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  1. Article ; Online: Advancing preclinical cancer models to assess clinically relevant outcomes.

    Golebiewska, Anna / Fields, Ryan C

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 230

    Abstract: Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are key in evaluating therapeutics prior clinical trials. In this editorial, we invite contributions for a ... ...

    Abstract Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are key in evaluating therapeutics prior clinical trials. In this editorial, we invite contributions for a BMC Cancer's Collection of articles addressing 'Advances in pre-clinical cancer models' towards relivable outcomes at the preclinical stage.
    MeSH term(s) Humans ; Neoplasms/pathology ; Models, Biological
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10715-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How to move a "fried egg": membrane blebbing in oligodendrogliomas.

    Niclou, Simone P / Golebiewska, Anna

    Neuro-oncology

    2023  Volume 25, Issue 6, Page(s) 1044–1046

    MeSH term(s) Humans ; rho GTP-Binding Proteins ; Oligodendroglioma ; Carcinogenesis ; Cell Transformation, Neoplastic
    Chemical Substances rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noad039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Individual corporate reputation and perception of collective corporate reputation regarding stock market investments.

    Blajer-Gołębiewska, Anna

    PloS one

    2021  Volume 16, Issue 9, Page(s) e0257323

    Abstract: There are two different concepts of corporate reputation grounded in individual and collective perceptions, respectively. The aim of this study was to identify how these two ways of conceiving of corporate reputation affect investors' decisions about ... ...

    Abstract There are two different concepts of corporate reputation grounded in individual and collective perceptions, respectively. The aim of this study was to identify how these two ways of conceiving of corporate reputation affect investors' decisions about whether or not to buy stock in a given company. As this problem tackles individual decision-making processes, we designed and applied an incentivised economic experiment based on vignette studies and focused on individual decisions of single investors. Subjects took part in an online game that imitates stock exchange conditions and that concerns corporate reputation and investing. We found that the individual propensity to invest is not directly based on an investor's perception (rooted in historical share price and other objective metrics) of a firm's reputation but rather on an investor's subjective recognition of collective corporate reputation in the market. This suggests a need to rethink the popular measures of corporate reputation in the context of studies of stock market investor decisions.
    MeSH term(s) Adult ; Choice Behavior ; Decision Making ; Humans ; Investments/statistics & numerical data ; Middle Aged ; Perception ; Risk-Taking ; Surveys and Questionnaires
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0257323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Periodic Solutions of Asymptotically Linear Autonomous Hamiltonian Systems with Resonance.

    Gołȩbiewska, Anna

    Journal of dynamics and differential equations

    2017  Volume 30, Issue 4, Page(s) 1509–1524

    Abstract: In this paper we define the index at infinity of an asymptotically linear autonomous Hamiltonian system. We use this index to prove the existence and bifurcation from infinity of periodic solutions of the system. We apply the degree ... ...

    Abstract In this paper we define the index at infinity of an asymptotically linear autonomous Hamiltonian system. We use this index to prove the existence and bifurcation from infinity of periodic solutions of the system. We apply the degree for
    Language English
    Publishing date 2017-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016858-5
    ISSN 1572-9222 ; 1040-7294
    ISSN (online) 1572-9222
    ISSN 1040-7294
    DOI 10.1007/s10884-017-9608-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Turning strength into weakness: protein degradation and autophagy as therapeutic targets in glioblastoma?

    Niclou, Simone P / Golebiewska, Anna

    Neuro-oncology

    2021  Volume 23, Issue 7, Page(s) 1041–1043

    MeSH term(s) Autophagy ; Brain Neoplasms/drug therapy ; Glioblastoma/drug therapy ; Humans ; Proteolysis
    Language English
    Publishing date 2021-04-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence.

    Oudin, Anais / Moreno-Sanchez, Pilar M / Baus, Virginie / Niclou, Simone P / Golebiewska, Anna

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 3

    Abstract: Background: Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical ... ...

    Abstract Background: Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical resection remains challenging, particularly in the orthotopic site. Here, we report a successful surgical resection of glioblastoma (GBM) in patient-derived orthotopic xenografts (PDOXs).
    Methods: We derived a cohort of 46 GBM PDOX models that faithfully recapitulate human disease in mice. We assessed the detection and quantification of intracranial tumors using magnetic resonance imaging (MRI).To evaluate feasibility of surgical resection in PDOXs, we selected two models representing histopathological features of GBM tumors, including diffuse growth into the mouse brain. Surgical resection in the mouse brains was performed based on MRI-guided coordinates. Survival study followed by MRI and immunohistochemistry-based evaluation of recurrent tumors allowed for assessment of clinically relevant parameters.
    Results: We demonstrate the utility of MRI for the noninvasive assessment of in vivo tumor growth, preoperative programming of resection coordinates and follow-up of tumor recurrence. We report tumor detection by MRI in 90% of GBM PDOX models (36/40), of which 55% (22/40) can be reliably quantified during tumor growth. We show that a surgical resection protocol in mice carrying diffuse primary GBM tumors in the brain leads to clinically relevant outcomes. Similar to neurosurgery in patients, we achieved a near total to complete extent of tumor resection, and mice with resected tumors presented significantly increased survival. The remaining unresected GBM cells that invaded the normal mouse brain prior to surgery regrew tumors with similar histopathological features and tumor microenvironments to the primary tumors.
    Conclusions: Our data positions GBM PDOXs developed in mouse brains as a valuable preclinical model for conducting therapeutic studies that involve surgical tumor resection. The high detectability of tumors by MRI across a substantial number of PDOX models in mice will allow for scalability of our approach toward specific tumor types for efficacy studies in precision medicine-oriented approaches. Additionally, these models hold promise for the development of enhanced image-guided surgery protocols.
    MeSH term(s) Humans ; Animals ; Mice ; Glioblastoma/diagnostic imaging ; Glioblastoma/surgery ; Glioblastoma/pathology ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/surgery ; Heterografts ; Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Tumor Microenvironment
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11774-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma.

    Yabo, Yahaya A / Niclou, Simone P / Golebiewska, Anna

    Neuro-oncology

    2021  Volume 24, Issue 5, Page(s) 669–682

    Abstract: Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and reversibly adapt to dynamic ... ...

    Abstract Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and reversibly adapt to dynamic microenvironmental conditions. Limited genetic evolution at recurrence further suggests that resistance mechanisms also largely operate at the phenotypic level. Here we review recent literature underpinning the role of GBM plasticity in creating gradients of heterogeneous cells including those that carry cancer stem cell (CSC) properties. A historical perspective from the hierarchical to the nonhierarchical concept of CSCs towards the recent appreciation of GBM plasticity is provided. Cellular states interact dynamically with each other and with the surrounding brain to shape a flexible tumor ecosystem, which enables swift adaptation to external pressure including treatment. We present the key components regulating intra-tumoral phenotypic heterogeneity and the equilibrium of phenotypic states, including genetic, epigenetic, and microenvironmental factors. We further discuss plasticity in the context of intrinsic tumor resistance, where a variable balance between preexisting resistant cells and adaptive persisters leads to reversible adaptation upon treatment. Innovative efforts targeting regulators of plasticity and mechanisms of state transitions towards treatment-resistant states are needed to restrict the adaptive capacities of GBM.
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Ecosystem ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Neoplastic Stem Cells/pathology
    Language English
    Publishing date 2021-12-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Resolution of CMV Infection in the Bowel on Vedolizumab Therapy.

    Rawa-Gołębiewska, Anna / Lenarcik, Małgorzata / Zagórowicz, Edyta

    Journal of Crohn's & colitis

    2019  Volume 13, Issue 9, Page(s) 1234–1235

    MeSH term(s) Adolescent ; Antibodies, Monoclonal, Humanized/therapeutic use ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/virology ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/drug therapy ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Rectum/pathology ; Rectum/virology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Gastrointestinal Agents ; vedolizumab (9RV78Q2002)
    Language English
    Publishing date 2019-03-11
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjz033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Book: Mikro- i makroekonomiczne aspekty tworzenia dobrobytu

    Blajer-Gołębiewska, Anna / Czerwonka, Leszek

    2014  

    Author's details pod red. Anny Blajer-Gołębiewskiej i Leszka Czerwonki
    Keywords Europa ; Lebensstandard ; Wohlfahrtsanalyse ; Bildungsniveau ; Einkommensverteilung ; Wirtschaftswachstum ; Wirtschaftsstruktur ; Wirtschaftsordnung ; Polen ; EU-Staaten
    Language Polish
    Size 176, [1] s, il, 24 cm
    Publisher Wydawn. Uniw. Gdańskiego
    Publishing place Gdańsk
    Document type Book
    Note Bibliogr. przy rozdz
    ISBN 8378651789 ; 9788378651789
    Database ECONomics Information System

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  10. Article: Colonoscopy quality: continuous improvement towards perfection.

    Rawa-Golebiewska, Anna / Kaminski, Michal F

    Endoscopy international open

    2018  Volume 6, Issue 11, Page(s) E1310–E1311

    Language English
    Publishing date 2018-11-07
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-0732-5216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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