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  1. Article ; Online: Management of upper gastrointestinal symptoms in patients with autoimmune gastritis.

    Gomez Cifuentes, Juan D / Sparkman, Jordan / Graham, David Y

    Current opinion in gastroenterology

    2022  Volume 38, Issue 6, Page(s) 600–606

    Abstract: Purpose of review: Autoimmune gastritis is characterized by atrophy of acid secreting parietal cells resulting in achlorhydria. Upper gastrointestinal symptoms are common in autoimmune gastritis and frequently result in prescriptions for acid ... ...

    Abstract Purpose of review: Autoimmune gastritis is characterized by atrophy of acid secreting parietal cells resulting in achlorhydria. Upper gastrointestinal symptoms are common in autoimmune gastritis and frequently result in prescriptions for acid suppressant medications despite the inability of the stomach to secrete acid. Evidence-based recommendations for management of gastrointestinal symptoms in autoimmune gastritis are lacking.
    Recent findings: The most common symptoms in patients with autoimmune gastritis are dyspepsia, heartburn, and regurgitation. Gastroesophageal reflux should be confirmed by pH-impedance testing and is typically weakly acid or alkaline. Therapy for reflux focuses on mechanical prevention of reflux (i.e., elevation of the head of the bed and alginates) or when severe, antireflux surgery. The etiology of dyspepsia in autoimmune gastritis is unclear and largely unstudied. In the first half of the 20th century, oral administration of acid to "aid digestion" was widely used with reported success. However, randomized, placebo-controlled trials are lacking. Here, we provide suggestions for attempting gastric acidification therapy.
    Summary: Upper GI symptoms are common in autoimmune gastritis. Their pathogenesis and therapy remain incompletely understood. Acid suppressant medications are useless and should be discontinued. A trial of acid replacement therapy is recommended especially in the form of placebo-controlled trials.
    MeSH term(s) Alginates/therapeutic use ; Dyspepsia/drug therapy ; Gastritis/diagnosis ; Gastritis/drug therapy ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/therapy ; Heartburn/drug therapy ; Humans
    Chemical Substances Alginates
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000878
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    Zs.A 2072: Show issues Location:
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  2. Article ; Online: Curious Colonoscopy Findings in a Patient With Autosomal Dominant Polycystic Kidney Disease.

    Mathew, Christo / Gomez Cifuentes, Juan D / Mansour, Nabil M

    Gastroenterology

    2022  Volume 162, Issue 6, Page(s) 1595–1596

    MeSH term(s) Colonoscopy ; Female ; Humans ; Kidney ; Male ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.01.055
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  3. Article ; Online: Closure of refractory gastrocutaneous fistula with endoscopically guided percutaneous suturing with the use of miniature biopsy forceps.

    Garcia, Rogelio / Gomez Cifuentes, Juan D / Aloor, Fuad / Keihanian, Tara / Ryou, Marvin / Abidi, Wasif M

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 8, Issue 7, Page(s) 260–262

    Abstract: Video 1Closure of a refractory gastrocutaneous fistula with endoscopically guided percutaneous suturing with the use of miniature biopsy forceps. ...

    Abstract Video 1Closure of a refractory gastrocutaneous fistula with endoscopically guided percutaneous suturing with the use of miniature biopsy forceps.
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2023.03.006
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  4. Article ; Online: Relief of malignant gastric outlet obstruction with lumen-apposing metallic stent-assisted percutaneous endoscopic gastrostomy tube after Roux-en-Y gastric bypass.

    Berger, Scott N / Gomez Cifuentes, Juan D / Keihanian, Tara / Abidi, Wasif M / Patel, Kalpesh K

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 8, Issue 2, Page(s) 64–67

    Abstract: Video 1Xxx. ...

    Abstract Video 1Xxx.
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2022.09.005
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  5. Article ; Online: New Model to Predict Recurrence After Endoscopic Mucosal Resection of Non-pedunculated Colonic Polyps ≥ 20 mm.

    Gomez Cifuentes, Juan D / Berger, Scott / Caskey, Kadon / Jove, Andre / Sealock, Robert / Hair, Clark / Velez, Maria / Jarbrink-Sehgal, Maria / Thrift, Aaron P / da Costa, Wilson L / Gyanprakash, Ketwaroo

    Digestive diseases and sciences

    2023  Volume 68, Issue 10, Page(s) 3935–3942

    Abstract: Background: Polyp recurrence is common after endoscopic mucosal resection (EMR) of non-pedunculated colonic polyps ≥ 20 mm. Two models haven been published for polyp recurrence prediction: Sydney EMR recurrence tool (SERT) and the size, morphology, ... ...

    Abstract Background: Polyp recurrence is common after endoscopic mucosal resection (EMR) of non-pedunculated colonic polyps ≥ 20 mm. Two models haven been published for polyp recurrence prediction: Sydney EMR recurrence tool (SERT) and the size, morphology, colonic site, and access to target (SMSA) score. None of these models have been evaluated in a real-world United States (U.S.) cohort. We aimed to evaluate the external validity of these two models and develop a new model.
    Methods: Retrospective cohort study of patients with non-pedunculated polyps ≥ 20 mm that underwent EMR between 1/1/2012 and 6/30/2020. Univariate and multivariate analysis were performed to identify predictors of polyp recurrence to build a new model. Receiver Operating Characteristic (ROC) curves for the new model, SERT and a modified version of SMSA were derived and compared.
    Results: A total of 461 polyps from 461 unique patients were included for analysis. The average polyp size was 29.1 ± 12.4 mm. Recurrence rate at first or second surveillance colonoscopy was 29.0% at a 15.6 months median follow up (IQR 12.3-17.4). A model was created with 4 variables from index colonoscopy: size > 40 mm, tubulovillous adenoma histology, right colon location and piecemeal resection. ROC curves showed that the Area Under the ROC (AUC) for the new model was 0.618, for SERT 0.538 and for mSMSA 0.550.
    Conclusion: SERT score and mSMSA have poor external validity to predict polyp recurrence after EMR of non-pedunculated polyps > 20 mm. Our new model is simpler and performs better in this multiethnic, non-referral cohort from the U.S.
    MeSH term(s) Humans ; Colonic Polyps/surgery ; Colonic Polyps/pathology ; Endoscopic Mucosal Resection ; Retrospective Studies ; Colonoscopy ; Colorectal Neoplasms/pathology
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-08054-5
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  6. Article: Regarding: Lui RN, Wong SH, Sánchez-Luna SA, et al. Overview of guidance for endoscopy during the coronavirus disease 2019 pandemic. J Gastroenterol Hepatol. 2020;35(5):749-759. doi:10.1111/jgh.15053

    Gomez Cifuentes, Juan D / Sparkman, Jordan / Choi, Kati / Sealock, Robert J

    J. gastroenterol. hepatol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32503087
    Database COVID19

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  7. Article ; Online: Evolution of endoscopic mucosal resection (EMR) technique and the reduced recurrence of large colonic polyps from 2012 to 2020.

    Gomez Cifuentes, Juan D / Berger, Scott / Caskey, Kadon / Jove, Andre / Sealock, Robert J / Hair, Clark / Velez, Maria / Jarbrink-Sehgal, Maria / Thrift, Aaron P / da Costa, Wilson / Gyanprakash, Ketwaroo

    Scandinavian journal of gastroenterology

    2022  Volume 58, Issue 4, Page(s) 435–440

    Abstract: Background: Endoscopic mucosal resection (EMR) is an effective method for removing non-pedunculated polyps ≥ 20 mm. We aimed to examine changes in EMR techniques over a 9-year period and evaluate frequency of histologic-confirmed recurrence.: Methods!# ...

    Abstract Background: Endoscopic mucosal resection (EMR) is an effective method for removing non-pedunculated polyps ≥ 20 mm. We aimed to examine changes in EMR techniques over a 9-year period and evaluate frequency of histologic-confirmed recurrence.
    Methods: We identified patients who underwent EMR of non-pedunculated polyps ≥ 20 mm at a safety net and the Veteran's Affairs (VA) hospital in Houston, Texas between 2012 and 2020. Odds ratios (ORs) and 95% confidence intervals (CI) for associations with recurrence risk were estimated using multivariable logistic regression.
    Results: 461 unique patients were included. The histologic-confirmed recurrence was 29.0% at 15.6 months median follow up (IQR 12.3 - 17.4). Polyps removed between 2018 and 2020 had a 0.43 decreased odds of recurrence
    Conclusions: Histologic-confirmed recurrence after EMR for non-pedunculated polyps ≥ 20 mm decreased over the seven year-period. Saline was associated with a higher risk of recurrence and the use of more viscous agents increased over time.
    MeSH term(s) Humans ; Colonic Polyps/surgery ; Endoscopic Mucosal Resection/methods ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2022.2134734
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    Zs.A 567: Show issues Location:
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  8. Article ; Online: Clinical Risk Prediction Model for Neoadjuvant Therapy in Resectable Esophageal Adenocarcinoma.

    Thota, Prashanthi N / Alkhayyat, Motasem / Gomez Cifuentes, Juan D / Haider, Mahnur / Bena, James / McMichael, John / Sohal, Davender P / Raja, Siva / Sanaka, Madhusudhan R

    Journal of clinical gastroenterology

    2020  Volume 56, Issue 2, Page(s) 125–132

    Abstract: Goals and background: Clinical staging with endoscopic ultrasound (EUS) and positron emission tomography (PET) is used to identify esophageal adenocarcinoma (EAC) patients with locally advanced disease and therefore, benefit from neoadjuvant therapy. ... ...

    Abstract Goals and background: Clinical staging with endoscopic ultrasound (EUS) and positron emission tomography (PET) is used to identify esophageal adenocarcinoma (EAC) patients with locally advanced disease and therefore, benefit from neoadjuvant therapy. However, EUS is operator dependent and subject to interobserver variability. Therefore, we aimed to identify clinical predictors of locally advanced EAC and build a predictive model that can be used as an adjunct to current staging methods.
    Study: This was a cross-sectional study of patients with EAC who underwent preoperative staging with EUS and PET scan followed by definitive therapy at our institution from January 2011 to December 2017. Demographic data, symptoms, endoscopic findings, EUS, and PET scan findings were obtained.
    Results: Four hundred and twenty-six patients met the study criteria, of which 86 (20.2%) patients had limited stage EAC and 340 (79.8%) had locally advanced disease. The mean age was 65.4±10.3 years of which 356 (83.6%) were men and 393 (92.3%) were White. On multivariable analysis, age (above 75 or below 65 y), dysphagia [odds ratio (OR): 2.84], weight loss (OR: 2.06), protruding tumor (OR: 2.99), and tumor size >2 cm (OR: 3.3) were predictive of locally advanced disease, while gastrointestinal bleeding (OR: 0.36) and presence of visible Barrett's esophagus (OR: 0.4) were more likely to be associated with limited stage. A nomogram for predicting the risk of locally advanced EAC was constructed and internally validated.
    Conclusions: We constructed a nomogram to facilitate an individualized prediction of the risk of locally advanced EAC. This model can aid in decision making for neoadjuvant therapy in EAC.
    MeSH term(s) Adenocarcinoma/diagnosis ; Aged ; Barrett Esophagus/pathology ; Cross-Sectional Studies ; Esophageal Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Predictive Value of Tests
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001489
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