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Article ; Online: Dialogue system for designing technological processes

Golovin Dmitry / Samotin Ivan / Pocebneva Irina / Vasilyeva Olga

E3S Web of Conferences, Vol 376, p

2023 Volume 01094

Abstract: The paper deals with the issues of automation of technological design, for which it is proposed to introduce the concept of a structured reference space of a technological process, which is understood as a special design created on a set of processes ... ...

Abstract	The paper deals with the issues of automation of technological design, for which it is proposed to introduce the concept of a structured reference space of a technological process, which is understood as a special design created on a set of processes used in the manufacture of products, on which their ratio is set for individual subsets of the materialization processes of a product. To describe the reference space of the technological process, a method for solving methodological and mathematical problems is proposed - according to the information image of objects and processes; analysis and synthesis of processes; synthesis of equipment layout diagrams; machine methods of systematization. The latter made it possible to develop a qualitatively new approach to organizing data on technological processes, based on an object model for representing and processing information.
Keywords	design automation ; technological process ; reference space ; object model ; database ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Multiscale Mechanical Performance of Wood: From Nano- to Macro-Scale across Structure Hierarchy and Size Effects.

Golovin, Yuri I / Gusev, Alexander A / Golovin, Dmitry Yu / Matveev, Sergey M / Vasyukova, Inna A

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: This review describes methods and results of studying the mechanical properties of wood at all scales: from nano- to macro-scale. The connection between the mechanical properties of material and its structure at all these levels is explored. It is shown ... ...

Abstract	This review describes methods and results of studying the mechanical properties of wood at all scales: from nano- to macro-scale. The connection between the mechanical properties of material and its structure at all these levels is explored. It is shown that the existing size effects in the mechanical properties of wood, in a range of the characteristic sizes of the structure of about six orders of magnitude, correspond to the empirical Hall-Petch relation. This "law" was revealed more than 60 years ago in metals and alloys and later in other materials. The nature, as well as the particular type of the size dependences in different classes of materials can vary, but the general trend, "the smaller the stronger", remains true both for wood and for other cellulose-containing materials. The possible mechanisms of the size effects in wood are being discussed. The correlations between the mechanical and thermophysical properties of wood are described. Several examples are used to demonstrate the possibility to forecast the macromechanical properties of wood by means of contactless thermographic express methods based on measuring temperature diffusivity. The research technique for dendrochronological and dendroclimatological studies by means of the analysis of microhardness and Young's modulus radial dependences in annual growth rings is described.
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12071139
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: E. coli

Usvaliev, Azizbek D / Belogurova, Natalia G / Pokholok, Konstantin V / Finko, Alexander V / Prusov, Andrey N / Golovin, Dmitry Yu / Miroshnikov, Konstantin A / Golovin, Yuri I / Klyachko, Natalia L

Pharmaceutics

2023 Volume 15, Issue 7

Abstract: The spreading of microbial pathogens with more and more resistance to traditional low-molecular antibiotic agents demands new approaches to antibacterial therapy. The employment of bacteriophage enzymes capable of breaking bacterial cell walls has ... ...

Abstract	The spreading of microbial pathogens with more and more resistance to traditional low-molecular antibiotic agents demands new approaches to antibacterial therapy. The employment of bacteriophage enzymes capable of breaking bacterial cell walls has attracted much interest within this context. The specific features of the morphology of Gram-negative bacteria prevent the effective direct usage of lytic enzymes and require assistance from additional helpers to facilitate cell lysis. The current work is devoted to the study of boosting the lysis of
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15071871
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Article: Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications.

Golovin, Yuri I / Golovin, Dmitry Yu / Vlasova, Ksenia Yu / Veselov, Maxim M / Usvaliev, Azizbek D / Kabanov, Alexander V / Klyachko, Natalia L

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 9

Abstract: The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this ... ...

Abstract	The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11092255
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Article ; Online: Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models.

Semkova, Jordanka / Benghin, Victor / Guo, Jingnan / Zhang, Jian / Da Pieve, Fabiana / Krastev, Krasimir / Matviichuk, Yuri / Tomov, Borislav / Shurshakov, Vyacheslav / Drobyshev, Sergey / Mitrofanov, Igor / Golovin, Dmitry / Litvak, Maxim

Life sciences in space research

2022 Volume 39, Page(s) 119–130

Abstract: The knowledge of the space radiation environment in spacecraft transition and in Mars vicinity is of importance for the preparation of the human exploration of Mars. ExoMars Trace Gas Orbiter (TGO) was launched on March 14, 2016 and was inserted into ... ...

Abstract	The knowledge of the space radiation environment in spacecraft transition and in Mars vicinity is of importance for the preparation of the human exploration of Mars. ExoMars Trace Gas Orbiter (TGO) was launched on March 14, 2016 and was inserted into circular Mars science orbit (MSO) with a 400 km altitude in March 2018. The Liulin-MO dosimeter is a module of the Fine Resolution Epithermal Neutron Detector (FREND) aboard ExoMars TGO and has been measuring the radiation environment during the TGO interplanetary travel to Mars and continues to do so in the TGO MSO. One of the scientific objectives of the Liulin-MO investigations is to provide data for verification and benchmarking of the Mars radiation environment models. In this work we present results of comparisons of the flux measured by the Liulin-MO in TGO Mars orbit with calculated estimations. Described is the methodology for estimation the particle flux in Liulin-MO detectors in MSO, which includes modeling the albedo spectra and procedure for calculation the fluxes, recorded by Liulin-MO on the basis of the detectors shielding model. The galactic cosmic rays (GCR) and Mars albedo radiation contribution to the detectors count rate was taken into account. The GCR particle flux was calculated using the Badhwar O'Neil 2014 model for December 1, 2018. Detailed calculations of the albedo spectra of protons, helium ions, neutrons and gamma rays at 70 km height, performed with Atmospheric Radiation Interaction Simulator (AtRIS), were used for deriving the albedo radiation fluxes at the TGO altitude. In particular, the sensitivity of the Liulin-MO semiconductor detectors to neutron and gamma radiation has been considered in order to calculate the contribution of the neutral particles to the detected flux. The results from the calculations suggest that the contribution of albedo radiation can be about 5% of the measured total flux from GCR and albedo at the TGO altitude. The critical effect of TGO orientation, causing different shading of the GCR flux by Mars, is also analysed in detail. The comparison between the measurements and estimations shows that the measured fluxes exceed the calculated values by at least 20% and that the effect of TGO orientation change is approximately the same for the calculated and measured fluxes. Accounting for the ACR contribution, secondary radiation and the gradient of GCR spectrum from 1 AU to 1.5 AU, the calculated flux may increase to match the measurement results. The results can serve for the benchmarking of GCRs models at Martian orbit.
MeSH term(s)	Humans ; Radiation Dosimeters ; Extraterrestrial Environment ; Orbit ; Radiation Monitoring/methods ; Mars
Language	English
Publishing date	2022-08-24
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-5532
ISSN (online)	2214-5532
DOI	10.1016/j.lssr.2022.08.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Relationship between Thermal Diffusivity and Mechanical Properties of Wood.

Golovin, Yuri I / Tyurin, Alexander I / Golovin, Dmitry Yu / Samodurov, Alexander A / Matveev, Sergey M / Yunack, Maria A / Vasyukova, Inna A / Zakharova, Olga V / Rodaev, Vyacheslav V / Gusev, Alexander A

Materials (Basel, Switzerland)

2022 Volume 15, Issue 2

Abstract: This paper describes an experimental study of the relationships between thermal diffusivity and mechanical characteristics including Brinell hardness, microhardness, and Young's modulus of common pine ( ...

Abstract	This paper describes an experimental study of the relationships between thermal diffusivity and mechanical characteristics including Brinell hardness, microhardness, and Young's modulus of common pine (
Language	English
Publishing date	2022-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15020632
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Article ; Online: Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022.

Life sciences in space research

2023 Volume 39, Page(s) 106–118

Abstract: The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, ... ...

Abstract	The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, dose rates and estimation of dose equivalent rates at ExoMars TGO Mars science orbit, provided by Liulin-MO from May 2018 to June 2022. The period of measurements covers the declining and minimum phases of the solar activity in 24th solar cycle and the rising phase of the 25th cycle. Compared are the radiation values of the galactic cosmic rays (GCR) obtained during the different phases of the solar activity. The highest values of the dose rate and flux from GCR are registered from March to August 2020. At the minimum of 24th and transition to 25th solar cycle the dose rate from GCR is 15.9 ± 1.6 µGy h
MeSH term(s)	Solar Activity ; Space Flight ; Orbit ; Radiation Monitoring/methods ; Cosmic Radiation
Language	English
Publishing date	2023-03-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-5532
ISSN (online)	2214-5532
DOI	10.1016/j.lssr.2023.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enzyme Release from Polyion Complex by Extremely Low Frequency Magnetic Field.

Vlasova, Kseniya Yu / Vishwasrao, Hemant / Abakumov, Maxim A / Golovin, Dmitry Yu / Gribanovsky, Sergey L / Zhigachev, Alexander O / Poloznikov, Andrey А / Majouga, Alexander G / Golovin, Yuri I / Sokolsky-Papkov, Marina / Klyachko, Natalia L / Kabanov, Alexander V

Scientific reports

2020 Volume 10, Issue 1, Page(s) 4745

Abstract: Remote nano-magneto-mechanical actuation of magnetic nanoparticles (MNPs) by non-heating extremely low frequency magnetic field (ELF MF) is explored as a tool for non-invasive modification of bionanomaterials in pharmaceutical and medical applications. ... ...

Abstract	Remote nano-magneto-mechanical actuation of magnetic nanoparticles (MNPs) by non-heating extremely low frequency magnetic field (ELF MF) is explored as a tool for non-invasive modification of bionanomaterials in pharmaceutical and medical applications. Here we study the effects of ELF MF (30-160 Hz, 8-120 kA/m) on the activity and release of a model enzyme, superoxide dismutase 1 (SOD1) immobilized by polyion coupling on dispersed MNPs aggregates coated with poly(L-lysine)-block-poly(ethylene glycol) block copolymer (s-MNPs). Such fields do not cause any considerable heating of MNPs but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations in adjacent materials. We observed the changes in the catalytic activity of immobilized SOD1 as well as its release from the s-MNPs/SOD1 polyion complex upon application of the ELF MF for 5 to 15 min. At longer exposures (25 min) the s-MNPs/SOD1 dispersion destabilizes. The bell-shaped effect of the field frequency with maximum at f = 50 Hz and saturation effect of field strength (between 30 kA/m and 120 kA/m at f = 50 Hz) are reported and explained. The findings are significant as one early indication of the nano-magneto-mechanical disruption by ELF MF of cooperative polyion complexes that are widely used for design of current functional healthcare bionanomaterials.
MeSH term(s)	Biopharmaceutics ; Enzymes, Immobilized ; Magnetic Fields ; Magnetic Iron Oxide Nanoparticles ; Nanostructures ; Polyethylene Glycols ; Polymers ; Superoxide Dismutase-1/metabolism
Chemical Substances	Enzymes, Immobilized ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2020-03-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-61364-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields.

Golovin, Yuri I / Gribanovsky, Sergey L / Golovin, Dmitry Y / Klyachko, Natalia L / Majouga, Alexander G / Master, Аlyssa M / Sokolsky, Marina / Kabanov, Alexander V

Journal of controlled release : official journal of the Controlled Release Society

2015 Volume 219, Page(s) 43–60

Abstract: The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery ... ...

Abstract	The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia.
MeSH term(s)	Drug Delivery Systems ; Hyperthermia, Induced ; Magnetic Fields ; Nanomedicine ; Nanoparticles/administration & dosage
Language	English
Publishing date	2015-09-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2015.09.038
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Article ; Online: Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field.

Le-Deygen, Irina M / Vlasova, Kseniya Yu / Kutsenok, Ekaterina O / Usvaliev, Azizbek D / Efremova, Maria V / Zhigachev, Alexander O / Rudakovskaya, Polina G / Golovin, Dmitry Yu / Gribanovsky, Sergey L / Kudryashova, Elena V / Majouga, Alexander G / Golovin, Yury I / Kabanov, Alexander V / Klyachko, Natalia L

Nanomedicine : nanotechnology, biology, and medicine

2019 Volume 21, Page(s) 102065

Abstract: This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were ... ...

Abstract	This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. The effect of ELF MF on the membrane fluidity was greater in case of 70 × 12 nm magnetite nanorods adsorbed on the liposomes surface compared to liposomes with ~7 nm spherical MNPs embedded within lipid membranes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues.
MeSH term(s)	Liposomes ; Magnetic Fields ; Membrane Fluidity ; Models, Chemical ; Nanotubes/chemistry ; Permeability
Chemical Substances	Liposomes
Language	English
Publishing date	2019-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2019.102065
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