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Article: Difference Between COVID-19 Alpha Variant B.1.1.7 and the Original Virus in Gastrointestinal Symptoms and Mortality: Does a Negative Correlation Exist?

Niv, Yaron / Kuniavsky, Michael / Bronshtein, Olga / Goldschmidt, Nethanel / Hanhart, Shuli / Konson, Alexander / Mahalla, Hannah

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 7, Page(s) 453–455

Abstract: Background: Up to half the patients diagnosed with acute coronavirus disease 2019 (COVID-19) presented with gastrointestinal symptoms. Gastric mucosal cells, enterocytes, and colonocytes express the viral entry receptor angiotensin-converting enzyme 2 ( ... ...

Abstract	Background: Up to half the patients diagnosed with acute coronavirus disease 2019 (COVID-19) presented with gastrointestinal symptoms. Gastric mucosal cells, enterocytes, and colonocytes express the viral entry receptor angiotensin-converting enzyme 2 (ACE2) and coreceptor transmembrane protease serine 2 (TMPRSS2) and are prone to infection. Direct infection of gastrointestinal epithelial cells has been demonstrated. COVID-19 disease was first diagnosed in Israel at the end of February 2020 with 842,536 confirmed cases and 6428 deaths by the end of June 2021. In our multicenter, retrospective cohort study, we looked for gastrointestinal signs and symptoms in two periods and correlated them with mortality. Period 1 included the first and second waves and the original virus. Period 2 represented the third wave and the alpha variant. Objectives: To reveal gastrointestinal signs and symptoms in two periods and correlate them with mortality. Methods: From 22,302 patients hospitalized in general medical centers, we randomly selected 3582 from Period 1 and 1106 from Period 2. The study was performed before vaccinations were available. Results: Gastrointestinal signs and symptoms, diarrhea, vomiting, abdominal pain, and taste/smell loss were significantly more prevalent during Period 1. Thirty-day mortality and in-hospital mortality were significantly higher in Period 2 than in Period 1, 25.20% vs. 13.68%, and 21.17% vs. 12.87%, respectively (P < 0.001). Conclusions: Thirty-day mortality and in-hospital mortality rates were 1.84 and 1.64 times higher from 6 November 2020 to 15 January 2021, the alpha variant, and in negative correlation with gastrointestinal symptoms.
MeSH term(s)	Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Retrospective Studies ; Gastrointestinal Diseases/diagnosis
Language	English
Publishing date	2023-07-17
Publishing country	Israel
Document type	Multicenter Study ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article ; Online: Pregnancy-associated ruptured splenic arteriovenous malformation: A rare but fatal complication in hereditary hemorrhagic telangiectasia.

Kabiri, Doron / Gavra, Hadar / Keidar Haran, Tal / Goldschmidt, Neta / Elazary, Ram / Mei-Zahav, Meir

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 283, Page(s) 158–159

MeSH term(s)	Female ; Pregnancy ; Humans ; Telangiectasia, Hereditary Hemorrhagic/complications ; Arteriovenous Malformations/complications ; Arteriovenous Malformations/diagnostic imaging
Language	English
Publishing date	2023-02-11
Publishing country	Ireland
Document type	Letter
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.02.004
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Article: Gibt es eine ordoliberale Entwicklungsidee?

Goldschmidt, Nils

Geschichte der Entwicklungstheorien , p. 181-200

Walter Euckens Analyse des gesellschaftlichen und wirtschaftlichen Wandels

2016 , Page(s) 181–200

Author's details	von Nils Goldschmidt, Siegen
Keywords	Entwicklungstheorie ; Sozialer Wandel ; Ordnungsökonomik
Language	German
Publisher	Duncker & Humblot
Publishing place	Berlin
Document type	Article
ISBN	3-428-14988-2 ; 978-3-428-14988-9
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Article ; Online: Early lymphocyte collection for anti-CD19 CART production improves T-cell fitness in patients with relapsed/refractory diffuse large B-cell lymphoma.

Dubnikov Sharon, T / Assayag, M / Avni, B / Kfir-Erenfeld, S / Lebel, E / Gatt, M E / Goldschmidt, N / Stepensky, P / Asherie, N / Grisariu, S

British journal of haematology

2023 Volume 202, Issue 1, Page(s) 74–85

Abstract: Background: Chimeric antigen receptor (CAR) T cells targeted to the CD19 B-cell antigen form an approved treatment for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). However, since this therapy is administered after ... ...

Abstract	Background: Chimeric antigen receptor (CAR) T cells targeted to the CD19 B-cell antigen form an approved treatment for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). However, since this therapy is administered after multiple lines of treatment and exposure to lymphotoxic agents, there is an urgent need to optimize this modality of treatment. Methods: To circumvent the difficulties of harvesting adequate and optimal T cells from DLBCL patients and improve CART therapy, we suggest an earlier lymphopheresis (i.e. at first relapse, before salvage treatment). We conducted a prospective study and evaluated the potential benefit of an earlier lymphopheresis (early group, n = 22) on the clinical outcome of CD19-CART infused DLBCL patients, in comparison with standard lymphopheresis (i.e. at second relapse and beyond; standard group, n = 23). Results: An increased percentage of naïve T cells and increased in vitro T-cell functionality were observed in the early group. Additionally, these cells exhibit a lower exhaustion profile than T cells collected in the standard group. Conclusion: While improved T-cell phenotype and function in the lymphopheresis product did not translate into significantly improved clinical outcomes, a trend towards better overall survival (OS) and progression-free survival (PFS) was observed. Early lymphopheresis maximizes the potential of salvage therapies, without compromising CAR T-cell quality.
MeSH term(s)	Humans ; Antigens, CD19 ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Non-Hodgkin/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Prospective Studies ; Receptors, Antigen, T-Cell ; T-Lymphocytes
Chemical Substances	Antigens, CD19 ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18816
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Article: Performing Duplex within 72 Hours of Transient Ischemic Attack May Decrease Mortality, the Israeli National Program for Quality Indicators experience.

Niv, Yaron / Kuniavsky, Michael / Bronshtein, Olga / Goldschmidt, Nethanel / Hanhart, Shuli / Konson, Alexander / Mahalla, Hannah

The Israel Medical Association journal : IMAJ

2022 Volume 23, Issue 6, Page(s) 369–372

Abstract: Background: With diagnostic imaging, such as a duplex of the carotid arteries, finding of stenosis and atherosclerotic plaque and consequent end arterectomy may be important for decreasing the danger of developing cerebrovascular accident after ... ...

Abstract	Background: With diagnostic imaging, such as a duplex of the carotid arteries, finding of stenosis and atherosclerotic plaque and consequent end arterectomy may be important for decreasing the danger of developing cerebrovascular accident after transient ischemic attack (TIA). Objectives: To measure performance rates of duplex of carotid arteries within 72 hours of TIA diagnosis. Methods: The denominator included all patients who were admitted to emergency departments because of TIA, and the numerator included those who underwent duplex within 72 hours of admission. Inclusion criteria included all patients older than 18 years who were admitted because of TIA according to the ICD9 codes. Results: Measuring this indicator started in 2015 with 5504 patients and a 58% success rate. The figures for the years 2016, 2017, and 2018 were 5309, 5447, and 5278 patients with success rates of 73%, 79%, and 83%, respectively. Six of 26 hospitals (23.0%) reached the target of 80% in 2018. From 2015 to 2018 a total of 21,538 patients were admitted to emergency departments in Israel and diagnosed with TIA. Of these, 15,722 (72.9%) underwent duplex within 72 hours. The mortality rate within 30 days from diagnosis was 0.81% in patients who performed duplex within 72 hours of diagnosis and 2.37% in patients who did not, odds ratio 2.676, 95% confidence interval 2.051-3.492, P < 0.0001. These results indicate a statistically significant decrease of 65.82. Conclusions: A significant decrease in mortality was noted in patients with a new diagnosis of TIA who underwent duplex within 72 hours of diagnosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Carotid Arteries/diagnostic imaging ; Carotid Stenosis/diagnostic imaging ; Female ; Humans ; Ischemic Attack, Transient/complications ; Ischemic Attack, Transient/mortality ; Israel ; Male ; Middle Aged ; Plaque, Atherosclerotic/diagnostic imaging ; Quality Indicators, Health Care ; Stroke/etiology ; Stroke/prevention & control ; Time Factors ; Ultrasonography, Doppler, Duplex/methods
Language	English
Publishing date	2022-02-08
Publishing country	Israel
Document type	Journal Article ; Multicenter Study
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Die Zukunft der Ordnungspolitik in der Sozialen Marktwirtschaft

Goldschmidt, Nils

Zeitschrift für Wirtschaftspolitik Vol. 63, No. 1 , p. 3-14

2014 Volume 63, Issue 1, Page(s) 3–14

Author's details	Nils Goldschmidt
Language	German
Publisher	Lucius & Lucius
Publishing place	Stuttgart
Document type	Article
ZDB-ID	865276-4
ISSN	0721-3808
Database	ECONomics Information System

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Article ; Online: Prior exposure to chemotherapy does not reduce the in vitro maturation potential of oocytes obtained from ovarian cortex in cancer patients.

Karavani, Gilad / Vedder, Koral / Gutman-Ido, Einat / Gruda Sussman, Raizl / Goldschmidt, Neta / Mordechai-Daniel, Talya / Ben-Meir, Assaf / Imbar, Tal

Human reproduction (Oxford, England)

2023 Volume 38, Issue 9, Page(s) 1705–1713

Abstract: Study question: Does chemotherapy exposure affect IVM potential of immature oocytes retrieved from the ovarian cortex following ovarian tissue cryopreservation (OTC) for fertility preservation?: Summary answer: The IVM potential of oocyte retrieved ... ...

Abstract	Study question: Does chemotherapy exposure affect IVM potential of immature oocytes retrieved from the ovarian cortex following ovarian tissue cryopreservation (OTC) for fertility preservation? Summary answer: The IVM potential of oocyte retrieved from ovarian cortex following OTC is not affected by prior exposure to chemotherapy but primarily dependent on patient's age, while successful retrieval of immature oocytes from the ovarian tissue is negatively affected by chemotherapy and its timing. What is known already: The potential and feasibility of IVM in premenarche patients was previously demonstrated, in smaller studies. The scarce data that exist on the IVM potential of oocytes retrieved during OTC following chemotherapy support the feasibility of this process, however, this was not previously shown in the premenarche cancer patients population or in larger cohorts. Study design, size, duration: A retrospective cohort study evaluating 229 cancer patients aged 1-39 years with attempted retrieval of oocytes from the ovarian tissue and the medium following OTC in a university affiliated fertility preservation unit between 2002 and 2021. Participants/materials, setting, methods: A total of 172 chemotherapy naïve and 57 chemotherapy exposed patients aged 1-39 years underwent OTC in university affiliated tertiary infertility and IVF center. OTC and IVM outcomes were compared between the chemotherapy naïve and exposed groups. The main outcome measure was mean IVM rate per patient in the chemotherapy naïve and exposed groups, with subgroup analysis of a 1:1 chemotherapy exposed group matched for age at OTC and type of malignancy. We additionally analyzed premenarche and postmenarche patients' outcomes separately and investigated the effect of time from chemotherapy to IVM, malignancy type and chemotherapy regimen on oocyte number and IVM outcomes in the chemotherapy exposed group. Main results and the role of chance: While the number of retrieved oocytes and percentage of patients with at least one oocyte retrieved was higher in the chemotherapy naïve group (8.7 ± 7.9 versus 4.9 ± 5.6 oocytes and 87.2% versus 73.7%, P < 0.001 and P = 0.016, respectively), IVM rate and number of mature oocytes were comparable between the groups (29.0 ± 25.0% versus 28. 9 ± 29.2% and 2.8 ± 3.1 versus 2.2 ± 2.8, P = 0.979 and P = 0.203, respectively). Similar findings were shown in subgroup analyses for premenarche and postmenarche groups. The only parameter found to be independently associated with IVM rate in a multivariable model was menarche status (F = 8.91, P = 0.004). Logistic regression models similarly showed that past chemotherapy exposure is negatively associated with successful retrieval of oocytes while older age and menarche are predictive of successful IVM. An age and the type of malignancy matched (1:1) chemotherapy naïve and exposed groups were created (25 patients in each group). This comparison demonstrated similar IVM rate (35.4 ± 30.1% versus 31.0 ± 25.2%, P = 0.533) and number of matured oocytes (2.7 ± 3.0. versus 3.0 ± 3.9 oocytes, P = 0.772). Type of malignancy and chemotherapy regimen including alkylating agents were not associated with IVM rate. Limitations, reasons for caution: This study's inherited retrospective design and the long study period carries the possible technological advancement and differences. The chemotherapy exposed group was relatively small and included different age groups. We could only evaluate the potential of the oocytes to reach metaphase II in vitro but not their fertilization potential or clinical outcomes. Wider implications of the findings: IVM is feasible even after chemotherapy broadening the fertility preservation options of cancer patients. The use of IVM for fertility preservation, even after exposure to chemotherapy, should be further studied for optimal postchemotherapy timing safety and for the in vitro matured oocytes potential for fertilization. Study funding/competing interest(s): No funding was received for this study by any of the authors. The authors report that no competing interests. Trial registration number: N/A.
MeSH term(s)	Female ; Humans ; Retrospective Studies ; In Vitro Oocyte Maturation Techniques ; Oocytes ; Ovary ; Neoplasms/complications
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/dead142
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Article ; Online: Refractory pure red cell aplasia associated with chronic lymphocytic leukemia successfully treated with ibrutinib.

Goldschmidt, Neta / Rund, Deborah

Leukemia & lymphoma

2016 Volume 58, Issue 2, Page(s) 498–500

MeSH term(s)	Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biomarkers ; Biopsy ; Blood Cell Count ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/adverse effects ; Pyrazoles/therapeutic use ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use ; Red-Cell Aplasia, Pure/diagnosis ; Red-Cell Aplasia, Pure/etiology ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Biomarkers ; Protein Kinase Inhibitors ; Pyrazoles ; Pyrimidines ; ibrutinib (1X70OSD4VX)
Language	English
Publishing date	2016-10-18
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2016.1182163
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Article ; Online: Dose-adjusted EPOCH-R is not superior to sequential R-CHOP/R-ICE as a frontline treatment for newly diagnosed primary mediastinal B-cell lymphoma: Results of a bi-center retrospective study.

Morgenstern, Yael / Aumann, Shlomzion / Goldschmidt, Neta / Gatt, Moshe E / Nachmias, Boaz / Horowitz, Netanel A

Cancer medicine

2021 Volume 10, Issue 24, Page(s) 8866–8875

Abstract: Purpose: Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). Despite its aggressive course, PMBCL is considered curable. While in recent years dose-adjusted (DA) EPOCH-R (rituximab, etoposide, ... ...

Abstract	Purpose: Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). Despite its aggressive course, PMBCL is considered curable. While in recent years dose-adjusted (DA) EPOCH-R (rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) has become widely endorsed as first-line therapy for newly-diagnosed PMBCL, the optimal treatment for this disease and the role of radiotherapy (RT) remains unclear. DA-EPOCH-R provides good clinical outcomes, albeit is associated with short- and long-term toxicity. To address this issue, the current retrospective bi-icenter analysis compared efficacy and toxicity of DA-EPOCH-R and a less toxic R-CHOP/R-ICE regimen used for the treatment of newly-diagnosed PMBCL. Patients and methods: The study included all patients with a histologically confirmed PMBCL diagnosis treated with DA-EPOCH-R or R-CHOP/R-ICE between 01/2013-12/2020 at two tertiary medical centers. Patient demographic and clinical data were derived from institutional electronic medical records. The analysis included 56 patients: 31 received DA-EPOCH-R and 25 - R-CHOP/R-ICE. Results: At a median follow-up of 1.9 years (IQR 3.1 years), similar progression-free survival (2.1 versus 2.4 years; p = 0.7667), overall survival (2.5 versus 2.7 years; p = 0.8047) and complete response (80%) were observed in both groups. However, DA-EPOCH-R was associated with significantly longer hospitalization required for its administration (p < 0.001) and a trend for higher frequency of infections, stomatitis, thrombotic complications and febrile neutropenia-related hospitalizations. Conclusion: DA-EPOCH-R and R-CHOP/R-ICE provide similarly encouraging outcomes in newly-diagnosed PMBCL patients. R-CHOP/R-ICE is associated with lower toxicity and significantly reduced hospitalization. Our findings suggest that this regimen may be considered as an alternative to DA-EPOCH-R in this patient population.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Etoposide/pharmacology ; Etoposide/therapeutic use ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Male ; Mediastinal Neoplasms/drug therapy ; Mediastinal Neoplasms/mortality ; Prednisone/pharmacology ; Prednisone/therapeutic use ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Vincristine/pharmacology ; Vincristine/therapeutic use
Chemical Substances	Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.4387
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Article ; Online: Quality Indicators for Prevention of Infection in the Surgical Site: The Israeli National Program for Quality Indicators Experience.

Niv, Yaron / Kuniavsky, Michael / Bronshtein, Olga / Goldschmidt, Nethanel / Hanhart, Shuli / Levine, David / Mahalla, Hannah

Quality management in health care

2021 Volume 30, Issue 2, Page(s) 81–86

Abstract: Background and objectives: The Israeli National Program for Quality Indicators (INPQ) sets as its primary goal to promote high-quality health care within selected core areas in the Israeli health system. Surgical site infection is one of the most common ...

Abstract	Background and objectives: The Israeli National Program for Quality Indicators (INPQ) sets as its primary goal to promote high-quality health care within selected core areas in the Israeli health system. Surgical site infection is one of the most common types of acquired infections. The INPQ supports 3 distinct indicators concerning suitable antibiotic treatment in colorectal surgery, cesarean sections, and surgery for femoral neck fractures. Methods: We measured the number of patients who received prophylactic antibiotics, beginning an hour before the first cut and stopping after 24 hours in 1 of the 3 operations, according to the International Classification of Diseases, Ninth Revision (ICD-9) codes. Goals for success have been established annually according to the results of the previous year. Data computed for each operation included socioeconomic status, dates of hospitalization and release, date of death, date of birth, gender, date of operation, time of beginning and end of the operation, and time of beginning and end of anesthesia. Results: Within 3 to 5 years, we achieved a significant increase in appropriate prophylactic antibiotic use from 78% to 85%, 78% to 95%, and 66% to 88% for colorectal surgery (n = 9404), cesarean sections (n = 141 362), and femoral joint operations (n = 30 728), respectively. The mortality rate was lower, 1.85% versus 0.55% in patients who received proper antibiotic therapy (odds ratio [OR] = 3.141; 95% confidence interval [CI], 1.829-5.394, P < .0001), 0.031% versus 0.006% (OR = 6.741; 95% CI, 1.879-21.187; P = .003), and 5.59% versus 4.51% (OR = 1.253; 95% CI, 1.091-1.439; P = .001), respectively. Conclusion: Prophylactic antibiotic treatment is strongly recommended by medical guidelines. The experience of the INPQ supports this approach. We demonstrate a significant lower mortality rate in patients who have been properly treated.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Female ; Hospitalization ; Humans ; Pregnancy ; Quality Indicators, Health Care ; Surgical Wound Infection/drug therapy ; Surgical Wound Infection/prevention & control
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1162319-6
ISSN	1550-5154 ; 1063-8628
ISSN (online)	1550-5154
ISSN	1063-8628
DOI	10.1097/QMH.0000000000000312
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