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  1. Article ; Online: Nitric oxide status in sickle cell anemia.

    Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2012  Volume 34, Issue 4, Page(s) 255

    Language English
    Publishing date 2012-09-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20120063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Histopathological evaluation of the bone marrow in refractory anemia with ring sideroblasts and thrombocytosis associated to the JAK2-V617F mutation.

    Duarte, Fernando Barroso / Rocha, Francisco Dário / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 1, Page(s) 69–70

    Language English
    Publishing date 2014-02-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Histopathological evaluation of the bone marrow in refractory anemia with ring sideroblasts and thrombocytosis associated to the JAK2-V617F mutation.

    Duarte, Fernando Barroso / Filho, Francisco Dário Rocha / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 1, Page(s) 69–70

    Language Portuguese
    Publishing date 2014-03-12
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Idiopathic cytopenia of undetermined significance and systemic lupus erythematosus.

    Gonçalves, Romelia Pinheiro / Duarte, Fernando Barroso / Barbosa, Maritza Cavalcante

    Revista brasileira de hematologia e hemoterapia

    2013  Volume 35, Issue 5, Page(s) 372–373

    Language English
    Publishing date 2013-11-14
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20130068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immunosuppressive CD14

    Viana, Carlos Eduardo Menezes / Matos, Daniel Mazza / Oliveira, Maria de Fátima / da Costa, Alanna Carla / Filho, Tarcísio Paulo de Almeida / Filho, Pedro Aurio Maia / Nunes, Francisca Mylena Melgaço / Nogueira Dos Santos, Thayna / Gonçalves, Romélia Pinheiro / Queiroz, José Ajax Nogueira

    Acta tropica

    2021  Volume 224, Page(s) 106154

    Abstract: Chagas Disease (CD) is a neglected illness whose immunopathological mechanisms have not yet been plainly elucidated. The asymptomatic (indeterminate) form of CD is a long-term condition and approximately 20% to 35% of the individuals with this form ... ...

    Abstract Chagas Disease (CD) is a neglected illness whose immunopathological mechanisms have not yet been plainly elucidated. The asymptomatic (indeterminate) form of CD is a long-term condition and approximately 20% to 35% of the individuals with this form evolve into one of the three chronic symptomatic clinical forms of CD, namely: cardiac, digestive or cardio-digestive (mixed). A variant of blood monocytes characterized by low expression of the HLA-DR antigen (CD14
    MeSH term(s) Chagas Disease ; Flow Cytometry ; HLA-DR Antigens ; Humans ; Lipopolysaccharide Receptors ; Monocytes
    Chemical Substances HLA-DR Antigens ; Lipopolysaccharide Receptors
    Language English
    Publishing date 2021-09-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2021.106154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Myelodysplastic syndrome versus idiopathic cytopenia of undetermined significance: the role of morphology in distinguishing between these entities.

    Dos Santos, Talyta Ellen de Jesus / Gonçalves, Romélia Pinheiro / Duarte, Fernando Barroso

    Revista brasileira de hematologia e hemoterapia

    2013  Volume 35, Issue 6, Page(s) 438–439

    Language English
    Publishing date 2013-11-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20130069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comet assay in myelodysplastic syndromes.

    Teixeira Neto, Paulo Florentino / Pinheiro, Ronald Feitosa / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2012  Volume 34, Issue 4, Page(s) 317

    Language English
    Publishing date 2012-09-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20120080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immunosuppressive CD14+/HLA-DRlow/‒ monocytes in patients with Chagas Disease

    Viana, Carlos Eduardo Menezes / Matos, Daniel Mazza / Oliveira, Maria de Fátima / da Costa, Alanna Carla / Filho, Tarcísio Paulo de Almeida / Filho, Pedro Aurio Maia / Nunes, Francisca Mylena Melgaço / Nogueira dos Santos, Thayna / Gonçalves, Romélia Pinheiro / Queiroz, José Ajax Nogueira

    Acta tropica. 2021 Dec., v. 224

    2021  

    Abstract: Chagas Disease (CD) is a neglected illness whose immunopathological mechanisms have not yet been plainly elucidated. The asymptomatic (indeterminate) form of CD is a long-term condition and approximately 20% to 35% of the individuals with this form ... ...

    Abstract Chagas Disease (CD) is a neglected illness whose immunopathological mechanisms have not yet been plainly elucidated. The asymptomatic (indeterminate) form of CD is a long-term condition and approximately 20% to 35% of the individuals with this form evolve into one of the three chronic symptomatic clinical forms of CD, namely: cardiac, digestive or cardio-digestive (mixed). A variant of blood monocytes characterized by low expression of the HLA-DR antigen (CD14⁺/HLA-DRˡᵒʷ/‒) constitutes a subtype of myeloid-derived suppressor cells (MDSCs) whose main function is to regulate exacerbated inflammatory processes. The development of the symptomatic forms of CD can be related to the interaction between the host's immune system and the CD14⁺/HLA-DRˡᵒʷ/‒ immunosuppressive monocytes. Here, we evaluated, by flow cytometry, the absolute number and the HLA-DR antigenic density of this population of MDSCs in 57 patients with the diagnosis of CD: 34 with the symptomatic clinical forms (26 cardiac and 8 mixed) and 23 with the asymptomatic (indeterminate) form. The asymptomatic form exhibited a greater number of CD14⁺/HLA-DRˡᵒʷ/‒ monocytes and, accordingly, a low HLA-DR antigenic density, when compared to the symptomatic forms. It is possible to speculate that the predominance of CD14⁺/HLA-DRˡᵒʷ/– monocytes in the patients with the asymptomatic (indeterminate) form might have been a factor that could delay or even prevent the evolution of the asymptomatic form to the symptomatic forms of Chagas Disease.
    Keywords Chagas disease ; antigens ; evolution ; flow cytometry ; immunosuppression ; monocytes
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2021.106154
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 52/75: Show issues

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  9. Article ; Online: Monocyte chemoatractant protein-1: a potential biomarker of renal lesion and its relation with oxidative status in sickle cell disease.

    dos Santos, Talyta Ellen de Jesus / Gonçalves, Romélia Pinheiro / Barbosa, Maritza Cavalcante / da Silva, Geraldo Bezerra / Daher, Elizabeth De Francesco

    Blood cells, molecules & diseases

    2015  Volume 54, Issue 3, Page(s) 297–301

    Abstract: Background: The aim of this study was to evaluate the monocyte chemoatractant protein-1 (MCP-1) as a novel biomarker of renal lesion in sickle cell disease (SCD) and correlate it with oxidative stress.: Methods: This is a prospective study with SCD ... ...

    Abstract Background: The aim of this study was to evaluate the monocyte chemoatractant protein-1 (MCP-1) as a novel biomarker of renal lesion in sickle cell disease (SCD) and correlate it with oxidative stress.
    Methods: This is a prospective study with SCD patients followed at a tertiary center in Brazil. Urine samples were collected to dosage of protein, MCP-1, malondialdehyde (MDA) and urinary creatinine. Patients taking hydroxyurea (SSHU) were compared to those not taking the drug (SS). Patients' data were also compared to a control group of 15 healthy blood donors.
    Results: MCP-1 dosage was increased in SCD patients (Control: 42.12±27.6; SSHU: 168.2±90.1 and SS: 231.4±123.7 p<0.0001). SS patients presented higher levels of MCP-1 in comparison to SSHU group (SSHU: 168.2±90.10 and SS: 231.4±123.7; p=0.023). The same results were observed for MDA (Control: 2:29±1:13; SSHU: 5.60±2.39 and SS: 7.23±2.64, p<0.0001) and NO (control: 2.25±1.9; SSHU: 56.54±9.1 and SS: 39.1±9.02, p<0.0001). A positive correlation was obtained between MCP-1 and MDA (r=0.34, p=0.01); albuminuria (r=0.5, p=0.03); NO (r=0.39, p=0.005).
    Conclusion: The outcomes of the study suggest that MCP-1 is a predictive biomarker of renal lesion that can also reflect damage caused by oxidative stress present in SCD.
    MeSH term(s) Adult ; Albuminuria/etiology ; Albuminuria/metabolism ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/urine ; Brazil/epidemiology ; Chemokine CCL2/urine ; Female ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Kidney Diseases/urine ; Male ; Middle Aged ; Oxidative Stress ; Prospective Studies ; Young Adult
    Chemical Substances CCL2 protein, human ; Chemokine CCL2
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2014.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: The role of iron overload on oxidative stress in sickle cell anemia.

    Dos Santos, Talyta Ellen de Jesus / de Sousa, Geane Félix / Barbosa, Maritza Cavalcante / Gonçalves, Romélia Pinheiro

    Biomarkers in medicine

    2012  Volume 6, Issue 6, Page(s) 813–819

    Abstract: Unlabelled: Repeated blood transfusions in patients with sickle cell anemia (SCA) increases the risk of iron overload (IO), contributing to oxidative stress.: Materials & methods: Blood samples of 15 SCA patients without IO (group 1) and 15 SCA ... ...

    Abstract Unlabelled: Repeated blood transfusions in patients with sickle cell anemia (SCA) increases the risk of iron overload (IO), contributing to oxidative stress.
    Materials & methods: Blood samples of 15 SCA patients without IO (group 1) and 15 SCA patients with IO (group 2) and 30 healthy individuals were collected to investigate oxidative stress. IO was categorized using repeated measures of serum ferritin. The biomarkers evaluated were plasmatic malondialdehyde (MDA), nitrite and erythrocyte catalase.
    Results: MDA and nitrite were higher in group 2 than in group 1 and the healthy group (p < 0.001 for MDA and nitrite). Catalase presented lower in group 2 than group 1 and the healthy group (p < 0.001). We obtained a positive correlation between ferritin and MDA (r = 0.40; p < 0.02), and between ferritin and nitrite (r = 0359; p = 0.023).
    Conclusion: The results demonstrated that IO is an important risk factor for enhanced oxidative stress in SCA.
    MeSH term(s) Adult ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/therapy ; Female ; Ferritins/blood ; Humans ; Iron Overload/complications ; Iron Overload/etiology ; Iron Overload/metabolism ; Male ; Malondialdehyde/blood ; Nitrites/blood ; Oxidative Stress ; Transfusion Reaction
    Chemical Substances Nitrites ; Malondialdehyde (4Y8F71G49Q) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.12.71
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6985: Show issues Location:
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