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  1. Article: Osteochondromyxoma: Review of a rare carney complex criterion.

    Golden, Todd / Siordia, Juan A

    Journal of bone oncology

    2016  Volume 5, Issue 4, Page(s) 194–197

    Abstract: Osteochondromyxoma is an extremely rare bone tumor associated with 1% of Carney complex patients and constitutes one of its 11 diagnostic criteria. This narrative review of osteochondromyxoma is based on a search of all references to the topic in PubMed, ...

    Abstract Osteochondromyxoma is an extremely rare bone tumor associated with 1% of Carney complex patients and constitutes one of its 11 diagnostic criteria. This narrative review of osteochondromyxoma is based on a search of all references to the topic in PubMed, Web Of Science, SCOPUS, ScienceDirect, and JSTOR databases. Special attention was focused on case reports, leading to a review encompassing the case reports to date, as well as related animal model studies. This review covers the current understanding of osteochondromyxoma, highlighting its variability while providing consensus on the most common clinical presentation, pathological findings, and genetic features of this rare bone tumor.
    Language English
    Publishing date 2016-07-12
    Publishing country Netherlands
    Document type Review ; Journal Article
    ISSN 2212-1366
    ISSN 2212-1366
    DOI 10.1016/j.jbo.2016.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CLIPPERS: An Increasingly Recognized Chronic Inflammatory Central Nervous System Disorder.

    Joshi, Kshipra / Golden, Todd / Ghazala, Sehem

    The American journal of medicine

    2018  Volume 132, Issue 2, Page(s) e35–e36

    MeSH term(s) Aged ; Anti-Inflammatory Agents/therapeutic use ; Central Nervous System Diseases/diagnostic imaging ; Central Nervous System Diseases/drug therapy ; Central Nervous System Diseases/pathology ; Female ; Humans ; Inflammation/diagnostic imaging ; Inflammation/drug therapy ; Inflammation/pathology ; Methylprednisolone/therapeutic use ; Rare Diseases
    Chemical Substances Anti-Inflammatory Agents ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2018.09.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Abciximab-induced acute profound thrombocytopenia postpercutaneous coronary intervention.

    Golden, Todd / Ghazala, Sehem / Wadeea, Rita / Junna, Shilpa

    BMJ case reports

    2017  Volume 2017

    Abstract: Abciximab (c7E3 Fab) is one of the three potent intravenous glycoprotein IIb/IIIa receptor inhibitors (along with eptifibatide and tirofiban) that have shown significant positive outcomes when used in patients with intracoronary thrombus. However, major ... ...

    Abstract Abciximab (c7E3 Fab) is one of the three potent intravenous glycoprotein IIb/IIIa receptor inhibitors (along with eptifibatide and tirofiban) that have shown significant positive outcomes when used in patients with intracoronary thrombus. However, major side effects have been reported with its use including hypotension, major bleeding and thrombocytopenia. This case is a 53-year-old man presenting with acute chest pain diagnosed with non-ST-elevation myocardial infarction, who underwent percutaneous coronary intervention with abciximab and heparin infusion and developed acute profound thrombocytopenia (platelet count <20,000/L) within 9 hours of infusion. This case demonstrates the importance of routinely monitoring the platelet count prior to and 2-4 hours following abciximab infusion and differentiating other causes of acute profound thrombocytopenia, particularly pseudothrombocytopenia and heparin-induced thrombocytopenia.
    MeSH term(s) Abciximab ; Angioplasty ; Antibodies, Monoclonal/adverse effects ; Chest Pain/etiology ; Diagnosis, Differential ; Humans ; Immunoglobulin Fab Fragments/adverse effects ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/therapy ; Platelet Aggregation Inhibitors/adverse effects ; Thrombocytopenia/blood ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis
    Chemical Substances Antibodies, Monoclonal ; Immunoglobulin Fab Fragments ; Platelet Aggregation Inhibitors ; Abciximab (X85G7936GV)
    Language English
    Publishing date 2017-07-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-221182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact on the Volume of Pathology Reports Before and During the COVID-19 Pandemic in SEER Cancer Registries.

    Chtourou, Amina / Sanchez, Pamela V / Golden, Todd / Chen, Huann-Sheng / Schwartz, Stephen M / Wu, Xiao-Cheng / Hernandez, Brenda Y / Harrison, Jovanka N / Penberthy, Lynne / Negoita, Serban

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2023  Volume 32, Issue 11, Page(s) 1591–1598

    Abstract: Introduction: Health care procedures including cancer screening and diagnosis were interrupted due to the COVID-19 pandemic. The extent of this impact on cancer care in the United States is not fully understood. We investigated pathology report volume ... ...

    Abstract Introduction: Health care procedures including cancer screening and diagnosis were interrupted due to the COVID-19 pandemic. The extent of this impact on cancer care in the United States is not fully understood. We investigated pathology report volume as a reflection of trends in oncology services pre-pandemic and during the pandemic.
    Methods: Electronic pathology reports were obtained from 11 U.S. central cancer registries from NCI's SEER Program. The reports were sorted by cancer site and document type using a validated algorithm. Joinpoint regression was used to model temporal trends from January 2018 to February 2020, project expected counts from March 2020 to February 2021 and calculate observed-to-expected ratios. Results were stratified by sex, age, cancer site, and report type.
    Results: During the first 3 months of the pandemic, pathology report volume decreased by 25.5% and 17.4% for biopsy and surgery reports, respectively. The 12-month O/E ratio (March 2020-February 2021) was lowest for women (O/E 0.90) and patients 65 years and older (O/E 0.91) and lower for cancers with screening (melanoma skin, O/E 0.86; breast, O/E 0.88; lung O/E 0.89, prostate, O/E 0.90; colorectal, O/E 0.91) when compared with all other cancers combined.
    Conclusions: These findings indicate a decrease in cancer diagnosis, likely due to the COVID-19 pandemic. This decrease in the number of pathology reports may result in a stage shift causing a subsequent longer-term impact on survival patterns.
    Impact: Investigation on the longer-term impact of the pandemic on pathology services is vital to understand if cancer care delivery levels continue to be affected.
    MeSH term(s) Male ; Humans ; Female ; United States/epidemiology ; SEER Program ; Pandemics ; Incidence ; COVID-19/epidemiology ; Registries ; Melanoma
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upper-extremity function prospectively predicts adverse discharge and all-cause COPD readmissions: a pilot study.

    Ehsani, Hossein / Mohler, Martha Jane / Golden, Todd / Toosizadeh, Nima

    International journal of chronic obstructive pulmonary disease

    2018  Volume 14, Page(s) 39–49

    Abstract: Background: Frailty can inform management approaches for individuals with COPD. However, inpatient measures of frailty are seldom employed because they are time-consuming or inapplicable for bed-bound patients. We investigated the feasibility and ... ...

    Abstract Background: Frailty can inform management approaches for individuals with COPD. However, inpatient measures of frailty are seldom employed because they are time-consuming or inapplicable for bed-bound patients. We investigated the feasibility and potential of an innovative sensor-based upper-extremity function (UEF) test for frailty assessment in predicting adverse outcomes.
    Methods: Hospitalized patients with COPD-related exacerbations (aged ≥55 years) were recruited and performed the UEF test within 24 hours of admission. UEF parameters were obtained and fed into our previously developed frailty model to calculate frailty status (non-frail, pre-frail, and frail) and frailty score (0: extreme resilience to 1: extreme frailty). In-hospital (length of stay) and post-discharge (discharge disposition, 30-day exacerbation with treatment, and all-cause 30-day readmission) outcomes were collected. Associations between UEF frailty and outcomes were investigated using ANOVA and logistic models adjusted for demographic data.
    Results: In total, 42 patients were recruited. All participants were able to perform the UEF test. Based on UEF, participants were stratified into three groups of non-frail (n=6, frailty score =0.18±0.09), pre-frail (n=14, frailty score =0.45±0.09), and frail (n=22, frailty score =0.78±0.11). Both frailty status and frailty score were significantly associated with unfavorable discharge disposition (
    Conclusion: In agreement with previous work, the current findings underline the importance of measuring frailty for risk-stratification of COPD patients. The UEF was feasible and easily performed among all hospitalized COPD patients. In this study, we have shown that, using our quick and objective frailty measures, COPD patients can be prospectively risk-stratified in terms of unfavorable discharge disposition and all-cause 30-day readmissions.
    MeSH term(s) Aged ; Biomechanical Phenomena ; Decision Support Techniques ; Feasibility Studies ; Female ; Frail Elderly ; Frailty/diagnosis ; Frailty/physiopathology ; Frailty/therapy ; Geriatric Assessment/methods ; Humans ; Length of Stay ; Longitudinal Studies ; Male ; Middle Aged ; Patient Admission ; Patient Discharge ; Patient Readmission ; Physical Examination/instrumentation ; Physical Examination/methods ; Pilot Projects ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/therapy ; Risk Assessment ; Risk Factors ; Time Factors ; Upper Extremity/physiopathology
    Language English
    Publishing date 2018-12-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S182802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma.

    Golden, Todd Rabkin / Solnicky, Veronika / Wadeea, Rita / Ghazala, Sehem

    BMJ case reports

    2018  Volume 2018

    Abstract: We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history. ...

    Abstract We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history.
    MeSH term(s) Acidosis, Lactic/chemically induced ; Aged ; Coma/chemically induced ; Humans ; Hypnotics and Sedatives/adverse effects ; Male ; Pentobarbital/adverse effects ; Status Epilepticus/drug therapy
    Chemical Substances Hypnotics and Sedatives ; Pentobarbital (I4744080IR)
    Language English
    Publishing date 2018-02-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-223482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A rare case of pyogenic pericarditis secondary to

    Ghazala, Sehem / Golden, Todd Rabkin / Farran, Sumaya / Zangeneh, Tirdad T

    BMJ case reports

    2018  Volume 2018

    Abstract: We report an extremely rare case of purulent pericarditis caused by the normally commensal oral flora, ...

    Abstract We report an extremely rare case of purulent pericarditis caused by the normally commensal oral flora,
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/therapeutic use ; Diagnosis, Differential ; Echocardiography ; Female ; Humans ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/drug therapy ; Pericardial Effusion/microbiology ; Pericarditis/diagnostic imaging ; Pericarditis/drug therapy ; Pericarditis/microbiology ; Pericardium/diagnostic imaging ; Pericardium/microbiology ; Streptococcal Infections/complications ; Streptococcal Infections/diagnostic imaging ; Streptococcal Infections/drug therapy ; Streptococcus constellatus/isolation & purification ; Tomography, X-Ray Computed
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-223804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts.

    Kong, Denice / Lee, Nancy / Dela Cruz, Imma Donna / Dames, Charlyn / Maruthamuthu, Stalinraja / Golden, Todd / Rajalingam, Raja

    Human immunology

    2021  Volume 82, Issue 8, Page(s) 581–587

    Abstract: Hematopoietic stem cell transplantation (HSCT) from HLA-matched donors significantly decreases the risks of graft-rejection and graft-versus-host disease. Long-range PCR- amplicon-based next-generation sequencing (NGS) is increasingly used as a ... ...

    Abstract Hematopoietic stem cell transplantation (HSCT) from HLA-matched donors significantly decreases the risks of graft-rejection and graft-versus-host disease. Long-range PCR- amplicon-based next-generation sequencing (NGS) is increasingly used as a standalone method in clinical laboratories to determine HLA compatibility for HSCT and solid-organ transplantation. We hypothesized that an allelic dropout is a frequent event in the long-range PCR amplicon-based NGS HLA typing method. To test the hypothesis, we typed 4,006 samples concurrently using a commercially available long-range PCR amplicon-based NGS-typing and short exon-specific amplicon-based reverse sequence-specific oligonucleotide (rSSO) methods. The concordance between the NGS and rSSO typing results was 100% at HLA-A, -B, -C, -DRB1, -DRB3, -DRB5, -DQA1, DPA1 loci. However, 4.5% of the samples (179/4006) showed allelic-dropouts at one of the other three loci: HLA-DRB4 (3.9%), HLA-DPB1 (0.4%), and HLA-DQB1*(0.15%). The allelic-dropouts are not associated with specific haplotypes, and some dropouts can be reagent lot-specific. Although DRB1-DRB3/4/5-DQB1 linkages help to diagnose these allelic-dropouts in some cases, the rSSO typing was crucial to identify the dropouts in DQB1 and DPB1 loci. These results uncover the critical limitations of using long-range PCR amplicon-based NGS as a standalone method in clinical histocompatibility laboratories and advocate the need for strategies to diagnose and resolve allelic-dropouts.
    MeSH term(s) Alleles ; HLA Antigens/genetics ; Haplotypes ; Hematopoietic Stem Cell Transplantation ; High-Throughput Nucleotide Sequencing/methods ; Histocompatibility Testing/methods ; Histocompatibility Testing/standards ; Humans ; Oligonucleotides ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/standards
    Chemical Substances HLA Antigens ; Oligonucleotides
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2021.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Integration of electronic pathology reporting with clinical trial matching for advanced prostate cancer.

    Borno, Hala T / Duffy, Christine / Zhang, Sylvia / Canchola, Alison J / Loya, Zinnia / Golden, Todd / Oh, Debora L / Odisho, Anobel Y / Gomez, Scarlett

    Urologic oncology

    2021  Volume 39, Issue 8, Page(s) 494.e7–494.e14

    Abstract: Introduction: Racial/ethnic diversity in prostate cancer (CaP) clinical trials (CTs) is essential to address CaP disparities. California Cancer Registry mandated electronic reporting (e-path) of structured data elements from pathologists diagnosing ... ...

    Abstract Introduction: Racial/ethnic diversity in prostate cancer (CaP) clinical trials (CTs) is essential to address CaP disparities. California Cancer Registry mandated electronic reporting (e-path) of structured data elements from pathologists diagnosing cancer thereby creating an opportunity to identify and approach patients rapidly. This study tested the utility of an online CT matching tool (called Trial Library) used in combination with e-path to improve matching of underrepresented CaP patients into CTs at time of diagnosis.
    Methods: This was a nonrandomized, single-arm feasibility study among patients with a new pathologic diagnosis of high-risk CaP (Gleason Score ≥8). Eligible patients were sent recruitment materials and enrolled patients were introduced to Trial Library.
    Results: A total of 419 case listings were assessed. Patients were excluded due to physician contraindication, not meeting baseline eligibility, or unable to be reached. Final participants (N = 52) completed a baseline survey. Among study participants, 77% were White, 10% were Black/Hispanic/Missing, and 14% were Asian. The majority of the study participants were over 65 years of age (81%) and Medicare insured (62%). Additionally, 81% of participants reported using the Internet to learn about CaP. The majority (62%) of participants reported that Trial Library increased their interest in CT participation.
    Conclusions: The current study demonstrated that leveraging structured e-path data reporting to a population-based cancer registry to recruit men with high risk CaP to clinical research is feasible and acceptable. We observed that e-path may be linked with an online CT matching tool, Trial Library. Future studies will prioritize recruitment from reporting facilities that serve more racially/ethnically diverse patient populations.
    MeSH term(s) Aged ; Aged, 80 and over ; Clinical Trials as Topic/statistics & numerical data ; Electronic Health Records/statistics & numerical data ; Ethnicity/statistics & numerical data ; Feasibility Studies ; Follow-Up Studies ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Non-Randomized Controlled Trials as Topic ; Pathology, Clinical/methods ; Patient Selection ; Prognosis ; Prostatic Neoplasms/pathology ; Racial Groups/statistics & numerical data
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prevalence of depression in China during the early stage of the COVID-19 pandemic: a cross-sectional study in an online survey sample.

    Liu, Weina / Yu, Fengyun / Geldsetzer, Pascal / Yang, Juntao / Wang, Zhuoran / Golden, Todd / Jiao, Lirui / Chen, Qiushi / Liu, Haitao / Wu, Peixin / Wang, Chen / Bärnighausen, Till / Chen, Simiao

    BMJ open

    2022  Volume 12, Issue 3, Page(s) e056667

    Abstract: Objectives: We aimed to determine (1) the prevalence of depression during the COVID-19 pandemic among Chinese adults and (2) how depression prevalence varied by province and sociodemographic characteristics.: Design: Cross-sectional study.: Setting! ...

    Abstract Objectives: We aimed to determine (1) the prevalence of depression during the COVID-19 pandemic among Chinese adults and (2) how depression prevalence varied by province and sociodemographic characteristics.
    Design: Cross-sectional study.
    Setting: National online survey in China.
    Participants: We conducted a cross-sectional online survey among adults registered with the survey company KuRunData from 8 May 2020 to 8 June 2020. We aimed to recruit 300-360 adults per province (n=14 493), with a similar distribution by sex and rural-urban residency as the general population within each of these provinces.
    Primary outcome: Participants completed the Patient Health Questionaire-9 (PHQ-9). We calculated the prevalence of depression (defined as a PHQ-9 score ≥10) nationally and separately for each province.
    Analysis: Covariate-unadjusted and covariate-adjusted logistic regression models were used to examine how the prevalence of depression varied by adults' sociodemographic characteristics. All analyses used survey sampling weights.
    Results: The survey was initiated by 14 493 participants, with 10 000 completing all survey questions and included in the analysis. The prevalence of depression in the national sample was 6.3% (95% CI 5.7% to 6.8%). A higher odds of depression was associated with living in an urban area (OR 1.50; 95% CI 1.18 to 1.90) and working as a nurse (OR 3.06; 95% CI 1.41 to 6.66). A lower odds of depression was associated with participants who had accurate knowledge of COVID-19 transmission prevention actions (OR 0.71; 95% CI 0.51 to 0.98), the knowledge that saliva is a main transmission route (OR 0.80; 95% CI 0.64 to 0.99) and awareness of COVID-19 symptoms (OR, 0.82; 95% CI 0.68 to 1.00).
    Conclusion: Around one in 20 adults in our online survey sample had a PHQ-9 score suggestive of depression. Interventions and policies to prevent and treat depression during the COVID-19 pandemic in China may be particularly needed for nurses and those living in urban areas.
    MeSH term(s) Adult ; Anxiety/epidemiology ; COVID-19/epidemiology ; China/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Humans ; Pandemics ; Prevalence ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-056667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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