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Article ; Online: Epidemiology Evidence for Health Effects of 150 per- and Polyfluoroalkyl Substances: A Systematic Evidence Map.

Radke, Elizabeth G / Wright, J Michael / Christensen, Krista / Lin, Cynthia J / Goldstone, Alexandra E / Lemeris, Courtney / Thayer, Kristina A

Environmental health perspectives

2022 Volume 130, Issue 9, Page(s) 96003

Abstract: Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large class of chemicals with widespread use and persistence in the environment and in humans; however, most of the epidemiology research has focused on a small subset.: Objectives: ... ...

Abstract	Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large class of chemicals with widespread use and persistence in the environment and in humans; however, most of the epidemiology research has focused on a small subset. Objectives: The aim of this systematic evidence map (SEM) is to summarize the epidemiology evidence on approximately 150 lesser studied PFAS prioritized by the EPA for tiered toxicity testing, facilitating interpretation of those results as well as identification of priorities for risk assessment and data gaps for future research. Methods: The Populations, Exposure, Comparators, and Outcomes (PECO) criteria were intentionally broad to identify studies of any health effects in humans with information on associations with exposure to the identified PFAS. Systematic review methods were used to search for literature that was screened using machine-learning software and manual review. Studies meeting the PECO criteria underwent quantitative data extraction and evaluation for risk of bias and sensitivity using the Integrated Risk Information System approach. Results: 193 epidemiology studies were identified, which included information on 15 of the PFAS of interest. The most commonly studied health effect categories were metabolic ( Discussion: Most of the PFAS in this SEM have little to no epidemiology data available to inform evaluation of potential health effects. Although exposure to the 15 PFAS that had data was fairly low in most studies, these less-studied PFAS may be used as replacements for "legacy" PFAS, leading to potentially greater exposure. It is impractical to generate epidemiology evidence to fill the existing gaps for all potentially relevant PFAS. This SEM highlights some of the important research gaps that currently exist. https://doi.org/10.1289/EHP11185.
MeSH term(s)	Female ; Fluorocarbons/chemistry ; Fluorocarbons/toxicity ; Humans ; Male ; Reproduction
Chemical Substances	Fluorocarbons
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP11185
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Article ; Online: Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY-BPA.

Howdeshell, Kembra L / Beverly, Brandiese E J / Blain, Robyn B / Goldstone, Alexandra E / Hartman, Pamela A / Lemeris, Courtney R / Newbold, Retha R / Rooney, Andrew A / Bucher, John R

Birth defects research

2023 Volume 115, Issue 15, Page(s) 1345–1397

Abstract: Background: The Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA) was a collaborative research effort to better link academic research with governmental guideline studies. This review explores the secondary goal ... ...

Abstract	Background: The Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA) was a collaborative research effort to better link academic research with governmental guideline studies. This review explores the secondary goal of CLARITY-BPA: to identify endpoints or technologies from CLARITY-BPA and prior/concurrent literature from these laboratories that may enhance the capacity of rodent toxicity studies to detect endocrine disrupting chemicals (EDCs). Methods: A systematic literature search was conducted with search terms for BPA and the CLARITY-BPA participants. Relevant studies employed a laboratory rodent model and reported results on 1 of the 10 organs/organ systems evaluated in CLARITY-BPA (brain and behavior, cardiac, immune, mammary gland, ovary, penile function, prostate gland and urethra, testis and epididymis, thyroid hormone and metabolism, and uterus). Study design and findings were summarized, and a risk-of-bias assessment was conducted. Results: Several endpoints and methods were identified as potentially helpful to detect effects of EDCs. For example, molecular and quantitative morphological approaches were sensitive in detecting alterations in early postnatal development of the brain, ovary, and mammary glands. Hormone challenge studies mimicking human aging reported increased susceptibility of the prostate to disease following developmental BPA exposure. Statistical analyses for nonmonotonic dose responses, and computational approaches assessing multiple treatment-related outcomes concurrently in linked hormone-sensitive organ systems, reported effects at low BPA doses. Conclusions: This review provided an opportunity to evaluate the unique insights provided by nontraditional assessments in CLARITY-BPA to identify technologies and endpoints to enhance detection of EDCs in future studies.
MeSH term(s)	Male ; Female ; Humans ; Endocrine Disruptors/toxicity ; Organizations ; Benzhydryl Compounds/toxicity ; Phenols/toxicity
Chemical Substances	Endocrine Disruptors ; bisphenol A (MLT3645I99) ; Benzhydryl Compounds ; Phenols
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2104792-3
ISSN	2472-1727
ISSN (online)	2472-1727
DOI	10.1002/bdr2.2238
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Article ; Online: Evaluating health risks associated with exposure to ambient surface waters during recreational activities: A systematic review and meta-analysis.

Russo, Gary S / Eftim, Sorina E / Goldstone, Alexandra E / Dufour, Alfred P / Nappier, Sharon P / Wade, Timothy J

Water research

2020 Volume 176, Page(s) 115729

Abstract: Recreational water quality guidelines protect the public from health risks associated with water recreation by helping to prevent unacceptable concentrations of pathogenic organisms in ambient water. However, illness risk is associated with both the ... ...

Abstract	Recreational water quality guidelines protect the public from health risks associated with water recreation by helping to prevent unacceptable concentrations of pathogenic organisms in ambient water. However, illness risk is associated with both the concentration of pathogens in the water and the degree of contact with those pathogens. Different recreational activities can result in different levels of contact with ambient water containing water-borne pathogens. We conducted a systematic literature review and meta-analysis to evaluate risks of illness associated with different recreational activities and different levels of contact to ambient surface waters. We screened 8,618 potentially relevant studies for quantitative measures of risk using inclusion/exclusion criteria established in advance. We categorized recreational activities as swimming, sports-related contact, minimal contact, and sand contact. We combined relative risks using a random effects meta-analysis for adverse health outcome categories representing gastrointestinal illness, respiratory illness, skin, eye, ear, nose, throat, and cold/flu illness. We identified 92 studies meeting our inclusion criteria. Pooled risk estimates indicate significant elevation of gastrointestinal illness with the recreational activity categories swimming (2.19, 95% CI: 1.82, 2.63) and sports-related contact (2.69, 95% CI: 1.04, 6.92), and nonsignificant elevation of gastrointestinal illness with minimal contact (1.27, 95% CI: 0.74, 2.16). We also found a significant elevation of respiratory illness with swimming (1.78, 95% CI: 1.38, 2.29) and sports-related contact (1.49, 95% CI: 1.00, 2.24), and no elevation of respiratory illness with minimal contact (0.90, 95% CI: 0.71, 1.14). This study suggests that exposures associated with different types of recreational activities are important characteristics of the exposure pathway when assessing illness risk associated with recreation in ambient surface waters.
MeSH term(s)	Recreation ; Risk Assessment ; Swimming ; Swimming Pools ; Water Microbiology ; Water Quality
Language	English
Publishing date	2020-03-19
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2020.115729
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Article: Urinary Concentrations of Phthalates in Couples Planning Pregnancy and Its Association with 8-Hydroxy-2′-deoxyguanosine, a Biomarker of Oxidative Stress: Longitudinal Investigation of Fertility and the Environment Study

Guo, Ying / Weck, Jennifer / Sundaram, Rajeswari / Goldstone, AlexandraE / Buck Louis, Germaine / Kannan, Kurunthachalam

Environmental Science & Technology. 2014 Aug. 19, v. 48, no. 16

2014

Abstract: Oxidative stress has been recognized as one of the most important contributors to infertility in both males and females. Exposure to many environmental chemicals, such as phthalates, has been shown to induce oxidative stress. In a longitudinal study ... ...

Abstract	Oxidative stress has been recognized as one of the most important contributors to infertility in both males and females. Exposure to many environmental chemicals, such as phthalates, has been shown to induce oxidative stress. In a longitudinal study designed to assess exposure to environmental chemicals and fecundity in couples who were planning pregnancy, 894 urine samples were collected from 469 couples from Michigan and Texas during 2005–2009. The concentrations of 14 phthalate metabolites and a marker of oxidative stress, 8-hydroxy-2′-deoxyguanosine (8-OHdG), were determined in these samples. Concentrations, profiles, and estimated daily intakes (DIs) of phthalates were positively associated with 8-OHdG. The median concentrations of monomethyl phthalate (mMP), monoethyl phthalate (mEP), mono(3-carboxypropyl) phthalate (mCPP), mono-n-butyl phthalate (mBP), mono(2-isobutyl) phthalate (miBP), monobenzyl phthalate (mBzP), Σ5mEHP (sum of five metabolites of di(2-ethylhexyl) phthalate (DEHP)) and Σ14phthalates (sum of 14 urinary phthalate metabolites) were 0.48, 85.2, 4.50, 7.66, 4.36, 3.80, 54.8, and 249 μg/g creatinine, respectively. The estimated DI values for DEHP in 39 individuals were above the U.S. Environmental Protection Agency’s (EPA) reference dose (RfD) of 20 μg/kg-bw/day. The mean and median concentrations of 8-OHdG were 6.02 and 3.13 μg/g creatinine, respectively, which were significantly higher in females than in males. Statistically significant associations were found between 8-OHdG and urinary concentrations of mEP, and Σ5mEHP for females. Similarly, a significant association was found between 8-OHdG and DIs estimated for select phthalates. Our results suggested that phthalate exposure increases oxidative stress, which can be a mechanism for the diminished fertility observed in couples who were highly exposed to select phthalates.
Keywords	United States Environmental Protection Agency ; biomarkers ; creatinine ; fecundity ; females ; longitudinal studies ; males ; metabolites ; oxidative stress ; phthalates ; planning ; pregnancy ; urine ; Michigan ; Texas
Language	English
Dates of publication	2014-0819
Size	p. 9804-9811.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5851
DOI	10.1021%2Fes5024898
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Urinary concentrations of phthalates in couples planning pregnancy and its association with 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative stress: longitudinal investigation of fertility and the environment study.

Guo, Ying / Weck, Jennifer / Sundaram, Rajeswari / Goldstone, Alexandra E / Louis, Germaine Buck / Kannan, Kurunthachalam

Environmental science & technology

2014 Volume 48, Issue 16, Page(s) 9804–9811

Abstract	Oxidative stress has been recognized as one of the most important contributors to infertility in both males and females. Exposure to many environmental chemicals, such as phthalates, has been shown to induce oxidative stress. In a longitudinal study designed to assess exposure to environmental chemicals and fecundity in couples who were planning pregnancy, 894 urine samples were collected from 469 couples from Michigan and Texas during 2005-2009. The concentrations of 14 phthalate metabolites and a marker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were determined in these samples. Concentrations, profiles, and estimated daily intakes (DIs) of phthalates were positively associated with 8-OHdG. The median concentrations of monomethyl phthalate (mMP), monoethyl phthalate (mEP), mono(3-carboxypropyl) phthalate (mCPP), mono-n-butyl phthalate (mBP), mono(2-isobutyl) phthalate (miBP), monobenzyl phthalate (mBzP), Σ5mEHP (sum of five metabolites of di(2-ethylhexyl) phthalate (DEHP)) and Σ14phthalates (sum of 14 urinary phthalate metabolites) were 0.48, 85.2, 4.50, 7.66, 4.36, 3.80, 54.8, and 249 μg/g creatinine, respectively. The estimated DI values for DEHP in 39 individuals were above the U.S. Environmental Protection Agency's (EPA) reference dose (RfD) of 20 μg/kg-bw/day. The mean and median concentrations of 8-OHdG were 6.02 and 3.13 μg/g creatinine, respectively, which were significantly higher in females than in males. Statistically significant associations were found between 8-OHdG and urinary concentrations of mEP, and Σ5mEHP for females. Similarly, a significant association was found between 8-OHdG and DIs estimated for select phthalates. Our results suggested that phthalate exposure increases oxidative stress, which can be a mechanism for the diminished fertility observed in couples who were highly exposed to select phthalates.
MeSH term(s)	8-Hydroxy-2'-Deoxyguanosine ; Adolescent ; Adult ; Biomarkers/urine ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/urine ; Environment ; Family Characteristics ; Family Planning Services ; Female ; Fertility ; Humans ; Longitudinal Studies ; Male ; Michigan ; Middle Aged ; Oxidative Stress ; Phthalic Acids/urine ; Pregnancy ; Texas ; Young Adult
Chemical Substances	Biomarkers ; Phthalic Acids ; phthalic acid (6O7F7IX66E) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2014-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/es5024898
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Urinary bisphenol A and semen quality, the LIFE Study.

Goldstone, Alexandra E / Chen, Zhen / Perry, Melissa J / Kannan, Kurunthachalam / Louis, Germaine M Buck

Reproductive toxicology (Elmsford, N.Y.)

2014 Volume 51, Page(s) 7–13

Abstract: Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer products, has been negatively associated with sperm quality. This study aimed to estimate the association between BPA and 35 measures of semen quality among ... ...

Abstract	Bisphenol A (BPA), a high-production volume industrial chemical found in several consumer products, has been negatively associated with sperm quality. This study aimed to estimate the association between BPA and 35 measures of semen quality among reproductive aged men recruited from 16 counties in Michigan and Texas, 2005-2009. Of 501 enrolled males, 418 (83.4%) provided a urine sample and at least one semen sample. Linear and logistic regression models assessed the association between urinary BPA levels and individual semen quality endpoints. Generalized estimating equations were used to account for repeated measures of semen quality and adjusted models accounted for 11 a priori covariates. Geometric mean total urinary BPA concentration among participants was 0.55ng/mL (95% CI 0.49-0.63). A negative relation between BPA and DNA fragmentation was the sole significant finding in adjusted linear regression (β=-0.0544, p=0.035) and suggestive of less sperm DNA damage.
MeSH term(s)	Adult ; Benzhydryl Compounds/urine ; DNA Fragmentation ; Environmental Pollutants/urine ; Humans ; Male ; Michigan/epidemiology ; Phenols/urine ; Prospective Studies ; Semen Analysis ; Texas/epidemiology
Chemical Substances	Benzhydryl Compounds ; Environmental Pollutants ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2014-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2014.11.003
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Article ; Online: Evaluation of the risk of bias in non-randomized studies of interventions (ROBINS-I) and the 'target experiment' concept in studies of exposures: Rationale and preliminary instrument development.

Morgan, Rebecca L / Thayer, Kristina A / Santesso, Nancy / Holloway, Alison C / Blain, Robyn / Eftim, Sorina E / Goldstone, Alexandra E / Ross, Pam / Guyatt, Gordon / Schünemann, Holger J

Environment international

2018 Volume 120, Page(s) 382–387

Abstract: Assessing the risk of bias (RoB) of individual studies is a critical part in determining the certainty of a body of evidence from non-randomized studies (NRS) that evaluate potential health effects due to environmental exposures. The recently released ... ...

Abstract	Assessing the risk of bias (RoB) of individual studies is a critical part in determining the certainty of a body of evidence from non-randomized studies (NRS) that evaluate potential health effects due to environmental exposures. The recently released RoB in NRS of Interventions (ROBINS-I) instrument has undergone careful development for health interventions. Using the fundamental design of ROBINS-I, which includes evaluating RoB against an ideal target trial, we explored developing a version of the instrument to evaluate RoB in exposure studies. During three sequential rounds of assessment, two or three raters (evaluators) independently applied ROBINS-I to studies from two systematic reviews and one case-study protocol that evaluated the relationship between environmental exposures and health outcomes. Feedback from raters, methodologists, and topic-specific experts informed important modifications to tailor the instrument to exposure studies. We identified the following areas of distinction for the modified instrument: terminology, formulation of the ideal target randomized experiment, guidance for cross-sectional studies and exposure assessment (both quality of measurement method and concern for potential exposure misclassification), and evaluation of issues related to study sensitivity. Using the target experiment approach significantly impacts the process for how environmental and occupational health studies are considered in the Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-synthesis framework.
MeSH term(s)	Bias ; Cross-Sectional Studies ; Environmental Exposure ; Humans ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2018-08-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2018.08.018
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Article ; Online: A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.

Pelch, Katherine / Wignall, Jessica A / Goldstone, Alexandra E / Ross, Pam K / Blain, Robyn B / Shapiro, Andrew J / Holmgren, Stephanie D / Hsieh, Jui-Hua / Svoboda, Daniel / Auerbach, Scott S / Parham, Fredrick M / Masten, Scott A / Walker, Vickie / Rooney, Andrew / Thayer, Kristina A

Toxicology

2019 Volume 424, Page(s) 152235

Abstract: Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental ... ...

Abstract	Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine or blood, and consumer products. Compared to BPA, relatively little is known about potential toxicity of these compounds. This scoping review aimed to summarize the human, animal, and mechanistic toxicity data for 24 BPA analogues of emerging interest to research and regulatory communities. PubMed was searched from March 1, 2015 to January 5, 2019 and combined with the results obtained from literature searches conducted through March 23, 2015, in The National Toxicology Program's Research Report 4 (NTP RR-04), "Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives". Study details are presented in interactive displays using Tableau Public. In total, 5748 records were screened for inclusion. One hundred sixty seven studies were included from NTP RR-04 and 175 studies were included from the updated literature search through January 2019. In total, there are 22, 117, and 221 human epidemiological, experimental animal, or in vitro studies included. The most frequently studied BPA analogues are bisphenol S (BPS), bisphenol F (4,4-BPF), and bisphenol AF (BPAF). Notable changes in the literature since 2015 include the growing body of human epidemiological studies and in vivo studies conducted in zebrafish. Numerous new endpoints were also evaluated across all three evidence streams including diabetes, obesity, and oxidative stress. However, few studies have addressed endpoints such as neurodevelopmental outcomes or impacts on the developing mammary or prostate glands, which are known to be susceptible to disruption by BPA. Further, there remains a critical need for better exposure information in order to prioritize experimental studies. Moving forward, researchers should also ensure that full dose responses are performed for all main effects in order to support hazard and risk characterization efforts. The evidence gathered here suggests that hazard and risk characterizations should expand beyond BPA in order to consider BPA structural and functional analogues.
MeSH term(s)	Animals ; Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/chemistry ; Endocrine Disruptors/toxicity ; Humans ; Phenols/chemistry ; Phenols/toxicity
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2019-06-12
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	184557-3
ISSN	1879-3185 ; 0300-483X
ISSN (online)	1879-3185
ISSN	0300-483X
DOI	10.1016/j.tox.2019.06.006
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Article: Systematic Evidence Map (SEM) Template: Report Format and Methods Used for the US EPA Integrated Risk Information System (IRIS) Program, Provisional Peer Reviewed Toxicity Value (PPRTV) Program, and Other “Fit for Purpose” Literature-Based Human Health Analyses

Thayer, Kristina A. / Angrish, Michelle / Arzuaga, Xabier / Carlson, Laura M. / Davis, Allen / Dishaw, Laura / Druwe, Ingrid / Gibbons, Catherine / Glenn, Barbara / Jones, Ryan / Phillip Kaiser, J. / Keshava, Channa / Keshava, Nagalakshmi / Kraft, Andrew / Lizarraga, Lucina / Persad, Amanda / Radke, Elizabeth G / Rice, Glenn / Schulz, Brittany /

Environment international. 2022 Aug. 09,

2022

Abstract: Systematic evidence maps (SEMs) are gaining visibility in environmental health for their utility to serve as problem formulation tools and assist in decision-making, especially for priority setting. SEMs are now routinely prepared as part of the ... ...

Abstract	Systematic evidence maps (SEMs) are gaining visibility in environmental health for their utility to serve as problem formulation tools and assist in decision-making, especially for priority setting. SEMs are now routinely prepared as part of the assessment development process for the US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) and Provisional Peer Reviewed Toxicity Value (PPRTV) assessments. SEMs can also be prepared to explore the available literature for an individual chemical or groups of chemicals of emerging interest. This document describes the typical methods used to produce SEMs for the IRIS and PPRTV Programs, as well as “fit for purpose” applications using a variety of examples drawn from existing analyses. It is intended to serve as an example base template that can be adapted as needed for the specific SEM. The presented methods include workflows intended to facilitate rapid production. The Populations, Exposures, Comparators and Outcomes (PECO) criteria are typically kept broad to identify mammalian animal bioassay and epidemiological studies that could be informative for human hazard identification. In addition, a variety of supplemental content is tracked, e.g., studies presenting information on in vitro model systems, non-mammalian model systems, exposure-level-only studies in humans, pharmacokinetic models, and absorption, distribution, metabolism, and excretion (ADME). The availability of New Approach Methods (NAMs) evidence is also tracked (e.g., high throughput, transcriptomic, in silico, etc.). Genotoxicity studies may be considered as PECO relevant or supplemental material, depending on the topic and context of the review. Standard systematic review practices (e.g., two independent reviewers per record) and specialized software applications are used to search and screen the literature and may include the use of machine learning software. Mammalian bioassay and epidemiological studies that meet the PECO criteria after full-text review are briefly summarized using structured web-based extraction forms with respect to study design and health system(s) assessed. Extracted data is available in interactive visual formats and can be downloaded in open access formats. Methods for conducting study evaluation are also presented which is conducted on a case-by-case basis, depending on the usage of the SEM.
Keywords	Internet ; United States Environmental Protection Agency ; absorption ; bioassays ; computer simulation ; computer software ; decision making ; environment ; environmental health ; excretion ; experimental design ; genotoxicity ; hazard identification ; human health ; humans ; information systems ; pharmacokinetics ; risk ; systematic review ; transcriptomics
Language	English
Dates of publication	2022-0809
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107468
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Corrigendum to "Systematic evidence map (SEM) template: Report format and methods used for the US EPA Integrated Risk Information System (IRIS) program, Provisional Peer Reviewed Toxicity Value (PPRTV) program, and other "fit for purpose" literature-based human health analyses" [Environ. Int. 169 (2022) 107468].

Thayer, Kristina A / Angrish, Michelle / Arzuaga, Xabier / Carlson, Laura M / Davis, Allen / Dishaw, Laura / Druwe, Ingrid / Gibbons, Catherine / Glenn, Barbara / Jones, Ryan / Phillip Kaiser, J / Keshava, Channa / Keshava, Nagalakshmi / Kraft, Andrew / Lizarraga, Lucina / Persad, Amanda / Radke, Elizabeth G / Rice, Glenn / Schulz, Brittany /

Environment international

2023 Volume 176, Page(s) 107929

Language	English
Publishing date	2023-04-29
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107929
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