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  1. Article ; Online: The effect of substituent position and solvent on thermal Z‒E isomerization of dihydroquinolylazotetrazole dyes: kinetic, thermodynamic, and spectral approaches.

    Golovina, Galina V / Egorov, Anton E / Khodot, Evgenii N / Kostyukov, Alexey A / Timokhina, Elena N / Astakhova, Tatiana Yu / Nekipelova, Tatiana D

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2023  Volume 23, Issue 1, Page(s) 177–187

    Abstract: Kinetic and thermodynamic parameters have been investigated for the thermal Z‒E isomerization of dihydroquinolylazotetrazole dyes with alkyl substituents (Me, t-Bu, and Adm) at positions 1 (dyes 2) and 2 (dyes 3) of the tetrazole moiety in two solvents ... ...

    Abstract Kinetic and thermodynamic parameters have been investigated for the thermal Z‒E isomerization of dihydroquinolylazotetrazole dyes with alkyl substituents (Me, t-Bu, and Adm) at positions 1 (dyes 2) and 2 (dyes 3) of the tetrazole moiety in two solvents of different polarity, acetonitrile (MeCN) and toluene. The experimental results show crucial dependence of these parameters on a substituent position in the tetrazole moiety and on a solvent. For dyes 2, E
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-023-00511-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Blood Pressure Response and Symptoms During Active Standing Test Among Hospitalized and Outpatients With Heart Failure: Results From the GRAVITY-HF Prospective Observational Cohort Study.

    Soloveva, Anzhela / Fedorova, Darya / Fudim, Marat / Vinogradova, Nadezhda / Chemodanova, Alena / Kozlova, Anastasia / Fomin, Igor / Skuratova, Mariya / Shneidmiller, Natalia / Golovina, Galina / Kosmacheva, Elena / Gubareva, Ekaterina / Teterina, Marina / Godunko, Elena / Chesnikova, Anna / Okunev, Igor / Kashtalap, Vasily / Kuznetsova, Mariia / Dzhioeva, Olga /
    Kopeva, Kristina / Zvartau, Nadezhda / Villevalde, Svetlana

    Journal of cardiac failure

    2024  

    Abstract: Background: We conducted a multicenter, prospective, observational study to describe the incidence of orthostatic hypotension (OH) and orthostatic hypertension (OHtn) and its association with symptoms at standing and outcomes in patients with heart ... ...

    Abstract Background: We conducted a multicenter, prospective, observational study to describe the incidence of orthostatic hypotension (OH) and orthostatic hypertension (OHtn) and its association with symptoms at standing and outcomes in patients with heart failure (HF).
    Methods and results: 321 active standing tests were performed in 87 inpatients during admission, and 316 tests were performed in 208 outpatients during follow-up. Blood pressure (BP) was measured by an automatic device 4 times in the supine position and at 1, 3 and 5 minutes of standing. Patients were queried about symptoms of orthostatic intolerance. The incidence of OH and OHtn was similar in both groups at baseline (classical OH 11%-22%, OHtn 3%-8%, depending on definition and timing). Reproducibility of BP changes with standing was low. Up to 50% of cases with abnormal responses were asymptomatic. Symptoms were variable and occurred mainly during the first minute of standing and had a U-shaped association with BP changes. OH in outpatients with HF was associated with a higher risks of death or readmission due to HF.
    Conclusions: Patients with HF have variable hemodynamic responses and symptoms during repeated active standing tests. OH might identify outpatients with HF who are at risk of long-term negative outcomes.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.12.017
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  3. Book: Gesamtausgabe

    Marx, Karl / Engels, Friedrich / Golovina, Galina

    : (MEGA)

    2013  

    Institution Internationale Marx-Engels-Stiftung
    Author's details Karl Marx; Friedrich Engels. Hrsg. von der Internationalen Marx-Engels-Stiftung Amsterdam
    Language German ; English
    Size XXI, 655 S., Ill., Faks.
    Publisher Akad.-Verl
    Publishing place Berlin
    Document type Book
    Accompanying material Diakritische Zeichen und Siglen (1 Bl.)
    ISBN 9783050049847 ; 3050049847
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Gesamtausgabe

    Marx, Karl / Engels, Friedrich / Golovina, Galina

    : (MEGA)

    2013  

    Institution Internationale Marx-Engels-Stiftung
    Author's details Karl Marx; Friedrich Engels. Hrsg. von der Internationalen Marx-Engels-Stiftung Amsterdam
    Language German
    Size S. 661 - 1529, 25 cm
    Publisher Akad.-Verl
    Publishing place Berlin
    Document type Book
    Note Literaturverz. S. 1487 - 1529 ; Mit Reg.
    ISBN 9783050049847 ; 3050049847
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book: Gesamtausgabe

    Marx, Karl / Engels, Friedrich / Golovina, Galina

    : (MEGA)

    2013  

    Institution Internationale Marx-Engels-Stiftung
    Author's details Karl Marx; Friedrich Engels. Hrsg. von der Internationalen Marx-Engels-Stiftung Amsterdam
    Language German
    Size S. 661 - 1529, 25 cm
    Publisher Akad.-Verl
    Publishing place Berlin
    Document type Book
    Note Literaturverz. S. 1487 - 1529 ; Mit Reg.
    ISBN 9783050049847 ; 3050049847
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Gesamtausgabe

    Marx, Karl / Engels, Friedrich / Golovina, Galina

    : (MEGA)

    2013  

    Institution Internationale Marx-Engels-Stiftung
    Author's details Karl Marx; Friedrich Engels. Hrsg. von der Internationalen Marx-Engels-Stiftung Amsterdam
    Language German ; English
    Size XXI, 655 S., Ill., Faks.
    Publisher Akad.-Verl
    Publishing place Berlin
    Document type Book
    Accompanying material Diakritische Zeichen und Siglen (1 Bl.)
    ISBN 9783050049847 ; 3050049847
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Can the result of a tilt test be predicted in the first five minutes?

    Duplyakov, Dmitry / Golovina, Galina / Sysuenkova, Elena / Garkina, Svetlana

    Cardiology journal

    2011  Volume 18, Issue 5, Page(s) 521–526

    Abstract: Background: Head-up tilt testing (HUT) plays a pivotal role in the management of vasovagal syncope (VVS). Heart rate variability (HRV) is a well-known method used for noninvasive evaluation of autonomic nervous system activity. However, different ... ...

    Abstract Background: Head-up tilt testing (HUT) plays a pivotal role in the management of vasovagal syncope (VVS). Heart rate variability (HRV) is a well-known method used for noninvasive evaluation of autonomic nervous system activity. However, different results have been obtained in studies that have evaluated the HRV response to HUT in patients with VVS.
    Methods: One hundred fourteen patients with recurrent VVS were enrolled in the study. According to the results of HUT, patients were divided into five groups: positive (n = 30) and negative (n = 23) Westminster; positive (n = 44) and negative (n = 11) Italian. Fourteen healthy volunteers with no history of syncope comprised the control group. Spectral indices of HRV variability were analyzed for three short-term intervals.
    Results: Both protocols showed similar distribution of responses to tilt-testing. In the supine position, significant differences were observed between patients from groups 1, 2 and 3 in comparison with the control and Italian negative groups. They had significantly lower initial results of LF(1) [nu] and LF(1)/HF(1) ratio, and higher HF(1) [nu] values. The onset of HUT in patients with positive Westminster protocol was characterized by an almost two-fold increase in LF [nu] and decrease in HF [nu] compared to all other patients. LF(2)/HF(2) ratio in the Westminster positive group had increased more than five times since the baseline level, while during the last period, LF(3)/HF(3) ratio had increased more than six times.
    Conclusions: Patients with VVS have disturbed sympathovagal balance at rest. Our data suggests that the results of HUT could be predicted by analyzing the spectral parameters of HRV during the first five minutes of the test. The reaction to orthostasis in patients with syncope during the Westminster protocol was more severe compared to the Italian protocol group and the control group. Vasovagal response during the Italian protocol may be triggered by drug-induced vasodilatation.
    MeSH term(s) Adolescent ; Adult ; Autonomic Nervous System/physiopathology ; Blood Pressure ; Case-Control Studies ; Chi-Square Distribution ; Female ; Fourier Analysis ; Heart Rate ; Humans ; Male ; Middle Aged ; Patient Positioning ; Posture ; Predictive Value of Tests ; Recurrence ; Russia ; Signal Processing, Computer-Assisted ; Syncope, Vasovagal/diagnosis ; Syncope, Vasovagal/physiopathology ; Tilt-Table Test ; Time Factors ; Young Adult
    Language English
    Publishing date 2011-05-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2488680-4
    ISSN 1897-5593 ; 1897-5593
    ISSN (online) 1897-5593
    ISSN 1897-5593
    DOI 10.5603/cj.2011.0007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6770: Show issues Location:
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  8. Article ; Online: Is it possible to accurately differentiate neurocardiogenic syncope from epilepsy?

    Duplyakov, Dmitry / Golovina, Galina / Garkina, Svetlana / Lyukshina, Natalia

    Cardiology journal

    2010  Volume 17, Issue 4, Page(s) 420–427

    Abstract: Global cerebral hypoperfusion resulting in syncope, and asynchronous discharge of cerebral neurons leading to seizure, are two major mechanisms of transient loss of consciousness. They both have a lot in common in clinical and historical settings, ... ...

    Abstract Global cerebral hypoperfusion resulting in syncope, and asynchronous discharge of cerebral neurons leading to seizure, are two major mechanisms of transient loss of consciousness. They both have a lot in common in clinical and historical settings, although with a high prevalence of incorrect diagnosis, even by well-trained staff. The aim of this review was to try to combine data from both a cardiologist's and a neurologist's perspective (history taking, special questionnaires, serum prolactin, EEG, CT/MRI, tilt-testing, loop recorders).
    MeSH term(s) Biomarkers/blood ; Diagnosis, Differential ; Diagnostic Imaging ; Electrocardiography ; Electroencephalography ; Epilepsy/complications ; Epilepsy/diagnosis ; Humans ; Medical History Taking ; Predictive Value of Tests ; Prolactin/blood ; Syncope, Vasovagal/complications ; Syncope, Vasovagal/diagnosis ; Tilt-Table Test ; Unconsciousness/etiology
    Chemical Substances Biomarkers ; Prolactin (9002-62-4)
    Language English
    Publishing date 2010
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2488680-4
    ISSN 1897-5593 ; 1897-5593
    ISSN (online) 1897-5593
    ISSN 1897-5593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6770: Show issues Location:
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  9. Article ; Online: Syncope, seizure-induced bradycardia and asystole: two cases and review of clinical and pathophysiological features.

    Duplyakov, Dmitry / Golovina, Galina / Lyukshina, Natalia / Surkova, Elena / Elger, Christian E / Surges, Rainer

    Seizure

    2014  Volume 23, Issue 7, Page(s) 506–511

    Abstract: Episodes of transient loss of consciousness (TLOC) are commonly due to syncope or epileptic seizures. The distinction between both entities on clinical grounds and eyewitness accounts can be challenging and is often hampered by similar clinical features. ...

    Abstract Episodes of transient loss of consciousness (TLOC) are commonly due to syncope or epileptic seizures. The distinction between both entities on clinical grounds and eyewitness accounts can be challenging and is often hampered by similar clinical features. We briefly summarize syncope-related symptoms and present the case of a female patient who suffered from TLOC episodes due to both reflex syncope and epileptic seizures. Seizure-induced syncope is a rare complication particularly of non-generalized temporal lobe seizures and may be suspected in people with epilepsy who report new semiological features with sudden onset of atonia, TLOC and seizure-related falls. We review epidemiological, clinical and electroencephalographic aspects of seizure-related asystole and syncope and discuss their clinical relevance. The implantation of a cardiac pacemaker appears to efficiently prevent seizure-related falls and consecutive injuries and is an important treatment option if full seizure-control cannot be achieved in these patients. We describe a second case of a patient with refractory temporal lobe epilepsy and seizure-related syncope which ceased after the implantation of a cardiac pacemaker.
    MeSH term(s) Bradycardia/diagnosis ; Bradycardia/etiology ; Electrocardiography ; Electroencephalography ; Female ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Humans ; Middle Aged ; Seizures/complications ; Syncope/complications
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2014.03.004
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    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II.

    Sonoda, Hiroyuki / Morimoto, Hideto / Yoden, Eiji / Koshimura, Yuri / Kinoshita, Masafumi / Golovina, Galina / Takagi, Haruna / Yamamoto, Ryuji / Minami, Kohtaro / Mizoguchi, Akira / Tachibana, Katsuhiko / Hirato, Tohru / Takahashi, Kenichi

    Molecular therapy : the journal of the American Society of Gene Therapy

    2018  Volume 26, Issue 5, Page(s) 1366–1374

    Abstract: Mucopolysaccharidosis II (MPS II) is an X-linked recessive lysosomal storage disease caused by mutations in the iduronate-2-sulfatase (IDS) gene. Since IDS catalyzes the degradation of glycosaminoglycans (GAGs), deficiency in this enzyme leads to ... ...

    Abstract Mucopolysaccharidosis II (MPS II) is an X-linked recessive lysosomal storage disease caused by mutations in the iduronate-2-sulfatase (IDS) gene. Since IDS catalyzes the degradation of glycosaminoglycans (GAGs), deficiency in this enzyme leads to accumulation of GAGs in most cells in all tissues and organs, resulting in severe somatic and neurological disorders. Although enzyme replacement therapy with human IDS (hIDS) has been used for the treatment of MPS II, this therapy is not effective for defects in the CNS mainly because the enzyme cannot cross the blood-brain barrier (BBB). Here, we developed a BBB-penetrating fusion protein, JR-141, which consists of an anti-human transferrin receptor (hTfR) antibody and intact hIDS. The TfR-mediated incorporation of JR-141 was confirmed by using human fibroblasts in vitro. When administrated intravenously to hTfR knockin mice or monkeys, JR-141, but not naked hIDS, was detected in the brain. In addition, the intravenous administration of JR-141 reduced the accumulation of GAGs both in the peripheral tissues and in the brain of hTfR knockin mice lacking Ids, an animal model of MPS II. These data provide a proof of concept for the translation of JR-141 to clinical study for the treatment of patients with MPS II with CNS disorders.
    MeSH term(s) Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/pharmacokinetics ; Antibodies, Monoclonal/pharmacology ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Brain/drug effects ; Brain/metabolism ; Cell Line ; Disease Models, Animal ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Mice ; Mice, Knockout ; Mucopolysaccharidosis II/drug therapy ; Mucopolysaccharidosis II/genetics ; Mucopolysaccharidosis II/metabolism ; Receptor, IGF Type 2/genetics ; Receptor, IGF Type 2/metabolism ; Receptors, Transferrin/antagonists & inhibitors ; Recombinant Fusion Proteins ; Tissue Distribution/drug effects
    Chemical Substances Antibodies, Monoclonal ; Receptor, IGF Type 2 ; Receptors, Transferrin ; Recombinant Fusion Proteins ; cation-dependent mannose-6-phosphate receptor
    Language English
    Publishing date 2018-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2018.02.032
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