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  1. Article ; Online: Initial immune response after exposure to

    Aiello, Alessandra / Najafi-Fard, Saeid / Goletti, Delia

    Frontiers in immunology

    2023  Volume 14, Page(s) 1244556

    Abstract: Tuberculosis (TB), caused ... ...

    Abstract Tuberculosis (TB), caused by
    MeSH term(s) Humans ; Mycobacterium tuberculosis ; SARS-CoV-2 ; COVID-19 ; Latent Tuberculosis ; Immunity ; Communicable Diseases
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1244556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Research tests for the diagnosis of tuberculosis infection.

    Alonzi, Tonino / Repele, Federica / Goletti, Delia

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 9, Page(s) 783–795

    Abstract: Introduction: Despite huge efforts, tuberculosis (TB) is still a major public health threat worldwide, it is estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). For controlling TB and reducing Mtb ... ...

    Abstract Introduction: Despite huge efforts, tuberculosis (TB) is still a major public health threat worldwide, it is estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). For controlling TB and reducing Mtb transmission it is fundamental to diagnose TB infection (TBI) as well as the progressors from TBI to disease to identify those requiring preventive therapy. At present, there is no gold standard test for TBI diagnosis although several new methodologies have been attempted.
    Areas covered: This review provides an update on the most recent approaches to develop reliable tests to diagnose TBI and progressors from infection to disease. Experimental tests are based on either the direct identification of Mtb (i.e., Mtb DNA upon host cells isolation; Mtb proteins or peptides) or host response (i.e., levels and quality of specific anti-Mtb antibodies; host blood transcriptome signatures).
    Expert opinion: The experimental tests described are very interesting. However, further investigation and randomized clinical trials are needed to improve the sensitivity and specificity of these new research-based tests. More reliable proofs-of-concept and simplification of technical procedures are necessary to develop new diagnostic tools for identifying TBI patients and those that will progress from infection to TB disease.
    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Tuberculosis/microbiology ; Mycobacterium tuberculosis/genetics ; Sensitivity and Specificity
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2240230
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  3. Article ; Online: Baricitinib Therapy in Covid-19 Pneumonia - An Unmet Need Fulfilled.

    Goletti, Delia / Cantini, Fabrizio

    The New England journal of medicine

    2021  Volume 384, Issue 9, Page(s) 867–869

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adult ; Alanine/analogs & derivatives ; Azetidines ; COVID-19/drug therapy ; Humans ; Purines ; Pyrazoles ; SARS-CoV-2 ; Sulfonamides
    Chemical Substances Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; baricitinib (ISP4442I3Y) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2034982
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  4. Article: The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic.

    Petrone, Linda / Sette, Alessandro / de Vries, Rory D / Goletti, Delia

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe ... ...

    Abstract Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe COVID-19 and contributing to the success of vaccination effort. T-cell responses after vaccination largely mirror those of natural infection in magnitude and functional capacity, but not in breadth, as T-cells induced by vaccination exclusively target the surface spike glycoprotein. T-cell responses offer a long-lived line of defense and, unlike humoral responses, largely retain reactivity against the SARS-CoV-2 variants. Given the increasingly recognized role of T-cell responses in protection against severe COVID-19, the circulation of SARS-CoV-2 variants, and the potential implementation of novel vaccines, it becomes imperative to continuously monitor T-cell responses. In addition to "classical" T-cell assays requiring the isolation of peripheral blood mononuclear cells, simple whole-blood-based interferon-γ release assays have a potential role in routine T-cell response monitoring. These assays could be particularly useful for immunocompromised people and other clinically vulnerable populations, where interactions between cellular and humoral immunity are complex. As we continue to live alongside COVID-19, the importance of considering immunity as a whole, incorporating both humoral and cellular responses, is crucial.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070862
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  5. Article ; Online: Armed conflict and human displacement may lead to an increase in the burden of tuberculosis in Europe.

    Dahl, Victor Naestholt / Tiberi, Simon / Goletti, Delia / Wejse, Christian

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 124 Suppl 1, Page(s) S104–S106

    MeSH term(s) Humans ; Tuberculosis/epidemiology ; Warfare ; Europe/epidemiology ; Armed Conflicts
    Language English
    Publishing date 2022-03-29
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.03.040
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The role of IGRA in the diagnosis of tuberculosis infection, differentiating from active tuberculosis, and decision making for initiating treatment or preventive therapy of tuberculosis infection.

    Goletti, Delia / Delogu, Giovanni / Matteelli, Alberto / Migliori, Giovanni Battista

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 124 Suppl 1, Page(s) S12–S19

    Abstract: Objectives: The World Health Organization estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the ... ...

    Abstract Objectives: The World Health Organization estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to register the infections and treatment completion.
    Design: we reviewed the literature regarding the tests available for TB infection diagnosis, the preventive therapies options and the cascade of care for controlling TB at a public health level.
    Results: current tests for TB infection diagnosis as IFN-γ release assays or tuberculin skin tests are based on the detection of an immune response to Mtb in the absence of clinical disease. The main limit is their low accuracy to detect progressors to disease. New preventive treatments are available with short duration that are associated with better adherence. Options to register TB infections are presented.
    Conclusions: Tests to diagnose TB infection are available but they lack accuracy to identify the progressors from infection to TB disease. Shorter preventive TB therapy are available but need to be implemented worldwide. A TB infection registry is crucial for improving the cascade of care leading to a better TB control.
    Language English
    Publishing date 2022-03-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.02.047
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    Zs.A 4516: Show issues Location:
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  7. Article ; Online: Impact of the COVID-19 pandemic on the real-world diagnostic infrastructure for tuberculosis-An ESGMYC collaborative study.

    Paulowski, Laura / Filip, Roxana / Jankovic Makek, Mateja / Guglielmetti, Lorenzo / Goletti, Delia / van Ingen, Jakko / Kranzer, Katharina / Maurer, Florian P

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0291404

    Abstract: We determined the impact of the COVID-19 pandemic on mycobacterial diagnostic services. 40 laboratories from 22 countries completed an online questionnaire covering the redeployment of the laboratory infrastructure and/or staff for SARS-CoV-2 testing, ... ...

    Abstract We determined the impact of the COVID-19 pandemic on mycobacterial diagnostic services. 40 laboratories from 22 countries completed an online questionnaire covering the redeployment of the laboratory infrastructure and/or staff for SARS-CoV-2 testing, staff shortages and supply chain disruptions. 28 laboratories reported monthly numbers of samples processed for mycobacterial investigations and monthly numbers of M. tuberculosis complex (MTBC) PCRs performed between October 1st 2018 and October 31st 2020. More than half (23/40) of the participating TB laboratories reported having performed COVID-19 diagnostics in the early phase of the pandemic, in part with negative impact on the mycobacterial service activities. All participating laboratories reported shortages of consumables and laboratory equipment due to supply chain issues. Average monthly sample numbers decreased by 24% between January 2020 and October 2020 compared to pre-pandemic averages. At the end of the study period, most participating laboratories had not returned to pre-pandemic average MTBC PCR throughput.
    MeSH term(s) Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; Pandemics ; COVID-19 Testing ; SARS-CoV-2 ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Mycobacterium
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291404
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  8. Article ; Online: Transcriptional biomarkers for predicting development of tuberculosis: progress and clinical considerations.

    Esmail, Hanif / Cobelens, Frank / Goletti, Delia

    The European respiratory journal

    2020  Volume 55, Issue 3

    MeSH term(s) Biomarkers ; Humans ; Mycobacterium tuberculosis/genetics ; Tuberculosis/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01957-2019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  9. Article ; Online: The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group.

    Melkie, Solomon Tibebu / Arias, Lilibeth / Farroni, Chiara / Jankovic Makek, Mateja / Goletti, Delia / Vilaplana, Cristina

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and ...

    Abstract Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. To improve the diagnostic performance of traditional serology, a combination of different
    MeSH term(s) BCG Vaccine ; Humans ; Mycobacterium tuberculosis ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/prevention & control ; Tuberculosis Vaccines ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/prevention & control
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0218-2021
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    Zs.A 3265: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions.

    Carlini, Valentina / Noonan, Douglas M / Abdalalem, Eslam / Goletti, Delia / Sansone, Clementina / Calabrone, Luana / Albini, Adriana

    Frontiers in immunology

    2023  Volume 14, Page(s) 1161067

    Abstract: Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, ... ...

    Abstract Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions. Given the pivotal role of IL-10 in immune modulation, this cytokine could have relevant implications in pathologies characterized by hyperinflammatory state, such as cancer, or infectious diseases as in the case of COVID-19 and Post-COVID-19 syndrome. Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation. Pharmacological strategies aimed to potentiate or restore IL-10 immunomodulatory action may represent novel promising avenues to counteract cytokine storm arising from hyperinflammation and effectively mitigate severe complications. Natural bioactive compounds, derived from terrestrial or marine photosynthetic organisms and able to increase IL-10 expression, could represent a useful prevention strategy to curb inflammation through IL-10 elevation and will be discussed here. However, the multifaceted nature of IL-10 has to be taken into account in the attempts to modulate its levels.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Interleukin-10 ; SARS-CoV-2/metabolism ; Inflammation/drug therapy ; Cytokines/metabolism ; Neoplasms
    Chemical Substances Interleukin-10 (130068-27-8) ; Cytokines
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1161067
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