Article ; Online: Neuroanatomical characterization of the G protein-coupled receptor activity evoked by galanin-related ligands.
Journal of chemical neuroanatomy
2022 Volume 128, Page(s) 102226
Abstract: Galanin neuropeptide is distributed throughout the mammalian nervous system modulating a plethora of diverse physiological functions, including nociception, cognition and neuroendocrine regulation. The regulation of the galaninergic system is an ... ...
Abstract | Galanin neuropeptide is distributed throughout the mammalian nervous system modulating a plethora of diverse physiological functions, including nociception, cognition and neuroendocrine regulation. The regulation of the galaninergic system is an interesting approach for the treatment of different diseases associated to those systems. Nevertheless, the pharmacological selectivity and activities of some galanin receptor (GalR) ligands are still in discussion and seem to depend on the dose, the receptor subtype and the second messengers to which they are coupled at different brain areas. The activity of different GalR ligands on G |
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MeSH term(s) | Rats ; Animals ; Galanin/metabolism ; Receptors, Galanin/metabolism ; Ligands ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology ; Brain/metabolism ; Peptide Hormones/metabolism ; Mammals |
Chemical Substances | Galanin (88813-36-9) ; Receptors, Galanin ; Ligands ; Guanosine 5'-O-(3-Thiotriphosphate) (37589-80-3) ; Peptide Hormones |
Language | English |
Publishing date | 2022-12-23 |
Publishing country | Netherlands |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 639443-7 |
ISSN | 1873-6300 ; 0891-0618 |
ISSN (online) | 1873-6300 |
ISSN | 0891-0618 |
DOI | 10.1016/j.jchemneu.2022.102226 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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