proteins and an ER-trapped mutant LDL receptor. We further show that 4-PBA triggers the secretion of a KDEL-tagged luminal resident, implying that a compromised retention mechanism causes saturation of the KDEL retrieval system. The results indicate that stringent ER retention requires the COPII coat machinery to actively sort biosynthetic cargo from diffusible misfolded and resident ER proteins.
    Language English
    Publishing date 2017-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.26624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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