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  1. Article ; Online: Oxidative stress and high-density lipoprotein cholesterol: Cause or consequence?

    Gonçalves, Ana Cristina

    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

    2022  Volume 41, Issue 10, Page(s) 841–842

    MeSH term(s) Antioxidants ; Cholesterol, HDL ; Humans ; Oxidative Stress
    Chemical Substances Antioxidants ; Cholesterol, HDL
    Language Portuguese
    Publishing date 2022-07-12
    Publishing country Portugal
    Document type Journal Article
    ZDB-ID 632718-7
    ISSN 2174-2030 ; 0870-2551 ; 0304-4750
    ISSN (online) 2174-2030
    ISSN 0870-2551 ; 0304-4750
    DOI 10.1016/j.repc.2022.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Zinc: From Biological Functions to Therapeutic Potential.

    Costa, Maria Inês / Sarmento-Ribeiro, Ana Bela / Gonçalves, Ana Cristina

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn- ... ...

    Abstract The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. This review focuses on Zn's roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases.
    MeSH term(s) Humans ; Zinc/metabolism ; Trace Elements/metabolism ; Homeostasis/physiology ; Physiological Phenomena ; Carrier Proteins/metabolism
    Chemical Substances Zinc (J41CSQ7QDS) ; Trace Elements ; Carrier Proteins
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities.

    Jurkovicova, Dana / Neophytou, Christiana M / Gašparović, Ana Čipak / Gonçalves, Ana Cristina

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Resistance to chemo- and radiotherapy is a common event among cancer patients and a reason why new cancer therapies and therapeutic strategies need to be in continuous investigation and development. DNA damage response (DDR) comprises several pathways ... ...

    Abstract Resistance to chemo- and radiotherapy is a common event among cancer patients and a reason why new cancer therapies and therapeutic strategies need to be in continuous investigation and development. DNA damage response (DDR) comprises several pathways that eliminate DNA damage to maintain genomic stability and integrity, but different types of cancers are associated with DDR machinery defects. Many improvements have been made in recent years, providing several drugs and therapeutic strategies for cancer patients, including those targeting the DDR pathways. Currently, poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) are the DDR inhibitors (DDRi) approved for several cancers, including breast, ovarian, pancreatic, and prostate cancer. However, PARPi resistance is a growing issue in clinical settings that increases disease relapse and aggravate patients' prognosis. Additionally, resistance to other DDRi is also being found and investigated. The resistance mechanisms to DDRi include reversion mutations, epigenetic modification, stabilization of the replication fork, and increased drug efflux. This review highlights the DDR pathways in cancer therapy, its role in the resistance to conventional treatments, and its exploitation for anticancer treatment. Biomarkers of treatment response, combination strategies with other anticancer agents, resistance mechanisms, and liabilities of treatment with DDR inhibitors are also discussed.
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hematological Tumors.

    Alves, Raquel / Pires, Ana / Jorge, Joana / Balça-Silva, Joana / Gonçalves, Ana Cristina / Sarmento-Ribeiro, Ana Bela

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: The role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment ... ...

    Abstract The role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment advancements. In this study, we investigated the effects of batimastat (BB-94), an MMP inhibitor (MMPi), in single-administration and daily administration schemes in AML, MDS, and MM cell lines. We used four hematologic neoplasia cell lines: the HL-60 and NB-4 cells as AML models, the F36-P cells as an MDS model, and the H929 cells as a model of MM. We also tested batimastat toxicity in a normal human lymphocyte cell line (IMC cells). BB-94 decreases cell viability and density in a dose-, time-, administration-scheme-, and cell-line-dependent manner, with the AML cells displaying higher responses. The efficacy in inducing apoptosis and cell cycle arrests is dependent on the cell line (higher effects in AML cells), especially with lower daily doses, which may mitigate treatment toxicity. Furthermore, BB-94 activated apoptosis via caspases and ERK1/2 pathways. These findings highlight batimastat's therapeutic potential in hematological malignancies, with daily dosing emerging as a strategy to minimize adverse effects.
    MeSH term(s) Humans ; Apoptosis/drug effects ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Antineoplastic Agents/pharmacology ; Cytostatic Agents/pharmacology ; Cell Proliferation/drug effects ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/therapeutic use ; HL-60 Cells ; Matrix Metalloproteinase Inhibitors/pharmacology ; Cell Cycle Checkpoints/drug effects ; MAP Kinase Signaling System/drug effects ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Phenylalanine/analogs & derivatives ; Thiophenes
    Chemical Substances batimastat (BK349F52C9) ; Antineoplastic Agents ; Cytostatic Agents ; Hydroxamic Acids ; Matrix Metalloproteinase Inhibitors ; Phenylalanine (47E5O17Y3R) ; Thiophenes
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Recurrent Transient Ischemic Attacks and Stroke Due to Carotid Dissection During Air Travel: A Case Report.

    Mendes, Maricela / Gonçalves, Ana Cristina / Tarrio, João / Rodrigues, Eduardo / Luis, Tatiana / Perneta, Dalila

    Cureus

    2023  Volume 15, Issue 1, Page(s) e34340

    Abstract: Carotid artery dissection causes 2.5% of ischemic acute strokes and is more common in younger rather than older patients. Extracranial lesions often manifest as transient and reversible neurological deficits until a stroke occurs. In this case, we ... ...

    Abstract Carotid artery dissection causes 2.5% of ischemic acute strokes and is more common in younger rather than older patients. Extracranial lesions often manifest as transient and reversible neurological deficits until a stroke occurs. In this case, we describe a 60-year-old male patient with no known cardiovascular risk factors who experienced three transient ischemic attacks (TIAs) in four days while traveling in Portugal. At the emergency department, he was treated for an occipital headache associated with nausea and two episodes of decreased left upper-limb muscle strength lasting two to three minutes with spontaneous recovery. He requested discharge against medical advice so that he could travel home. During the return flight, he had a severe right parietal headache followed by decreased muscle strength in the left arm. After an emergency landing in Lisbon, he was referred to the local emergency department, where his neurological examination revealed preferential gaze to the right exceeding the midline, left homonymous hemianopsia, minor left central facial paresis, and spastic left brachial paresis. On the National Institutes of Health Stroke Scale, he scored 7. A head CT was performed, showing no acute vascular lesions (i.e., Alberta Stroke Program Early CT Score of 10). However, an image compatible with dissection was identified on CT angiography of the head and neck and confirmed by digital subtraction angiography. The patient underwent balloon angioplasty and placement of three stents in the right internal carotid artery with vascular permeabilization. This case highlights how prolonged and incorrect cervical posture and microtrauma secondary to aircraft turbulence may be associated with carotid artery dissection in predisposed individuals. The Aerospace Medical Association guidelines advocate that patients with a recent acute neurological event should avoid air travel until clinical stability is assured. As TIA is considered a harbinger of stroke, patients should be properly evaluated and avoid air travel for at least two days after the event.
    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.34340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies.

    Jorge, Joana / Neves, Joana / Alves, Raquel / Geraldes, Catarina / Gonçalves, Ana Cristina / Sarmento-Ribeiro, Ana Bela

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Lymphoid malignancies are a group of highly heterogeneous diseases frequently associated with constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway. Parthenolide is a natural compound used to treat migraines and arthritis and ... ...

    Abstract Lymphoid malignancies are a group of highly heterogeneous diseases frequently associated with constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway. Parthenolide is a natural compound used to treat migraines and arthritis and found to act as a potent NF-κB signaling inhibitor. This study evaluated in vitro parthenolide efficacy in lymphoid neoplasms. We assessed parthenolide metabolic activity in NCI-H929 (MM), Farage (GCB-DLBCL), Raji (BL), 697 and KOPN-8 (B-ALL), and CEM and MOLT-4 (T-ALL), by resazurin assay. Cell death, cell cycle, mitochondrial membrane potential (ΔΨ
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Apoptosis ; Sesquiterpenes/pharmacology ; I-kappa B Proteins ; Lymphoma/drug therapy
    Chemical Substances NF-kappa B ; Reactive Oxygen Species ; parthenolide (2RDB26I5ZB) ; Sesquiterpenes ; I-kappa B Proteins
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pinus pinea (L.) nut and kernel productivity in relation to cone, tree and stand characteristics

    Afonso, Anabela / Gonçalves, Ana Cristina / Pereira, Dulce G

    Agroforestry systems. 2020 Oct., v. 94, no. 5

    2020  

    Abstract: Pinus pinea stands have been identified as one of the target species for agroforestry systems in Europe. Its fruit yield is of importance to the local development, especially in the Mediterranean basin, due to its highly nutritional kernels and its ... ...

    Abstract Pinus pinea stands have been identified as one of the target species for agroforestry systems in Europe. Its fruit yield is of importance to the local development, especially in the Mediterranean basin, due to its highly nutritional kernels and its economic value. The objectives of this study were to analyze the relation between pine nut and kernel weight and its efficiencies in relation to cone and tree traits for different stand structures. The statistical analysis was carried out with correlation, multiple correlation analysis, hurdle-gamma regression, principal component and cluster analysis, with a dataset of about 3300 cones collected in four plots and 3 years. The results indicate that pine nut and kernel and its efficiencies depend on stand structure, year and tree characteristics. The principal component analysis and the cluster analysis enabled the identification of four groups of trees related to the pine nut and kernel efficiencies. The higher efficiencies per tree are attained in stands managed for fruit production, increasing with the decrease of the density.
    Keywords Pinus pinea ; agroforestry ; cluster analysis ; data collection ; economic valuation ; fruit yield ; fruits ; principal component analysis ; seeds ; stand structure ; trees ; Europe ; Mediterranean region
    Language English
    Dates of publication 2020-10
    Size p. 2065-2079.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 406958-4
    ISSN 1572-9680 ; 0167-4366
    ISSN (online) 1572-9680
    ISSN 0167-4366
    DOI 10.1007/s10457-020-00523-4
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3735: Show issues

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  8. Article: Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation.

    Jorge, Joana / Magalhães, Nisa / Alves, Raquel / Lapa, Beatriz / Gonçalves, Ana Cristina / Sarmento-Ribeiro, Ana Bela

    Biomedicines

    2022  Volume 10, Issue 9

    Abstract: Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies at pediatric ages and is characterized by different chromosomal rearrangements and genetic abnormalities involved in the differentiation and proliferation of lymphoid ...

    Abstract Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies at pediatric ages and is characterized by different chromosomal rearrangements and genetic abnormalities involved in the differentiation and proliferation of lymphoid precursor cells. Brusatol is a quassinoid plant extract extensively studied due to its antineoplastic effect through global protein synthesis and nuclear factor erythroid 2-related factor-2 (NRF2) signaling inhibition. NRF2 is the main regulator of cellular antioxidant response and reactive oxygen species (ROS), which plays an important role in oxidative stress regulation. This study aimed to evaluate the effect of brusatol in in vitro models of ALL. KOPN-8 (B-ALL), CEM (T-ALL), and MOLT-4 (T-ALL) cell lines were incubated with increasing concentrations of brusatol, and the metabolic activity was evaluated using the resazurin assay. Flow cytometry was used to evaluate cell death, cell cycle, mitochondrial membrane potential (Δψ
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10092207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Brittle Bone Disease: A Case Report.

    Luis, Tatiana / Gonçalves, Ana Cristina / Rodrigues, Eduardo / Mendes, Maricela / Teixeira, Tânia

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31259

    Abstract: Osteogenesis imperfecta (OI) is a rare genetic disorder. Due to considerable phenotypic variability, a classification was developed for OI subtypes based on clinical features and disease severity. A seven-day-old female was born at 40+1 weeks of ... ...

    Abstract Osteogenesis imperfecta (OI) is a rare genetic disorder. Due to considerable phenotypic variability, a classification was developed for OI subtypes based on clinical features and disease severity. A seven-day-old female was born at 40+1 weeks of gestation whose mother received routine antenatal care and had an uneventful pregnancy. In delivery, the newborn suffered bilateral collarbone fractures. After a week, she returned to an unscheduled appointment at the healthcare family unit due to an inconsolable cry and pain during mobilization of the left lower limb with three days of evolution, which were noticed by her parents. On examination, she presented edema in the right coxofemoral joint, asymmetry in the folds, and inconsolable crying during the mobilization of both hip joints. She was sent to the emergency department, where a pelvis X-ray was performed revealing a bilateral fracture of the femurs. During hospitalization, a genetic study revealed pathogenic variants of the
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Combination of Elacridar with Imatinib Modulates Resistance Associated with Drug Efflux Transporters in Chronic Myeloid Leukemia.

    Alves, Raquel / Gonçalves, Ana Cristina / Jorge, Joana / Almeida, António M / Sarmento-Ribeiro, Ana Bela

    Biomedicines

    2022  Volume 10, Issue 5

    Abstract: Multidrug resistance (MDR) development has emerged as a complication that compromises the success of several chemotherapeutic agents. In chronic myeloid leukemia (CML), imatinib resistance has been associated with changes ... ...

    Abstract Multidrug resistance (MDR) development has emerged as a complication that compromises the success of several chemotherapeutic agents. In chronic myeloid leukemia (CML), imatinib resistance has been associated with changes in
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10051158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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