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  1. Article ; Online: Neural features of sustained emotional information processing in autism spectrum disorder.

    Mazefsky, Carla A / Collier, Amanda / Golt, Josh / Siegle, Greg J

    Autism : the international journal of research and practice

    2020  Volume 24, Issue 4, Page(s) 941–953

    Abstract: Lay abstract: Many individuals with autism spectrum disorder struggle with emotions that are intense and interfering, which is referred to as emotion dysregulation. Prior research has established that individuals with autism may be more likely than ... ...

    Abstract Lay abstract: Many individuals with autism spectrum disorder struggle with emotions that are intense and interfering, which is referred to as emotion dysregulation. Prior research has established that individuals with autism may be more likely than individuals who are not autistic to have repetitive thoughts. It is possible that persistent thoughts about negative or distressing stimuli may contribute to emotion dysregulation in autism spectrum disorder. This study aimed to identify areas of the brain with evidence of persistent processing of negative information via functional magnetic resonance neuroimaging. We used a task that alternated between emotional processing of personally relevant negative words, neutral words, and a non-emotional task. Criteria were developed to define heightened and persistent emotional processing, and analyses were conducted to identify all brain regions satisfying these criteria. Participants included 25 adolescents with autism spectrum disorder and 23 typically developing adolescents who were similar to the autism spectrum disorder group in IQ, age, and gender ratios. Brain regions identified as having greater and continued processing following negative stimuli in the autism spectrum disorder group as compared with the typically developing group included the salience network and the prefrontal dorsolateral cortex. These areas have been previously implicated in emotion dysregulation outside of autism spectrum disorder. Collectively, brain activity in the identified regions was associated with parent-reported emotion dysregulation in the autism spectrum disorder group. These results help to identify a potential process in the brain associated with emotion dysregulation in autism spectrum disorder. This information may be useful for the development of treatments to decrease emotion dysregulation in autism spectrum disorder.
    MeSH term(s) Adolescent ; Autism Spectrum Disorder ; Brain/diagnostic imaging ; Cognition ; Emotions ; Female ; Humans ; Magnetic Resonance Imaging ; Male
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/1362361320903137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emotion Dysregulation is Substantially Elevated in Autism Compared to the General Population: Impact on Psychiatric Services.

    Conner, Caitlin M / Golt, Josh / Shaffer, Rebecca / Righi, Giulia / Siegel, Matthew / Mazefsky, Carla A

    Autism research : official journal of the International Society for Autism Research

    2020  Volume 14, Issue 1, Page(s) 169–181

    Abstract: Emerging evidence suggests that emotion regulation (ER) impairment in those with ASD is associated with poor mental health. This study used the Emotion Dysregulation Inventory, a new norm-referenced ER measure with clinical cut-offs, developed and ... ...

    Abstract Emerging evidence suggests that emotion regulation (ER) impairment in those with ASD is associated with poor mental health. This study used the Emotion Dysregulation Inventory, a new norm-referenced ER measure with clinical cut-offs, developed and validated in ASD and non-ASD samples, to establish rates of ER impairment and understand its association with psychiatric service use in ASD. Parents of 6-17 year olds in three well-characterized samples (nationally representative US
    MeSH term(s) Adolescent ; Autism Spectrum Disorder ; Autistic Disorder ; Child ; Emotional Regulation ; Emotions ; Humans ; Mental Health Services
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Comparative Study of Suicidality and Its Association with Emotion Regulation Impairment in Large ASD and US Census-Matched Samples.

    Conner, Caitlin M / Golt, Josh / Righi, Giulia / Shaffer, Rebecca / Siegel, Matthew / Mazefsky, Carla A

    Journal of autism and developmental disorders

    2020  Volume 50, Issue 10, Page(s) 3545–3560

    Abstract: Evidence suggests increased rates of suicidality in autism spectrum disorder (ASD), but the research has rarely used comparison samples and the role of emotion dysregulation has not been considered. We compared the prevalence of parent-reported ... ...

    Abstract Evidence suggests increased rates of suicidality in autism spectrum disorder (ASD), but the research has rarely used comparison samples and the role of emotion dysregulation has not been considered. We compared the prevalence of parent-reported suicidality ideation and considered the role of emotion dysregulation in 330 psychiatric inpatient youth with ASD, 1169 community youth with ASD surveyed online, and 1000 youth representative of the US census. The prevalence of suicidal ideation was three and five times higher in the community and inpatient ASD samples, respectively, compared to the general US sample. In the ASD groups, greater emotion dysregulation was associated with suicidal ideation. Implications include consideration of emotion regulation as a potential mechanism and treatment target for suicidality in ASD.
    MeSH term(s) Adolescent ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/psychology ; Censuses ; Child ; Emotional Regulation/physiology ; Emotions/physiology ; Female ; Humans ; Male ; Prevalence ; Suicidal Ideation ; Suicide/psychology ; Suicide/trends ; Surveys and Questionnaires ; United States/epidemiology
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-020-04370-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anxiety and Depression Reduction as Distal Outcomes of a College Transition Readiness Program for Adults with Autism.

    Capriola-Hall, Nicole N / Brewe, Alexis M / Golt, Josh / White, Susan W

    Journal of autism and developmental disorders

    2020  Volume 51, Issue 1, Page(s) 298–306

    Abstract: Young adults with autism spectrum disorder (ASD) experience increased rates of anxiety and depression which can impact academic success. The Stepped Transition in Education Program for Students with ASD (STEPS) applies cognitive-behavioral principles to ... ...

    Abstract Young adults with autism spectrum disorder (ASD) experience increased rates of anxiety and depression which can impact academic success. The Stepped Transition in Education Program for Students with ASD (STEPS) applies cognitive-behavioral principles to help young adults with ASD improve their adjustment to postsecondary education. We aimed to determine if STEPS had an effect on anxiety and depression. Treatment-seeking adults with ASD (n = 32; Mage = 19.74) were randomized to STEPS or transition as usual (TAU; i.e., waitlist control group). STEPS participants evinced significantly greater declines in depressive symptoms from pre-treatment to post-treatment compared to the waitlist. Anxiety symptoms did not significantly change. Results suggest that transition support for young people with ASD may improve mental health.
    MeSH term(s) Academic Success ; Adolescent ; Adult ; Anxiety/epidemiology ; Anxiety/psychology ; Anxiety/therapy ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/psychology ; Autism Spectrum Disorder/therapy ; Depression/epidemiology ; Depression/psychology ; Depression/therapy ; Female ; Humans ; Loneliness/psychology ; Male ; Random Allocation ; Self-Control/psychology ; Students/psychology ; Surveys and Questionnaires ; Treatment Outcome ; Universities ; Young Adult
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-020-04549-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Observed emotional reactivity in response to frustration tasks in psychiatrically hospitalized youth with autism spectrum disorder.

    Northrup, Jessie B / Goodwin, Matthew / Montrenes, Joshua / Vezzoli, Jessica / Golt, Josh / Peura, Christine B / Siegel, Matthew / Mazefsky, Carla

    Autism : the international journal of research and practice

    2020  Volume 24, Issue 4, Page(s) 968–982

    Abstract: Lay abstract: Large emotional reactions (e.g. outbursts, tantrums) can be common and distressing in the lives of individuals with autism spectrum disorder and their families. Most previous research that has examined these types of emotional responses ... ...

    Abstract Lay abstract: Large emotional reactions (e.g. outbursts, tantrums) can be common and distressing in the lives of individuals with autism spectrum disorder and their families. Most previous research that has examined these types of emotional responses have used questionnaire data or focused only on young children. In addition, very little research has included individuals across a large range of intellectual and functional abilities or individuals with more severe emotional and/or behavioral difficulties. This study examined emotional reactions to frustrating tasks in 6-21-year-olds with autism spectrum disorder who were psychiatrically hospitalized due to emotional and/or behavioral difficulties. We describe change in the amount, intensity, duration, and range of emotional reactions that the participants displayed from a neutral activity to the frustrating tasks and then to a neutral recovery period. We also examined associations between characteristics of the participants and these emotional reactions. We found that younger children displayed more negative emotions across the neutral and frustrating tasks; however, age did not relate to how big their reactions to frustration were. Furthermore, we found that individuals with fewer adaptive skills (i.e. age-appropriate life skills) and minimally verbal individuals had bigger reactions and recovered less following the frustration tasks. The results highlight the importance of examining emotional reactions in individuals with lower verbal and adaptive abilities and for interventions to consider the connection between verbal and adaptive skills and emotional reactions.
    MeSH term(s) Adolescent ; Adolescent, Institutionalized ; Adult ; Autism Spectrum Disorder ; Child ; Child, Institutionalized ; Child, Preschool ; Emotions ; Ethnic Groups ; Frustration ; Humans ; Inpatients ; Male ; Minority Groups
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/1362361320908108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improving emotion regulation ability in autism: The Emotional Awareness and Skills Enhancement (EASE) program.

    Conner, Caitlin M / White, Susan W / Beck, Kelly B / Golt, Josh / Smith, Isaac C / Mazefsky, Carla A

    Autism : the international journal of research and practice

    2018  Volume 23, Issue 5, Page(s) 1273–1287

    Abstract: Emotion regulation impairments are common among individuals with autism spectrum disorder and are believed to often underlie commonly seen problems with aggression, depression, and anxiety. The Emotional Awareness and Skills Enhancement program was ... ...

    Abstract Emotion regulation impairments are common among individuals with autism spectrum disorder and are believed to often underlie commonly seen problems with aggression, depression, and anxiety. The Emotional Awareness and Skills Enhancement program was developed to reduce emotion regulation impairment and thereby improve behavioral disturbance, via mindfulness. Emotional Awareness and Skills Enhancement consists of a 16-week individual therapy treatment targeting emotion regulation impairments among individuals with autism spectrum disorder. We describe the conceptual framework and development of the program and present data on feasibility and preliminary efficacy from a pilot trial. The Emotional Awareness and Skills Enhancement manual was developed using a participatory action framework, based on emotion regulation research specific to autism spectrum disorder and input from individuals with autism spectrum disorder, therapists, and parents of children with autism spectrum disorder. Emotional Awareness and Skills Enhancement was piloted in a two-site open trial with 20 participants with autism spectrum disorder (12-17 years old, confirmed autism spectrum disorder diagnosis, IQ > 80).Outcome data support program feasibility and acceptability to participants, as well as significant improvement in emotion regulation impairments and related concerns.Findings offer preliminary support for both the feasibility and clinical effectiveness of the Emotional Awareness and Skills Enhancement program.
    MeSH term(s) Adolescent ; Anxiety/psychology ; Autism Spectrum Disorder/psychology ; Autism Spectrum Disorder/rehabilitation ; Autistic Disorder/psychology ; Autistic Disorder/rehabilitation ; Child ; Cognitive Behavioral Therapy/methods ; Depression/psychology ; Emotional Regulation ; Feasibility Studies ; Female ; Humans ; Male ; Mindfulness/methods ; Patient Acceptance of Health Care ; Pilot Projects
    Language English
    Publishing date 2018-11-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/1362361318810709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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