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Book ; Online: Plant Genetics and Molecular Breeding

Martínez-Gómez, Pedro

2019

Abstract: The development of new plant varieties is a long and tedious process involving the generation of large seedling populations for the selection of the best individuals. While the ability of breeders to generate large populations is almost unlimited, the ... ...

Abstract	The development of new plant varieties is a long and tedious process involving the generation of large seedling populations for the selection of the best individuals. While the ability of breeders to generate large populations is almost unlimited, the selection of these seedlings is the main factor limiting the generation of new cultivars. Molecular studies for the development of marker-assisted selection (MAS) strategies are particularly useful when the evaluation of the character is expensive, time-consuming, or with long juvenile periods. The papers published in the Special Issue "Plant Genetics and Molecular Breeding" report highly novel results and testable new models for the integrative analysis of genetic (phenotyping and transmission of agronomic characters), physiology (flowering, ripening, organ development), genomic (DNA regions responsible for the different agronomic characters), transcriptomic (gene expression analysis of the characters), proteomic (proteins and enzymes involved in the expression of the characters), metabolomic (secondary metabolites), and epigenetic (DNA methylation and histone modifications) approaches for the development of new MAS strategies. These molecular approaches together with an increasingly accurate phenotyping will facilitate the breeding of new climate-resilient varieties resistant to abiotic and biotic stress, with suitable productivity and quality, to extend the adaptation and viability of the current varieties
Keywords	Science (General) ; Biology (General)
Size	1 electronic resource (628 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	eng ; Open Access
HBZ-ID	HT020307381
ISBN	9783039211753 ; 9783039211760 ; 3039211757 ; 3039211765
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Effectiveness of stress arousal reappraisal and stress-is-enhancing mindset interventions on task performance outcomes: a meta-analysis of randomized controlled trials.

Bosshard, Michel / Gomez, Patrick

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7923

Abstract: Stress arousal reappraisal (SAR) and stress-is-enhancing (SIE) mindset interventions aim to promote a more adaptive stress response by educating individuals about the functionality of stress. As part of this framework, an adaptive stress response is ... ...

Abstract	Stress arousal reappraisal (SAR) and stress-is-enhancing (SIE) mindset interventions aim to promote a more adaptive stress response by educating individuals about the functionality of stress. As part of this framework, an adaptive stress response is coupled with improved performance on stressful tasks. The goal of this meta-analysis is to evaluate the effectiveness of these interventions on task performance. The literature search yielded 44 effect sizes, and a random-effects model with Knapp-Hartung adjustment was used to pool them. The results revealed an overall small significant improvement in task performance (d = 0.23, p < 0.001). The effect size was significantly larger for mixed interventions (i.e., SAR/SIE mindset instructions combined with additional content, k = 5, d = 0.45, p = 0.004) than SAR-only interventions (k = 33, d = 0.22, p < 0.001) and SIE mindset-only interventions (k = 6, d = 0.18, p = 0.22) and tended to be larger for public performance tasks than cognitive written tasks (k = 14, d = 0.34, p < 0.001 vs. k = 30, d = 0.20, p = 0.002). Although SAR and SIE mindset interventions are not "silver bullets", they offer a promising cost-effective low-threshold approach to improve performance across various domains.
MeSH term(s)	Humans ; Task Performance and Analysis ; Randomized Controlled Trials as Topic ; Motivation
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58408-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Long-Term Monitoring of Aphid-Transmitted Viruses in Melon and Zucchini Crops: Genetic Diversity and Population Structure of Cucurbit Aphid-Borne Yellows Virus and Watermelon Mosaic Virus.

Rabadán, M P / Juárez, M / Gómez, P

Phytopathology

2023 Volume 113, Issue 9, Page(s) 1761–1772

Abstract: Understanding the emergence and prevalence of viral diseases in crops requires the systematic epidemiological monitoring of viruses, as well as the analysis of how ecological and evolutionary processes combine to shape viral population dynamics. Here, we ...

Abstract	Understanding the emergence and prevalence of viral diseases in crops requires the systematic epidemiological monitoring of viruses, as well as the analysis of how ecological and evolutionary processes combine to shape viral population dynamics. Here, we extensively monitored the occurrence of six aphid-transmitted viruses in melon and zucchini crops in Spain for 10 consecutive cropping seasons between 2011 and 2020. The most prevalent viruses were cucurbit aphid-borne yellows virus (CABYV) and watermelon mosaic virus (WMV), found in 31 and 26% of samples with yellowing and mosaic symptoms. Other viruses, such as zucchini yellow mosaic virus, cucumber mosaic virus, Moroccan watermelon mosaic virus, and papaya ring spot virus, were detected less frequently (<3%) and mostly in mixed infections. Notably, our statistical analysis showed a significant association between CABYV and WMV in melon and zucchini hosts, suggesting that mixed infections might be influencing the evolutionary epidemiology of these viral diseases. We then carried out a comprehensive genetic characterization of the full-length genome sequences from CABYV and WMV isolates by using the Pacific Biosciences single-molecule real-time (PacBio) high-throughput technology to assess the genetic variation and structure of their populations. Our results showed that the CABYV population displayed seven codons under positive selection, and although most isolates clustered in the Mediterranean clade, a subsequent analysis of molecular variance revealed a significant, fine-scale temporal structure, which was in part explained by the level of the variance between isolates from single and mixed infections. In contrast, the WMV population genetic analysis showed that most of the isolates grouped into the Emergent clade, with no genetic differentiation and under purifying selection. These results underlie the epidemiological relevance of mixed infections for CABYV and provide a link between genetic diversity and CABYV dynamics at the whole-genome level.
MeSH term(s)	Animals ; Cucurbitaceae ; Aphids ; Cucurbita ; Coinfection ; Plant Diseases ; Luteoviridae/genetics ; Crops, Agricultural ; Vegetables ; Genetic Variation ; Virus Diseases
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-10-22-0394-V
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Article: Three dimensional analysis of the exhalation flow in the proximity of the mouth.

Berlanga, F A / Gomez, P / Esteban, A / Liu, L / Nielsen, P V

Heliyon

2024 Volume 10, Issue 4, Page(s) e26283

Abstract: The human exhalation flow is characterized in this work from the three-dimensional velocimetry results obtained by using the stereo particle image velocimetry (SPIV) measurement technique on the flow emitted from a realistic airway model. For this ... ...

Abstract	The human exhalation flow is characterized in this work from the three-dimensional velocimetry results obtained by using the stereo particle image velocimetry (SPIV) measurement technique on the flow emitted from a realistic airway model. For this purpose, the transient exhalation flow through the mouth of a person performing two different breaths corresponding to two metabolic rates, standing relaxed (SR) and walking active (WA), is emulated and studied. To reproduce the flow realistically, a detailed three-dimensional model obtained from computed tomography measurements on real subjects is used. To cope with the variability of the experimental data, a subsequent analysis of the results is performed using the TR-PIV (time resolved particle image velocimetry) technique. Exhalation produces a transient jet that becomes a puff when flow emission ends. Three-dimensional vector fields of the jet velocity are obtained in five equally spaced transverse planes up to a distance of Image 1 from the mouth at equally spaced time instants Image 2 which will be referred to as phases (
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26283
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Article ; Online: Type 1 Diabetes Screening and Diagnosis.

Gomez, Patricia / Sanchez, Janine

Endocrinology and metabolism clinics of North America

2023 Volume 53, Issue 1, Page(s) 17–26

Abstract: Those with concerning signs or symptoms should be evaluated for type 1 diabetes (T1D). Those with first-degree relatives with T1D or based on the presence of high-risk genes are at increased risk and benefit from screening. Universal screening should be ... ...

Abstract	Those with concerning signs or symptoms should be evaluated for type 1 diabetes (T1D). Those with first-degree relatives with T1D or based on the presence of high-risk genes are at increased risk and benefit from screening. Universal screening should be considered in light of new potential therapies to delay disease progression. Although oral glucose tolerance test is the gold standard for T1D staging, there are multiple tools available when oral glucose tolerance test is not feasible. Risk score calculations increase the ability to predict disease progression. Testing should be repeated when symptoms of overt diabetes mellitus are not present.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/diagnosis ; Risk Factors ; Disease Progression
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2023.09.008
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Article ; Online: Persistent Hypoglycemia and Hyperinsulinism in a Patient With

Nunez Stosic, Mariana / Gomez, Patricia

JCEM case reports

2023 Volume 1, Issue 2, Page(s) luad032

Abstract: We report a 3-year-old girl with persistent hypoglycemia and hyperinsulinism secondary ... ...

Abstract	We report a 3-year-old girl with persistent hypoglycemia and hyperinsulinism secondary to
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luad032
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Article: [No title information]

Montano Gomez, Pedro

Journal international de bioethique et d'ethique des sciences

2021 Volume 33, Issue 1, Page(s) 85–101

Abstract: There are many reasons why we might think that the human species might be in danger. We talk about global warming which produces major unusual natural disasters; increasingly destructive weapons; serious terrorist attacks with chemical weapons, etc. But ... ...

Title translation	Chapitre 5. La protección de la especie humana. El rol del Derecho.
Abstract	There are many reasons why we might think that the human species might be in danger. We talk about global warming which produces major unusual natural disasters; increasingly destructive weapons; serious terrorist attacks with chemical weapons, etc. But we cannot ignore one of the threats hanging over the human species, which is transhumanism or posthumanism. It is from the point of view of this last subject, on which much has already been written, that we will try to focus our analysis, paying particular attention to the question relating to gene editing (CRISPR/Cas 9).
MeSH term(s)	Gene Editing ; Humans
Language	Spanish
Publishing date	2021-07-11
Publishing country	France
Document type	Journal Article
ISSN	2608-1008
ISSN	2608-1008
DOI	10.3917/jibes.331.0085
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Article ; Online: La mediación sanitaria en Chile.

Munuera Gómez, Pilar

Revista medica de Chile

2021 Volume 148, Issue 6, Page(s) 792–798

Abstract: Mediation can approximate opposing positions and reach agreements that offer viable solutions for the problems posed by parties. The favorable results, the statements of the professionals and the welfare of the parties who participate in it are some of ... ...

Title translation	Medical mediation in the international context.
Abstract	Mediation can approximate opposing positions and reach agreements that offer viable solutions for the problems posed by parties. The favorable results, the statements of the professionals and the welfare of the parties who participate in it are some of the reasons for its growth. Its fields of action are diverse, creating a space where the protagonists solve their problems and transform their relationships without having to resort to lengthy and costly legal processes to reach valid agreements. Mediation allows to dejudicialize health care and improve the relationships that are created in all its services. Its implantation in health organizations will favor a more humanized attention by eliminating conflicts, thus elevating the quality and degree of well-being of all the professionals who participate.
MeSH term(s)	Delivery of Health Care ; Humans ; Negotiating
Language	Spanish
Publishing date	2021-01-22
Publishing country	Chile
Document type	Journal Article
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/S0034-98872020000600792
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Article ; Online: Effects of low nitrogen supply on biochemical and physiological parameters related to nitrate and water, involving nitrate transporters and aquaporins in Citrus macrophylla.

Garcia-Gomez, P / Olmos-Ruiz, R / Nicolas-Espinosa, J / Carvajal, M

Plant biology (Stuttgart, Germany)

2023 Volume 25, Issue 6, Page(s) 944–955

Abstract: A reduction in chemical N-based fertillizer was investigated in Citrus plants. As N and water uptake are connected, the relationship between the physiological response to reductions in N was studied in relation to N metabolism and water. We examined the ... ...

Abstract	A reduction in chemical N-based fertillizer was investigated in Citrus plants. As N and water uptake are connected, the relationship between the physiological response to reductions in N was studied in relation to N metabolism and water. We examined the response of new and mature leaves and roots of Citrus macrophylla, grown under controlled conditions, and given different concentrations of N: 16, 8 or 4 mM. Differences in growth and development were determined for biochemical (mineral content, photosynthetic pigments, proteins and nitrate and nitrite reductase activity), physiological (photosynthesis and transpiration), and molecular (relative expression of nitrate transporters and aquaporins) parameters. Only plants given 4 mM N showed a reduction in growth. Although there were changes in NR activity, protein synthesis, and chlorophyll content in both 8 and 4 mM N plants that were highly related to aquaporin and nitrate transporter expression. The results revealed new findings on the relationship between aquaporins and nitrate transporters in new leaves of Citrus, suggesting a mechanism for ensuring growth under low N when new tissues are being formed.
MeSH term(s)	Nitrates/metabolism ; Nitrate Transporters ; Nitrogen/metabolism ; Water/metabolism ; Citrus ; Plant Leaves/metabolism ; Aquaporins/metabolism ; Aquaporins/pharmacology ; Plant Roots/metabolism
Chemical Substances	Nitrates ; Nitrate Transporters ; Nitrogen (N762921K75) ; Water (059QF0KO0R) ; Aquaporins
Language	English
Publishing date	2023-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1464075-2
ISSN	1438-8677 ; 1435-8603
ISSN (online)	1438-8677
ISSN	1435-8603
DOI	10.1111/plb.13553
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Article ; Online: Analysis of oncological drugs authorised in Spain in the last decade: association between clinical benefit and reimbursement.

Nieto-Gómez, P / Castaño-Amores, C / Rodríguez-Delgado, A / Álvarez-Sánchez, R

The European journal of health economics : HEPAC : health economics in prevention and care

2023 Volume 25, Issue 2, Page(s) 257–267

Abstract: Background: Our study aimed to assess whether there was a relationship between clinical benefits and reimbursement decisions as well as the inclusion of economic evaluations in therapeutic positioning reports (IPTs) and to explore factors influencing ... ...

Abstract	Background: Our study aimed to assess whether there was a relationship between clinical benefits and reimbursement decisions as well as the inclusion of economic evaluations in therapeutic positioning reports (IPTs) and to explore factors influencing reimbursement decisions. Materials and methods: We analysed all anti-cancer drugs approved in Spain from 2010 to September 2022. The clinical benefit of each drug were evaluated using the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) 1.1. The characteristics of these drugs were obtained from the Spanish Agency of Medicines and Medical Devices. Reimbursement status information was obtained using BIFIMED, a web resource available in Spanish and consulted the agreements of the Interministerial Committee on Pricing of Medicines (CIPM). Results: In total, 73 drugs were included involving 197 indications. Almost half of the indications had substantial clinical benefit (49.8% yes vs. 50.3% no). Of the 153 indications with a reimbursement decision, 61 (56.5%) reimbursed indications had substantial clinical benefit compared to 14 (31.1%) of the non-reimbursed (p < 0.01). The median gain of overall survival was 4.9 months (2.8-11.2) for reimbursed indications and 2.9 months (1.7-5) in non-reimbursed (p < 0.05). Only six (3%) indications had an economic evaluation in the IPT. Conclusion: Our study revealed that there is a relationship between substantial clinical benefit and the reimbursement decision in Spain. However, we also found that the overall survival gain was modest, and a significant proportion of the reimbursed indications had no substantial clinical benefit. Economic evaluations in IPTs are infrequent and cost-effectiveness analysis is not provided by CIPM.
MeSH term(s)	Humans ; Spain ; Antineoplastic Agents/therapeutic use ; Medical Oncology ; Cost-Benefit Analysis ; Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2045253-6
ISSN	1618-7601 ; 1618-7598
ISSN (online)	1618-7601
ISSN	1618-7598
DOI	10.1007/s10198-023-01584-9
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