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  1. Article ; Online: Disrupting the Definition of Heart Failure: A Rose by Any Other Name.

    Goldberg, Lee R

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 23, Page(s) 2243–2245

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Cluster Analysis
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.04.013
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  2. Article ; Online: The Pleiotropic Effects of SGLT2 Inhibitors: Remodeling the Treatment of Heart Failure.

    Goldberg, Lee R

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 3, Page(s) 256–258

    MeSH term(s) Heart Failure/drug therapy ; Humans ; Sodium-Glucose Transporter 2 Inhibitors ; Stroke Volume
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.11.029
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 196: Show issues

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  3. Article ; Online: The pleiotropic cardiovascular effects of sodium-glucose cotransporter-2 inhibitors.

    Tanna, Monique S / Goldberg, Lee R

    Current opinion in cardiology

    2021  Volume 36, Issue 6, Page(s) 764–768

    Abstract: Purpose of review: Throughout the history of medicine, scientists and clinicians have observed unanticipated drug effects leading at times to an entirely new use for a drug class, and other times eliminating them from practice. The sodium-glucose ... ...

    Abstract Purpose of review: Throughout the history of medicine, scientists and clinicians have observed unanticipated drug effects leading at times to an entirely new use for a drug class, and other times eliminating them from practice. The sodium-glucose cotransporter-2 (SGLT2) inhibitors are one such class of drugs. These agents were initially studied as diabetic agents and their unanticipated and significant cardiovascular benefit has now created a new class of drugs for an entirely new population. Here we review the pleiotropic cardiovascular effects of SGLT2 inhibitors, the potential mechanisms of action, side effect profile and future directions.
    Recent findings: Large clinical trials have evaluated the cardiovascular outcomes of SGLT2 inhibitors including myocardial infarction and strokes as well as new onset and worsening systolic heart failure.
    Summary: SGLT2 inhibitors are being incorporated into the guidelines for the treatment of heart failure with the goal of preventing heart failure hospitalizations and promoting positive ventricular remodeling in patients with or without diabetes. The reduction in cardiovascular events including cardiovascular death, myocardial infarction, and other atherosclerotic effects appears to be driven by baseline risk with those who have known atherosclerosis seeing a reduction in events but those without disease seeing less benefit.
    MeSH term(s) Cardiovascular System ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Humans ; Sodium ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2556: Show issues Location:
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  4. Article ; Online: Heart Transplantation for Uhl Anomaly in an Adult.

    Toubat, Omar / Han, Jason J / Predina, Jarrod D / Goldberg, Lee R / Ibrahim, Michael E

    JACC. Case reports

    2024  Volume 29, Issue 10, Page(s) 102322

    Abstract: Uhl anomaly is characterized by the morphologic absence of right ventricular myocardium and is an exceedingly rare cause of nonischemic cardiomyopathy. We report the first case of a successful heart transplantation in a 41-year-old patient who presented ... ...

    Abstract Uhl anomaly is characterized by the morphologic absence of right ventricular myocardium and is an exceedingly rare cause of nonischemic cardiomyopathy. We report the first case of a successful heart transplantation in a 41-year-old patient who presented in cardiogenic shock from Uhl anomaly causing decompensated right ventricular failure.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102322
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  5. Article ; Online: Synchronized Diaphragmatic Stimulation for the Treatment of Symptomatic Heart Failure: A Novel Implantable Therapy Concept.

    Fudim, Marat / Mirro, Michael / Goldberg, Lee R

    JACC. Basic to translational science

    2022  Volume 7, Issue 3, Page(s) 322–323

    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2022.02.012
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  6. Article ; Online: Venoarterial Extracorporeal Membrane Oxygenation to Heart Transplant-An Inflamed Bridge?-Reply.

    Hanff, Thomas C / Goldberg, Lee R / Birati, Edo Y

    JAMA cardiology

    2020  Volume 6, Issue 3, Page(s) 362–363

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Heart Transplantation ; Humans ; Risk Factors
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.6127
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  7. Article ; Online: Synchronized Diaphragmatic Stimulation for Heart Failure With a Reduced Left Ventricular Ejection Fraction Using the VisONE System: A First-in-Patient Study With Extended Population.

    Jorbenadze, Ana / Goldberg, Lee R / Shaburishvili, Tamaz / Zuber, Michel / Mirro, Michael / Fudim, Marat

    Structural heart : the journal of the Heart Team

    2022  Volume 6, Issue 6, Page(s) 100103

    Abstract: Background: Synchronized diaphragmatic stimulation (SDS) produces localized contractions of the diaphragm gated to the cardiac cycle to transiently modulate intrathoracic pressures, thereby impacting cardiac function for heart failure patients with ... ...

    Abstract Background: Synchronized diaphragmatic stimulation (SDS) produces localized contractions of the diaphragm gated to the cardiac cycle to transiently modulate intrathoracic pressures, thereby impacting cardiac function for heart failure patients with reduced ejection fraction (HFrEF). This study prospectively evaluated the safety and 1-year effectiveness of SDS in an expanded first-in-patient cohort using multiple implant methods.
    Methods: Symptomatic patients with HFrEF despite guideline-directed therapy were enrolled. Patients were evaluated at 3, 6 and 12 months for adverse events, quality of life (SF-36 QOL), echocardiography and 6-minute hall walk distance. The SDS system consists of 2 bipolar, active-fixation leads, and an implantable pulse generator.
    Results: Nineteen men were enrolled (age 63 [57, 67] years, New York Heart Association class II [53%]/III [47%], N-terminal pro B-type natriuretic peptide 1779 [886, 2309] pg/mL, left ventricular ejection fraction 27 [23, 33] %). Three implant techniques (abdominal laparoscopy: sensing and stimulating leads on the inferior diaphragm (n = 15); subxiphoid access for an epicardial sensing lead and abdominal laparoscopy for stimulation on the inferior diaphragm (n = 2); thoracoscopy to place an epicardial sensing lead and a stimulating lead on the superior diaphragm (n = 2)) were employed with 100% success. Patients were unaware of diaphragmatic stimulation. From discharge to 12 months, 6-minute hall walk distance increased (315 [296, 332]m to 340 [319, 384]m;
    Conclusions: These data demonstrate that SDS can be delivered using alternative implantation methods without raising safety concerns and suggest improved outcomes over 1 ​year of follow-up. Adequately powered randomized trials are now needed to confirm these findings.
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ISSN 2474-8714
    ISSN (online) 2474-8714
    DOI 10.1016/j.shj.2022.100103
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  8. Article ; Online: A Parallel Need for Cardiovascular Care for Female Carriers of Duchenne and Becker Muscular Dystrophy.

    Wang, Teresa / Day, Sharlene M / Goldberg, Lee R / Owens, Anjali T / Reza, Nosheen

    Journal of cardiac failure

    2022  Volume 28, Issue 7, Page(s) 1235–1236

    MeSH term(s) Female ; Heart Failure ; Humans ; Muscular Dystrophy, Duchenne/diagnosis ; Muscular Dystrophy, Duchenne/therapy
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.03.359
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    Zs.A 4340: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Diagnostic Utility of SGLT2 Inhibitors to Facilitate Myocardial Glucose Suppression During Evaluation of Myocardial Inflammation.

    Selvaraj, Senthil / Vidula, Mahesh K / Claggett, Brian / Rojulpote, Chaitanya / Bhattaru, Abhijit / Clancy, Caitlin B / Rossman, Milton / Pryma, Daniel A / Goldberg, Lee R / Bravo, Paco E

    JACC. Cardiovascular imaging

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2024.02.011
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    Zs.A 6846: Show issues Location:
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  10. Article ; Online: Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.

    Arenas, Daniel J / Beltran, Sourik / Zhou, Sara / Goldberg, Lee R

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19795

    Abstract: Although the cardiotoxic effects of cocaine are universally recognized, the association between cocaine and cardiomyopathy and/or heart failure is poorly understood. To conduct a comprehensive review and meta-analysis on the association between cocaine, ... ...

    Abstract Although the cardiotoxic effects of cocaine are universally recognized, the association between cocaine and cardiomyopathy and/or heart failure is poorly understood. To conduct a comprehensive review and meta-analysis on the association between cocaine, heart failure, and cardiomyopathy, we first conducted a broad-term search in PubMed, Embase, Web of Science, and Scopus for human studies containing primary data on the relationship between cocaine and heart failure or cardiomyopathy. We were interested in studies with data beyond acute coronary syndromes. Retrieved studies were grouped into different categories based on possible hypotheses to test by meta-analysis. A second search with specific terms was then conducted. For grouped studies with sufficient clinical and methodological homogeneity, effect sizes were calculated and combined for meta-analysis by the Random Effects model. There is in general a need for more primary data studies that investigate heart failure and/or cardiomyopathy in cocaine users for mechanisms independent of ischemia. There were, however, enough studies to combine by meta-analyses that showed that chronic cocaine use is associated with anatomical and functional changes more consistent with diastolic heart failure instead of the commonly taught dilated cardiomyopathy pathway. In patients without a history of ACS, chronic cocaine use was not associated with significantly reduced EF. The few studies on acute cocaine had conflicting results on whether single-dose intravascular cocaine results in acute heart failure. Studies identified that included beta-blockade therapy in cocaine users with cardiac disease suggest that beta-blockers are not unsafe and that may be effective in the treatment of cocaine-associated heart failure. Chronic cocaine use is associated with anatomical and physiological changes of the heart muscle that are potentially reversible with beta-blockade therapy.
    MeSH term(s) Animals ; Humans ; Adrenergic beta-Antagonists/therapeutic use ; Cardiomyopathies/chemically induced ; Cocaine/therapeutic use ; Heart Failure/chemically induced
    Chemical Substances Adrenergic beta-Antagonists ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2020-11-13
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-76273-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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