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  1. Article ; Online: Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system.

    Gonçalves, Cristiano César Rodrigues Augusto / Feitosa, Beatriz Memória / Cavalcante, Beatriz Vieira / Lima, André Lucas Grangeiro de Sá Barreto / de Souza, Caroline Martins / Joventino, Larissa Brandão / Cavalcante, Marcelo Borges

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2023  Volume 90, Issue 3, Page(s) e13757

    Abstract: Currently, obesity is considered a global public health problem. It is the main risk factor for noncommunicable diseases and reproductive complications, such as recurrent miscarriage (RM). RM affects approximately 1% of couples of reproductive age, and ... ...

    Abstract Currently, obesity is considered a global public health problem. It is the main risk factor for noncommunicable diseases and reproductive complications, such as recurrent miscarriage (RM). RM affects approximately 1% of couples of reproductive age, and recent studies suggest that its prevalence is increasing. Immunological abnormalities may be responsible for a significant number of cases of unexplained RM. Obesity is recognized as a chronic low-grade inflammatory condition. The accumulation of fat in obese adipose tissue promotes changes in the local and systemic immune response. Adipokines, exosomes, micro-RNAs, lipids, and other factors released or secreted by adipose tissue are responsible for the interconnection between obesity and the immune system. Obesity-induced dysregulation of the innate and acquired immune response is also involved in the immunopathology of pregnancy loss in patients with unexplained RM. Therefore, understanding the communication pathways between maternal adipose tissue and the immune response in women living with obesity and RM is an important objective. Thus, diagnostic tools and new immunomodulatory therapies may be proposed for the management of patients with concurrent obesity and RM.
    MeSH term(s) Pregnancy ; Humans ; Female ; Abortion, Habitual/epidemiology ; Obesity/epidemiology ; MicroRNAs ; Immune System ; Adipose Tissue
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-08-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Dietary Inflammatory Index as a predictor of pregnancy outcomes: Systematic review and meta-analysis.

    de Freitas, Natércia Paula Alves / Carvalho, Thiago Ribeiro / Gonçalves, Cristiano César Rodrigues Augusto / da Silva, Pedro Henrique Alcântara / de Melo Romão, Lourena Guedes / Kwak-Kim, Joanne / Cavalcante, Marcelo Borges

    Journal of reproductive immunology

    2022  Volume 152, Page(s) 103651

    Abstract: Unhealthy diets have been linked to low-grade chronic inflammation, a condition known to play a role in the pathophysiology of non-communicable diseases as well as pregnancy complications. The Dietary Inflammatory Index (DII) is a tool for evaluating the ...

    Abstract Unhealthy diets have been linked to low-grade chronic inflammation, a condition known to play a role in the pathophysiology of non-communicable diseases as well as pregnancy complications. The Dietary Inflammatory Index (DII) is a tool for evaluating the inflammatory potential of various diets. The goal of this systematic review and meta-analysis is to assess the current state of evidence on the use of DII as a predictor of pregnancy outcomes in pregnant women. This study was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PROSPERO, number CRD42021288966). DII was evaluated as a predictor of obstetric complications in observational studies. The search was conducted in PubMed/Medline, Embase, and Web of Science. Data from eligible studies were extracted independently by two reviewers. The Newcastle-Ottawa Scale was used to assess the methodological quality of the studies. A total of eight studies were eligible for the review. In a meta-analysis of continuous and categorical variables, DII was a predictor of any obstetric complications [mean difference: 0.39, 95 %CI 0.02-0.75, (p = 0.04); and odds ratio: 1.24, 95 %CI 1.11-1.40, (p = 0.0002)]. High DII was associated with pregnancy complications, particularly preeclampsia/hypertensive disorder of pregnancy and preterm birth. The DII is a tool that can assist in the food and therapeutic planning of pregnant women with obstetric risks. Well-designed clinical trials are necessary, especially studies that focus on recurrent pregnancy losses and implantation failures.
    MeSH term(s) Diet ; Female ; Humans ; Infant, Newborn ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications ; Pregnancy Outcome ; Premature Birth
    Language English
    Publishing date 2022-06-03
    Publishing country Ireland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2022.103651
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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