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Article ; Online: Metformin and lamotrigine sorption on a digestate amended soil in presence of trace metal contamination.

Baldasso, Veronica / Sayen, Stéphanie / Gomes, Carlos A R / Frunzo, Luigi / Almeida, C Marisa R / Guillon, Emmanuel

2024 Volume 466, Page(s) 133635

Abstract: The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate ... ...

Abstract	The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate their sorption behaviour on soil upon digestate application. Experiments were conducted on soil and digestate-amended soil as a function of time to study kinetic processes, and at equilibrium also regarding the influence of trace metals (Pb, Ni, Cr, Co, Cu, Zn) at ratio pharmaceutical/metal 1/1, 1/10, and 1/100. Pharmaceutical desorption experiments were also conducted to assess their potential mobility to groundwater. Results revealed that digestate amendment increased metformin and lamotrigine adsorbed amounts by 210% and 240%, respectively, increasing organic matter content. Metformin adsorption kinetics were best described by Langmuir model and those of lamotrigine by Elovich and intraparticle diffusion models. Trace metals did not significantly affect the adsorption of metformin in amended soil while significantly decreased that of lamotrigine by 12-39%, with exception for Cu
MeSH term(s)	Soil ; Metals, Heavy/analysis ; Lamotrigine ; Anticonvulsants ; Metformin ; Soil Pollutants/analysis ; Trace Elements ; Adsorption ; Pharmaceutical Preparations
Chemical Substances	Soil ; Metals, Heavy ; Lamotrigine (U3H27498KS) ; Anticonvulsants ; Metformin (9100L32L2N) ; Soil Pollutants ; Trace Elements ; Pharmaceutical Preparations
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133635
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Article ; Online: Study-test congruence of response levels in item stimulus-response priming.

Gomes, Carlos A / Mayes, Andrew

Memory & cognition

2020 Volume 48, Issue 5, Page(s) 839–855

Abstract: We investigated stimulus-response (S-R) memory links during object priming using a binary associative size judgement paradigm. At study, participants decided which of two objects was bigger in real life and, at test, made the same or the reverse ... ...

Abstract	We investigated stimulus-response (S-R) memory links during object priming using a binary associative size judgement paradigm. At study, participants decided which of two objects was bigger in real life and, at test, made the same or the reverse judgement. We examined the effects of response congruence on item S-R priming in the associative paradigm. In Experiment 1, a task reversal manipulation had minimal impact on RT priming when classifications were congruent for both recombined objects between study and test. Experiment 2 found that RT priming was more disrupted by classification incongruence of the selected than of the nonselected item alone, with incongruence of the nonselected object having no effect on RTs. Experiment 3, however, found that classification incongruence of both items eliminated RT priming, indicating that a significant effect of classification incongruence for the nonselected item is only evident if both items are classification-incongruent. Finally, across all experiments, we found that accuracy was more sensitive than RTs to decision/action incongruence. We interpret these findings in light of a two-stream account of S-R priming, and suggest a few extensions to account for interactions between S-R links of recombined items.
MeSH term(s)	Adult ; Humans ; Judgment ; Photic Stimulation ; Reaction Time ; Repetition Priming ; Young Adult
Language	English
Publishing date	2020-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	185691-1
ISSN	1532-5946 ; 0090-502X
ISSN (online)	1532-5946
ISSN	0090-502X
DOI	10.3758/s13421-020-01021-9
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Article ; Online: Can pupillometry distinguish accurate from inaccurate familiarity?

Gomes, Carlos A / Montaldi, Daniela / Mayes, Andrew

Psychophysiology

2021 Volume 58, Issue 8, Page(s) e13825

Abstract: Pupillometry, the measurement of pupil diameter, has become increasingly popular as a tool to investigate human memory. It has long been accepted that the pupil is able to distinguish familiar from completely novel items, a phenomenon known as "pupil old/ ...

Abstract	Pupillometry, the measurement of pupil diameter, has become increasingly popular as a tool to investigate human memory. It has long been accepted that the pupil is able to distinguish familiar from completely novel items, a phenomenon known as "pupil old/new effect". Surprisingly, most pupillometric studies on the pupil old/new effect tend to disregard the possibility that the pupillary response to familiarity memory may not be entirely exclusive. Here, we investigated whether the pupillary response to old items correctly judged familiar (hits; accurate familiarity) can be differentiated from the pupillary response to new items wrongly judged familiar (false alarms; inaccurate familiarity). We found no evidence that the two processes could be isolated, as both accurate and inaccurate familiarity showed nearly identical mean and across-time pupillary responses. However, both familiarity hits and false alarms showed pupillary responses unequivocally distinct from those observed during either recollection or novelty detection, which suggests that the pupil measure of familiarity hits and/or false alarms was sufficiently sensitive. The pupillary response to false alarms may have been partially driven by perceptual fluency, since novel objects incorrectly judged to be old (i.e., false alarms) showed a higher degree of similarity to studied images than items correctly judged as novel (i.e., correct rejections). Thus, our results suggest that pupil dilation may not be able to distinguish accurate from inaccurate familiarity using standard recognition memory paradigms, and they also suggest that the pupillary response during familiarity feelings may also partly reflect perceptual fluency.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Pupil/physiology ; Reaction Time/physiology ; Recognition, Psychology/physiology ; Visual Perception/physiology ; Young Adult
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.13825
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Article: Does long-term object priming depend on the explicit detection of object identity at encoding?

Gomes, Carlos A / Mayes, Andrew

Frontiers in psychology

2015 Volume 6, Page(s) 270

Abstract: It is currently unclear whether objects have to be explicitly identified at encoding for reliable behavioral long-term object priming to occur. We conducted two experiments that investigated long-term object and non-object priming using a selective- ... ...

Abstract	It is currently unclear whether objects have to be explicitly identified at encoding for reliable behavioral long-term object priming to occur. We conducted two experiments that investigated long-term object and non-object priming using a selective-attention encoding manipulation that reduces explicit object identification. In Experiment 1, participants either counted dots flashed within an object picture (shallow encoding) or engaged in an animacy task (deep encoding) at study, whereas, at test, they performed an object-decision task. Priming, as measured by reaction times (RTs), was observed for both types of encoding, and was of equivalent magnitude. In Experiment 2, non-object priming (faster RTs for studied relative to unstudied non-objects) was also obtained under the same selective-attention encoding manipulation as in Experiment 1, and the magnitude of the priming effect was equivalent between experiments. In contrast, we observed a linear decrement in recognition memory accuracy across conditions (deep encoding of Experiment 1 > shallow encoding Experiment 1 > shallow encoding of Experiment 2), suggesting that priming was not contaminated by explicit memory strategies. We argue that our results are more consistent with the identification/production framework than the perceptual/conceptual distinction, and we conclude that priming of pictures largely ignored at encoding can be subserved by the automatic retrieval of two types of instances: one at the motor level and another at an object-decision level.
Language	English
Publishing date	2015-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2015.00270
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Article ; Online: Temporal dynamics of fMRI signal changes during conditioned interoceptive pain-related fear and safety acquisition and extinction.

Labrenz, Franziska / Spisák, Tamás / Ernst, Thomas M / Gomes, Carlos A / Quick, Harald H / Axmacher, Nikolai / Elsenbruch, Sigrid / Timmann, Dagmar

Behavioural brain research

2022 Volume 427, Page(s) 113868

Abstract: Associative learning and memory mechanisms drive interoceptive signaling along the gut-brain axis, thus shaping affective-emotional reactions and behavior. Specifically, learning to predict potentially harmful, visceral pain is assumed to succeed within ... ...

Abstract	Associative learning and memory mechanisms drive interoceptive signaling along the gut-brain axis, thus shaping affective-emotional reactions and behavior. Specifically, learning to predict potentially harmful, visceral pain is assumed to succeed within very few trials. However, the temporal dynamics of cerebellar and cerebral fMRI signal changes underlying early acquisition and extinction of learned fear signals and the concomitant evolvement of safety learning remain incompletely understood. 3 T fMRI data of healthy individuals from three studies were uniformly processed across the whole brain and the cerebellum. All studies employed differential delay conditioning (N = 94) with one visual cue (CS
MeSH term(s)	Avoidance Learning ; Brain Mapping/methods ; Extinction, Psychological/physiology ; Fear/physiology ; Humans ; Magnetic Resonance Imaging ; Phobic Disorders ; Visceral Pain
Language	English
Publishing date	2022-03-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2022.113868
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Article: Temporal dynamics of fMRI signal changes during conditioned interoceptive pain-related fear and safety acquisition and extinction

Labrenz, Franziska / Spisák, Tamás / Ernst, Thomas M. / Gomes, Carlos A. / Quick, Harald H. / Axmacher, Nikolai / Elsenbruch, Sigrid / Timmann, Dagmar

Behavioural Brain Research

2022

Title translation	Zeitliche Dynamik von fMRI-Signaländerungen während des Erwerbs und der Löschung von konditionierter interozeptiver Angst und Sicherheit durch Schmerz (DeepL)
Abstract	Associative learning and memory mechanisms drive interoceptive signaling along the gut-brain axis, thus shaping affective-emotional reactions and behavior. Specifically, learning to predict potentially harmful, visceral pain is assumed to succeed within very few trials. However, the temporal dynamics of cerebellar and cerebral fMRI signal changes underlying early acquisition and extinction of learned fear signals and the concomitant evolvement of safety learning remain incompletely understood. 3 T fMRI data of healthy individuals from three studies were uniformly processed across the whole brain and the cerebellum. All studies employed differential delay conditioning (N = 94) with one visual cue (CS+) being repeatedly paired with visceral pain as unconditioned stimulus (US) while a second cue remained unpaired (CS-). During subsequent extinction (N = 51), all CS were presented without US. Behavioral results revealed increased CS+-aversiveness and CS--pleasantness after conditioning and diminished valence ratings for both CS following extinction. During early acquisition, the CS- induced linearly increasing neural activation in the insula, midcingulate cortex, hippocampus, precuneus as well as cerebral and cerebellar somatomotor regions. The comparison between acquisition and extinction phases yielded a CS- induced linear increase in the posterior cingulate cortex and precuneus during early acquisition, while there was no evidence for linear fMRI signal changes for the CS+ during acquisition and for both CS during extinction. Based on theoretical accounts of discrimination and temporal difference learning, these results suggest a gradual evolvement of learned safety cues that engage emotional arousal, memory, and cortical modulatory networks. As safety signals are presumably more difficult to learn and to discriminate from learned threat cues, the underlying temporal dynamics may reflect enhanced salience and prediction processing as well as increasing demands for attentional resources and the integration of multisensory information. Maladaptive responses to learned safety signals are a clinically relevant phenotype in multiple conditions, including chronic visceral pain, and can be exceptionally resistant to modification or extinction. Through sustained hypervigilance, safety seeking constitutes one key component in pain and stress-related avoidance behavior, calling for future studies targeting the mechanisms of safety learning and extinction to advance current cognitive-behavioral treatment approaches.
Keywords	Biological Neural Networks ; Biologische Neuronale Netze ; Brain ; Conditioned Fear ; Conditioning ; Extinction (Learning) ; Extinktion (Lernen) ; Gehirn ; Interoception ; Interozeption ; Konditionierte Furcht ; Konditionierung ; Pain ; Safety ; Schmerz ; Sicherheit (Unfallverhütung)
Language	English
Document type	Article
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2022.113868
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Article ; Online: Unmasking selective path integration deficits in Alzheimer's disease risk carriers.

Science advances

2020 Volume 6, Issue 35, Page(s) eaba1394

Abstract: Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD ( ...

Abstract	Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Apolipoprotein E4/genetics ; Entorhinal Cortex ; Heterozygote ; Humans ; Magnetic Resonance Imaging ; Young Adult
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aba1394
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Article: Unmasking selective path integration deficits in Alzheimer's disease risk carriers

Science Advances

2020 Volume 6, Issue 35, Page(s) No

Title translation	Aufdeckung selektiver Pfadintegrationsdefizite bei Alzheimer-Risikoträgern
Abstract	Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (APOE epsilon 4-carriers). Because the EC harbors grid cells, a likely neural substrate of path integration (PI), we examined PI performance in APOE epsilon 4-carriers during a virtual navigation task. We report a selective impairment in APOE epsilon 4-carriers specifically when recruitment of compensatory navigational strategies via supportive spatial cues was disabled. A separate fMRI study revealed that PI performance was associated with the strength of entorhinal grid-like representations when no compensatory strategies were available, suggesting grid cell dysfunction as a mechanistic explanation for PI deficits in APOE epsilon 4-carriers. Furthermore, posterior cingulate/retrosplenial cortex was involved in the recruitment of compensatory navigational strategies via supportive spatial cues. Our results provide evidence for selective PI deficits in AD risk carriers, decades before potential disease onset.
Keywords	Alzheimer's Disease ; Alzheimersche Krankheit ; Apolipoprotein E ; At Risk Populations ; Entorhinal Cortex ; Entorhinaler Kortex ; Functional Magnetic Resonance Imaging ; Funktionelle Magnetresonanztomographie ; Predisposition ; Prädisposition ; Risikogruppen ; Räumliche Navigation ; Spatial Navigation
Language	English
Document type	Article
ZDB-ID	2810933-8
ISSN	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aba1394
Database	PSYNDEX

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Article: N-(2-Carboxyethyl)chitosans: regioselective synthesis, characterisation and protolytic equilibria.

Skorik, Yury A / Gomes, Carlos A R / Vasconcelos, M Teresa S D / Yatluk, Yury G

Carbohydrate research

2003 Volume 338, Issue 3, Page(s) 271–276

Abstract: N-(2-Carboxyethyl)chitosans were obtained by reaction of low molecular weight chitosan with a low degree of acetylation and 3-halopropionic acids under mild alkaline media (pH 8-9, NaHCO3) at 60 degrees C. The chemical structure of the derivatives ... ...

Abstract	N-(2-Carboxyethyl)chitosans were obtained by reaction of low molecular weight chitosan with a low degree of acetylation and 3-halopropionic acids under mild alkaline media (pH 8-9, NaHCO3) at 60 degrees C. The chemical structure of the derivatives obtained was determined by 1H and 13C NMR spectroscopies. It was found that alkylation of chitosan by 3-halopropionic acids proceeds exclusively at the amino groups. The products obtained are described in terms of their degrees of carboxyethylation and ratio of mono-, di-substitution and free amine content. The protonation constants of amino and carboxylate groups of a series of N-(2-carboxyethyl)chitosans were determined by pH-titration at ionic strength 0.1 M KNO3 and 25 degrees C.
MeSH term(s)	Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Chitin/analogs & derivatives ; Chitin/chemical synthesis ; Chitin/chemistry ; Chitosan ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Static Electricity
Chemical Substances	Biocompatible Materials ; Chitin (1398-61-4) ; Chitosan (9012-76-4)
Language	English
Publishing date	2003-01-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/s0008-6215(02)00432-9
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Article: Complexation models of N-(2-carboxyethyl)chitosans with copper(II) ions.

Skorik, Yury A / Gomes, Carlos A R / Podberezskaya, Nina V / Romanenko, Galina V / Pinto, Luiz F / Yatluk, Yury G

Biomacromolecules

2005 Volume 6, Issue 1, Page(s) 189–195

Abstract: The copper(II) complex formation equilibria of N-(2-carboxyethyl)chitosans with three different degrees of substitution (DS = 0.42, 0.92, and 1.61) were studied in aqueous solution by pH-potentiometric and UV-spectrophotometric techniques. It was ... ...

Abstract	The copper(II) complex formation equilibria of N-(2-carboxyethyl)chitosans with three different degrees of substitution (DS = 0.42, 0.92, and 1.61) were studied in aqueous solution by pH-potentiometric and UV-spectrophotometric techniques. It was demonstrated that the complexation model of CE-chitosans depends on DS: the [Cu(Glc-NR(2))(2)] complexes are predominant for two lower substituted samples ("bridge model", log beta(12) = 10.06 and 11.6, respectively), whereas the increase of DS leads to formation mainly of the [Cu(Glc-NR(2))] complexes ("pendant model", log beta(11) = 6.41). As a model for copper complexation with a disubstituted residue of CE-chitosan, the complex of N-methyliminodipropionate [CuMidp(H(2)O)].(H(2)O) was synthesized and structurally characterized by XRD. The unit cell consists of two crystallographically nonequivalent Cu atoms having slightly distorted square pyramidal coordination; Midp constitutes the basal plane of the pyramid and acts as a tetradentate NO(3) chelate-bridging ligand by the formation of two six-membered chelate rings (average Cu-O 1.99 A, Cu-N 2.04 A) and a bridge via carbonyl O atom (average Cu-O 1.99 A), an apical position is occupied by a water molecule (average Cu-Ow 2.30 A).
MeSH term(s)	Carbohydrate Conformation ; Carbohydrate Sequence ; Chitosan/analogs & derivatives ; Chitosan/chemistry ; Copper/chemistry ; Crystallography, X-Ray ; Hydrogen-Ion Concentration ; Models, Molecular ; Molecular Sequence Data ; Organometallic Compounds/chemistry ; Potentiometry/methods ; Spectrophotometry, Ultraviolet/methods
Chemical Substances	Organometallic Compounds ; Copper (789U1901C5) ; Chitosan (9012-76-4)
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1525-7797
ISSN	1525-7797
DOI	10.1021/bm049597r
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