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  1. AU="Gomez-Pinedo, Ulises"
  2. AU="König, Philipp"
  3. AU=DeRosa Antonio P

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  1. Article: Editorial: Current advances in genetic presentations of dementia and aging, volume II.

    Xu, Yuzhen / Gomez-Pinedo, Ulises / Liu, Jun / Hong, Daojun / Xu, Jun

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1202532

    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1202532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Current advances in genetic dementia and aging.

    Xu, Yuzhen / Hong, Daojun / Gomez-Pinedo, Ulises / Liu, Jun / Xu, Jun

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 1020547

    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1020547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: The Use of Biomaterials With Stem and Precursor Cells in Diseases of the Central Nervous System; A Step to Clinical Trials.

    Ramos-Zúñiga, Rodrigo / Guerrero-Cázares, Hugo / Gómez-Pinedo, Ulises / Matias-Guiu, Jorge

    Frontiers in neurology

    2021  Volume 12, Page(s) 654890

    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.654890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chitosan-Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine.

    Ojeda-Hernández, Doddy Denise / Canales-Aguirre, Alejandro A / Matias-Guiu, Jordi A / Matias-Guiu, Jorge / Gómez-Pinedo, Ulises / Mateos-Díaz, Juan Carlos

    International journal of molecular sciences

    2022  Volume 23, Issue 20

    Abstract: Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages ... ...

    Abstract Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.
    MeSH term(s) Chitosan/chemistry ; Biocompatible Materials/chemistry ; Coumaric Acids/therapeutic use ; Tissue Engineering ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Anti-Infective Agents/chemistry
    Chemical Substances Chitosan (9012-76-4) ; Biocompatible Materials ; Coumaric Acids ; Anti-Infective Agents
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: COVID-19 in CNS and PNS: Basic and Clinical Focus on the Mechanisms of Infection and New Tools for the Therapeutic Approach.

    Matias-Guiu, Jorge / Matias-Guiu, Jordi A / Garrido, Carmen / Pimienta, Genaro / Reyes, Patricio F / Baig, Abdul Mannan / Gomez-Pinedo, Ulises

    Frontiers in neurology

    2022  Volume 13, Page(s) 838227

    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.838227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1

    Fernández-Beltrán, Luis C / Ali, Zeinab / Larrad-Sanz, Angélica / Lopez-Carbonero, Juan I / Godoy-Corchuelo, Juan M / Jimenez-Coca, Irene / Garcia-Toledo, Irene / Bentley, Liz / Gomez-Pinedo, Ulises / Matias-Guiu, Jordi A / Gil-Moreno, Maria Jose / Matias-Guiu, Jorge / Corrochano, Silvia

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2671

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays altered levels in ALS. Genetically reducing leptin levels (Lepob/+) to maintain body weight improved motor performance and extended survival in female SOD1G93A mice, although the exact molecular mechanisms behind these effects remain elusive. Here, we corroborated the sexual dimorphism in circulating leptin levels in ALS patients and in SOD1G93A mice. We reproduced a previous strategy to generate a genetically deficient leptin SOD1G93A mice (SOD1G93ALepob/+) and studied the transcriptomic profile in the subcutaneous adipose tissue and the spinal cord. We found that leptin deficiency reduced the inflammation pathways activated by the SOD1G93A mutation in the adipose tissue, but not in the spinal cord. These findings emphasize the importance of considering sex-specific approaches in metabolic therapies and highlight the role of leptin in the systemic modulation of ALS by regulating immune responses outside the central nervous system.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Adipose Tissue/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Disease Models, Animal ; Haploinsufficiency ; Leptin/metabolism ; Mice, Transgenic ; Spinal Cord/metabolism ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism
    Chemical Substances Leptin ; SOD1 protein, human ; Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1) ; Lep protein, mouse ; Sod1 protein, mouse (EC 1.15.1.1)
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52439-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies.

    Gómez-Pinedo, Ulises / Matías-Guiu, Jordi A / Ojeda-Hernandez, Denise / de la Fuente-Martin, Sarah / Kamal, Ola Mohamed-Fathy / Benito-Martin, Maria Soledad / Selma-Calvo, Belen / Montero-Escribano, Paloma / Matías-Guiu, Jorge

    Cells

    2023  Volume 12, Issue 11

    Abstract: The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or ... ...

    Abstract The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
    MeSH term(s) Humans ; Methylprednisolone/pharmacology ; Oligodendroglia ; Myelin Sheath ; Axons ; Cell Differentiation
    Chemical Substances Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12111515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical or neuroimaging profiles in the assessment of genetic variants associated with neurodegenerative diseases.

    Matías-Guiu, Jorge / Torre-Fuentes, Laura / Gomez-Pinedo, Ulises / Matías-Guiu, Jordi A

    CNS neuroscience & therapeutics

    2019  Volume 25, Issue 4, Page(s) 419–421

    MeSH term(s) Brain ; Gait ; Humans ; Neurodegenerative Diseases ; Neuroimaging ; Parkinson Disease
    Language English
    Publishing date 2019-02-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2423467-9
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.13112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mesenchymal Stem Cell-Based Therapies in the Post-Acute Neurological COVID Syndrome: Current Landscape and Opportunities.

    León-Moreno, Lilia Carolina / Reza-Zaldívar, Edwin Estefan / Hernández-Sapiéns, Mercedes Azucena / Villafaña-Estarrón, Erika / García-Martin, Marina / Ojeda-Hernández, Doddy Denise / Matias-Guiu, Jordi A / Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Canales-Aguirre, Alejandro Arturo

    Biomolecules

    2023  Volume 14, Issue 1

    Abstract: One of the main concerns related to SARS-CoV-2 infection is the symptoms that could be developed by survivors, known as long COVID, a syndrome characterized by persistent symptoms beyond the acute phase of the infection. This syndrome has emerged as a ... ...

    Abstract One of the main concerns related to SARS-CoV-2 infection is the symptoms that could be developed by survivors, known as long COVID, a syndrome characterized by persistent symptoms beyond the acute phase of the infection. This syndrome has emerged as a complex and debilitating condition with a diverse range of manifestations affecting multiple organ systems. It is increasingly recognized for affecting the Central Nervous System, in which one of the most prevalent manifestations is cognitive impairment. The search for effective therapeutic interventions has led to growing interest in Mesenchymal Stem Cell (MSC)-based therapies due to their immunomodulatory, anti-inflammatory, and tissue regenerative properties. This review provides a comprehensive analysis of the current understanding and potential applications of MSC-based interventions in the context of post-acute neurological COVID-19 syndrome, exploring the underlying mechanisms by which MSCs exert their effects on neuroinflammation, neuroprotection, and neural tissue repair. Moreover, we discuss the challenges and considerations specific to employing MSC-based therapies, including optimal delivery methods, and functional treatment enhancements.
    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Mesenchymal Stem Cells/physiology ; Central Nervous System
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis.

    Ojeda-Hernández, Doddy Denise / Hernández-Sapiéns, Mercedes A / Reza-Zaldívar, Edwin E / Canales-Aguirre, Alejandro / Matías-Guiu, Jordi A / Matías-Guiu, Jorge / Mateos-Díaz, Juan Carlos / Gómez-Pinedo, Ulises / Sancho-Bielsa, Francisco

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor ... ...

    Abstract Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into the target tissue have limited its application. A series of recent studies have focused on the cell secretome, showing it to provide the most benefits of cell therapy. Exosomes are a key component of the cell secretome, participating in the transfer of bioactive molecules. These nano-sized vesicles offer many therapeutical advantages, such as the capacity to cross the blood-brain barrier, an enrichable cargo, and a customizable membrane. Moreover, integrating of biomaterials into exosome therapy could lead to new tissue-specific therapeutic strategies. In this work, the use of exosomes and their integration with biomaterials is presented as a novel strategy in the treatment of MS.
    Language English
    Publishing date 2022-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12091417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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