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Book ; Thesis: Einfluss der endoskopischen Ventiltherapie auf die Hyperkapnie bei Patientinnen/Patienten mit einem chronisch ventilatorischen Versagen auf dem Boden eines fortgeschrittenen Lungenemphysems

Rötting, Matthias / Gompelmann, Daniela

2022

Institution	Universität Heidelberg
Author's details	vorgelegt von Matthias Rötting ; Doktormutter: Frau Prof. Dr. med. Daniela Gompelmann
Language	German
Size	IX, 77 Blätter, Illustrationen, Diagramme
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
HBZ-ID	HT030643729
Database	Catalogue ZB MED Medicine, Health

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Article: Hope for Patients with Homogeneous Emphysema?

Gompelmann, Daniela

Chronic obstructive pulmonary diseases (Miami, Fla.)

2018 Volume 5, Issue 2, Page(s) 84–86

Language	English
Publishing date	2018-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2771715-X
ISSN	2372-952X
ISSN	2372-952X
DOI	10.15326/jcopdf.5.2.2018.0135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Women in Interventional Pulmonology: Results from a Worldwide Survey.

Brock, Judith / Zehetmayer, Sonja / Gompelmann, Daniela

Respiration; international review of thoracic diseases

2023 Volume 102, Issue 8, Page(s) 613–620

Abstract: Background and objectives: Gender inequality in medicine remains an issue. Despite the increasing proportion of female physicians, women still appear underrepresented in interventional pulmonology (IP) careers. To date, no data are available on the ... ...

Abstract	Background and objectives: Gender inequality in medicine remains an issue. Despite the increasing proportion of female physicians, women still appear underrepresented in interventional pulmonology (IP) careers. To date, no data are available on the gender distribution in IP. Method: An online survey was sent to pulmonary physicians internationally between July and December 2022. The survey included questions on gender diversity in the pulmonology departments, such as the proportion of male, female, and gender diverse physicians performing bronchoscopy, career progression, and social life. Results: Responses from 92 physicians (mean age 45 ± 10 years) from 47 hospitals across 17 countries were analysed, of whom 52% were women. Overall, 79% of the respondents were pulmonologists and 83% perform bronchoscopy. Although men continue to dominate bronchoscopy (65 vs. 43%) and are more likely to be involved in research (89 vs. 77%), the observed difference is statistically not significant (p = 0.135 and p = 0.281). Leading positions are held by 60% of male respondents and 23% of female respondents (p = 0.002). Men are also more often reported to have academic awards. Discrimination based on gender was reported by 5.3% of all men and 26.8% of all women (p = 0.023). Conclusions: Men and women are almost equally involved in IP, especially in female-led bronchoscopy units. However, leading positions and academic awards are still predominantly held by men.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Pulmonary Medicine ; Physicians ; Physicians, Women ; Surveys and Questionnaires ; Pulmonologists
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000531581
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Endoskopische Interventionen beim Lungenemphysem

Gompelmann, Daniela

Der Klinikarzt

2018 Volume 47, Issue 03, Page(s) 56–61

Abstract: Die endoskopische Lungenvolumenreduktion (ELVR) ist bei ausgewählten Patienten mit einem schwergradigen Lungenemphysem, die trotz Ausschöpfen der leitliniengerechten konservativen Behandlung Symptome sowie eine erhebliche ... ...

Abstract	Die endoskopische Lungenvolumenreduktion (ELVR) ist bei ausgewählten Patienten mit einem schwergradigen Lungenemphysem, die trotz Ausschöpfen der leitliniengerechten konservativen Behandlung Symptome sowie eine erhebliche lungenfunktionelle Einschränkung aufweisen, eine additive Therapieoption. Die Ventiltherapie, als einzige vollständig reversible Methode, führt bei Patienten mit fehlender interlobärer Kollateralventilation durch eine Atelektasenbildung des emphysematös destruierten Lungenlappens zur Volumenreduktion. Bei den alternativen, nicht-blockierenden Techniken (Coil-Therapie, bronchoskopische Thermoablation, polymerische Lungenvolumenreduktion), die hingegen unabhängig von der Kollateralventilation sind, wird eine Volumenreduktion durch Kompression des Lungenparenchyms bzw. durch einen inflammatorischen Reiz induziert. Die derzeit verfügbare Datenlage ist für die endoskopische Ventiltherapie bereits umfassend, während hingegen für die nicht-blockierenden Techniken weitere randomisierte Studien notwendig sind, um diese Verfahren mit hinreichender Evidenz zu etablieren.
Language	German
Publishing date	2018-03-01
Publisher	© Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2106610-3
ISSN	1439-3859 ; 0341-2350
ISSN (online)	1439-3859
ISSN	0341-2350
DOI	10.1055/a-0572-1397
Database	Thieme publisher's database

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Article ; Online: Angioedema as a predominant symptom of

Bal, Christina / Baumgartner, Ruth / Gompelmann, Daniela / Idzko, Marco

BMJ case reports

2021 Volume 14, Issue 3

Abstract: A 41-year-old woman was referred to our hospital with a 6-week history of severe angioedema, dyspnoea and coughing. Initial investigations focused on common causes of angioedema. Clinical presentation and resistance to treatment with antihistamines and ... ...

Abstract	A 41-year-old woman was referred to our hospital with a 6-week history of severe angioedema, dyspnoea and coughing. Initial investigations focused on common causes of angioedema. Clinical presentation and resistance to treatment with antihistamines and steroids made histamine-mediated angioedema unlikely. Bradykinin-mediated angioedema, such as hereditary or drug-induced angioedema, was excluded by a thorough history investigation and laboratory testing for C1-esterase and C4.In rare cases, exogen pathogens cause angioedema. After profound testing for respiratory pathogens,
MeSH term(s)	Adult ; Angioedema/diagnosis ; Angioedema/etiology ; Antibodies, Bacterial ; Bordetella pertussis ; Bradykinin ; Female ; Humans ; Whooping Cough/complications ; Whooping Cough/diagnosis ; Whooping Cough/drug therapy
Chemical Substances	Antibodies, Bacterial ; Bradykinin (S8TIM42R2W)
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-239243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interventionelle Bronchoskopie: was ist möglich und was ist sinnvoll?

Sarmand, Nilab / Gompelmann, Daniela

Deutsche medizinische Wochenschrift (1946)

2018 Volume 143, Issue 15, Page(s) 1097–1102

Abstract: Interventional bronchoscopy plays a significant role in the treatment of various pulmonary diseases. Different endoscopic therapeutic modalities are available for the management of central airway obstruction (CAO) that represent a common indication for ... ...

Title translation	Interventional Bronchoscopy: What is Possible and What Makes Sense?
Abstract	Interventional bronchoscopy plays a significant role in the treatment of various pulmonary diseases. Different endoscopic therapeutic modalities are available for the management of central airway obstruction (CAO) that represent a common indication for interventional bronchoscopy. The latest development in the field of CAO management are biodegradable stents, that would maintain the airway patency over time, then gradually degrade and vanish from the airway. Other indications for interventional bronchoscopy are chronic obstructive pulmonary disease (COPD), emphysema, asthma and chronic bronchitis. Thereby, various techniques of endoscopic lung volume reduction (ELVR) that address at hyperinflation reduction extend the therapeutic spectrum of patients with severe emphysema. Targeted lung denervation that aims a persistent bronchodilation present an area of current research in the field of COPD and asthma. In patients with chronic bronchitis, cryospray therapy that is performed within clinical trials may reduce the amount of secretion.
MeSH term(s)	Airway Obstruction/therapy ; Argon Plasma Coagulation ; Brachytherapy ; Bronchoscopy/methods ; Cryosurgery ; Laser Therapy ; Lung Diseases/therapy ; Photochemotherapy ; Pneumonectomy ; Stents ; Tracheal Stenosis/therapy
Language	German
Publishing date	2018-07-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0551-2626
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sustained Treatment Response after Intravenous Cyclophosphamide in a Patient with Therapy-Resistant COVID-19 Acute Respiratory Distress Syndrome: A Case Report.

Haselwanter, Patrick / Bal, Christina / Gompelmann, Daniela / Idzko, Marco / Prosch, Helmut / Zauner, Christian / Schneeweiss-Gleixner, Mathias

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Treatment of acute respiratory distress syndrome (ARDS) represents a severe complication of coronavirus disease 2019 (COVID-19) infection and is often challenging in intensive care treatment. Potential positive effects of intravenous cyclophosphamide ... ...

Abstract	Treatment of acute respiratory distress syndrome (ARDS) represents a severe complication of coronavirus disease 2019 (COVID-19) infection and is often challenging in intensive care treatment. Potential positive effects of intravenous cyclophosphamide have been reported in interstitial lung diseases (ILDs). However, there are no data on the use of high-dose cyclophosphamide in therapy-resistant COVID-19 ARDS. We report the case of a 32-year-old male patient admitted to the intensive care unit (ICU) of the Medical University of Vienna due to severe COVID-19 ARDS who required venovenous extracorporeal membrane oxygenation (ECMO) with a total runtime of 85 days. Despite all these therapeutic efforts, he remained in a condition of therapy-resistant ARDS. Unfortunately, the patient was denied for lung transplantation. However, a significant improvement in his respiratory condition was achieved after the administration of an intravenous regimen of cyclophosphamide and prednisolone. After a period of consecutive stabilization, the patient was transferred to the normal ward after 125 days of intensive care treatment. There is a substantial lack of therapeutic options in therapy-resistant ARDS. Our case report suggests that cyclophosphamide may represent a new treatment strategy in therapy-resistant ARDS. Due to its severe adverse effect profile, cyclophosphamide should be used after careful evaluation of a patient's general condition.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175506
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Article: Cardiovascular Diseases in COPD: From Diagnosis and Prevalence to Therapy.

Papaporfyriou, Anastasia / Bartziokas, Konstantinos / Gompelmann, Daniela / Idzko, Marco / Fouka, Evangelia / Zaneli, Stavrina / Bakakos, Petros / Loukides, Stelios / Papaioannou, Andriana I

Life (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Chronic obstructive pulmonary disease (COPD) is considered one of the leading causes of mortality. Cardiovascular comorbidities are diagnosed often in COPD patients, not only because of the common risk factors these two diseases share, but also because ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is considered one of the leading causes of mortality. Cardiovascular comorbidities are diagnosed often in COPD patients, not only because of the common risk factors these two diseases share, but also because of the systemic inflammation which characterizes COPD and has deleterious effects in the cardiovascular system. The comorbid cardiovascular diseases in COPD result in several difficulties in the holistic treatment of these patients and affect outcomes such as morbidity and mortality. Several studies have reported that mortality from cardiovascular causes is common among COPD patients, while the risk for acute cardiovascular events increases during COPD exacerbations and remains high for a long time even after recovery. In this review, we focus on the prevalence of cardiovascular comorbidities in COPD patients, presenting the evidence regarding the interaction of the pathophysiological pathways which characterize each disease. Furthermore, we summarize information regarding the effects of cardiovascular treatment on COPD outcomes and vice versa. Finally, we present the current evidence regarding the impact of cardiovascular comorbidities on exacerbations, quality of life and survival of COPD patients.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13061299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endobronchial Valve Replacements in Patients with Advanced Emphysema After Endoscopic Lung Volume Reduction.

Brock, Judith Maria / Schuster, Paul Ulrich / Böhmker, Felix / Eberhardt, Ralf / Gompelmann, Daniela / Kontogianni, Konstantina / Trudzinski, Franziska / Benjamin, Nicola / Herth, Felix

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 933–943

Abstract: Purpose: Up to 41% of patients with endobronchial valve implantation need revision bronchoscopies and valve replacements most likely due to valve dysfunction or lack of benefit. So far, no data is available whether valve replacements lead to the desired ...

Abstract	Purpose: Up to 41% of patients with endobronchial valve implantation need revision bronchoscopies and valve replacements most likely due to valve dysfunction or lack of benefit. So far, no data is available whether valve replacements lead to the desired lobar volume reduction and therapy benefit. Patients and methods: We conducted a single-center retrospective analysis of patients with endobronchial valve implantation and at least one valve replacement. Indications and number of revision bronchoscopies and valve replacements were evaluated. Therapy benefit regarding lung function and exercise capacity as well as development of complete lobar atelectasis was investigated and possible predictors identified. Results: We identified 73 patients with 1-12 revision bronchoscopies and 1-5 valve replacements. The main indication for revision bronchoscopy in this group was lack of therapy benefit (44.2%). Lung function and exercise capacity showed improvements in about one-third of patients even years after the initial implantation. A total of 26% of all patients showed a complete lobar atelectasis at the end of the observation period, 56.2% had developed lung volume reduction. The logistic regression revealed the development of a previous complete lobar atelectasis as predictor for a complete lobar atelectasis at final follow-up. Oral cortisone long-term therapy was also shown as predictive factor. The probability for a final complete lobar atelectasis was 69.2% if a lobar atelectasis had developed before. Conclusion: Valve replacements are more likely to be beneficial in patients who develop a re-aeration of a previous lobar atelectasis following valve implantation. Every decision for revision bronchoscopy must be taken carefully.
MeSH term(s)	Humans ; Pneumonectomy/adverse effects ; Retrospective Studies ; Pulmonary Disease, Chronic Obstructive/surgery ; Treatment Outcome ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/surgery ; Emphysema ; Pulmonary Atelectasis/diagnostic imaging ; Pulmonary Atelectasis/etiology ; Pulmonary Atelectasis/surgery ; Bronchoscopy/adverse effects ; Forced Expiratory Volume
Language	English
Publishing date	2023-05-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S408674
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ventilatory support and inflammatory peptides in hospitalised patients with COVID-19: A prospective cohort trial.

Gysan, Maximilian Robert / Milacek, Christopher / Bal, Christina / Zech, Andreas / Brugger, Jonas / Milos, Ruxandra-Iulia / Antoniewicz, Lukasz / Idzko, Marco / Gompelmann, Daniela

PloS one

2023 Volume 18, Issue 11, Page(s) e0293532

Abstract: Purpose: Several studies have shown that SARS-CoV-2 can induce a massive release of cytokines which contributes to disease severity and mortality. Therefore, cytokine levels in the serum may help to predict disease severity and survival in COVID-19 ... ...

Abstract	Purpose: Several studies have shown that SARS-CoV-2 can induce a massive release of cytokines which contributes to disease severity and mortality. Therefore, cytokine levels in the serum may help to predict disease severity and survival in COVID-19 patients. Methods: In this prospective trial, 88 patients who were hospitalised for COVID-19 were enrolled. Blood samples for serum peptide measurements were taken at the time closest to hospitalisation, at day 5, 9 and 13 (±1). The concentrations of cytokines (IL-1α, IL-1β, IL-1RA, IL-6, L-7, L-10, IFN-γ and TNF-α), chemokines (CCL-3, CCL-4 and CCL-7) and growth factors (G-CSF, GM-CSF and VEGF) were assessed and correlated with the type of ventilation, occurrence of consolidations on imaging and the level of care. Results: COVID-19 patients (median age 68 years, IQR 55-77) stayed in hospital between 5-171 days. Compared to patients in the general care unit, patients in the intermediate care unit (IMCU) and intensive care unit (ICU) presented significantly elevated serum IL-6 (p = 0.004) and lower IFN-γ levels (p = 0.005), respectively. The peak inspiratory pressure in ventilated patients correlated positively with IL-1RA, G-CSF and inversely with IFN-γ serum levels (all p<0.05). VEGF serum levels inversely correlated with the fraction of inspired oxygen in patients receiving high-flow nasal canula oxygen therapy (p = 0.047). No significant correlation between serum concentrations of the measured peptides and the type of ventilation, occurrence of radiological consolidations or in-hospital mortality has been observed. Conclusion: IL1-RA, IL-6, IFN-γ, G-CSF, CCL-7 and VEGF serum levels could prove helpful as biomarkers to assess disease severity and the need for intensive care in COVID-19 patients.
MeSH term(s)	Humans ; Infant ; COVID-19/therapy ; Interleukin 1 Receptor Antagonist Protein ; SARS-CoV-2/metabolism ; Vascular Endothelial Growth Factor A ; Prospective Studies ; Interleukin-6 ; Cytokines/metabolism ; Granulocyte Colony-Stimulating Factor ; Oxygen
Chemical Substances	Interleukin 1 Receptor Antagonist Protein ; Vascular Endothelial Growth Factor A ; Interleukin-6 ; Cytokines ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0293532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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