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  1. Article ; Online: Palmar midcarpal instability a narrative review of the literature: Have we reached a consensus on a treatment?

    Gomez-Sierra, Maria Antonia / Sandoval, Alejandro

    Injury

    2023  Volume 54 Suppl 6, Page(s) 110722

    Abstract: Palmar midcarpal instability (PMCI) is a wrist condition that requires treatment through non-surgical rehabilitation programs or surgical stabilization. This condition's natural history is poorly understood, and the optimal treatment approach remains ... ...

    Abstract Palmar midcarpal instability (PMCI) is a wrist condition that requires treatment through non-surgical rehabilitation programs or surgical stabilization. This condition's natural history is poorly understood, and the optimal treatment approach remains unknown. Non-surgical treatments are initially implemented, followed by surgical stabilization if necessary. Arthrodesis and soft tissue stabilization are the two main surgical options for PMCI, with no established gold standard for treatment. A systematic review of 12 articles comparing arthrodesis and soft tissue stabilization was conducted to identify the optimal treatment approach for PMCI. Arthrodesis techniques, such as lunotriquetral arthrodesis, showed high functional outcomes but also high reintervention rates due to nonunion. Soft tissue stabilization techniques showed superior functional outcomes with less mobility loss and lower reintervention rates compared to arthrodesis. However, more studies are required to determine the optimal soft tissue technique. Based on this review we created a treatment algorithm for PMCI starting with non-surgical treatment first, followed by surgical stabilization if needed. Soft tissue stabilization techniques are preferred over arthrodesis due to better functional outcomes and lower reintervention rates. However, each patient's treatment approach should be individualized and evaluated independently to determine the best course of action. PMCI is a rare wrist condition, and further research is needed to better understand its natural history and establish a gold standard for treatment. The lack of literature comparing the two surgical options underscores the need for further research to determine the optimal treatment approach. Nonetheless, the current evidence suggests that soft tissue stabilization is a promising alternative to arthrodesis, providing superior functional outcomes and lower reintervention rates.
    MeSH term(s) Humans ; Consensus ; Joint Instability/surgery ; Wrist Joint/surgery ; Arthrodesis/methods
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2023.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Instrument-based anterolateral rotatory laxity assessment of the knee has a high intra-observer and inter-observer reliability: a systematic review.

    Martinez-Cano, Juan Pablo / Familiari, Filippo / Vinagre, Gustavo / Moatshe, Gilbert / Gomez-Sierra, Maria Antonia / Marín Fermín, Theodorakys

    Journal of ISAKOS : joint disorders & orthopaedic sports medicine

    2023  Volume 9, Issue 2, Page(s) 221–226

    Abstract: Importance: A reliable evaluation of anterolateral rotatory instability in the anterior cruciate ligament (ACL) deficient knee is important to help surgeons determine which patients might need concurrent anterolateral augmentation procedures.: ... ...

    Abstract Importance: A reliable evaluation of anterolateral rotatory instability in the anterior cruciate ligament (ACL) deficient knee is important to help surgeons determine which patients might need concurrent anterolateral augmentation procedures.
    Objective: The purpose of this study was to systematically review studies that assess the intra-observer and inter-observer reliability of instruments used to measure anterolateral rotatory laxity of the knee.
    Evidence review: A comprehensive literature review was conducted according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, using PubMed, Embase, Scopus, and Google Scholar databases for original, English-language studies evaluating the reliability of objective or instrument-based anterolateral rotatory laxity of the knee until October 31, 2022. Reliability data were extracted from text, tables, and figures.
    Findings: Twelve studies, with patients between the ages of 14-63 years, were included. The instruments used to measure anterolateral rotatory knee laxity included inertial sensors (n ​= ​9), magnetic resonance imaging (n ​= ​1), and navigation systems (n ​= ​2). The global intra-observer intraclass correlation coefficient for these devices was between 0.63 and 0.97, and the global inter-observer reliability was between 0.63 and 0.99.
    Conclusion and relevance: Instrument-based anterolateral rotatory knee laxity assessment has moderate to good intra- and inter-observer reliability. Evaluating anterolateral instability in ACL-deficient knees with these devices could help in decision-making when considering anterolateral augmentation.
    Level of evidence: IV.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Anterior Cruciate Ligament Injuries/diagnosis ; Anterior Cruciate Ligament Injuries/surgery ; Reproducibility of Results ; Joint Instability/diagnosis ; Joint Instability/surgery ; Knee Joint/surgery ; Anterior Cruciate Ligament/surgery
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ISSN 2059-7762
    ISSN (online) 2059-7762
    DOI 10.1016/j.jisako.2023.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Damage control in orthopaedical and traumatology.

    Rondanelli, Alfredo Martínez / Gómez-Sierra, María Antonia / Ossa, Arley Alberto / Hernández, Rubén Darío / Torres, Mauricio

    Colombia medica (Cali, Colombia)

    2021  Volume 52, Issue 2, Page(s) e4184802

    Abstract: In Orthopedics, damage control is indicated in patients with pelvic and/or long bone fractures associated with hemodynamic instability. It is inappropriate to perform a complex definitive reduction and fixation surgery for severely injured trauma ... ...

    Abstract In Orthopedics, damage control is indicated in patients with pelvic and/or long bone fractures associated with hemodynamic instability. It is inappropriate to perform a complex definitive reduction and fixation surgery for severely injured trauma patients with hemodynamic instability. In these cases, it is recommended to perform minimally invasive procedures that temporarily stabilize the fractures and bleeding control. Closed or open fractures of the long bones such as femur, tibia, humerus, and pelvis can lead to hemodynamic instability and shock. Thus, orthopedic damage control becomes a priority. However, if the patient is hemodynamically stable, it is recommended to stabilize all fractures with an early permanent internal fixation. These patients will have a shorter hospital length of stay and a reduction in mechanical ventilation, blood components transfusions and complications. Therefore, the concept of orthopedic damage control should be individualized according to the hemodynamic status and the severity of the injuries. Open fractures, dislocations, and vascular injuries could lead to permanent sequelae and complications if a correct management and approach are not performed.
    MeSH term(s) Fractures, Bone/surgery ; Humans ; Multiple Trauma ; Traumatology
    Language English
    Publishing date 2021-06-30
    Publishing country Colombia
    Document type Journal Article ; Review
    ZDB-ID 2059694-7
    ISSN 1657-9534 ; 0120-8322
    ISSN (online) 1657-9534
    ISSN 0120-8322
    DOI 10.25100/cm.v52i2.4802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Conference proceedings: Use of negative-pressure wound therapy to overcome venous congestion in fingertip reimplantation

    Gomez Sierra, Maria Antonia / Bermudez, Julio Cesar

    2020  , Page(s) IFSSH19–1425

    Event/congress 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT); Berlin; ; International Federation of Societies for Hand Therapy; 2019
    Keywords Medizin, Gesundheit ; Fingertip ; Reimplantation ; VAC ; Venus Congestion ; Negative Pressure
    Publishing date 2020-02-06
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19ifssh0266
    Database German Medical Science

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  5. Article: Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis.

    Lackington, William A / Gomez-Sierra, Maria Antonia / González-Vázquez, Arlyng / O'Brien, Fergal J / Stoddart, Martin J / Thompson, Keith

    Frontiers in bioengineering and biotechnology

    2020  Volume 8, Page(s) 582012

    Abstract: Although most bone fractures typically heal without complications, a small proportion of patients (≤10%) experience delayed healing or potential progression to non-union. Interleukin-1 (IL-1β) plays a crucial role in fracture healing as an early driver ... ...

    Abstract Although most bone fractures typically heal without complications, a small proportion of patients (≤10%) experience delayed healing or potential progression to non-union. Interleukin-1 (IL-1β) plays a crucial role in fracture healing as an early driver of inflammation. However, the effects of IL-1β can impede the healing process if they persist long after the establishment of a fracture hematoma, making it a promising target for novel therapies. Accordingly, the overall objective of this study was to develop a novel gene-based therapy that mitigates the negative effects of IL-1β-driven inflammation while providing a structural template for new bone formation. A collagen-hydroxyapatite scaffold (CHA) was used as a platform for the delivery of nanoparticles composed of pDNA, encoding for IL-1 receptor antagonist (IL-1Ra), complexed to the robust non-viral gene delivery vector, polyethyleneimine (PEI). Utilizing pDNA encoding for Gaussia luciferase and GFP as reporter genes, we found that PEI-pDNA nanoparticles induced a transient gene expression profile in rat bone marrow-derived mesenchymal stromal cells (BM-MSCs), with a transfection efficiency of 14.8 ± 1.8% in 2D. BM-MSC viability was significantly affected by PEI-pDNA nanoparticles as evaluated using CellTiter Blue; however, after 10 days in culture this effect was negligible. Transfection with PEI-pIL-1Ra nanoparticles led to functional IL-1Ra production, capable of antagonizing IL-1β-induced expression of secreted embryonic alkaline phosphatase from HEK-Blue-IL-1β reporter cells. Sustained treatment with IL-1β (0.1, 1, and 10 ng/ml) had a dose-dependent negative effect on BM-MSC osteogenesis, both in terms of gene expression (
    Language English
    Publishing date 2020-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.582012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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