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Article: Multivariate optimization of dual-sorbent dynamic headspace extraction of volatiles in wine analysis

Vyviurska, O. / Hanobikova, M. / Gomes, A. A. / Spanik, I.

2021 Volume 365, Issue Art. 130449, Page(s) 8 pp. +Suppl.

Abstract: Dynamic headspace extraction; Wine analysis; Gas chromatography; Tokaj region; Multivariate optimization. ...

Institution	Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, 81237 Bratislava, Slovakia
Abstract	Dynamic headspace extraction; Wine analysis; Gas chromatography; Tokaj region; Multivariate optimization.
Language	English
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
Database	Viticulture and Oenology Abstracts

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Article: A fast and inexpensive approach to characterize Slovak Tokaj selection wines using infrared spectroscopy and chemometrics

Machynakova, A. / Schneider, M. P. / Khvalbota, L. / Vyviurska, O. / Spanik, I. / Gomes, A. A.

Food Chemistry

2021 Volume 357, Issue Art. 129715, Page(s) 7 pp. + Suppl.

Abstract: Tokaj; One class classification; Infrared spectroscopy; Multivariate calibration. ...

Institution	Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinskeho 9, 812 37 Bratislava, Slovakia
Abstract	Tokaj; One class classification; Infrared spectroscopy; Multivariate calibration.
Language	English
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
Database	Viticulture and Oenology Abstracts

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Article: Slovak Tokaj wines classification with respect to geographical origin by means of one class approaches

Gomes, A. A. / Khvalbota, L. / Machynakova, A. / Furdikova, K. / Zini, C. A. / Spanik, I.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

2021 Volume 257, Issue Art. 119770, Page(s) 7 pp.

Abstract: Botrytized wine; UV–VIS spectrometry; Multivariate classification; Variable selection; Tokaj. ...

Institution	Instituto de Quimica, Universidade Federal do Rio Grande do Sul, Avenida Bento Goncalves, 9500, 91501-970 Porto Alegre, RS, Brazil
Abstract	Botrytized wine; UV–VIS spectrometry; Multivariate classification; Variable selection; Tokaj.
Language	English
Document type	Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
Database	Viticulture and Oenology Abstracts

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Article ; Online: DNA Mismatch Repair-Deficient Colorectal Carcinoma: Referral Rate for Genetic Cancer Risk Assessment in a Brazilian Cancer Center.

Gomes, A A D / Macedo, M P / Torrezan, G T / Zenun, G R / Aguiar, S / Begnami, M D / Carraro, D M / Formiga, M N

Journal of gastrointestinal cancer

2020 Volume 52, Issue 3, Page(s) 997–1002

Abstract: Background: Approximately 15% of colorectal cancers (CRCs) are deficient in DNA mismatch repair proteins (dMMR), a characteristic that can occur in both sporadic and hereditary CRC. Due to sparse studies on dMMR CRC in the Brazilian population, we ... ...

Abstract	Background: Approximately 15% of colorectal cancers (CRCs) are deficient in DNA mismatch repair proteins (dMMR), a characteristic that can occur in both sporadic and hereditary CRC. Due to sparse studies on dMMR CRC in the Brazilian population, we conducted a retrospective analysis of referral rates for Genetic Cancer Risk Assessment of this population and also describing clinical and molecular characterization of these tumors. Methods: A retrospective, longitudinal, and unicenter study that included patients with dMMR CRC detected by IHC analysis from Pathology Database of our institution, from January 2015 to July 2017. Results: MMR IHC testing was performed in 998 CRC tumors, and 78 tumors (7.8%) had dMMR. The mean age at diagnosis was 56.8 years (17-90), and most patients were female (41 out of 78, 52.6%). Of the 52 patients with right-sided CRC, 40 tumors (77%) had loss of the MLH1 and/or PMS2 expression, and 12 tumors (23%) had loss of MSH2 and/or MSH6 expression (p = 0.005). From 78 patients with dMMR CRC, only 43 patients (55.1%) were referred for genetic counseling (GC), and of them, only 33 patients (76.7%) really went to GC consultation. A total of 21 patients with dMMR CRC performed genetic testing. Conclusion: Overall, genetic referral was less than expected in our population. Most of dMMR CRC patients did not receive GC, even in a cancer center, either due to the absence of referral or personal decision and few patients who pursued genetic counseling performed genetic testing.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Cancer Care Facilities ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA Mismatch Repair/genetics ; Female ; Genetic Counseling/statistics & numerical data ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Risk Assessment ; Young Adult
Language	English
Publishing date	2020-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-020-00467-z
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Article: Maturation and maceration effects on tropical red wines assessed by chromatography and analysis of variance - principal component analysis

Barbara, J. A. / Silva, E. A. S. / Biasoto, A. C. T. / Gomes, A. A. / Correa, L. C. / Leao, P. C. S. / Zini, C. A.

Journal of the Brazilian Chemical Society

2019 Volume 30, Issue 7, Page(s) 1357–1377

Abstract: Effects of grape maturity, maceration length during winemaking and interaction of both of them on physicochemical parameters, phenolic and volatile composition were investigated in tropical Syrah wines with the aim of finding the best conditions to ... ...

Institution	Instituto de Quimica, Universidade Federal do Rio Grande do Sul, Avenida Bento Goncalves, 9500, 91501-970 Porto Alegre-RS, Brazil
Abstract	Effects of grape maturity, maceration length during winemaking and interaction of both of them on physicochemical parameters, phenolic and volatile composition were investigated in tropical Syrah wines with the aim of finding the best conditions to produce wines that are rich in phenols and positive aroma active compounds. A headspace solid phase micro extraction and gas chromatography with mass spectrometry (HS-SPME-GC-MS) method was improved and validated for the analysis of 41 volatiles. Principal component analysis (PCA) and analysis of variance (ANOVA)-PCA coupled with inspection of statistically significant loadings were important to access the effects of maturation and maceration on wine composition. Wines made from riper grapes (21-23 °Brix) stood out in relation to color intensity, total phenolic compounds, and presented high levels of anthocyanins, flavonols, procyanidin A2, and linalool (floral). Thirty days of maceration were linked to higher levels of some flavan-3-ols, gallic acid, a few esters (fruity) and alcohols, (E)-nerolidol (floral), while nonanoic acid (unpleasant aroma) reduced its concentration with prolonged maceration.
Language	English
Document type	Article
ISSN	0103-5053
DOI	10.21577/0103-5053.20190032
Database	Viticulture and Oenology Abstracts

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Article: Speciation analysis based on digital image colorimetry: iron (II/III) in white wine

Santos, N. o / Porto, I. S. A. / Schneider, M. P. / Santos, A. M. P. dos / Gomes, A. A. / Ferreira, S. L. C.

Talanta

2019 Volume 194, Page(s) 86–89

Abstract: iron speciation; wine samples; digital image; 1,2 ortho-phenanthroline. ...

Institution	Universidade Federal da Bahia, Instituto de Quimica, Grupo de Pesquisa em Quimica e Quimiometria, Campus Ondina, CEP: 40170-115, Salvador, Bahia, Brazil
Abstract	iron speciation; wine samples; digital image; 1,2 ortho-phenanthroline.
Language	English
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2018.09.102
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Article ; Online: Impact of mother donor, peripheral blood stem cells and measurable residual disease on outcomes after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in children with acute leukaemia.

Rocha, V / Arcuri, L J / Seber, A / Colturato, V / Zecchin, V G / Kuwahara, C / Nichele, S / Gouveia, R / Fernandes, J F / Macedo, A V / Tavares, R / Daudt, L / De Souza, M P / Darrigo-Jr, L G / Villela, N C / Mariano, L C B / Ginani, V C / Zanette, A / Loth, G /

Gomes, A A / Hamerschlak, N / Flowers, M E / Bonfim, C

Bone marrow transplantation

2021 Volume 56, Issue 12, Page(s) 3042–3048

Abstract: Haploidentical hematopoietic-cell transplantation using post-transplant cyclophosphamide(Haplo-PTCy) is a feasible procedure in children with haematologic malignancies. However, data of a large series of children with acute leukaemia(AL) in this setting ... ...

Abstract	Haploidentical hematopoietic-cell transplantation using post-transplant cyclophosphamide(Haplo-PTCy) is a feasible procedure in children with haematologic malignancies. However, data of a large series of children with acute leukaemia(AL) in this setting is missing. We analysed 144 AL Haplo-PTCy paediatric recipients; median age was 10 years. Patients had acute lymphoblastic(ALL; n = 86) or myeloblastic leukaemia(AML; n = 58) and were transplanted in remission(CR1: n = 40; CR2: n = 57; CR3+: n = 27) or relapse (n = 20). Bone marrow was the graft source in 57%; donors were father (54%), mother (35%), or sibling (11%). Myeloablative conditioning was used in 87%. Median follow-up was 31 months. At day +100, cumulative incidence (CI) of neutrophil recovery and acute GVHD (II-IV) were 94% and 40%, respectively. At 2-years, CI of chronic GVHD and relapse, were 31%, 40%, and estimated 2-year overall survival (OS), leukaemia-free survival (LFS) and graft-versus-host-relapse-free survival (GRFS) were 52%, 44% and 34% respectively. For patients transplanted in remission, positive measurable residual disease (MRD) prior to transplant was associated with decreased LFS (p = 0.05) and GRFS (p = 0.003) and increased risk of relapse (p = 0.02). Mother donor was associated with increased risk of chronic GVHD (p = 0.001), decreased OS (p = 0.03) and GRFS (p = 0.004). Use of PBSC was associated with increased risk of chronic GVHD (p = 0.04). In conclusion, achieving MRD negativity pre-transplant, avoiding use of mother donors and PBSC as graft source may improve outcomes of Haplo-PTCy in children with AL.
MeSH term(s)	Child ; Cyclophosphamide/therapeutic use ; Female ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/complications ; Mothers ; Neoplasm Recurrence, Local ; Peripheral Blood Stem Cells ; Retrospective Studies ; Transplantation Conditioning/methods ; Transplantation, Haploidentical/adverse effects
Chemical Substances	Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2021-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-021-01453-0
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Article ; Online: Occurrence of Neospora caninum and Toxoplasma gondii DNA in brain tissue from hoary foxes (Pseudalopex vetulus) in Brazil.

Nascimento, C O M / Silva, M L C R / Kim, P C P / Gomes, A A B / Gomes, A L V / Maia, R C C / Almeida, J C / Mota, R A

Acta tropica

2015 Volume 146, Page(s) 60–65

Abstract: The hoary fox (Pseudalopex vetulus) is a wild canid native to Brazil and is commonly found in the semiarid northeastern area living in contact with cattle. The main purpose of this study was to investigate the presence of Neospora caninum and Toxoplasma ... ...

Abstract	The hoary fox (Pseudalopex vetulus) is a wild canid native to Brazil and is commonly found in the semiarid northeastern area living in contact with cattle. The main purpose of this study was to investigate the presence of Neospora caninum and Toxoplasma gondii DNA in hoary foxes, in the state of Paraíba, Brazil. Brain tissue samples were collected from 49 hoary foxes. From the samples, DNA extraction and the polymerase chain reaction (PCR) were performed using specific primers for N. caninum and T. gondii. The prevalences found were 14.3% (7/49) for T. gondii and 12.2% (6/49) for N. caninum. The molecular identities of the amplified products were confirmed by means of the sequencing reaction. This study demonstrated the presence of N. caninum and T. gondii DNA in free-ranging hoary foxes in Brazil for the first time, thus confirming that this species is an intermediate host.
MeSH term(s)	Animals ; Brain/parasitology ; Brazil/epidemiology ; Cattle ; Coccidiosis/diagnosis ; DNA, Protozoan/isolation & purification ; Disease Vectors ; Foxes/parasitology ; Neospora/genetics ; Neospora/isolation & purification ; Polymerase Chain Reaction/veterinary ; Toxoplasma/genetics ; Toxoplasma/isolation & purification ; Toxoplasmosis, Animal/diagnosis ; Toxoplasmosis, Animal/parasitology
Chemical Substances	DNA, Protozoan
Language	English
Publishing date	2015-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2015.02.016
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Article ; Online: Validation of a Leishmania infantum ELISA rapid test for serological diagnosis of Leishmania chagasi in dogs.

Marcondes, M / Biondo, A W / Gomes, A A D / Silva, A R S / Vieira, R F C / Camacho, A A / Quinn, John / Chandrashekar, R

Veterinary parasitology

2011 Volume 175, Issue 1-2, Page(s) 15–19

Abstract: Canine visceral leishmaniasis (CVL) is caused by Leishmania donovani complex parasites including L. donovani, Leishmania infantum and Leishmania chagasi. As some studies suggest that L. chagasi and L. infantum may be very similar or even the same species, ...

Abstract	Canine visceral leishmaniasis (CVL) is caused by Leishmania donovani complex parasites including L. donovani, Leishmania infantum and Leishmania chagasi. As some studies suggest that L. chagasi and L. infantum may be very similar or even the same species, the aim of the present study was to evaluate a commercial rapid ELISA test, originally designed for L. infantum, in the diagnosis of CVL in dogs naturally infected by L. chagasi. A total of 400 serum canine samples, including 283 positive dogs for CVL from an endemic area, 86 clinically healthy dogs from a non-endemic area and 31 dogs seropositive for confounding infectious agents (Trypanosoma cruzi, Toxoplasma gondii, Neospora caninum, Babesia canis and Ehrlichia canis) were used for test validation. An overall sensitivity of 94.7% (95% CI=91.41-97.01%) and specificity of 90.6% (95% CI=83.80-95.21%) was found, with a high degree of agreement (k=0.8445) to the indirect ELISA. When confounding infectious diseases were excluded, specificity increased to 100% (95% CI=95.8-100%), with a higher degree of agreement (k=0.8928). In conclusion, the commercial kit designed for L. infantum was a highly sensitive and specific device for detection of L. chagasi infection in dogs, which indicates high immunoreactivity similarities between L. infantum and L. chagasi.
MeSH term(s)	Animals ; Dogs ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Leishmania infantum/immunology ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/veterinary ; Male ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2011-01-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2010.09.036
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Article: Validation of a Leishmania infantum ELISA rapid test for serological diagnosis of Leishmania chagasi in dogs

Marcondes, M / Biondo, A.W / Gomes, A.A.D / Silva, A.R.S / Vieira, R.F.C / Camacho, A.A / Quinn, John / Chandrashekar, R

Veterinary parasitology. 2011 Jan. 10, v. 175, no. 1-2

2011

Abstract	Canine visceral leishmaniasis (CVL) is caused by Leishmania donovani complex parasites including L. donovani, Leishmania infantum and Leishmania chagasi. As some studies suggest that L. chagasi and L. infantum may be very similar or even the same species, the aim of the present study was to evaluate a commercial rapid ELISA test, originally designed for L. infantum, in the diagnosis of CVL in dogs naturally infected by L. chagasi. A total of 400 serum canine samples, including 283 positive dogs for CVL from an endemic area, 86 clinically healthy dogs from a non-endemic area and 31 dogs seropositive for confounding infectious agents (Trypanosoma cruzi, Toxoplasma gondii, Neospora caninum, Babesia canis and Ehrlichia canis) were used for test validation. An overall sensitivity of 94.7% (95% CI=91.41-97.01%) and specificity of 90.6% (95% CI=83.80-95.21%) was found, with a high degree of agreement (k =0.8445) to the indirect ELISA. When confounding infectious diseases were excluded, specificity increased to 100% (95% CI=95.8-100%), with a higher degree of agreement (k =0.8928). In conclusion, the commercial kit designed for L. infantum was a highly sensitive and specific device for detection of L. chagasi infection in dogs, which indicates high immunoreactivity similarities between L. infantum and L. chagasi.
Keywords	Babesia canis ; Ehrlichia canis ; Leishmania donovani ; Leishmania infantum ; Neospora caninum ; Toxoplasma gondii ; Trypanosoma cruzi ; dogs ; enzyme-linked immunosorbent assay ; infectious diseases ; pathogens ; serodiagnosis ; visceral leishmaniasis
Language	English
Dates of publication	2011-0110
Size	p. 15-19.
Publishing place	Amsterdam; New York: Elsevier
Document type	Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2010.09.036
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