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Article: Giant Conjunctival Cyst of the Orbit in a Patient with Previous Enucleation.

Ponces Ramalhão, João / Rodrigues, Diogo / Vieira, Beatriz / Gonçalves Afonso, Miguel / Baptista, Pedro Manuel / Lamas, Nuno Jorge / Araújo, Maria

Case reports in ophthalmology

2024 Volume 15, Issue 1, Page(s) 250–255

Abstract: Introduction: Conjunctival cysts of the orbit development are a rare complication in enucleated patients. They result from the entrapment of conjunctival epithelium within the orbit.: Case presentation: We report the case of a 25-year-old man with a ... ...

Abstract	Introduction: Conjunctival cysts of the orbit development are a rare complication in enucleated patients. They result from the entrapment of conjunctival epithelium within the orbit. Case presentation: We report the case of a 25-year-old man with a history of enucleation for a retinoblastoma of the right eye who presented with difficulty in fitting his eye prothesis. On his past medical records, there was no reference to the placement of any orbital implant at the time of the surgery. Biomicroscopy of the right eye revealed a thickened bulbar conjunctiva, an inferior symblepharon, and a translucid central area with vascularization. Imaging was remarkable for a cystic cavity filling the whole right orbit. Biopsy revealed the diagnosis of a conjunctival cyst, and drainage was performed, alleviating the patient's symptoms. Conclusion: Orbital conjunctival cysts may pose a clinical problem, and treatment modalities include surgical excision, absolute alcohol injection, and trichloroacetic acid injection.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000535598
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IgG4-related hepatic inflammatory pseudotumour: could MRI suggest the correct diagnosis?

Primitivo, Ana / Oliveira, Maria Helena / Gonçalves, Afonso

BMJ case reports

2021 Volume 14, Issue 8

Abstract: We report a case of a 62-year-old woman, HIV positive, with a 3-week history of jaundice and elevated cholestatic enzymes. Imaging studies displayed intrahepatic biliary dilatation and a central liver lesion. Pathology described lesions of active ... ...

Abstract	We report a case of a 62-year-old woman, HIV positive, with a 3-week history of jaundice and elevated cholestatic enzymes. Imaging studies displayed intrahepatic biliary dilatation and a central liver lesion. Pathology described lesions of active cholangitis, lymphoplasmacytic infiltration and fibrosis, suggesting a hepatic inflammatory pseudotumour (IPT) IgG4 related. IgG4-related lymphoplasmacytic form of IPT belongs to IgG4-related diseases. We discuss the importance to include IgG4-related hepatic IPT as part of the differential diagnosis of any liver lesion, highlighting potential imaging clues that may help in establishing the correct diagnosis.
MeSH term(s)	Female ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease/diagnostic imaging ; Liver/diagnostic imaging ; Magnetic Resonance Imaging ; Middle Aged
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-244572
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Passive control of dynamic stall in a H-Darrieus Vertical Axis Wind Turbine using blade leading-edge protuberances

Gonçalves, Afonso N.C. / Pereira, José M.C. / Sousa, João M.M.

Applied energy. 2022 July 15,

2022

Abstract: Dynamic stall flow conditions affect the performance of most Vertical Axis Wind Turbine (VAWT) designs; however, the associated losses are especially relevant in smaller turbines, such as those typically used in urban environment applications. The work ... ...

Abstract	Dynamic stall flow conditions affect the performance of most Vertical Axis Wind Turbine (VAWT) designs; however, the associated losses are especially relevant in smaller turbines, such as those typically used in urban environment applications. The work described in this paper experimentally evaluated the effectiveness of leading-edge protuberances in controlling the aforementioned stall behavior. A numerical study was first performed to define the leading-edge geometry to be subsequently tested in the wind tunnel. A custom experimental setup was also developed for this purpose. The wind tunnel measurements of the modified turbine showed significant performance gains over the baseline and a considerably improved self-starting behavior. The power coefficient increase was between 46% and 20% for wind velocities ranging from 5.5 m/s to 9 m/s, respectively. Nevertheless, the tip-speed ratio characteristics of the studied turbine were not meaningfully affected by the use of leading-edge protuberances.
Keywords	energy ; geometry ; urban areas ; wind tunnels ; wind turbines
Language	English
Dates of publication	2022-0715
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2022.119700
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of a Low-Cost Virtual Reality Surround-Screen Projection System.

Goncalves, Afonso / Borrego, Adrian / Latorre, Jorge / Llorens, Roberto / Bermudez I Badia, Sergi

IEEE transactions on visualization and computer graphics

2022 Volume 28, Issue 12, Page(s) 4452–4461

Abstract: Two of the most popular mediums for virtual reality are head-mounted displays and surround-screen projection systems, such as CAVE Automatic Virtual Environments. In recent years, HMDs suffered a significant reduction in cost and have become widespread ... ...

Abstract	Two of the most popular mediums for virtual reality are head-mounted displays and surround-screen projection systems, such as CAVE Automatic Virtual Environments. In recent years, HMDs suffered a significant reduction in cost and have become widespread consumer products. In contrast, CAVEs are still expensive and remain accessible to a limited number of researchers. This study aims to evaluate both objective and subjective characteristics of a CAVE-like monoscopic low-cost virtual reality surround-screen projection system compared to advanced setups and HMDs. For objective results, we measured the head position estimation accuracy and precision of a low-cost active infrared (IR) based tracking system, used in the proposed low-cost CAVE, relatively to an infrared marker-based tracking system, used in a laboratory-grade CAVE system. For subjective characteristics, we investigated the sense of presence and cybersickness elicited in users during a visual search task outside personal space, beyond arms reach, where the importance of stereo vision is diminished. Thirty participants rated their sense of presence and cybersickness after performing the VR search task with our CAVE-like system and a modern HMD. The tracking showed an accuracy error of 1.66 cm and .4 mm of precision jitter. The system was reported to elicit presence but at a lower level than the HMD, while causing significant lower cybersickness. Our results were compared to a previous study performed with a laboratory-grade CAVE and support that a VR system implemented with low-cost devices could be a viable alternative to laboratory-grade CAVEs for visual search tasks outside the user's personal space.
MeSH term(s)	Humans ; User-Computer Interface ; Computer Graphics ; Virtual Reality ; Smart Glasses
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1941-0506
ISSN (online)	1941-0506
DOI	10.1109/TVCG.2021.3091485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spontaneous regression of hepatocellular carcinoma: myth or reality?

Costa-Santos, Maria Pia / Gonçalves, Afonso / Ferreira, Alexandre Oliveira / Nunes, Joana

BMJ case reports

2020 Volume 13, Issue 2

Abstract: We present a case of a 68-year-old man with chronic hepatitis C infection, with no evidence of chronic liver disease during the first years of follow-up, diagnosed with a hepatocellular carcinoma (HCC) with 40 mm (α-fetoprotein (AFP) 205 ng/mL). He ... ...

Abstract	We present a case of a 68-year-old man with chronic hepatitis C infection, with no evidence of chronic liver disease during the first years of follow-up, diagnosed with a hepatocellular carcinoma (HCC) with 40 mm (α-fetoprotein (AFP) 205 ng/mL). He underwent segmental liver resection and pathology analysis was consistent with HCC and cirrhosis in the adjacent liver. Four months after surgery, AFP raised up to 126 661 ng/mL and abdominal MRI revealed a multinodular HCC. Patient rejected treatment with sorafenib and started megestrol and an herbal medicine, soursop (
MeSH term(s)	Aged ; Annona ; Antineoplastic Agents, Hormonal/therapeutic use ; Carcinoma, Hepatocellular/therapy ; Hepatitis C, Chronic ; Humans ; Liver Neoplasms/therapy ; Male ; Megestrol/therapeutic use ; Neoplasm Regression, Spontaneous ; Plant Preparations/therapeutic use
Chemical Substances	Antineoplastic Agents, Hormonal ; Plant Preparations ; Megestrol (EA6LD1M70M)
Language	English
Publishing date	2020-02-10
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-233509
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Article ; Online: Time course of lung ultrasound findings in patients with COVID-19 pneumonia and cardiac dysfunction.

Leote, Joao / Judas, Tiago / Broa, Ana Luísa / Lopes, Miguel / Abecasis, Francisca / Pintassilgo, Inês / Gonçalves, Afonso / Gonzalez, Filipe

The ultrasound journal

2022 Volume 14, Issue 1, Page(s) 28

Abstract: Background: Lung ultrasound (LUS) is a valuable tool to predict and monitor the COVID-19 pneumonia course. However, the influence of cardiac dysfunction (CD) on LUS findings remains to be studied. Our objective was to determine the effect of CD on LUS ... ...

Abstract	Background: Lung ultrasound (LUS) is a valuable tool to predict and monitor the COVID-19 pneumonia course. However, the influence of cardiac dysfunction (CD) on LUS findings remains to be studied. Our objective was to determine the effect of CD on LUS in hospitalized patients with COVID-19 pneumonia. Material and methods: Fifty-one patients with COVID-19 pneumonia participated in the study. Focused echocardiography (FoCUS) was carried out on day 1 to separate patients into two groups depending on whether they had FoCUS signs of CD (CD+ vs CD-). LUS scores, based on the thickness of the pleural line, the B-line characteristics, and the presence or not of consolidations, were obtained three times along the patient's admission (D1, D5, D10) and compared between CD+ and CD- patients. A correlation analysis was carried out between LUS scores and the ratio of the arterial partial pressure of oxygen to the fraction of the inspired oxygen (P/F ratio). Results: Twenty-two patients were CD+ and 29 patients were CD-. Among the CD+ patients, 19 were admitted to the intensive care unit (ICU), seven received invasive mechanical ventilation (IMV), and one did not survive. Among the CD- patients, 11 were admitted to the ICU, one received IMV and seven did not survive. CD+ patients showed a significantly lower P/F ratio than CD- patients. However, LUS scores showed no between-group differences, except for fewer subpleural consolidations in the upper quadrants of CD+ than on CD- patients. Conclusion: In patients with COVID-19, CD contributed to a worse clinical course, but it did not induce significant changes in LUS. Our findings suggest that pathophysiological factors other than those reflected by LUS may be responsible for the differences in clinical condition between CD+ and CD- patients.
Language	English
Publishing date	2022-07-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2965029-X
ISSN	2524-8987 ; 2036-3176
ISSN (online)	2524-8987
ISSN	2036-3176
DOI	10.1186/s13089-022-00278-2
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Article ; Online: The Benefits of Custom Exergames for Fitness, Balance, and Health-Related Quality of Life: A Randomized Controlled Trial with Community-Dwelling Older Adults.

Gonçalves, Afonso / Muñoz, John / Cameirão, Mónica S / Gouveia, Élvio Rúbio / Sousa, Honorato / Bermúdez I Badia, Sergi

Games for health journal

2021 Volume 10, Issue 4, Page(s) 245–253

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Exercise Therapy/methods ; Exercise Therapy/psychology ; Exercise Therapy/statistics & numerical data ; Female ; Humans ; Independent Living/psychology ; Independent Living/statistics & numerical data ; Male ; Middle Aged ; Physical Fitness/psychology ; Postural Balance/physiology ; Quality of Life/psychology ; Range of Motion, Articular/physiology
Language	English
Publishing date	2021-08-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2650543-5
ISSN	2161-7856 ; 2161-783X
ISSN (online)	2161-7856
ISSN	2161-783X
DOI	10.1089/g4h.2020.0092
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Article ; Online: Lessons Learned from Gamifying Functional Fitness Training Through Human-Centered Design Methods in Older Adults.

Muñoz, John Edison / Gonçalves, Afonso / Rúbio Gouveia, Élvio / Cameirão, Mónica S / Bermúdez I Badia, Sergi

Games for health journal

2019 Volume 8, Issue 6, Page(s) 387–406

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Exercise Therapy/methods ; Female ; Games, Recreational ; Humans ; Male ; Physical Fitness ; User-Computer Interface ; Video Games
Language	English
Publishing date	2019-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2650543-5
ISSN	2161-7856 ; 2161-783X
ISSN (online)	2161-7856
ISSN	2161-783X
DOI	10.1089/g4h.2018.0028
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Article ; Online: Immunoparalysis in critically ill children.

Neves, Filipa Loureiro / Amaral, Mariana Nunes Gonçalves Afonso / da Silva, Sandra Filomena Durães / Silva, Isabel Maria Melo / Laranjeira, Paula Margarida Dos Santos / Pinto, Carla Regina de Jesus / Paiva, Artur Augusto / Dias, Andrea Sofia da Silva / Coelho, Maria Leonor Almeida Carvalho Vieira

Immunology

2022 Volume 168, Issue 4, Page(s) 597–609

Abstract: Immunoparalysis is associated with poorer outcomes in the paediatric intensive care unit (PICU) setting. We aimed to determine the group of patients with higher chances of immunoparalysis and correlate this status with increased risks of nosocomial ... ...

Abstract	Immunoparalysis is associated with poorer outcomes in the paediatric intensive care unit (PICU) setting. We aimed to determine the group of patients with higher chances of immunoparalysis and correlate this status with increased risks of nosocomial infection and adverse clinical parameters. We conducted an exploratory study with prospective data collection in a university-affiliated tertiary medical, surgical, and cardiac PICU. Fifteen patients with multiple organ dysfunction syndrome were included over a period of 6 months. Monocyte's human leucocyte antigen (HLA)-DR expression and tumour necrosis factor (TNF)-α and interleukin (IL)-6 production were measured by flow-cytometry at three time points (T1 = 1-2 days; T2 = 3-5 days; T3 = 6-8 days). Using the paediatric logistic organ dysfunction-2 score to assess initial disease severity, we established the optimal cut-off values of the evaluated parameters to identify the subset of patients with a higher probability of immunoparalysis. A comparative analysis was performed between them. Sixty per cent were males; the median age was 4.1 years. Considering the presence of two criteria in T1 (classical monocytes mean fluorescence intensity [MFI] for HLA-DR ≤ 1758.5, area under the curve (AUC) = 0.775; and frequency of monocytes producing IL-6 ≤ 68.5%, AUC = 0.905) or in T3 (classical monocytes MFI of HLA-DR ≤ 2587.5, AUC = 0.675; and frequency of monocytes producing TNF-α ≤ 93.5%, AUC = 0.833), a variable to define immunoparalysis was obtained (100% sensitivity, 81.5% specificity). Forty per cent of patients were assigned to the immunoparalysis group. In this: a higher frequency of nosocomial infection (p = 0.011), vasoactive inotropic score (p = 0.014) and length of hospital stay (p = 0.036) was observed. In the subgroup with the diagnosis of sepsis/septic shock (n = 5), patients showed higher percentages of non-classical monocytes (p = 0.004). No mortality was recorded. A reduction in classical monocytes HLA-DR expression with lower frequencies of monocytes producing TNF-α and IL-6 during the first week of critical illness, appears to be a good marker of immunoparalysis; these findings relate to an increased risk of nosocomial infection and deleterious outcomes. The increased frequency of non-classical monocytes in patients with sepsis/septic shock is suggestive of a better prognosis.
MeSH term(s)	Male ; Humans ; Child ; Child, Preschool ; Female ; Shock, Septic ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Critical Illness ; HLA-DR Antigens ; Cross Infection ; Monocytes ; Sepsis
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-6 ; HLA-DR Antigens
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13595
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Article: An unusual fat-containing presacral tumor in an elderly patient.

Leite, Maria Inês / Gonçalves, Afonso / Ferreira, Ana Cristina / Ortiz, Santiago / Esteves, Rui / Távora, Isabel

Case reports in radiology

2014 Volume 2014, Page(s) 674365

Abstract: The authors present a case of a presacral myelolipoma diagnosed in an 84-year-old male patient with longstanding pelvic pain and past medical history of bladder cancer. Pelvic computed tomography (CT) revealed a well-encapsulated and lobulated presacral ... ...

Abstract	The authors present a case of a presacral myelolipoma diagnosed in an 84-year-old male patient with longstanding pelvic pain and past medical history of bladder cancer. Pelvic computed tomography (CT) revealed a well-encapsulated and lobulated presacral mass, with mixed fat and soft-tissue attenuation. Magnetic resonance (MR) imaging provided further confirmation of macroscopic intralesional fat and excluded either adjacent bone invasion or bladder cancer recurrence. A presacral myelolipoma was suspected based on imaging findings, with liposarcoma and teratoma having also been considered for the differential diagnosis. The histological confirmation of the tumor was only attained postoperatively. This case report alerts to the possible presacral location of myelolipomas, which should be considered for every fat-containing lesion detected in this region. The main clinical, imaging, and differential diagnoses of this entity are reviewed in this paper.
Language	English
Publishing date	2014-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627655-0
ISSN	2090-6870 ; 2090-6862
ISSN (online)	2090-6870
ISSN	2090-6862
DOI	10.1155/2014/674365
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