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  1. Article ; Online: Impact of active surveillance and decolonization strategies for methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit.

    Gollerkeri, Sonia / Oliver, Caroline / Maria, Messina / Green, Daniel A / Wu, Fann / Paul, Anshu A / Hill-Ricciuti, Alexandra / Mathema, Barun / Sahni, Rakesh / Saiman, Lisa

    Journal of perinatology : official journal of the California Perinatal Association

    2024  

    Abstract: Objective: To assess the impact of active surveillance and decolonization strategies on methicillin-resistant Staphylococcus aureus (MRSA) infection rates in a NICU.: Study design: MRSA infection rates were compared before (2014-2016) and during ( ... ...

    Abstract Objective: To assess the impact of active surveillance and decolonization strategies on methicillin-resistant Staphylococcus aureus (MRSA) infection rates in a NICU.
    Study design: MRSA infection rates were compared before (2014-2016) and during (2017-2022) an active surveillance program. Eligible infants were decolonized with chlorohexidine gluconate (CHG) bathing and/or topical mupirocin. Successful decolonization and rates of recolonization were assessed.
    Results: Fifty-two (0.57%) of 9 100 hospitalized infants had invasive MRSA infections from 2014 to 2022; infection rates declined non-significantly. During the 6-year surveillance program, the risk of infection was 16.9-times [CI
    Conclusions: MRSA infection rates did not significantly decline in association with an active surveillance and decolonization program. Alternatives to mupirocin and CHG are needed to facilitate decolonization.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-024-01902-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Healthcare-Associated Respiratory Syncytial Virus in Children's Hospitals.

    Saiman, Lisa / Coffin, Susan E / Kociolek, Larry K / Zerr, Danielle M / Milstone, Aaron M / Aldrich, Margaret L / Vargas, Celibell Y / Zapata, Giovanny / Zalot, Morgan A / Reyna, Megan E / Adler, Amanda / Voskertchian, Annie / Egbert, Emily R / Alba, Luis / Gollerkeri, Sonia / Ruggieri, Madelyn / Finelli, Lyn / Choi, Yoonyoung

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue 5, Page(s) 265–272

    Abstract: Background: Outbreaks of healthcare-associated respiratory syncytial virus (HA-RSV) infections in children are well described, but less is known about sporadic HA-RSV infections. We assessed the epidemiology and clinical outcomes associated with ... ...

    Abstract Background: Outbreaks of healthcare-associated respiratory syncytial virus (HA-RSV) infections in children are well described, but less is known about sporadic HA-RSV infections. We assessed the epidemiology and clinical outcomes associated with sporadic HA-RSV infections.
    Methods: We retrospectively identified hospitalized children ≤18 years old with HA-RSV infections in six children's hospitals in the United States during the respiratory viral seasons October-April in 2016-2017, 2017-2018, and 2018-2019 and prospectively from October 2020 through November 2021. We evaluated outcomes temporally associated with HA-RSV infections including escalation of respiratory support, transfer to the pediatric intensive care unit (PICU), and in-hospital mortality. We assessed demographic characteristics and comorbid conditions associated with escalation of respiratory support.
    Results: We identified 122 children (median age 16.0 months [IQR 6, 60 months]) with HA-RSV. The median onset of HA-RSV infections was hospital day 14 (IQR 7, 34 days). Overall, 78 (63.9%) children had two or more comorbid conditions; cardiovascular, gastrointestinal, neurologic/neuromuscular, respiratory, and premature/ neonatal comorbidities were most common. Fifty-five (45.1%) children required escalation of respiratory support and 18 (14.8%) were transferred to the PICU. Five (4.1%) died during hospitalization. In the multivariable analysis, respiratory comorbidities (aOR: 3.36 [CI95 1.41, 8.01]) were associated with increased odds of escalation of respiratory support.
    Conclusions: HA-RSV infections cause preventable morbidity and increase healthcare resource utilization. Further study of effective mitigation strategies for HA-respiratory viral infections should be prioritized; this priority is further supported by the impact of the COVID-19 pandemic on seasonal viral infections.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; United States/epidemiology ; Infant ; Adolescent ; Retrospective Studies ; Pandemics ; COVID-19/epidemiology ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections ; Hospitalization ; Cross Infection/epidemiology ; Delivery of Health Care ; Hospitals ; Respiratory Tract Infections
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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