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  1. Article ; Online: SARS-CoV-2: from herd immunity to hybrid immunity.

    Goldblatt, David

    Nature reviews. Immunology

    2022  Volume 22, Issue 6, Page(s) 333–334

    MeSH term(s) COVID-19 ; Humans ; Immunity, Herd ; SARS-CoV-2
    Language English
    Publishing date 2022-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00725-0
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  2. Article ; Online: The indirect effect of pneumococcal conjugate vaccine.

    Goldblatt, David

    The Lancet. Global health

    2016  Volume 5, Issue 1, Page(s) e6–e7

    MeSH term(s) Child ; Humans ; Pneumococcal Infections ; Pneumococcal Vaccines ; Vaccination ; Vaccines, Conjugate
    Chemical Substances Pneumococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2016-12-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(16)30338-2
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  3. Article ; Online: Recent advances in chronic granulomatous disease.

    Goldblatt, David

    The Journal of infection

    2014  Volume 69 Suppl 1, Page(s) S32–5

    Abstract: Chronic Granulomatous Disease (CGD) is a primary immunodeficiency caused by abnormities in the NADPH Oxidase that is involved in the respiratory burst responsible for initiating the killing of microbes ingested by phagocytic cells. The hallmark of CGD is ...

    Abstract Chronic Granulomatous Disease (CGD) is a primary immunodeficiency caused by abnormities in the NADPH Oxidase that is involved in the respiratory burst responsible for initiating the killing of microbes ingested by phagocytic cells. The hallmark of CGD is recurrent infection but the inflammatory complications can prove difficult to treat. New insights into the mechanisms responsible for the inflammatory complications have led to new therapies. The treatment of CGD colitis with an anti-tumour necrosis alpha agent has been shown to be successful but associated with significant infectious complications. Haematopoietic stem cell transplants offer the possibility of cure for those with ether a matched or unrelated donor transplant, with results of the latter improving significantly over recent years. Gene Therapy offers the promise of cure without the need for a transplant but better vectors are required.
    MeSH term(s) Genetic Therapy ; Granulomatous Disease, Chronic/diagnosis ; Granulomatous Disease, Chronic/etiology ; Granulomatous Disease, Chronic/therapy ; Hematopoietic Stem Cell Transplantation ; Humans
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2014.07.013
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  4. Book ; Online: On Blowback Traffic on the Internet

    Goldblatt, Dallan / Vuong, Calvin / Rabinovich, Michael

    2023  

    Abstract: This paper considers the phenomenon where a single probe to a target generates multiple, sometimes numerous, packets in response -- which we term "blowback". Understanding blowback is important because attackers can leverage it to launch amplified denial ...

    Abstract This paper considers the phenomenon where a single probe to a target generates multiple, sometimes numerous, packets in response -- which we term "blowback". Understanding blowback is important because attackers can leverage it to launch amplified denial of service attacks by redirecting blowback towards a victim. Blowback also has serious implications for Internet researchers since their experimental setups must cope with bursts of blowback traffic. We find that tens of thousands, and in some protocols, hundreds of thousands, of hosts generate blowback, with orders of magnitude amplification on average. In fact, some prolific blowback generators produce millions of response packets in the aftermath of a single probe. We also find that blowback generators are fairly stable over periods of weeks, so once identified, many of these hosts can be exploited by attackers for a long time.
    Keywords Computer Science - Networking and Internet Architecture
    Publishing date 2023-05-07
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Correlates of protection against SARS-CoV-2 infection and COVID-19 disease.

    Goldblatt, David / Alter, Galit / Crotty, Shane / Plotkin, Stanley A

    Immunological reviews

    2022  Volume 310, Issue 1, Page(s) 6–26

    Abstract: Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS-CoV-2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the highest ... ...

    Abstract Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS-CoV-2 coronavirus. Measurement of those antibodies by neutralization or binding assays both have predictive value, with binding antibody titers giving the highest statistical correlation. However, the protective functions of antibodies are multiple. Antibodies with multiple functions other than neutralization influence efficacy. The role of cellular responses can be discerned with respect to CD4
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; Epitopes/immunology ; Humans ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-06-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13091
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  6. Article ; Online: The Development of Immunological Assays to Evaluate the Level and Function of Antibodies Induced by Klebsiella pneumoniae O-Antigen Vaccines.

    Wagstaffe, Helen R / Johnson, Marina / Osman, Guled / Martin, Patricia / Carranza, Paula / Goldblatt, David

    mSphere

    2023  Volume 8, Issue 2, Page(s) e0068022

    Abstract: Klebsiella pneumoniae, a Gram-negative bacterium, has been listed as a critical pathogen for urgent intervention by the World Health Organization. With no licensed vaccine and increasing resistance to antibiotics, Klebsiella pneumoniae causes a high ... ...

    Abstract Klebsiella pneumoniae, a Gram-negative bacterium, has been listed as a critical pathogen for urgent intervention by the World Health Organization. With no licensed vaccine and increasing resistance to antibiotics, Klebsiella pneumoniae causes a high incidence of hospital- and community-acquired infections. Recently, there has been progress in anti-Klebsiella pneumoniae vaccine development, which has highlighted the lack of standardized assays to measure vaccine immunogenicity. We have developed and optimized methods to measure antibody level and function after vaccination with an in-development Klebsiella pneumoniae O-antigen vaccine. We describe the qualification of a Luminex-based multiplex antibody binding assay and both an opsonophagocytic killing assay and serum bactericidal assay to measure antibody function. Serum from immunized animals were immunogenic and capable of binding to and killing specific Klebsiella serotypes. Cross-reactivity was observed but limited among serotypes sharing antigenic epitopes. In summary, these results demonstrate the standardization of assays that can be used to test new anti-Klebsiella pneumoniae vaccine candidates, which is important for moving them into clinical trials.
    MeSH term(s) Animals ; Rabbits ; O Antigens ; Klebsiella pneumoniae ; Antibodies, Bacterial ; Phagocytosis ; Bacterial Vaccines
    Chemical Substances O Antigens ; Antibodies, Bacterial ; Bacterial Vaccines
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00680-22
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  7. Article ; Online: Opsonophagocytic Killing Assay to Measure Anti-Group A Streptococcus Antibody Functionality in Human Serum.

    Wagstaffe, Helen / Jones, Scott / Johnson, Marina / Goldblatt, David

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2414, Page(s) 373–386

    Abstract: The opsonophagocytic killing assay (OPKA) is designed to measure the functionality of strain-specific antibodies and, therefore, assess protective immunity or the immunogenicity of Group A Streptococcus (GAS) (type A Streptococcus pyogenes) vaccines. ... ...

    Abstract The opsonophagocytic killing assay (OPKA) is designed to measure the functionality of strain-specific antibodies and, therefore, assess protective immunity or the immunogenicity of Group A Streptococcus (GAS) (type A Streptococcus pyogenes) vaccines. Opsonization of GAS for phagocytosis is an important mechanism by which antibodies protect against disease in vivo. The Opsonophagocytic Index or Opsonic Index (OI) is the estimated dilution of antisera that kills 50% of the target bacteria. Here, we describe the protocol of the standardized GAS OPKA developed by Jones et al., 2018.
    MeSH term(s) Antibodies, Bacterial ; Biological Assay ; Humans ; Opsonin Proteins ; Phagocytosis ; Streptococcus pyogenes/immunology
    Chemical Substances Antibodies, Bacterial ; Opsonin Proteins
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1900-1_20
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  8. Article ; Online: Efficacy and effectiveness of ten-valent versus 13-valent pneumococcal conjugate vaccines - Authors' reply.

    Goldblatt, David / Madhi, Shabir A

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 7, Page(s) 693–694

    MeSH term(s) Pneumococcal Vaccines ; Vaccines, Conjugate
    Chemical Substances Pneumococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(19)30286-5
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  9. Article ; Online: Pneumococcal pneumonia.

    Goldblatt, David / Miller, Elizabeth

    Thorax

    2019  Volume 75, Issue 1, Page(s) 6–7

    MeSH term(s) Humans ; Pneumonia, Pneumococcal ; Streptococcus pneumoniae
    Language English
    Publishing date 2019-11-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2019-214135
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  10. Article ; Online: The duopoly of ten-valent and 13-valent pneumococcal conjugate vaccines: do they differ?

    Madhi, Shabir A / Goldblatt, David

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 5, Page(s) 453–454

    MeSH term(s) Humans ; Infant ; Pneumococcal Vaccines ; Vaccines, Conjugate ; Vietnam
    Chemical Substances Pneumococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2019-04-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(18)30785-0
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