LIVIVO - Search results -

Search results

Result 1 - 10 of total 28

Search options

Article: Chromatin structure and 3D architecture define differential functions of

Qiu, Kevin / Vu, Duc / Wang, Leran / Bookstaver, Anna / Dinh, Thang N / Goldfarb, Adam N / Tenen, Daniel G / Trinh, Bon Q

bioRxiv : the preprint server for biology

2024

Abstract: The precise spatio-temporal expression of the hematopoietic ETS transcription ... ...

Abstract	The precise spatio-temporal expression of the hematopoietic ETS transcription factor
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.01.573782
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Liver kinase B1 (LKB1) in murine erythroid progenitors modulates erythropoietin setpoint in association with maturation control.

White, Zollie / Elagib, Kamaleldin E / Gru, Alejandro A / Goldfarb, Adam N

Blood cells, molecules & diseases

2022 Volume 97, Page(s) 102688

Abstract: Erythropoiesis is a tightly regulated process. It is stimulated by decreased oxygen in circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys. An additional layer of control involves the coordinated sensing and use ... ...

Abstract	Erythropoiesis is a tightly regulated process. It is stimulated by decreased oxygen in circulation, which leads to the secretion of the hormone erythropoietin (Epo) by the kidneys. An additional layer of control involves the coordinated sensing and use of nutrients. Much cellular machinery contributes to sensing and responding to nutrient status in cells, and one key participant is the kinase LKB1. The current study examines the role of LKB1 in erythropoiesis using a murine in vivo and ex vivo conditional knockout system. In vivo analysis showed erythroid loss of LKB1 to be associated with a robust increase in serum Epo and mild reticulocytosis. Despite these abnormalities, no evidence of anemia or hemolysis was found. Further characterization using an ex vivo progenitor culture assay demonstrated accelerated erythroid maturation in the LKB1-deficient cells. Based on pharmacologic evidence, this phenotype appeared to result from impaired AMP-activated protein kinase (AMPK) signaling downstream of LKB1. These findings reveal a role for LKB1 in fine-tuning Epo-driven erythropoiesis in association with maturational control.
MeSH term(s)	AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Erythroid Precursor Cells/metabolism ; Erythropoiesis/genetics ; Erythropoiesis/physiology ; Erythropoietin/genetics ; Erythropoietin/metabolism ; Humans ; Liver/metabolism ; Mice ; Receptors, Erythropoietin/genetics ; Receptors, Erythropoietin/metabolism
Chemical Substances	Receptors, Erythropoietin ; Erythropoietin (11096-26-7) ; Stk11 protein, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2022-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/j.bcmd.2022.102688
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1138: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Coordinating red cell differentiation with cell cycle arrest: GATA-1 activation of p21.

Goldfarb, Adam N

Cell cycle (Georgetown, Tex.)

2010 Volume 9, Issue 11, Page(s) 2061

MeSH term(s)	Cell Differentiation ; Cell Line ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Erythroid Cells/cytology ; Erythroid Cells/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Proto-Oncogene Proteins c-kit/metabolism ; Proto-Oncogene Proteins c-myc/metabolism
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p21 ; GATA1 Transcription Factor ; GATA1 protein, human ; Proto-Oncogene Proteins c-myc ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2010-06-01
Publishing country	United States
Document type	Comment ; News
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5881: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Megakaryocyte ontogeny: Clinical and molecular significance.

Elagib, Kamaleldin E / Brock, Ashton T / Goldfarb, Adam N

Experimental hematology

2018 Volume 61, Page(s) 1–9

Abstract: Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect their capacity for platelet production. However, despite being smaller, more proliferative, and less polyploid, fetal Mks generally mature in the same manner as adult Mks. The ...

Abstract	Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect their capacity for platelet production. However, despite being smaller, more proliferative, and less polyploid, fetal Mks generally mature in the same manner as adult Mks. The phenotypic features unique to fetal Mks predispose patients to several disease conditions, including infantile thrombocytopenia, infantile megakaryoblastic leukemias, and poor platelet recovery after umbilical cord blood stem cell transplantations. Ontogenic Mk differences also affect new strategies being developed to address global shortages of platelet transfusion units. These donor-independent, ex vivo production platforms are hampered by the limited proliferative capacity of adult-type Mks and the inferior platelet production by fetal-type Mks. Understanding the molecular programs that distinguish fetal versus adult megakaryopoiesis will help in improving approaches to these clinical problems. This review summarizes the phenotypic differences between fetal and adult Mks, the disease states associated with fetal megakaryopoiesis, and recent advances in the understanding of mechanisms that determine ontogenic Mk transitions.
MeSH term(s)	Fetal Blood/cytology ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/pathology ; Models, Biological ; Morphogenesis/physiology ; Phenotype ; Thrombocytopenia/pathology
Language	English
Publishing date	2018-03-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2018.02.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 922: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.

Goldfarb, Adam N

Journal of cellular biochemistry

2009 Volume 107, Issue 3, Page(s) 377–382

Abstract: Transcription factors originally identified as drivers of erythroid differentiation subsequently became linked to megakaryopoiesis, reflecting the shared parentage of red cells and platelets. The divergent development of megakaryocytic and erythroid ... ...

Abstract	Transcription factors originally identified as drivers of erythroid differentiation subsequently became linked to megakaryopoiesis, reflecting the shared parentage of red cells and platelets. The divergent development of megakaryocytic and erythroid progenitors relies on signaling pathways that impose lineage-specific transcriptional programs on non-lineage-restricted protein complexes. One such signaling pathway involves RUNX1, a transcription factor upregulated in megakaryocytes and downregulated in erythroid cells. In this pathway, RUNX1 engages the erythro-megakaryocytic master regulator GATA-1 in a megakaryocytic transcriptional complex whose activity is highly dependent on the P-TEFb kinase complex. The implications of this pathway for normal and pathological megakaryopoiesis are discussed.
MeSH term(s)	Animals ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/metabolism ; Positive Transcriptional Elongation Factor B/metabolism ; Signal Transduction ; Transcription, Genetic
Chemical Substances	Core Binding Factor Alpha 2 Subunit ; GATA1 Transcription Factor ; Positive Transcriptional Elongation Factor B (EC 2.7.11.-)
Language	English
Publishing date	2009-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.22142
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1114: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Megakaryocytic irreversible P-TEFb activation.

Elagib, Kamaleldin E / Goldfarb, Adam N

Cell cycle (Georgetown, Tex.)

2014 Volume 13, Issue 12, Page(s) 1827–1828

MeSH term(s)	Animals ; Calpain/physiology ; Cell Transformation, Neoplastic/pathology ; GATA1 Transcription Factor/genetics ; Humans ; Leukemia/pathology ; Megakaryocytes/pathology ; Mutation/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; Ribonucleoproteins, Small Nuclear/metabolism
Chemical Substances	GATA1 Transcription Factor ; Ribonucleoproteins, Small Nuclear ; Positive Transcriptional Elongation Factor B (EC 2.7.11.-) ; Calpain (EC 3.4.22.-)
Language	English
Publishing date	2014-05-27
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.29324
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5881: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: ERK expands its empire.

Goldfarb, Adam N

Leukemia research

2005 Volume 29, Issue 11, Page(s) 1235–1236

MeSH term(s)	Animals ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Granulocyte Colony-Stimulating Factor/antagonists & inhibitors ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocytes/cytology ; Granulocytes/drug effects ; Granulocytes/physiology ; Interleukin-3/pharmacology ; Interleukin-6/pharmacology ; MAP Kinase Signaling System/physiology ; Mice ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/physiology
Chemical Substances	Interleukin-3 ; Interleukin-6 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2005-11
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2005.05.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1321: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.

Rubinstein, Jeremy D / Elagib, Kamaleldin E / Goldfarb, Adam N

The Journal of biological chemistry

2012 Volume 287, Issue 23, Page(s) 19207–19215

Abstract: Signaling via the intracellular second messenger cyclic AMP (cAMP) has long been implicated in the repression of megakaryocytic differentiation. However, the mechanisms by which cAMP signaling impairs megakaryopoiesis have never been elucidated. In a ... ...

Abstract	Signaling via the intracellular second messenger cyclic AMP (cAMP) has long been implicated in the repression of megakaryocytic differentiation. However, the mechanisms by which cAMP signaling impairs megakaryopoiesis have never been elucidated. In a human CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocytic differentiation in a protein kinase A-dependent manner. Using this system to screen for downstream effectors, we identified the transcription factor E2A as a key target in a novel repressive signaling pathway. Specifically, forskolin acting through protein kinase A-induced E2A down-regulation and enforced expression of E2A overrode the inhibitory effects of forskolin on megakaryopoiesis. The dependence of megakaryopoiesis on critical thresholds of E2A expression was confirmed in vivo in haploinsufficient mice and ex vivo using shRNA knockdown in human progenitors. Using a variety of approaches, we further identified p21 (encoded by CDKN1A) as a functionally important megakaryopoietic regulator residing downstream of E2A. These results thus implicate the E2A-CDKN1A transcriptional axis in the control of megakaryopoiesis and reveal the lineage-selective inhibition of this axis as a likely mechanistic basis for the inhibitory effects of cAMP signaling.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation/physiology ; Cyclic AMP/genetics ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; HEK293 Cells ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/metabolism ; Mice ; Mice, Mutant Strains ; Second Messenger Systems/physiology ; Thrombopoiesis/physiology ; Transcription, Genetic/physiology
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; CDKN1A protein, human ; Cdkn1a protein, mouse ; Cyclin-Dependent Kinase Inhibitor p21 ; TCF3 protein, human ; Tcf3 protein, mouse ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
Language	English
Publishing date	2012-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M112.366476
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1.

Delehanty, Lorrie L / Bullock, Grant C / Goldfarb, Adam N

Blood

2012 Volume 120, Issue 20, Page(s) 4219–4228

Abstract: In red cell development, the differentiation program directed by the transcriptional regulator GATA1 requires signaling by the cytokine erythropoietin, but the mechanistic basis for this signaling requirement has remained unknown. Here we show that ... ...

Abstract	In red cell development, the differentiation program directed by the transcriptional regulator GATA1 requires signaling by the cytokine erythropoietin, but the mechanistic basis for this signaling requirement has remained unknown. Here we show that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation. Mice deficient for HDAC5 show resistance to anemic challenge and altered marrow responsiveness to erythropoietin injections. In ex vivo studies, HDAC5(-/-) progenitors display enhanced entry into and passage through the erythroid lineage, as well as evidence of erythropoietin-independent differentiation. These results reveal a molecular pathway that contributes to cytokine regulation of hematopoietic differentiation and offer a potential mechanism for fine tuning of lineage-restricted transcription factors by lineage-specific cytokines.
MeSH term(s)	Acetylation ; Anemia/enzymology ; Anemia/genetics ; Anemia/pathology ; Animals ; Carbazoles/pharmacology ; Cell Lineage ; Cytokines/physiology ; Enzyme Activation ; Erythroid Precursor Cells/cytology ; Erythroid Precursor Cells/enzymology ; Erythropoiesis/drug effects ; Erythropoiesis/physiology ; Erythropoietin/pharmacology ; Erythropoietin/therapeutic use ; GATA1 Transcription Factor/physiology ; Histone Deacetylases/physiology ; Humans ; Indoles/pharmacology ; Maleimides/pharmacology ; Mice ; Mice, Inbred C57BL ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/physiology ; Protein Kinase Inhibitors/pharmacology ; Protein Processing, Post-Translational ; RNA Interference ; RNA, Small Interfering/pharmacology ; Signal Transduction
Chemical Substances	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide ; Carbazoles ; Cytokines ; GATA1 Transcription Factor ; Gata1 protein, mouse ; Indoles ; Maleimides ; Protein Kinase Inhibitors ; RNA, Small Interfering ; Erythropoietin (11096-26-7) ; Go 6976 (136194-77-9) ; protein kinase C nu (EC 2.7.1.-) ; Protein Kinase C (EC 2.7.11.13) ; Hdac5 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2012-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2011-10-387050
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Regulation of RUNX1 transcriptional function by GATA-1.

Elagib, Kamaleldin E / Goldfarb, Adam N

Critical reviews in eukaryotic gene expression

2007 Volume 17, Issue 4, Page(s) 271–280

Abstract: Runt-related transcription factor 1 (RUNX1) and GATA-1 are both transcription factors known to play essential roles in hematopoiesis. Genetic alterations of each are associated with abnormal platelet development, as well as predisposition to leukemia. In ...

Abstract	Runt-related transcription factor 1 (RUNX1) and GATA-1 are both transcription factors known to play essential roles in hematopoiesis. Genetic alterations of each are associated with abnormal platelet development, as well as predisposition to leukemia. In addition, in vitro and animal studies indicate that both factors are involved in megakaryopoiesis. We and others have previously shown that RUNX1 and GATA-1 physically interact and cooperate in the activation of megakaryocytic promoters such as alpha IIb integrin and glycoprotein Ibalpha. Moreover, transcriptional cooperation of RUNX1 with GATA-1 is conserved back to Drosophila in which RUNX1 and GATA-1 homologs cooperate in crystal cell development. In this article, we will review the molecular and functional significance of the transcriptional cross talk between RUNX1 and GATA-1. In particular, we will elaborate on recent data which suggest that GATA-1 targets RUNX1 for modification, in particular phosphorylation by cyclin-dependent kinases. Furthermore, targeting of RUNX1 by GATA-1 for phosphorylation may convert RUNX1 from a repressor to an activator. This is a potential mechanism of transcriptional cooperation and may be an essential step in megakaryocytic differentiation.
MeSH term(s)	Animals ; Core Binding Factor Alpha 2 Subunit/genetics ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/physiology ; Gene Expression Regulation/physiology ; Humans ; Megakaryocytes/cytology ; Mice ; Mutation ; Phosphorylation ; Transcription, Genetic/physiology
Chemical Substances	Core Binding Factor Alpha 2 Subunit ; GATA1 Transcription Factor ; Gata1 protein, mouse ; Runx1 protein, mouse
Language	English
Publishing date	2007-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1071345-1
ISSN	1045-4403
ISSN	1045-4403
DOI	10.1615/critreveukargeneexpr.v17.i4.20
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3226: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito