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  1. AU="Goldenstein, Patrícia T"
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  1. Artikel ; Online: Factors Associated with Intradialytic Phosphate Removal in Hemodialysis Patients before and after Parathyroidectomy.

    Lima, Carolina M / Goldenstein, Patrícia T / Dos Reis, Luciene M / Jorgetti, Vanda / Elias, Rosilene M / Moysés, Rosa M A

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Band 18, Heft 10, Seite(n) 1346–1348

    Mesh-Begriff(e) Humans ; Phosphates ; Parathyroidectomy/adverse effects ; Renal Dialysis ; Kidney Failure, Chronic/therapy ; Blood Pressure
    Chemische Substanzen Phosphates
    Sprache Englisch
    Erscheinungsdatum 2023-05-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Fractures in chronic kidney disease: pursuing the best screening and management.

    Goldenstein, Patrícia T / Jamal, Sophie A / Moysés, Rosa M A

    Current opinion in nephrology and hypertension

    2015  Band 24, Heft 4, Seite(n) 317–323

    Abstract: Purpose of review: Osteoporotic fractures are common and cause increased sickness and death. Men and women with chronic kidney disease (CKD) are at particularly high risk of osteoporotic fractures. Currently, however, there are no guidelines concerning ... ...

    Abstract Purpose of review: Osteoporotic fractures are common and cause increased sickness and death. Men and women with chronic kidney disease (CKD) are at particularly high risk of osteoporotic fractures. Currently, however, there are no guidelines concerning noninvasive methods to assess fracture risk in CKD. Further, approved treatments to prevent fractures in otherwise healthy men and women are only recommended for use with caution in those with CKD. This review focuses on the recent data that support the use of noninvasive methods to assess fracture risk in CKD and highlights new therapies that could be used in fracture prevention in CKD.
    Recent findings: Data from prospective studies demonstrate that low bone mineral density predicts fracture in CKD patients. Post-hoc analyses demonstrate that agents approved for the treatment of postmenopausal osteoporosis (bisphosphonates, denosumab and teriparatide) when given to those with CKD are well tolerated and potentially efficacious with respect to fracture risk reduction.
    Summary: To date, patients, and nephrologists taking care of them, have largely ignored fracture risk assessment and treatment in CKD. This should change given recent data. Further studies are needed, specifically bone histomorphometric studies, which will increase our understanding of CKD-mineral bone disease (MBD) pathophysiology, and randomized clinical trials of therapy in patients with CKD.
    Mesh-Begriff(e) Animals ; Bone Density Conservation Agents/therapeutic use ; Humans ; Osteoporosis/complications ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/diagnosis ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporotic Fractures/complications ; Osteoporotic Fractures/diagnosis ; Osteoporotic Fractures/drug therapy ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Risk Assessment
    Chemische Substanzen Bone Density Conservation Agents
    Sprache Englisch
    Erscheinungsdatum 2015-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Parathyroidectomy: better late than never.

    Elias, Rosilene M / Goldenstein, Patricia T / Moyses, Rosa M A

    Kidney international

    2015  Band 88, Heft 3, Seite(n) 638

    Mesh-Begriff(e) Cardiovascular Diseases/mortality ; Female ; Humans ; Hyperparathyroidism, Secondary/surgery ; Kidney Failure, Chronic/therapy ; Male ; Parathyroidectomy
    Sprache Englisch
    Erscheinungsdatum 2015-09
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2015.217
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Hefte anzeigen Standort:
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  4. Artikel: Myocardial dysfunction and pulmonary edema post parathyroidectomy: the role of hypocalcemia.

    Lekas, Poli / Goldenstein, Patricia T / Bargman, Joanne M

    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

    2010  Band 26, Seite(n) 125–129

    Abstract: Cardiac disease is a common cause of morbidity in dialysis patients. Traditional and unique risk factors have both been incriminated in the pathogenesis of abnormal cardiac function in these patients. In the present report, we focus on the role of ... ...

    Abstract Cardiac disease is a common cause of morbidity in dialysis patients. Traditional and unique risk factors have both been incriminated in the pathogenesis of abnormal cardiac function in these patients. In the present report, we focus on the role of hypocalcemia post parathyroidectomy as a cause of abnormal myocardial function leading to pulmonary edema in a young peritoneal dialysis patient with angiographically-proven normal coronary arteries. The pulmonary edema reversed with correction of the hypocalcemia. Hypocalcemia should be added to the differential diagnosis of contributors to cardiac dysfunction in patients on dialysis. Post parathyroidectomy, patients may be at particular risk for this complication because of severe, protracted hypocalcemia.
    Mesh-Begriff(e) Adult ; Calcium Compounds/therapeutic use ; Cardiomyopathies/etiology ; Cardiomyopathies/physiopathology ; Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Hyperparathyroidism, Secondary/surgery ; Hypocalcemia/diagnosis ; Hypocalcemia/drug therapy ; Hypocalcemia/etiology ; Hypocalcemia/physiopathology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Parathyroidectomy/adverse effects ; Peritoneal Dialysis, Continuous Ambulatory ; Pulmonary Edema/etiology ; Pulmonary Edema/physiopathology
    Chemische Substanzen Calcium Compounds
    Sprache Englisch
    Erscheinungsdatum 2010
    Erscheinungsland Canada
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1197-8554
    ISSN 1197-8554
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Dialysis as a Treatment Option for a Patient With Normal Kidney Function and Familial Tumoral Calcinosis Due to a Compound Heterozygous FGF23 Mutation.

    Goldenstein, Patrícia T / Neves, Precil D / Balbo, Bruno E / Elias, Rosilene M / Pereira, Alexandre C / Onuchic, Luiz F / Jüppner, Harald / Jorgetti, Vanda / Abensur, Hugo / Moysés, Rosa Maria

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2018  Band 72, Heft 3, Seite(n) 457–461

    Abstract: Primary tumoral calcinosis is a rare autosomal recessive disorder characterized by ectopic calcified tumoral masses. Mutations in 3 genes (GALNT3, FGF23, and KL) have been linked to this human disorder. We describe a case of a 28-year-old man with a ... ...

    Abstract Primary tumoral calcinosis is a rare autosomal recessive disorder characterized by ectopic calcified tumoral masses. Mutations in 3 genes (GALNT3, FGF23, and KL) have been linked to this human disorder. We describe a case of a 28-year-old man with a history of painful firm masses over his right and left gluteal region, right clavicle region, knees, and left elbow. Biochemical analysis disclosed hyperphosphatemia (phosphate, 9.0 mg/dL) and normocalcemia (calcium, 4.8 mg/dL), with normal kidney function and fractional excretion of phosphate of 3%. Parathyroid hormone was suppressed (15 pg/mL), associated with a low-normal 25-hydroxyvitamin D (26 ng/mL) concentration but high 1,25-dihydroxyvitamin D concentration (92 pg/mL). Serum intact FGF-23 (fibroblast growth factor 23) was undetectable. Genetic analysis revealed tumoral calcinosis due to a compound heterozygous mutation in FGF23, c.201G>C (p.Gln67His) and c.466C>T (p.Gln156*). Due to lack of other treatment options and because the patient was facing severe vascular complications, we initiated a daily hemodialysis program even in the setting of normal kidney function. This unusual therapeutic option successful controlled hyperphosphatemia and reduced metastatic tumoral lesions. This is a report of a new mutation in FGF23 in which dialysis was an effective treatment option for tumoral calcinosis with normal kidney function.
    Mesh-Begriff(e) Adult ; Calcinosis/diagnostic imaging ; Calcinosis/genetics ; Calcinosis/therapy ; Fibroblast Growth Factors/genetics ; Humans ; Hyperostosis, Cortical, Congenital/diagnostic imaging ; Hyperostosis, Cortical, Congenital/genetics ; Hyperostosis, Cortical, Congenital/therapy ; Hyperphosphatemia/diagnostic imaging ; Hyperphosphatemia/genetics ; Hyperphosphatemia/therapy ; Kidney/physiology ; Male ; Mutation/genetics ; Renal Dialysis/methods ; Treatment Outcome
    Chemische Substanzen Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE)
    Sprache Englisch
    Erscheinungsdatum 2018-03-14
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2017.12.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Hefte anzeigen Standort:
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  6. Artikel ; Online: Quality of life after surgery in secondary hyperparathyroidism, comparing subtotal parathyroidectomy with total parathyroidectomy with immediate parathyroid autograft: Prospective randomized trial.

    Filho, Wellington Alves / van der Plas, Willemijn Y / Brescia, Marilia D G / Nascimento, Climerio P / Goldenstein, Patricia T / Neto, Ledo M Massoni / Arap, Sergio S / Custodio, Melani R / Bueno, Rodrigo O / Moyses, Rosa M A / Jorgetti, Vanda / Kruijf, Schelto / Montenegro, Fabio L M

    Surgery

    2018  Band 164, Heft 5, Seite(n) 978–985

    Abstract: Background: No prospective randomized data exist about the impact of various strategies of parathyroidectomy in secondary hyperparathyroidism patients on quality of life and its possible relationship with metabolic status after the operation.: Method!# ...

    Abstract Background: No prospective randomized data exist about the impact of various strategies of parathyroidectomy in secondary hyperparathyroidism patients on quality of life and its possible relationship with metabolic status after the operation.
    Method: In a prospective randomized trial, the Short Form 36 Health Survey Questionnaire was applied to 69 patients undergoing parathyroidectomy through various approaches: subtotal parathyroidectomy (n = 23), total parathyroidectomy (PTx) with autotransplantation of 45 fragments (n = 25) and PTx with autotransplantation of 90 fragments (n = 21). The questionnaire was completed at three moments: (1) preoperatively, (2) 6 months after surgery, and (3) 12 months after surgery.
    Results: Quality of life improved significantly in the physical component summary score in all three groups. Subtotal parathyroidectomy scores changed from 30.6 preoperatively to 51.7 6 months after surgery and 53.7 12 months after surgery. Total arathyroidectomy with autotransplantation of 45 fragments scores changed from 33.8 preoperatively to 52.6 6 months after surgery and 55.2 12 months after surgery. Total parathyroidectomy with autotransplantation of 90 fragments scores changed from 31.8 preoperatively to 50.5 6 months after surgery and 55.2 12 months after surgery (all groups P < .0001). No significant difference was detected in the physical component summary score change among the three groups. The physical component summary score was negatively correlated to age, parathormone, and alkaline phosphatase preoperatively.
    Conclusion: Parathyroidectomy significantly improves quality of life in hemodialysis patients with secondary hyperparathyroidism, regardless of the type of operation.
    Mesh-Begriff(e) Adult ; Age Factors ; Female ; Follow-Up Studies ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/surgery ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Parathyroid Glands/transplantation ; Parathyroid Hormone/blood ; Parathyroidectomy/adverse effects ; Parathyroidectomy/methods ; Preoperative Period ; Prospective Studies ; Quality of Life ; Renal Dialysis/adverse effects ; Surveys and Questionnaires/statistics & numerical data ; Transplantation, Autologous/adverse effects ; Transplantation, Autologous/methods ; Treatment Outcome
    Chemische Substanzen Parathyroid Hormone
    Sprache Englisch
    Erscheinungsdatum 2018-08-03
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.06.032
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Corrigendum to "Quality of life after surgery in secondary hyperparathyroidism comparing subtotal parathyroidectomy to total parathyroidectomy with immediate parathyroid autograft - a prospective randomized trial" [Surgery 164 (2018) 978-985].

    Filho, Wellington Alves / van der Plas, Willemijn Y / Brescia, Marilia D G / Nascimento, Climerio P / Goldenstein, Patricia T / Neto, Ledo M Massoni / Arap, Sergio S / Custodio, Melani R / Bueno, Rodrigo O / Moyses, Rosa M A / Jorgetti, Vanda / Kruijff, Schelto / Montenegro, Fabio L M

    Surgery

    2018  Band 165, Heft 2, Seite(n) 497

    Sprache Englisch
    Erscheinungsdatum 2018-11-28
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.11.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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