Article ; Online: Immune System Efficiency in Cancer and the Microbiota Influence.
Pathobiology : journal of immunopathology, molecular and cellular biology
2021 Volume 88, Issue 2, Page(s) 170–186
Abstract: The immune system plays a critical role in preventing cancer development and progression. However, the complex network of cells and soluble factor that form the tumor microenvironment (TME) can dictate the differentiation of tumor-infiltrating leukocytes ...
| Abstract | The immune system plays a critical role in preventing cancer development and progression. However, the complex network of cells and soluble factor that form the tumor microenvironment (TME) can dictate the differentiation of tumor-infiltrating leukocytes and shift the antitumor immune response into promoting tumor growth. With the advent of cancer immunotherapy, there has been a reinvigorated interest in defining how the TME shapes the antitumor immune response. This interest brought to light the microbiome as a novel player in shaping cancer immunosurveillance. Indeed, accumulating evidence now suggests that the microbiome may confer susceptibility or resistance to certain cancers and may influence response to therapeutics, particularly immune checkpoint inhibitors. As we move forward into the age of precision medicine, it is vital that we define the factors that influence the interplay between the triad immune system-microbiota-cancer. This knowledge will contribute to improve the therapeutic response to current approaches and will unravel novel targets for immunotherapy. |
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| MeSH term(s) | Animals ; Clinical Trials as Topic ; Disease Resistance ; Disease Susceptibility/microbiology ; Humans ; Immune System/pathology ; Immunotherapy/methods ; Mice ; Microbiota ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Precision Medicine ; Tumor Microenvironment |
| Language | English |
| Publishing date | 2021-02-15 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 1022703-9 |
| ISSN | 1423-0291 ; 1015-2008 |
| ISSN (online) | 1423-0291 |
| ISSN | 1015-2008 |
| DOI | 10.1159/000512326 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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